In the most comprehensive look yet at the safety of abortion, researchers at UC San Francisco have concluded that major complications are rare, occurring less than a quarter of a percent of the time, about the same frequency as colonoscopies. The study, published online on Monday, Dec. 8, 2014, in Obstetrics & Gynecology, analyzed data from more than 50,000 women enrolled in the Medi-Cal fee-for-service program who obtained abortions from 2009 to 2010, and looked for complications that occurred within six weeks of the procedure. The rate is similar to what has been ...

Glucose is a component of carbohydrates, and the main energy source used by brain cells. By studying rats, a team at Imperial College London identified a mechanism that appears to sense how much glucose is reaching the brain, and prompts animals to seek more if it detects a shortfall. The researchers believe it may play a role in driving our preference for sweet and starchy foods. The study, funded by the Biotechnology and Biological Sciences Research Council, is published in the Journal of Clinical Investigation. Dr James Gardiner, from the Department of Medicine, ...

Patients with plasma cell dyscrasis have high amounts of an abnormal immunoglobulin, called a paraprotein, in their blood. While many patients have no outward symptoms, paraproteins can impair immune function, thicken blood, and damage organs. Plasma cell dyscrasis may be inherited, but risk factors for this disease are poorly understood. A new study in the Journal of Clinical Investigation suggests that the presence of a modified host protein is associated with plasma cell dyscrasis risk. Michael Pfreundschuh and colleagues evaluated paraproteins in blood from patients ...

Glucose is the primary fuel for the brain. Therefore, it has been proposed that the brain must sense glucose and promote eating behaviors when levels are low. A new study in the Journal of Clinical Investigation reveals that activation of an enzyme, glucokinase, in a region of the hypothalamus called the arcuate nucleus specifically increases glucose uptake. Steve Bloom and colleagues at Imperial College London determined that glucokinase levels in the arcuate nucleus are dramatically increased in fasted rats. In their rodent models, activation of glucokinase in the acruate ...

Saturn's largest moon, Titan, is one of the few solar system bodies - and the only planetary moon - known to have fields of wind-blown dunes on its surface. (The others are Venus, Earth and Mars.) New research, using experimental results from the high-pressure wind tunnel at Arizona State University's Planetary Aeolian Laboratory, has found that previous estimates of how fast winds need to blow to move sand-size particles around on Titan are about 40 percent too low. A team of scientists led by Devon Burr of the University of Tennessee, Knoxville reported the findings ...

An enormous spectrum of light streams from the sun. We're most familiar with the conventional visible white light we see with our eyes from Earth, but that's just a fraction of what our closest star emits. NASA regularly watches the sun in numerous wavelengths because different wavelengths provide information about different temperatures and processes in space. Looking at all the wavelengths together helps to provide a complete picture of what's occurring on the sun over 92 million miles away - but no one has been able to focus on high energy X-rays from the sun until recently. In ...

COLUMBUS, Ohio - When it comes to specialized cancer surgery, it's generally true that the more experienced the surgeon, the better the outcome. The same might hold true for radiation therapy used to treat head and neck cancer, according to a new study led by researchers Evan Wuthrick, MD, assistant professor of radiation oncology at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James), and Maura Gillison, MD, PhD, professor of internal medicine and epidemiology at the OSUCCC - ...

A team of researchers at Dartmouth College and University of Pittsburgh found respondents who had smoked water pipe tobacco but not smoked cigarettes were at increased risk of cigarette smoking two years later as recently published online in JAMA Pediatrics. The study followed 2,541 adolescents and young adults for two years. Samir Soneji, PhD, a tobacco regulatory control researcher at Dartmouth and lead author on the study said, "We found hookah smoking increased the probability of trying cigarette smoking over the next two years by 19%." This longitudinal study ...

Drinking or eating from cans or bottles lined with Bisphenol A (BPA) could raise your blood pressure, according to new research reported in the American Heart Association's journal Hypertension. BPA, a chemical used as an epoxy lining for cans and plastic bottles, is everywhere, and its consumption has been associated with high blood pressure and heart rate variability. Previous studies have shown that BPA can leach into foods and drinks. "A 5 mm Hg increase in systolic blood pressure by drinking two canned beverages may cause clinically significant problems, particularly ...

Nine in 10 primary care physicians say that prescription drug abuse is a moderate or big problem in their communities and nearly half say they are less likely to prescribe opioids to treat pain compared to a year ago, new Johns Hopkins Bloomberg School of Public Health research suggests. Primary care doctors also appear to recognize many risks of prescription opioid use, including addiction and death by overdose, according to the findings reported in the Dec. 8 issue of JAMA Internal Medicine. "Our findings suggest that primary care providers have become aware of the ...

A survey of primary care physicians found the vast majority of practicing internists, family physicians and general practitioners consider prescription drug abuse to be a significant problem in their community and most physicians agreed opioids were overused to treat pain, according to a research letter published online by JAMA Internal Medicine. Primary care physicians are critical in maximizing the safe use of opioid pain-relieving medications. It is because of this that Catherine S. Hwang, M.S.P.H., of the Johns Hopkins Bloomberg School of Public Health, Baltimore, ...

Smoking water pipe tobacco from hookahs and using the smokeless tobacco snus were associated with initiating cigarette smoking and smoking cigarettes in the past 30 days among previously nonsmoking teenagers and young adults, according to a study published online by JAMA Pediatrics. The Food and Drug Administration regulates cigarettes, loose tobacco and smokeless tobacco products. However, the FDA does not regulate the manufacturing, distribution and marketing of other tobacco products, such as water pipe tobacco, and many of those products are used by teenagers and ...

Salt Lake City - Develop 100 drugs in 10 years. That's the ambitious goal set by a group of scientists and engineers at the University of Utah, founders of Recursion Pharmaceuticals, a start-up company that is able to quickly and affordably identify unexpected ways a drug could be used by testing it on diseased cells. The disruptive approach to drug development, aided by custom-designed software capable of tracking changes, or signs of healing, in cells, could speed discovery of therapies for so-called "orphan" diseases. Scientists at Recursion have already identified ...

(SACRAMENTO, Calif.) -- Children with autism spectrum disorder (ASD) were more than twice as likely to have been exposed in utero to preeclampsia, and the likelihood of an autism diagnosis was even greater if the mother experienced more severe disease, a large study by researchers with the UC Davis MIND Institute has found. Women with preeclampsia experience hypertension during the latter half of their pregnancies, and may have increased levels of protein in their urine and edema, or fluid retention. Preeclampsia can develop into eclampsia, a life-threatening condition ...

New York, NY, December 8, 2014 - Challenges to global health can evolve from policies and decisions that take years or decades to unfold. An article in the current issue of the Annals of Global Health describes the current state of asbestos use worldwide, a story that began over 100 years ago, and the real and contrived controversies regarding asbestos. At the peak of asbestos use in 1972 in the United States, more than 775,000 tons of asbestos were used, much of it by the construction trades and shipbuilding industry, in addition to the manufacturing of many consumer ...

There are strong economic incentives for governments to invest in early childhood nutrition, reports a new paper from the University of Waterloo and Cornell University. Published for the Copenhagen Consensus Centre, the paper reveals that every dollar spent on nutrition during the first 1,000 days of a child's life can provide a country up to $166 in future earnings. "The returns on investments in nutrition have high benefit-cost ratios, especially in countries with higher income levels and a growing economy," said Professor Susan Horton, of the School of Public Health ...

Older Latinos living in the U.S. who perceive their neighborhoods as safer and more walkable are less likely to develop severe depressive symptoms, and the effect may be long term, a new study suggests. Researchers examined links between the onset of depressive symptoms in 570 older Latino adults and various characteristics of the Greater Los Angeles neighborhoods they lived in, including crime, the availability and quality of sidewalks, traffic safety and aesthetics. Participants ranged in age from 60 to 90, and 351 of them screened positive for low levels of depression ...

The opioid pain-reliever tramadol appears to be associated with an increased risk of hospitalization for hypoglycemia, a potentially fatal condition caused by low blood sugar, according to a report published online by JAMA Internal Medicine. Tramadol hydrochloride is a weak opioid whose use has increased steadily worldwide. However, concerns have been raised about the drug and an increased risk for hypoglycemia. Because of increasing use of the doctor-prescribed pain reliever, researchers at McGill University and the Lady Davis Institute at the Jewish General Hospital ...

LOS ANGELES - (Dec. 8, 2014) - In the U.S. and around the globe, skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus (MRSA) continue to endanger the health and lives of patients and otherwise healthy individuals. Treatment is difficult because MRSA is resistant to many antibiotics, and the infections can recur, placing family members and other close contacts at risk of infection. A study reported online today in the Proceedings of the National Academy of Sciences USA holds new hope for preventing or reducing the severity of infections ...

Everyday events are easy to forget, but unpleasant ones can remain engraved in the brain. A new study published in the Proceedings of the National Academy of Sciences identifies a neural mechanism through which unpleasant experiences are translated into signals that trigger fear memories by changing neural connections in a part of the brain called the amygdala. The findings show that a long-standing theory on how the brain forms memories, called Hebbian plasticity, is partially correct, but not as simple as was originally proposed. The effort led by Joshua Johansen from ...

A new genetic therapy not only helped blind mice regain enough light sensitivity to distinguish flashing from non-flashing lights, but also restored light response to the retinas of dogs, setting the stage for future clinical trials of the therapy in humans. The therapy employs a virus to insert a gene for a common ion channel into normally blind cells of the retina that survive after the light-responsive rod and cone photoreceptor cells die as a result of diseases such as retinitis pigmentosa. Photoswitches - chemicals that change shape when hit with light -are then ...

CAMBRIDGE, Mass. (December 8, 2014) - Long known for its ability to help organisms successfully adapt to environmentally stressful conditions, the highly conserved molecular chaperone heat-shock protein 90 (HSP90) also enables estrogen receptor-positive (ER+) breast cancers to develop resistance to hormonal therapy. This HSP90-mediated evolutionary mechanism of drug resistance, reported by Whitehead Institute scientists in this week's online edition of the Proceedings of the National Academy of Sciences (PNAS), provides a strong therapeutic rationale for combining HSP90 ...

Two-dimensional (2D) layered materials are now attracting a lot of interest due to their unique optoelectronic properties at atomic thicknesses. Among them, graphene has been mostly investigated, but the zero-gap nature of graphene limits its practical applications. Therefore, 2D layered materials with intrinsic band gaps such as MoS2, MoSe2, and MoTe2 are of interest as promising candidates for ultrathin and high-performance optoelectronic devices. Here, Pil Ju Ko and colleagues at Toyohashi University of Technology, Japan have fabricated back-gated field-effect phototransistors ...

Hummingbirds' remarkable ability to hover in place is highly contingent on the tiny bird having a completely stationary visual field, according to University of British Columbia research published in the Proceedings of the National Academy of Sciences. UBC zoologists Benjamin Goller and Douglas Altshuler projected moving spiral and striped patterns in front of free-flying hummingbirds attempting to feed from a stationary feeder. Even minimal background pattern motion caused the hummingbirds to lose positional stability and drift. Giving the birds time to get used ...

A new advance in biomedical research at the University of Leicester could have potential in the future to assist with tackling diseases and conditions associated with ageing - as well as in treating cancer. The research, which has shown promise in clinical samples, has been published in the prestigious scientific journal, Cell Death and Disease. The group of scientists coordinated by Dr Salvador Macip from the Mechanisms of Cancer and Ageing Lab and the Department of Biochemistry of the University of Leicester carried out the study to find new ways of identifying old ...