BOSTON (June 4) − A study published in today's New England Journal of Medicine reports that the antibiotic dalbavancin is as effective as vancomycin, the current standard-of-care antibiotic used to treat serious bacterial skin and skin-structure infections. The study results establish dalbavancin as a therapy for Staphylococcus aureus infections, including methicillin-resistant S. aureus, or MRSA. Acute bacterial skin and skin-structure infections are among the most common reasons for the hospitalization of adults in the United States today, and the associated medical ...

Researchers at VIB and Ghent University have unraveled the mechanism of necroptosis. This is a type of cell death that plays a crucial role in numerous diseases, from viral infections and loss of auditory nerve cells to multiple sclerosis, acute heart failure and organ transplantation. Having detailed knowledge of the cell death process enables a targeted search for new drugs. Peter Vandenabeele (VIB/UGent): "The molecular mechanism of necroptosis was a complete mystery for a long time. Cells explode. But exactly how they do this was unclear. Now we have found that cells ...

June 4, 2014 (Toronto) – Women nearing menopause have higher levels of a brain protein linked to depression than both younger and menopausal women, a new study by the Centre for Addiction and Mental Health (CAMH) shows. This finding may explain the high rates of first-time depression seen among women in this transitional stage of life, known as perimenopause. "This is the first time that a biological change in the brain has been identified in perimenopause which is also associated with clinical depression," says Senior Scientist Dr. Jeffrey Meyer of CAMH's Campbell ...

Bottom Line: Modest differences exist between antidepressants with regard to weight gain among patients. Authors: Sarah R. Blumenthal, B.S., Massachusetts General Hospital, Boston, and colleagues. Background: Previous work has suggested an association between antidepressant use and weight gain. The potential health consequences could be significant because more than 10 percent of Americans are prescribed an antidepressant at any given time. Obesity is associated with a host of medical conditions, including cardiovascular disease, type 2 diabetes and high blood pressure. ...

Bottom Line: Major depressive disorder (MDD) with atypical features (including mood reactivity where people can feel better when positive things happen in life, increased appetite or weight gain) appears to be associated with obesity. Authors: Aurélie M. Lasserre, M.D., of Lausanne University Hospital, Switzerland, and colleagues. Background: MDD has tremendous public health impact worldwide. Obesity is another burden for public health. Understanding the mechanisms underlying the association between MDD and obesity is important. How the Study Was Conducted: The ...

Bottom Line: Roux-en-Y gastric bypass surgery resulted in the greatest average weight and appears to be the best treatment for type 2 diabetes mellitus (T2DM) compared to gastric banding and lifestyle intervention in a clinical trial that also highlights the challenges to completing a larger trial with patients with a body mass index (BMI) of 30 to 40. Author: Anita P. Courcoulas, M.D., M.P.H., of the University of Pittsburgh Medical Center, and colleagues. Background: Questions remain unanswered about the role of bariatric surgery in the treatment of T2DM, including ...

CORVALLIS, Ore. – Just in the past two weeks, the incidence of sea star wasting syndrome has exploded along the Oregon Coast and created an epidemic of historic magnitude, one that threatens to decimate Oregon's entire population of purple ochre sea stars. Prior to this, Oregon had been the only part of the West Coast that had been largely spared this devastating disease. The ochre sea star, which is the species most heavily affected by the disease in the intertidal zone, may be headed toward localized extinction in Oregon, according to researchers at Oregon State University ...

VIDEO: As more people use smart phones or tablets to pay bills, make purchases, store personal information and even control access to their houses, the need for robust password security has... Click here for more information. As more people use smart phones or tablets to pay bills, make purchases, store personal information and even control access to their houses, the need for robust password security has become more critical than ever. A new Rutgers University study shows that ...

Thanks to the simple use of an alcohol-impregnated cap, Loyola University Medical Center achieved a 68 percent decrease in the overall number of central line-associated bloodstream infections (CLABSI) over a 12-month period. A two-year study compared the use of disinfection caps to an intense scrub-the-hub intervention to standard care. Scrub-the-hub refers to cleaning catheter connector hubs and injection ports with alcohol for the recommended 15 seconds before accessing the central line, a catheter placed in a large vein to deliver medicine and liquids during hospitalization. ...

PHILADELPHIA — Advances in the understanding of the genetics of coronary artery disease, or CAD, will revitalize the field and lead to more therapeutic targets for new medicines to combat this common disease, suggests a genetics expert from the Perelman School of Medicine at the University of Pennsylvania in a Perspective article in the new issue of Science Translational Medicine. Daniel J. Rader, MD, chair of the Department of Genetics and associate director of the Institute for Translational Medicine and Therapeutics, asserts that the lagging search for new heart medicines ...

A team of UCLA researchers has identified a new gene involved in Parkinson's disease, a finding that may one day provide a target for a new drug to prevent and potentially even cure the debilitating neurological disorder. Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease, and there is no cure for the progressive and devastating illness. About 60,000 Americans are diagnosed with Parkinson's disease each year. It is estimated that as many as 1 million Americans live with Parkinson's disease, which is more than the number ...

CHAMPAIGN, Ill. — This growing season, crop researchers at the University of Illinois are experimenting with the use of drones – unmanned aerial vehicles – on the university's South Farms. Dennis Bowman, a crop sciences educator with U. of I. Extension, is using two drones to take aerial pictures of crops growing in research plots on the farms. He presented his findings to farmers and other researchers at the 2014 Ford / Iroquois County Agronomy Day meeting. Bowman intentionally made mistakes on one test plot – "areas where we didn't apply enough nitrogen fertilizer, ...

ROSEMONT, Ill.─The number of total knee replacement (TKR) surgeries more than tripled between 1993 and 2009, while the number of total hip replacements (THR) doubled during the same time period. A study appearing in the June Journal of Bone and Joint Surgery (JBJS) found that an increase in the prevalence of ovrweight and obesity in the U.S. accounted for 95 percent of the higher demand for knee replacements, with younger patients affected to a greater degree. "We observed that growth of knee replacement volumes was far outpacing that of hip replacements and were ...

A new study of supermassive black holes at the centers of galaxies has found magnetic fields play an impressive role in the systems' dynamics. In fact, in dozens of black holes surveyed, the magnetic field strength matched the force produced by the black holes' powerful gravitational pull, says a team of scientists from the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) and Max Planck Institute for Radio Astronomy (MPIfR) in Bonn, Germany. The findings are published in this week's issue of Nature. "This paper for the first time systematically ...

Neutrinos are tiny, neutral elementary particles that, contrary to the standard model of physics, have been proven to have mass. One possible explanation for this mass could be that neutrinos are their own antiparticles, so-called Majorana particles. Though experimental evidence for this is still lacking, many theoretical extensions of the standard model of physics predict the Majorana nature of neutrinos. If this hypothesis proves to be true, many previously unanswered questions about the origin of our universe and the origin of matter could be answered. 650 meters ...

Tropical Depression 2E strengthened into Tropical Storm Boris briefly on June 3 before making landfall in southern Mexico and weakening into a depression. While Boris was building to tropical storm strength, NASA's Aqua and TRMM satellites passed overhead identifying heavy rainfall and the extent of the storm. On June 3 at 19:15 UTC (3:15 p.m. EDT) the Moderate Resolution Imaging Spectroradiometer (MODIS) instrument aboard NASA's Aqua satellite captured a visible image of Tropical Storm Boris over Central America. Boris appeared circular in the imagery and its clouds ...

Cleveland . . . A geologist studied fossils to confirm that stones used in 19th century Ohio grain mills originated from France. Fossils embedded in these millstones were analyzed to determine that stones known as French buhr were imported from regions near Paris, France, to Ohio in the United States. Dr. Joseph Hannibal, curator of invertebrate paleontology at The Cleveland Museum of Natural History, was lead author on research published in the Society for Sedimentary Geology journal PALAIOS. The study documents a technique that uses fossils to definitively distinguish ...

RIVERSIDE, Calif. (http://www.ucr.edu) — A team of University of California, Riverside's Bourns College of Engineering students created a roof tile coating that when applied to an average-sized residential roof breaks down the same amount of smog-causing nitrogen oxides per year as a car driven 11,000 miles. They calculated 21 tons of nitrogen oxides would be eliminated daily if tiles on one million roofs were coated with their titanium dioxide mixture. They also calculated it would cost only about $5 for enough titanium dioxide to coat an average-sized residential roof. That ...

JACKSONVILLE, Fla. — Neuroscientists at Mayo Clinic in Florida and at Aarhus University in Denmark have shed light on why neurons in the brain's reward system can be miswired, potentially contributing to disorders such as attention deficit hyperactivity disorder (ADHD). They say findings from their study, published online today in Neuron, may increase the understanding of underlying causes of ADHD, potentially facilitating the development of more individualized treatment strategies. The scientists looked at dopaminergic neurons, which regulate pleasure, motivation, ...

WASHINGTON (June 4, 2014) — In order to meet new cancer program accreditation standards, institutions have placed new focus on patient navigation, psychosocial distress screening, and survivorship care plans. Recently published research by the George Washington University (GW) Cancer Institute found these new programs are experiencing "growing pains." The results of a nationwide survey conducted by the GW Cancer Institute and reviewed in the Journal of Oncology Navigation and Survivorship, found that health care professionals could most benefit from greater evaluation of ...

LA JOLLA, CA—June 4, 2014— Hemorrhagic fevers caused by Lassa, dengue and other viruses affect more than one million people annually and are often fatal, yet scientists have never understood why only some virus-infected people come down with the disease and others do not. But now, virologists and immunologists at The Scripps Research Institute (TSRI) have found a major clue to the mystery of "hemorrhagic fever" syndromes. In findings reported this week in an Early Edition of the Proceedings of the National Academy of Sciences, the team showed that Interferon Type I (IFN-I) ...

In a discovery decades in the making, scientists have detected the first of a "theoretical" class of stars first proposed in 1975 by physicist Kip Thorne and astronomer Anna Żytkow. Thorne-Żytkow objects (TŻOs) are hybrids of red supergiant and neutron stars that superficially resemble normal red supergiants, such as Betelguese in the constellation Orion. They differ, however, in their distinct chemical signatures that result from unique activity in their stellar interiors. TŻOs are thought to be formed by the interaction of two massive stars―a ...

New research reveals how the algae behind red tide thoroughly disables – but doesn't kill – other species of algae. The study shows how chemical signaling between algae can trigger big changes in the marine ecosystem. Marine algae fight other species of algae for nutrients and light, and, ultimately, survival. The algae that cause red tides, the algal blooms that color blue ocean waters red, carry an arsenal of molecules that disable some other algae. The incapacitated algae don't necessarily die, but their growth grinds to a halt. This could explain part of why blooms ...

DURHAM, N.C. -- Gamma and neutron imaging offer possible improvements over existing techniques such as X-ray or CT, but their safety is not yet fully understood. Using computer simulations, imaging the liver and breast with gamma or neutron radiation was found to be safe, delivering levels of radiation on par with conventional medical imaging, according to researchers at Duke Medicine. The findings, published in the June issue of the journal Medical Physics, will help researchers to move testing of gamma and neutron imaging into animals and later humans. Conventional ...

Anaheim, Calif., June 4, 2014 – For every 15 healthcare providers who receive the influenza vaccination, one fewer person in the community will contract an influenza-like illness, according to a study using California public health data from 2009 – 2012. In an abstract that will be presented on June 7 at the 41st Annual Conference of the Association for Professionals in Infection Control and Epidemiology (APIC), a researcher analyzed archival data from the California Department of Public Health to determine the relationship between vaccinating healthcare personnel against ...