The report – "Understanding the Rise in Fitness to Practise Complaints from Members of the General Public" – is published today. An increase in complaints has been seen across the UK, which suggests wider social trends rather than localised issues. A large number of complaints did not progress because the issues raised could not be identified, which suggests that the GMC is receiving complaints outside its remit. According to the report, this points towards problems with the wider complaint-handling system and culture. While the report does not point to any specific ...

Researchers at the University of East Anglia have made an important step in the race to discover whether other planets could develop and sustain life. New research published today in the journal Astrobiology shows the vital role of oceans in moderating climate on Earth-like planets. Until now, computer simulations of habitable climates on Earth-like planets have focused on their atmospheres. But the presence of oceans is vital for optimal climate stability and habitability. The research team from UEA's schools of Maths and Environmental Sciences created a computer ...

BOSTON – The most critical barrier for curing HIV-1 infection is the presence of the viral reservoir, the cells in which the HIV virus can lie dormant for many years and avoid elimination by antiretroviral drugs. Very little has been known about when and where the viral reservoir is established during acute HIV-1 infection, or the extent to which it is susceptible to early antiretroviral therapy (ART). Now a research team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) in collaboration with the U.S. Military HIV Research Program has demonstrated that ...

PHILADELPHIA -- In an analysis of small molecules called metabolites used by the body to make fuel in normal and cancerous cells in human kidney tissue, a research team from the Perelman School of Medicine at the University of Pennsylvania identified an enzyme key to applying the brakes on tumor growth. The team found that an enzyme called FBP1 – essential for regulating metabolism – binds to a transcription factor in the nucleus of certain kidney cells and restrains energy production in the cell body. What's more, they determined that this enzyme is missing from all kidney ...

Scientists reveal the structure of one of the most important and complicated proteins in cell division – a fundamental process in life and the development of cancer – in research published in Nature today (Sunday). Images of the gigantic protein in unprecedented detail will transform scientists' understanding of exactly how cells copy their chromosomes and divide, and could reveal binding sites for future cancer drugs. A team from The Institute of Cancer Research, London, and the Medical Research Council Laboratory of Molecular Biology in Cambridge produced the first ...

HOUSTON – (July 20, 2014) – A team of scientists from around the world led by Baylor College of Medicine and Washington University in St. Louis has completed the genome sequence of the common marmoset – the first sequence of a New World Monkey – providing new information about the marmoset's unique rapid reproductive system, physiology and growth, shedding new light on primate biology and evolution. The team published the work today in the journal Nature Genetics. "We study primate genomes to get a better understanding of the biology of the species that are most closely ...

Recent advances in imaging technology are transforming how scientists see the cellular universe, showing the form and movement of once grainy and blurred structures in stunning detail. But extracting the torrent of information contained in those images often surpasses the limits of existing computational and data analysis techniques, leaving scientists less than satisfied. Now, researchers at the Howard Hughes Medical Institute's Janelia Research Campus have developed a way around that problem. They have created a new computational method to rapidly track the three-dimensional ...

Most of the genetic risk for autism comes from versions of genes that are common in the population rather than from rare variants or spontaneous glitches, researchers funded by the National Institutes of Health have found. Heritability also outweighed other risk factors in this largest study of its kind to date. About 52 percent of the risk for autism was traced to common and rare inherited variation, with spontaneous mutations contributing a modest 2.6 percent of the total risk. "Genetic variation likely accounts for roughly 60 percent of the liability for autism, ...

PITTSBURGH—Using new statistical tools, Carnegie Mellon University's Kathryn Roeder has led an international team of researchers to discover that most of the genetic risk for autism comes from versions of genes that are common in the population rather than from rare variants or spontaneous glitches. Published in the July 20 issue of the journal "Nature Genetics," the study found that about 52 percent of autism was traced to common genes and rarely inherited variations, with spontaneous mutations contributing a modest 2.6 percent of the total risk. The research team — ...

Richland, Wash. -- When nuclear fuel gets recycled, the process releases radioactive krypton and xenon gases. Naturally occurring uranium in rock contaminates basements with the related gas radon. A new porous material called CC3 effectively traps these gases, and research appearing July 20 in Nature Materials shows how: by breathing enough to let the gases in but not out. The CC3 material could be helpful in removing unwanted or hazardous radioactive elements from nuclear fuel or air in buildings and also in recycling useful elements from the nuclear fuel cycle. CC3 ...

LIVERPOOL, UK – 20 July 2014: Scientists at the University of Liverpool have successfully tested a material that can extract atoms of rare or dangerous elements such as radon from the air. Gases such as radon, xenon and krypton all occur naturally in the air but in minute quantities – typically less than one part per million. As a result they are expensive to extract for use in industries such as lighting or medicine and, in the case of radon, the gas can accumulate in buildings. In the US alone, radon accounts for around 21,000 lung cancer deaths a year. Previous ...

Singapore, 21 July 2014 – A multi-disciplinary team of scientists from the National Cancer Centre Singapore, Duke-NUS Graduate Medical School Singapore, and Singapore General Hospital have made a seminal breakthrough in understanding the molecular basis of fibroadenoma, one of the most common breast tumours diagnosed in women. The team, led by Professors Teh Bin Tean, Patrick Tan, Tan Puay Hoon and Steve Rozen, used advanced DNA sequencing technologies to identify a critical gene called MED12 that was repeatedly disrupted in nearly 60% of fibroadenoma cases. Their findings ...

Researchers at the BBSRC-funded Babraham Institute, in collaboration with the Wellcome Trust Sanger Institute Single Cell Genomics Centre, have developed a powerful new single-cell technique to help investigate how the environment affects our development and the traits we inherit from our parents. The technique can be used to map all of the 'epigenetic marks' on the DNA within a single cell. This single-cell approach will boost understanding of embryonic development, could enhance clinical applications like cancer therapy and fertility treatments, and has the potential ...

A new study led by Old Dominion University and the University of Colorado Boulder indicates sea levels likely will continue to rise in the tropical Pacific Ocean off the coasts of the Philippines and northeastern Australia as humans continue to alter the climate. The study authors combined past sea level data gathered from both satellite altimeters and traditional tide gauges as part of the study. The goal was to find out how much a naturally occurring climate phenomenon called the Pacific Decadal Oscillation, or PDO, influences sea rise patterns in the Pacific, said ...

Nearly 60 percent of the risk of developing autism is genetic and most of that risk is caused by inherited variant genes that are common in the population and present in individuals without the disorder, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai and published in the July 20 edition of Nature Genetics. "We show very clearly that inherited common variants comprise the bulk of the risk that sets up susceptibility to autism," says Joseph D. Buxbaum, PhD, the study's lead investigator and Director of the Seaver Autism Center for ...

Berkeley — New technology under development at the University of California, Berkeley, could soon give bomb-sniffing dogs some serious competition. A team of researchers led by Xiang Zhang, UC Berkeley professor of mechanical engineering, has found a way to dramatically increase the sensitivity of a light-based plasmon sensor to detect incredibly minute concentrations of explosives. They noted that it could potentially be used to sniff out a hard-to-detect explosive popular among terrorists. Their findings are to be published Sunday, July 20, in the advanced online ...

The size and age of plants has more of an impact on their productivity than temperature and precipitation, according to a landmark study by University of Arizona researchers. UA professor Brian Enquist and postdoctoral researcher Sean Michaletz, along with collaborators Dongliang Cheng from Fujian Normal University in China and Drew Kerkhoff from Kenyon College in Gambier, Ohio, have combined a new mathematical theory with data from more than 1,000 forests across the world to show that climate has a relatively minor direct effect on net primary productivity, or the amount ...

A new study has found that turbulent mixing in the deep waters of the Southern Ocean, which has a profound effect on global ocean circulation and climate, varies with the strength of surface eddies – the ocean equivalent of storms in the atmosphere – and possibly also wind speeds. It is the first study to link eddies at the surface to deep mixing on timescales of months to decades. This new insight into how the Southern Ocean behaves will allow scientists to build computer models that can better predict how our climate is going to change in the future. The findings ...

In an innovative approach to HIV prevention, an interdisciplinary group of experts has come together for the first time to lay out a framework of best practices to optimize the role of the clinician in achieving an AIDS-free generation. The guidelines, which will be published online in the Journal of the American Medical Association (JAMA), integrate both cutting-edge biomedical advances and evidence-based behavioral interventions for the care of people living with HIV or at high risk for HIV infection. The recommendations, developed by an expert volunteer panel assembled ...

The only drug to receive FDA approval for reduction of the abdominal fat deposits that develop in some patients receiving antiviral therapy for HIV infection may also reduce the incidence of fatty liver disease in such patients. In a paper that will appear in the July 23/28 issue of JAMA – a theme issue on HIV/AIDS receiving early online release to coincide with the International AIDS Conference – Massachusetts General Hospital (MGH) investigators report that daily injections of tesamorelin significantly reduced fat in the liver without affecting glucose metabolism. "Tesamorelin's ...

The annual HIV diagnosis rate in the U.S. decreased more than 30 percent from 2002-2011, with declines observed in several key populations, although increases were found among certain age groups of men who have sex with men, especially young men, according to a study in the July 23/30 issue of JAMA, a theme issue on HIV/AIDS. The issue is being released early to coincide with the International AIDS Conference. "There has been increasing emphasis on care and treatment for persons with human immunodeficiency virus (HIV) in the United States during the past decade, including ...

HIV-infected patients also infected with hepatitis C virus (HCV) who received a combination of the medications sofosbuvir plus ribavirin had high rates of sustained HCV virologic response 12 weeks after cessation of therapy, according to a study in the July 23/30 issue of JAMA, a theme issue on HIV/AIDS. The issue is being released early to coincide with the International AIDS Conference. Up to 7 million persons worldwide are infected with both human immunodeficiency virus (HIV) and hepatitis C virus. Treatment of this coinfection has been limited due to the need to ...

Among adults in the African country of Malawi offered HIV self-testing, optional home initiation of care compared with standard HIV care resulted in a significant increase in the proportion of adults initiating antiretroviral therapy, according to a study in the July 23/30 issue of JAMA, a theme issue on HIV/AIDS. The issue is being released early to coincide with the International AIDS Conference. In 2012, an estimated 35 million individuals were infected with the human immunodeficiency virus (HIV) worldwide. Antiretroviral therapy (ART) substantially reduces the risk ...

Among heterosexual African couples in which the male was HIV positive and the female was not, receipt of antiretroviral pre-exposure preventive (PrEP) therapy did not result in significant differences in pregnancy incidence, birth outcomes, and infant growth compared to females who received placebo, according to a study in the July 23/30 issue of JAMA, a theme issue on HIV/AIDS. The authors note that these findings do not provide a definitive conclusion regarding the safety of PrEP therapy prior to pregnancy. The issue is being released early to coincide with the International ...

In a preliminary study, HIV-infected patients with excess abdominal fat who received the growth hormone-releasing hormone analog tesamorelin for 6 months experienced modest reductions in liver fat, according to a study in the July 23/30 issue of JAMA, a theme issue on HIV/AIDS. Patients infected with HIV demonstrate a high prevalence of nonalcoholic fatty liver disease, estimated at 30 percent to 40 percent. The issue is being released early to coincide with the International AIDS Conference. In human immunodeficiency virus (HIV) infection, abdominal fat accumulation ...