Boulder, Colo., USA - Seismic hazards in the Puget Lowland of northwestern Washington include deep earthquakes associated with the Cascadia subduction zone and shallow earthquakes associated with crustal faults across the region. Research presented in Geosphere this month establishes not only that one of the more prominent crustal faults, the Darrington-Devils Mountain fault zone, displays evidence of strong earthquakes in the past, but that it will likely be a source of strong earthquakes in the future. Paleoseismic investigations on the Darrington-Devils Mountain fault ...

New Rochelle, NY, November 13, 2014--The two U.S. FDA approved oligonucleotide-based drugs on the market both have a modified chemical backbone made of phosphorothioates. The therapeutic advantages of the phosphorothioate group and the new types of gene expression-regulation oligonucleotide drugs that it is enabling are detailed in a Review article in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers. The article is available free on the Nucleic Acid Therapeutics website until December 13, 2014. In the article "Phosphorothioates, ...

WEST LAFAYETTE, Ind. - Researchers from Purdue and Colorado State universities have discovered that the fungus responsible for thousand cankers disease, a lethal affliction of walnut trees and related species, has a rich genetic diversity that may make the disease more difficult to control. Adjunct assistant professor of forestry Keith Woeste and fellow researchers analyzed the genes of 209 samples of Geosmithia morbida from 17 regions of the U.S. to determine the genetic diversity of the fungus, its possible origin and how it spread throughout the West and to parts of ...

Anesthesia, long considered a blessing to patients and surgeons, has been a mystery for much of its 160-plus-year history in the operating room. No one could figure out how these drugs interact with the brain to block pain and induce a coma-like, memory-free state. The debate has divided the anesthesia research community into two camps: one that believes anesthetics primarily act on the cell membrane (the lipid bilayer) of nerve cells, perhaps altering it to the point that embedded proteins cannot function normally. The other says the membrane proteins themselves are ...

For the first time in history, a spacecraft has landed on a comet. The momentous event represents the culmination of 35 years of research on comets by Prof. Akiva Bar-Nun of Tel Aviv University's Department of Geosciences and other scientists working for the European Space Agency. At 08:35 GMT on Wednesday, November 12, the European Space Agency's Rosetta satellite released its lander Philae towards Comet 67P/Churyumov-Gerasimenko, a large mass of ice and dust some 316 million miles from Earth. The descent took approximately seven hours, with a signal confirming touchdown ...

West Lafayette, Ind. (November 13, 2014): Scientists with the U.S. Forest Service and Colorado State University examined a fungus native to North America, the native beetle that carries it, and their host tree and found something surprising: Geosmithia morbida and the walnut twig beetle co-evolved and, while the beetle/fungus complex was once the equivalent of a hang nail for a black walnut tree, it has become lethal. Research published today in the journal PLOS ONE by U.S. Forest Service scientist Keith Woeste, Colorado State University scientists Marcelo M. Zerillo ...

This news release is available in French. Montreal November 13, 2014 - Is it possible to change the amount of information the brain can store? Maybe, according to a new international study led by the Research Institute of the McGill University Health Centre (RI-MUHC). Their research has identified a molecule that puts a brake on brain processing and when removed, brain function and memory recall is improved. Published in the latest issue of Cell Reports, the study has implications for neurodevelopmental and neurodegenerative diseases, such as autism spectral disorders ...

TORONTO, ON (13 November 2014) Astronomers from the University of Toronto and the University of Arizona have provided the first direct evidence that an intergalactic "wind" is stripping galaxies of star-forming gas as they fall into clusters of galaxies. The observations help explain why galaxies found in clusters are known to have relatively little gas and less star formation when compared to non-cluster or "field" galaxies. Astronomers have theorized that as a field galaxy falls into a cluster of galaxies, it encounters the cloud of hot gas at the centre of the cluster. ...

Some plants form into new species with a little help from their friends, according to Cornell University research published Oct. 27 in the Proceedings of the National Academy of Sciences. The study finds that when plants develop mutually beneficial relationships with animals, mainly insects, those plant families become more diverse by evolving into more species over time. The researchers conducted a global analysis of all vascular plant families, more than 100 of which have evolved sugary nectar-secreting glands that attract and feed protective animals, such as ants. ...

Who would have thought a Sesame Street video starring the Cookie Monster, of all characters, could teach preschoolers self-control? But that's exactly what Deborah Linebarger, an associate professor in Teacher and Learning at the University of Iowa, found when she studied a group of preschoolers who repeatedly watched videos of Cookie Monster practicing ways to control his desire to eat a bowl of chocolate chip cookies. "Me want it," Cookie Monster sings in one video, "but me wait." In fact, preschoolers who viewed the Cookie Monster video were able to wait four ...

In a potential breakthrough against ovarian cancer, University of Guelph researchers have discovered how to both shrink tumours and improve drug delivery, allowing for lower doses of chemotherapy and reducing side effects. Their research appears today in the FASEB Journal, one of the world's top biology publications. "We hope that this study will lead to novel treatment approaches for women diagnosed with late-stage ovarian cancer," said Jim Petrik, a Guelph biomedical sciences professor. He worked on the study with Guelph graduate student Samantha Russell and cancer ...

LAWRENCE -- Like hedonistic rock stars that live by the "better to burn out than to fade away" credo, certain galaxies flame out in a blaze of glory. Astronomers have struggled to grasp why these young "starburst" galaxies -- ones that are very rapidly forming new stars from cold molecular hydrogen gas up to 100 times faster than our own Milky Way -- would shut down their prodigious star formation to join a category scientists call "red and dead." Starburst galaxies typically result from the merger or close encounter of two separate galaxies. Previous research had revealed ...

INDIANAPOLIS -- Researchers have identified two proteins that appear crucial to the development -- and patient relapse -- of acute myeloid leukemia. They have also shown they can block the development of leukemia by targeting those proteins. The studies, in animal models, could lead to new effective treatments for leukemias that are resistant to chemotherapy, said Reuben Kapur, Ph.D., Freida and Albrecht Kipp Professor of Pediatrics at the Indiana University School of Medicine. The research was reported today in the journal Cell Reports. "The issue in the field for ...

Plants all over the world are more sensitive to drought than many experts realized, according to a new study by scientists at UCLA and China's Xishuangbanna Tropical Botanical Garden. The research will improve predictions of which plant species will survive the increasingly intense droughts associated with global climate change. The research is reported online by Ecology Letters, the most prestigious journal in the field of ecology, and will be published in an upcoming print edition. Predicting how plants will respond to climate change is crucial for their conservation. ...

MOUNT VERNON, Wash. -- A new study by researchers at Washington State University shows that mechanical harvesting of cider apples can provide labor and cost savings without affecting fruit, juice, or cider quality. The study, published in the journal HortTechnology in October, is one of several studies focused on cider apple production in Washington State. It was conducted in response to growing demand for hard cider apples in the state and the nation. Quenching a thirst for cider Hard cider consumption is trending steeply upward in the region surrounding the food-conscious ...

As our society ages, a University of Montreal study suggests the health system should be focussing on comorbidity and specific types of disabilities that are associated with higher health care costs for seniors, especially cognitive disabilities. Comorbidity is defined as the presence of multiple disabilities. Michaël Boissonneault and Jacques Légaré of the university's Department of Demography came to this conclusion after assessing how individual factors are associated with variation in the public costs of healthcare by studying disabled Quebecers over ...

The scientists showed that the Parkin protein functions to repair or destroy damaged nerve cells, depending on the degree to which they are damaged People living with Parkinson's disease often have a mutated form of the Parkin gene, which may explain why damaged, dysfunctional nerve cells accumulate Dublin, Ireland, November 13th, 2014 - Scientists at Trinity College Dublin have made an important breakthrough in our understanding of Parkin - a protein that regulates the repair and replacement of nerve cells within the brain. This breakthrough generates a new perspective ...

There are no approved treatments or preventatives against Ebola virus disease, but investigators have now designed peptides that mimic the virus' N-trimer, a highly conserved region of a protein that's used to gain entry inside cells. The team showed that the peptides can be used as targets to help researchers develop drugs that might block Ebola virus from entering into cells. "In contrast to the most promising current approaches for Ebola treatment or prevention, which are species-specific, our 'universal' target will enable the selection of broad-spectrum inhibitors ...

In a study of middle-aged men who were overweight, researchers found that if a man's parents were older at the time of his birth, he was more likely to have lower blood pressure, more favorable cholesterol levels, and improved glucose metabolism. It's unknown whether the beneficial effect was due to having an older mother, an older father, or both. Additional studies are necessary to help shed light on the effects of parental age at childbirth on the metabolism of men and women. "In particular, more research is required to understand whether these effects are due to ...

In a study that looked at what factors might affect whether or not a patient receives intensive medical procedures in the last 6 months of life, investigators found that older age, Alzheimer's disease, cancer, living in a nursing home, and having an advance directive were associated with a lower likelihood of undergoing an intensive procedure. In contrast, living in a region with higher hospital care intensity and black race each doubled a patient's likelihood of undergoing an intensive procedure. "It's pretty striking the extent to which nonclinical factors--such as ...

Preeclampsia, a late-pregnancy disorder that is characterized by high blood pressure and organ damage, may be caused by problems related to meeting the oxygen demands of the growing fetus, experts say in a new Anaesthesia paper. Left untreated, preeclampsia can lead to serious--even fatal--complications for a pregnant woman and her baby. The new theory challenges the current view that pre-eclampsia is caused by a problem with the placenta. "When the fetus is not getting enough oxygen and nutrients for its growth--due to conditions in the mother, conditions in the placenta ...

Investigators recently set out to consider whether homicides involving social networking sites were unique and worthy of labels such as 'Facebook Murder', and to explore the ways in which perpetrators had used such sites in the homicides they had committed. The cases they identified were not collectively unique or unusual when compared with general trends and characteristics--certainly not to a degree that would necessitate the introduction of a new category of homicide or a broad label like 'Facebook Murder'. "Victims knew their killers in most cases, and the crimes ...

Stanching the free flow of blood from an injury remains a holy grail of clinical medicine. Controlling blood flow is a primary concern and first line of defense for patients and medical staff in many situations, from traumatic injury to illness to surgery. If control is not established within the first few minutes of a hemorrhage, further treatment and healing are impossible. At UC Santa Barbara, researchers in the Department of Chemical Engineering and at Center for Bioengineering (CBE) have turned to the human body's own mechanisms for inspiration in dealing with the ...

Researchers at the University of Texas Medical Branch at Galveston, in collaboration with The University of Texas Health Science Center at Houston (UTHealth), Baylor College of Medicine and the Georgia Regents University, report for the first time that the cholesterol-lowering drug simvastatin inhibits the growth of human uterine fibroid tumors. These new data are published online and scheduled to appear in the January print edition of the Journal of Biological Chemistry. Statins, such as simvastatin, are commonly prescribed to lower high cholesterol levels. Statins ...

A study from the Institute of Food Research has shown that Campylobacter's persistence in food processing sites and the kitchen is boosted by 'chicken juice.' Organic matter exuding from chicken carcasses, "chicken juice", provides these bacteria with the perfect environment to persist in the food chain. This emphasises the importance of cleaning surfaces in food preparation, and may lead to more effective ways of cleaning that can reduce the incidence of Campylobacter. The study was led by Helen Brown, a PhD student supervised by Dr Arnoud van Vliet at IFR, which is ...