DETROIT — A major new pediatric research study led by a Wayne State University researcher, funded by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health (NIH) and published this week in the New England Journal of Medicine (NEJM), has "major implications" for the treatment of urinary tract infections (UTIs) in millions of American children. The largest study of its kind in the world, it provides convincing evidence that children with a common urinary-tract abnormality known as "vesicoureteral reflux" (or "VUR") experience ...

The world first review explored interpersonal racism perpetrated by healthcare providers, a key driver of racial disparities in health. Interpersonal racism refers to racist interactions between individuals, rather than internalised or systemic or institutional racism. Researchers Ms Mandy Truong and Dr Naomi Priest from the University of Melbourne and Professor Yin Paradies from Deakin University, reviewed 37 studies published between 1995 and 2012 of racism among healthcare providers. The review assessed attitudes towards race held by physicians, nurses and allied ...

From jasmine to sandalwood, the alluring scents of the most luxurious perfumes might seem more art than science, but a new way to analyze them breaks from the tradition of relying only on experts' sense of smell to blend fragrances. Scientists report that they have developed a model that can help perfumers predict how various combinations of chemicals will smell. The study appears in the ACS journal Industrial & Engineering Chemistry Research. Miguel A. Teixeira and colleagues from LSRE laboratory in Portugal explain that the design of new fragrances for the perfume industry ...

Scientists have been linking an increasing range of behaviors and inclinations from monogamy to addiction to animals', including humans', underlying biology. To that growing list, they're adding division of labor — at least in killer bees. A report published in ACS' Journal of Proteome Research presents new data that link the amounts of certain neuropeptides in these notorious bees' brains with their jobs inside and outside the hive. Mario Sergio Palma and colleagues explain that dividing tasks among individuals in a group is a key development in social behavior among ...

While flexible gadgets such as "electronic skin" and roll-up touch screens are moving ever closer to reality, their would-be power sources are either too wimpy or too stiff. But that's changing fast. Scientists have developed a new device that's far thinner than paper, can flex and bend, and store enough energy to provide critical back-up power for portable electronics. Their report appears in the Journal of the American Chemical Society. In their paper, James Tour and colleagues point out that many materials that have been investigated for energy storage potential are ...

BETHESDA, MD – May 7, 2014 – The power of genome-wide association studies (GWAS) to detect genetic influences on human disease can be substantially increased using a statistical testing framework reported in the May issue of the journal GENETICS. Despite the proliferation of GWAS, the associations found so far have largely failed to account for the known effects of genes on complex disease — the problem of "missing heritability." Standard approaches also struggle to find combinations of multiple genes that affect disease risk in complex ways (known as genetic interactions). The ...

Earlier this year, bloggers scored a high-profile victory in their campaign against a common bread ingredient — also used in yoga mats and other plastics — when Subway announced it was dropping the substance from its dough recipe. The case highlights the powerful influence of online campaigns, and how they are changing the food industry, according to an article in Chemical & Engineering News (C&EN), the weekly news magazine of the American Chemical Society. Melody M. Bomgardner, senior editor at C&EN, notes that consumers' curiosity and outrage about what's in their ...

This news release is available in French. Children who wheeze are at risk of developing damage that will affect their lung function by the age of 6 years, according to researchers at CHU Sainte-Justine Hospital and the University of Montreal. These appear to be persistent, even if asthma symptoms seem to disappear at least temporarily by school age in several cases. Children with recurrent symptoms that are severe enough to warrant a visit to the emergency department are particularly at risk of seeing their lung function affected. This may persist in adulthood and into ...

Swiss scientists have discovered a new species of aculeate wasp, not hidden somewhere in a jungle on a remote continent, but in Central Europe, in a swampy area just a few kilometers from Zurich. The new species named "Polistes helveticus", or the Swiss paper wasp, was described in the open access journal ZooKeys. Paradoxically, this species has been long known in Central Europe but was confused for decades with a closely related species native to southern Europe. Only after the latter expanded its range to northern Switzerland, possibly following climate change, was ...

A recent study reported by Haigang Chang and co-workers from the First Affiliated Hospital of Xinxiang Medical University in China verified the effects of transient axonal glycoprotein-1 (TAG-1) on cell viability and p53, epidermal growth factor receptor (EGFR), and amyloid precursor protein (APP) intracellular C-terminal domain (AICD) expression in U251 glioma cells. Their pilot study showed that the signaling pathways induced by TAG-1, TAG-1/APP/AICD/p53 and TAG-1/APP/AICD/EGFR, did not inhibit glioma development by inhibiting cell proliferation or by inducing apoptosis. ...

Shuganjieyu capsule has been approved for clinical treatment by the State Food and Drug Administration of China since 2008. In the clinic, Shuganjieyu capsule is often used to treat mild to moderate depression. Prof. Jingping Zhao and team from the Second Xiangya Hospital, Central South University in China conducted a study to examine the effect of Shuganjieyu capsule on behavioral changes in a rat model of depression. They focused on the underlying mechanisms of Shuganjieyu capsule by examining brain-derived neurotrophic factor and phosphorylated cyclic adenosine monophosphate ...

Emotions like fear, anger, sadness, and joy enable people to adjust to their environment and react flexibly to stress and strain and are vital for cognitive processes, physiological reactions, and social behaviour. The processing of emotions is closely linked to structures in the brain, i.e. to what is known as the limbic system. Within this system the amygdala plays a central role – above all it processes negative emotions like anxiety and fear. If the activity of the amygdala becomes unbalanced, depression and anxiety disorders may develop. Researchers at the Psychiatric ...

The effects of Amyloid beta (Aβ)-Aβ-binding alcohol dehydrogenase (ABAD) may exacerbate Alzheimer's disease pathology. Therefore, blocking Aβ-ABAD-mediate effects with ABAD decoy peptide (ABAD-DP) may be a potential therapeutic strategy for Alzheimer's disease. Dr. Jiang Wu and team from the First Hospital of Jilin University in China successfully constructed a recombinant adenovirus constitutively secreting and expressing Aβ-ABAD decoy peptide (rAAV/ABAD-DP-6His). Their results showed that rAAV/ABAD-DP-6His increased superoxide dismutase activity in ...

In human cells, DNA occurs only in the cell nucleus as the carrier of genetic information. In order to protect it, specialized proteins regularly scan the individual strands for defects, and repair them. One example of this is the protein Rad50, a DNA sensor that binds to DNA and detects defective sites. A team of scientists headed by Prof. Jürgen Ruland of the TUM together with colleagues from the LMU have now discovered another important task performed by Rad50. There is normally no DNA in the cytoplasm surrounding the cell nucleus. However, if any does turn up there, ...

Amyloid-β (Aβ) plaques and neurofibrillary tangles are the main pathological hallmarks of Alzheimer's disease, as well as the loss of neurons and synapses. recent reports have shown that estrogen exerts neuroprotective effects. However, large clinical trials in postmenopausal women indicated adverse side-effects of estrogens, such as increased incidence of breast cancer and metrocarcinoma, thereby preventing clinical use of estrogen. Tongluojiunao (TLJN) is an herbal medicine consisting of two main components, geniposide and ginsenoside Rg1. Prof. Qian Hua and ...

University of Houston physicists have discovered a new thermoelectric material offering high performance at temperatures ranging from room temperature up to 300 degrees Celsius, or about 573 degrees Fahrenheit. "This new material is better than the traditional material, Bismuth telluride, and can be used for waste heat conversion into electricity much more efficiently," said Zhifeng Ren, M.D. Anderson Chair professor of physics at UH and the lead author of a paper describing the discovery, published online by Nano Energy. Ren, who is also principal investigator at the ...

LA JOLLA—By carefully controlling the levels of two proteins, researchers at the Salk Institute have discovered how to keep mammary stem cells—those that can form breast tissue—alive and functioning in the lab. The new ability to propagate mammary stem cells is allowing them to study both breast development and the formation of breast cancers. "What we've shown is that we can take these cells out of a mouse and study them and regulate them in the laboratory by providing them with a specific factor," says Peter C. Gray, a staff scientist in Salk's Clayton Foundation ...

HUNTSVILLE, TX (5/7/14) -- Gang members are twice as likely to become both a victim and an offender of a crime than non-gang members, as single acts of violence often lead to retribution between gangs as a whole, according to a new study. "In other words, gang members are not distinctly offenders or victims; instead, gang membership is a common source of both forms of violence," said David Pyrooz, an assistant professor at Sam Houston State University, College of Criminal Justice and principal author of the study. "Today's criminal offender is tomorrow's victim, and today's ...

SAN FRANCISCO -- Changes in tree-ring density in the Arctic may be evidence of changes in light intensity during the trees' growth, according to a new study by San Francisco State University researcher Alexander Stine. The finding has direct implications for the tree-ring "divergence problem," a phenomenon that has received considerable media attention but has been widely misinterpreted, said Stine, an assistant professor of Earth & climate sciences. Tree rings consist of a low density ring, which forms early in the growing season, and a high density ring that forms ...

Scientists have discovered a new species of long-snouted tyrannosaur, nicknamed Pinocchio rex, which stalked the Earth more than 66 million years ago. Researchers say the animal, which belonged to the same dinosaur family as Tyrannosaurus rex, was a fearsome carnivore that lived in Asia during the late Cretaceous period. The newly found ancient predator looked very different from most other tyrannosaurs. It had an elongated skull and long, narrow teeth compared with the deeper, more powerful jaws and thick teeth of a conventional T. rex. Palaeontologists were uncertain ...

"What a curious feeling," says Alice in Lewis Carroll's tale, as she shrinks to a fraction of her size, and everything around her suddenly looks totally unfamiliar. Scientists too have to get used to these curious feelings when they examine matter on tiny scales and at low temperatures: all the behaviour we are used to seeing around us is turned on its head. In research published today in the journal Nature Communications, UCL scientists have made a startling discovery about a familiar physical effect in this unfamiliar setting. Phase transitions are a category of ...

Atmospheric sprites have been known for nearly a century, but their origins were a mystery. Now, a team of researchers has evidence that sprites form at plasma irregularities and may be useful in remote sensing of the lower ionosphere. "We are trying to understand the origins of this phenomenon," said Victor Pasko, professor of electrical engineering, Penn State. "We would like to know how sprites are initiated and how they develop." Sprites are an optical phenomenon that occur above thunderstorms in the D region of the ionosphere, the area of the atmosphere just above ...

While research has made great strides in recent decades to improve and significantly extend the lives of patients with early breast cancer, the needs of patients with advanced or metastatic disease have largely been ignored. Moreover, despite the fact that the overall breast cancer death rate has dropped steadily over the last decade and significant improvements in survival have been made, metastatic breast cancer represents the leading cause of death among patients with the disease. In this context the Breast International Group (BIG) recently launched AURORA, which ...

SALT LAKE CITY, May 7, 2014 – A University of Utah-led team discovered a "hypervelocity star" that is the closest, second-brightest and among the largest of 20 found so far. Speeding at more than 1 million mph, the star may provide clues about the supermassive black hole at the center of our Milky Way and the halo of mysterious "dark matter" surrounding the galaxy, astronomers say. "The hypervelocity star tells us a lot about our galaxy – especially its center and the dark matter halo," says Zheng Zheng, an assistant professor of physics and astronomy and lead author ...

Theropod dinosaurs, a group which includes such famous species as Tyrannosaurus rex and Velociraptor, are often regarded as carnivorous and predatory animals, using their sharp teeth and claws to capture and dispatch prey. However, a detailed look at the claws on their forelimbs revealed that the form and shape of theropod claws are highly variable and might also have been used for other tasks. Inspired by this broad spectrum of claw morphologies, Dr Stephan Lautenschlager from Bristol's School of Earth Sciences studied the differences in claw shape and how these are ...