BLOOMINGTON, Ind. -- Air pollution regulations issued by the U.S. Environmental Protection Agency are estimated to save thousands of lives annually. A new study by researchers at Indiana University says these estimates are more uncertain than commonly believed. Researchers Kerry Krutilla, David H. Good and John D. Graham of the IU School of Public and Environmental Affairs analyzed the costs and expected lifesavings of nine regulations issued between 2011 and 2013. The bulk of these regulations require national emissions standards for hazardous air pollutants. The analysis ...

PITTSBURGH, May 26, 2015 - Researchers at the University of Pittsburgh School of Medicine have identified two new classes of RNAs that are closely associated with a protein known to be a prognostic biomarker for breast cancer and could play a role in progression of prostate cancer. Their findings were published in the June issue of the scientific journal RNA. Levels of human Y-box binding protein 1 (YB-1), which is involved in many cellular functions, have been shown to correlate with drug resistance and poor patient outcomes in a variety of cancers. The observation that ...

When Walt Disney created Mickey Mouse, he didn't give much thought to how he might bring his character to life in the real world. But robotics now puts that possibility within reach, so Disney researchers have found a way for a robot to mimic an animated character's walk. Beginning with an animation of a diminutive, peanut-shaped character that walks with a rolling, somewhat bow-legged gait, Katsu Yamane and his team at Disney Research Pittsburgh analyzed the character's motion to design a robotic frame that could duplicate the walking motion using 3D-printed links and ...

College Park, Md and Annapolis, Md -- A new study from researchers at the University of Maryland (UMD) and the National Socio-Environmental Synthesis Center (SESYNC) demonstrates that the highly contentious debate on climate change is fueled in part by how information flows throughout policy networks. The UMD and SESYNC researchers found that "echo chambers"--social network structures in which individuals with the same viewpoint share information with each other--play a significant role in climate policy communication. The researchers say that echo chambers may help ...

Ask any molecular plant biologist about RNA extractions and you might just open up the floodgates to the woes of troubleshooting. RNA extraction is a notoriously tricky and sensitive lab procedure. New protocols out of the University of Florida are quicker, more effective, and more reliable than previous methods. "Obtaining pure and intact RNA samples is essential for sequencing the active genes, or the transcriptome, of a plant," explains botanist Ingrid Jordon-Thaden, who developed the protocols. The protocols are given in bench-ready form with detailed notes and ...

Adam C. Levine, M.D., an emergency medicine physician at Rhode Island Hospital found that the World Health Organization's current weight-based guidelines for assessing malnutrition in children with diarrhea are not as reliable as measuring the child's upper arm circumference. His research was published in the Journal of Nutrition. Diarrhea is common among children who visit health facilities in developing nations. The traditional measures for determining whether a child is moderately or severely malnourished are based on assessing the child's weight directly. Levine found ...

Old-school field work meets cutting-edge technology! For decades, researchers have been making artificial eggs out of plaster, wood, and other materials to test how birds identify and reject the eggs that invading "brood parasites" sometimes sneak into their nests. But these methods have many limitations, and a new study published in the open-access journal PeerJ is the first to test the usefulness of 3D printed eggs for research on egg rejection. Brood parasites are birds that don't build nests of their own. Instead, they slip their eggs into the nests of other species, ...

Scientists at the Molecular Medicine Institute in Lisbon, Portugal, and at the University College London Ear Institute, United Kingdom, have developed a simple and efficient protocol to generate inner ear hair cells, the cells responsible for our hearing and sense of balance. This study is an important step for the future production of large numbers of these cells for use in cell transplantation therapies or large-scale drug screens. The research has just been published in the scientific journal Development at http://dev.biologists.org/. Sensory hair cells located in ...

COLUMBUS, Ohio - If you're watching television while using a second screen - like a smartphone or tablet - new research suggests that some of the most expensive marketing messages aimed at you are missing their mark. While the trend of "second screen" use has become pervasive, this is the first study to show that viewers have trouble recalling brands they see (or hear) on TV if they're using such devices. "Viewers don't even remember that your brand was there on TV because they were busy posting on Facebook or Twitter or reading email," said Jonathan Jensen, who led ...

Irvine, Calif., May 26, 2015 - The Millennium Drought in southeastern Australia forced Greater Melbourne, a city of 4.3 million people, to successfully implement innovations that hold critical lessons for water-stressed regions around the world, according to findings by UC Irvine and Australian researchers. It wasn't a new pipeline over the mountains, special rate hikes or a $6 billion desalination plant that kept faucets running. Rather, integrated outreach by utilities and agencies required to work together led to a culture shift among ordinary water users, according ...

CHARLOTTESVILLE, VA (MAY 26, 2015). A surgical skills laboratory and corresponding dissection curricula were established in the Department of Neurosurgery at the Cleveland Clinic in the 2011-2012 academic year. The authors describe how this came about and what it has meant for neurosurgical resident training and assessment of residents' surgical skills in the following paper: "Establishing a surgical skills laboratory and dissection curriculum for neurosurgical residency training" by James K. C. Liu, MD, and colleagues, published today online, ahead of print in the Journal ...

A new study has shed light on how cancer patients' attitudes and beliefs drive the use of complementary and alternative medicine. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings may help hospitals develop more effective and accessible integrative oncology services for patients. Although many cancer patients use complementary and alternative medicine, what drives this usage is unclear. To investigate, a team led by Jun Mao, MD and Joshua Bauml, MD, of the Abramson Cancer Center at the University of Pennsylvania's Perelman ...

This news release is available in French. Hormone therapy (HT) is prescribed to alleviate some of the symptoms of menopause in women. Menopausal women are more likely to be diagnosed with Alzheimer's disease but not other forms of dementia, and HT has been prescribed to treat cognitive decline in post-menopausal women with variable degrees of effectiveness. New research by Dr. Liisa Galea, at the University of British Columbia, suggests the form of estrogens used in HT and previous motherhood could be critical to explain why HT has variable effects. Research in ...

Being very overweight in your teens may double the risk of developing bowel cancer by the time you are middle aged, suggests research published online in the journal Gut. And a high level of an indicator of systemic inflammation--erythrocyte sedimentation rate, or ESR for short--at this age is also linked to heightened risk of the disease in later life, the study shows. Adult obesity and inflammation have been associated with an increased risk of bowel cancer, which is the third most common form of cancer among men, worldwide. However, less is known about how obesity ...

Road traffic noise is linked to a heightened risk of developing a mid-riff bulge, indicates research published online in Occupational & Environmental Medicine. Exposure to a combination of road traffic, rail, and aircraft noise may pose the greatest risk of acquiring a spare tyre--otherwise known as central obesity, and thought to be one of the most harmful types of fat deposition around the body--the findings suggest. The researchers assessed how much road traffic, rail, and aircraft noise 5075 people living in five suburban and rural areas around Stockholm, Sweden, ...

Patients aged 80 and above are significantly less likely to be investigated or aggressively treated after surgery than their younger counterparts, reveals a national audit of hospital deaths, published in the online journal BMJ Open. This is despite the fact that the oldest old have higher rates of trauma and multiple underlying conditions on admission, say the Australian researchers. Care in the oldest old may be less aggressive, or scaled down because the outcome is expected to be poor or treatment considered futile, they say. Perceived future quality of life issues ...

1. Appropriate duration of dual antiplatelet therapy still unclear Free abstract: http://www.annals.org/article.aspx?doi=10.7326/M15-0083 URL goes live when embargo lifts A systematic review of published evidence does little to clarify the appropriate duration of dual antiplatelet therapy (DAPT) following drug eluting stent placement. The evidence suggests that longer duration therapy decreases the risk for myocardial infarction, but increases the risk for major bleeding events, and may provide a slight increase in mortality. The results are published in Annals of Internal ...

Ovarian cancer is notoriously difficult to diagnose and treat, making it an especially fatal disease. Researchers at University of California, San Diego School of Medicine and Moores Cancer Center have now identified six mRNA isoforms (bits of genetic material) produced by ovarian cancer cells but not normal cells, opening up the possibility that they could be used to diagnose early-stage ovarian cancer. What's more, several of the mRNA isoforms code for unique proteins that could be targeted with new therapeutics. The study is published the week of May 25 by the Proceedings ...

Frailer older patients are at higher risk of readmission to hospital or death within 30 days after discharge from a general internal medicine ward, but health care professionals can assess who is at risk using the Clinical Frailty Scale, according to a study in CMAJ (Canadian Medical Association Journal) Readmission within 30 days after hospital discharge is common and also costly for the health care system. Identifying at-risk patients and addressing the factors contributing to readmission can help reduce recurrences. However, current tools are not able to predict accurately ...

This news release is available in French. Scientists measuring brain activity have found that in many regions, such as the sensory or motor cortex, activity sometimes oscillates at different frequencies, forming wave-like patterns. Despite the fact that such oscillations are frequently observed, and present in many brain regions, their functional role remains unclear. Research done by Dr. Christopher Pack, from McGill University, who looked at such waves occurring in a region of the visual cortex of the brain, suggests these oscillations could have a role in resetting ...

Cold Spring Harbor, NY -- A team of scientists at Cold Spring Harbor Laboratory (CSHL) has identified a set of genes that control stem cell production in tomato. Mutations in these genes explain the origin of mammoth beefsteak tomatoes. More important, the research suggests how breeders can fine-tune fruit size in potentially any fruit-bearing crop. The research appears online today in Nature Genetics. In its original, wild form the tomato plant produces tiny, berry-sized fruits. Yet among the first tomatoes brought to Europe from Mexico by conquistador Hernan Cortez in ...

UPTON, NY -- Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have just taken a big step toward the goal of engineering dynamic nanomaterials whose structure and associated properties can be switched on demand. In a paper appearing in Nature Materials, they describe a way to selectively rearrange the nanoparticles in three-dimensional arrays to produce different configurations, or phases, from the same nano-components. "One of the goals in nanoparticle self-assembly has been to create structures by design," said Oleg Gang, who led the work ...

New research conducted in a rural community in Pakistan highlights the crucial role that essential fatty acids play in human brain growth and function. A team co-led by the University of Exeter, working with experts in Singapore, has published findings in Nature Genetics which show that mutations in the protein Mfsd2a cause impaired brain development in humans. Mfsd2a is the transporter in the brain for a special type of fat called lysophosphatidylcholines (LPCs) -- which are composed of essential fatty acids like omega-3. This shows the crucial role of these fats in ...

Having a healthy gut may well depend on maintaining a complex signaling dance between immune cells and the stem cells that line the intestine. Scientists at the Buck Institute are now reporting significant new insight into how these complex interactions control intestinal regeneration after a bacterial infection. It's a dance that ensures repair after a challenge, but that also goes awry in aging fruit flies -- the work thus offers important new clues into the potential causes of age-related human maladies, such as irritable bowel syndrome, leaky gut and colorectal cancer. "We've ...

May 26, 2015, Shenzhen, China - Researchers from BGI reported the most complete haploid-resolved diploid genome (HDG) sequence based on de novo assembly with NGS technology and the pipeline developed lays the foundation for de novo assembly of genomes with high levels of heterozygosity. The latest study was published online today in Nature Biotechnology. The human genome is diploid, and knowledge of the variants on each chromosome is important for the interpretation of genomic information. In this study, researchers presented the assembly of a haplotype-resolved diploid ...