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Medicine 2014-06-03

Nutrition experts: Debate over value of vitamin, mineral supplements is far from over

CORVALLIS, Ore. – Researchers from the Linus Pauling Institute at Oregon State University and three other institutions have taken issue with recent claims that "the case is closed" on whether or not a multivitamin/mineral supplement should be taken by most people to help obtain needed micronutrients. In a correspondence to be published Tuesday in the Annals of Internal Medicine, the researchers reasoned that this type of dietary supplement helps fill nutritional gaps, improves general health, might help prevent chronic disease, will cause no harm and is easily worth the ...
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Medicine 2014-06-02

Young women fare worse than young men after heart attack

Women age 55 or younger may fare worse than their male counterparts after having a heart attack, according to new research presented at the American Heart Association's Quality of Care and Outcomes Research Scientific Sessions 2014. Researchers studied records and interviews of 3,501 people (67 percent women) who had heart attacks in the United States and Spain in 2008-12. One year after their heart attack, women were more likely than men to have: Poorer physical functioning Poorer mental functioning Lower quality of life More chest pain Worse physical limitations "Previous ...
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Medicine 2014-06-02

Hispanics cut medication adherence gap after Medicare Part D launch

Hispanics have reduced the gap with whites in taking prescribed heart medicines since the 2006 launch of Medicare's prescription drug benefit called Medicare Part D, according to a study presented at the American Heart Association's Quality of Care and Outcomes Research 2014 Scientific Sessions. Researchers reviewed prescription drug data from the national Medical Expenditure Panel for African-American and Hispanic Medicare recipients to find trends in medication adherence in the four years after the launch of Medicare Part D (2001-10). After Part D, adherence rates ...
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Medicine 2014-06-02

Simple change to Medicare Part D would yield $5 billion in savings

PITTSBURGH, June 2, 2014 – The federal government could save over $5 billion in the first year by changing the way the government assigns Part D plans for Medicare beneficiaries eligible for low-income subsidies, according to new research from the University of Pittsburgh Graduate School of Public Health. The results of the study, funded by the National Institutes of Health (NIH) and the U.S. Department of Health and Human Services (HHS), will be published in the June issue of the journal Health Affairs. Medicare Part D provides assistance to beneficiaries below 150 ...
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Medicine 2014-06-02

Choosing one drug over another to treat blindness could save Medicare billions

ANN ARBOR—If all eye doctors prescribed the less expensive of two drugs to treat two common eye diseases of older adults, taxpayer-funded Medicare plans could save $18 billion over a 10-year period, say researchers at the University of Michigan. Further, patients with the wet form of macular degeneration or who have diabetic macular edema could keep $4.6 billion in co-pays in their wallets, and the rest of the U.S. health care system could save $29 billion in private insurance payments and other costs, according to the team led by David Hutton, assistant professor of ...
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Physics 2014-06-02

Study examines political contributions made by physicians

Bottom Line: The percentage of physicians making campaign contributions in federal elections increased to 9.4 percent in 2012 from 2.6 percent in 1991, and during that time physician contributors shifted away from Republicans toward Democrats, especially in specialties dominated by women or those that are traditionally lower paying such as pediatrics. Author: Adam Bonica, Ph.D., of Stanford University, California, and colleagues. Background: Few analyses have been done regarding the political behavior of American physicians, especially as the numbers of women physicians ...
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Medicine 2014-06-02

One in 8 American children estimated to experience maltreatment by age 18

Bottom Line: One in 8 American children (12.5 percent) is estimated to experience a confirmed case of maltreatment before age 18, and the cumulative prevalence is highest for black children (1 in 5) and Native American children (1 in 7). Author: Christopher Wildeman, Ph.D., of Yale University, New Haven, Conn., and colleagues. Background: Childhood maltreatment (the neglect and physical, sexual and emotional abuse of children) is associated with negative physical, mental and social outcomes. A disparity exists between estimates of the prevalence based on retrospective ...
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Medicine 2014-06-02

No sign of 'obesity paradox' in obese patients with stroke

Bottom Line: Researchers found no evidence of an "obesity paradox" (some studies have suggested overweight or obese patients have lower mortality rates than underweight or normal weight patients) in patients with stroke. Author: Christian Dehlendorff, M.S., Ph.D., of the Danish Cancer Society Research Center, Copenhagen, Denmark, and colleagues. Background: Obesity often is associated with increased health related complications and death. But some studies have suggested an obesity paradox that may cause some to question striving for a normal weight. How the Study ...
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Medicine 2014-06-02

Expanded health coverage may improve cancer outcomes in young adults, study suggests

BOSTON -- Young adults who lack health care insurance are more likely to be diagnosed in advanced stages of cancer and have a higher risk of death, according to a study from Dana-Farber/Brigham and Women's Cancer Center (DF/BWCC) and Harvard Medical School. Consequently, the Affordable Care Act (ACA), or Obamacare, may improve cancer outcomes in young adults as it expands coverage to many who have been uninsured, said first author Ayal Aizer, MD, MHS, of the Harvard Radiation Oncology Program and senior author Paul Nguyen, MD, of Radiation Oncology at DF/BWCC in a report ...
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Science 2014-06-02

Nearly 1 in 8 American children are maltreated before age 18

By the time they reach age 18, about 12% of American children experience a confirmed case of maltreatment in the form of neglect, physical, sexual, or emotional abuse, according to a new study by researchers at Yale University. The numbers are even more sobering for black and Native American children, with one in five black children and one in seven Native American children experiencing maltreatment during the time period studied. The results are published in the June 2 issue of the journal JAMA Pediatrics. The authors estimated the cumulative prevalence of confirmed ...
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Medicine 2014-06-02

Study finds risk of recurrence low in smallest HER2+ breast cancer tumors

OAKLAND, Calif. June 2, 2014 – Patients with specific HER2+ breast cancer tumors had a low risk of the cancer recurring five years after diagnosis, even without chemotherapy or treatment with a common antibody, according to a Kaiser Permanente study published in the Journal of Clinical Oncology. Researchers reviewed 16,975 cases of breast cancer diagnosed in Kaiser Permanente patients between 2000 and 2006. They found that for patients with the smallest HER2+ tumors (0.5 centimeters or less) who did not receive treatment with the antibody trastuzumab or chemotherapy, ...
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The betrayal of the aphids
Science 2014-06-02

The betrayal of the aphids

RIVERSIDE, Calif. — Aphids are devastating insect pests and cause great losses to agriculture worldwide. These sap-feeding plant pests harbor in their body cavity bacteria, which are essential for the aphids' fecundity and survival. Buchnera, the bacterium, benefits also because it cannot grow outside the aphid. This mutually beneficial relationship is sabotaged, however, by the bacterium which proceeds to betray the aphid, a research team led by scientists at the University of California, Riverside has found. "Although this betrayal is unintentional, it nevertheless ...
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Physics 2014-06-02

First survey of ACOs reveals surprising level of physician leadership

LEBANON, NH (June 2, 2014) – In spite of early concerns that hospitals' economic strengths would lead them to dominate the formation of Accountable Care Organizations (ACOs), a new study published in the June issue of Health Affairs reveals the central role of physician leadership in the first wave of ACOs. "The broad reach of physician leadership in ACOs has important implications for the future of health care reform", said Carrie Colla, PhD, lead investigator of the study. "A central role for physicians in the leadership of ACOs is likely to have a powerful influence ...
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Environment 2014-06-02

Decomposing logs show local factors undervalued in climate change predictions

A new Yale-led study challenges the long-held assumption that climate is the primary driver of how quickly organic matter decomposes in different regions, a key piece of information used in formulating climate models. In a long-term analysis conducted across several sites in the eastern United States, a team of researchers found that local factors — from levels of fungal colonization to the specific physical locations of the wood — play a far greater role than climate in wood decomposition rates and the subsequent impacts on regional carbon cycling. Because decomposition ...
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Science 2014-06-02

Resveratrol supplements cause pancreatic problems in developing fetus

PORTLAND, Ore. — A widely available dietary supplement that had been considered safe — and that some claim provides anti-aging and other health benefits — caused significant developmental abnormalities in the pancreas of offspring of pregnant monkeys who were given the supplement, according to a study published today in the FASEB Journal, from the Federation of American Societies of Experimental Biology. Because of the results, authors of the study strongly recommend that pregnant women or women who might get pregnant avoid taking the supplement. The supplement contains ...
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Science 2014-06-02

JCI online ahead of print table of contents for June 2, 2014

Mucin concentration contributes to a sticky situation in cystic fibrosis Patients with cystic fibrosis (CF) accumulate thick, sticky mucus in the lungs that clogs the airways and leads to life-threatening lung infections. It has recently been proposed that differing concentrations of mucin with in mucus layers of the CF lung contribute to decreased mucus clearance; however, it has been challenging to accurately access mucin concentration. In this issue of the Journal of Clinical Investigation, Mehmet Kesimer and colleagues at the University of North Carolina applied size ...
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Modern ocean acidification is outpacing ancient upheaval, study suggests
Environment 2014-06-02

Modern ocean acidification is outpacing ancient upheaval, study suggests

Some 56 million years ago, a massive pulse of carbon dioxide into the atmosphere sent global temperatures soaring. In the oceans, carbonate sediments dissolved, some organisms went extinct and others evolved. Scientists have long suspected that ocean acidification played a part in the crisis—similar to today, as manmade CO2 combines with seawater to change its chemistry. Now, for the first time, scientists have quantified the extent of surface acidification from those ancient days, and the news is not good: the oceans are on track to acidify at least as much as they did ...
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Study: Hurricanes with female names more deadly than male-named storms
Environment 2014-06-02

Study: Hurricanes with female names more deadly than male-named storms

In the coming Atlantic hurricane season, watch out for hurricanes with benign-sounding names like Dolly, Fay or Hanna. According to a new article from a team of researchers at the University of Illinois, hurricanes with feminine names are likely to cause significantly more deaths than hurricanes with masculine names, apparently because storms with feminine names are perceived as less threatening. An analysis of more than six decades of death rates from U.S. hurricanes shows that severe hurricanes with a more feminine name result in a greater death toll, simply because ...
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ASU researcher leads national effort to transform undergraduate biology education
Social Science 2014-06-02

ASU researcher leads national effort to transform undergraduate biology education

TEMPE, Ariz. — During the past few decades, the field of biology has dramatically expanded, incorporating many diverse sub-disciplines and specialty areas such as microbiology and evolutionary biology. However, teaching biology to undergraduate students has not kept pace with the changes, and core biology curriculum varies widely from university to university, and classroom to classroom. In an effort to both capture the diversity of biology and condense what is taught, an Arizona State University researcher is leading a grassroots effort to improve biology education throughout ...
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New UGA research engineers microbes for the direct conversion of biomass to fuel
Engineering 2014-06-02

New UGA research engineers microbes for the direct conversion of biomass to fuel

Athens, Ga. – The promise of affordable transportation fuels from biomass—a sustainable, carbon neutral route to American energy independence—has been left perpetually on hold by the economics of the conversion process. New research from the University of Georgia has overcome this hurdle allowing the direct conversion of switchgrass to fuel. The study, published in the Proceedings of the National Academy of Sciences, documents the direct conversion of biomass to biofuel without pre-treatment, using the engineered bacterium Caldicellulosiruptor bescii. Pre-treatment ...
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Tracking potato famine pathogen to its home may aid $6 billion global fight
Technology 2014-06-02

Tracking potato famine pathogen to its home may aid $6 billion global fight

CORVALLIS, Ore. – The cause of potato late blight and the Great Irish Famine of the 1840s has been tracked to a pretty, alpine valley in central Mexico, which is ringed by mountains and now known to be the ancestral home of one of the most costly and deadly plant diseases in human history. Research published today in the Proceedings of the National Academy of Sciences, by researchers from Oregon State University, the USDA Agricultural Research Service and five other institutions, concludes that Phytophthora infestans originated in this valley and co-evolved with potatoes ...
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Medicine 2014-06-02

Tumor size is defining factor to response from promising melanoma drug

CHICAGO — In examining why some advanced melanoma patients respond so well to the experimental immunotherapy MK-3475, while others have a less robust response, researchers at Mayo Clinic in Florida found that the size of tumors before treatment was the strongest variable. MULTIMEDIA ALERT: Video and audio are available for download on the Mayo Clinic News Network. They say their findings, being presented June 2 at the 50th annual meeting of the American Society of Clinical Oncology (ASCO), offered several clinical insights that could lead to different treatment strategies ...
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Anti-diabetic drug slows aging and lengthens lifespan
Medicine 2014-06-02

Anti-diabetic drug slows aging and lengthens lifespan

A study by Belgian doctoral researcher Wouter De Haes (KU Leuven) and colleagues provides new evidence that metformin, the world's most widely used anti-diabetic drug, slows ageing and increases lifespan. In experiments reported in the journal Proceedings of the National Academy of Sciences, the researchers tease out the mechanism behind metformin's age-slowing effects: the drug causes an increase in the number of toxic oxygen molecules released in the cell and this, surprisingly, increases cell robustness and longevity in the long term. Mitochondria – the energy factories ...
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Medicine 2014-06-02

Marijuana shows potential in treating autoimmune disease

A team of University of South Carolina researchers led by Mitzi Nagarkatti, Prakash Nagarkatti and Xiaoming Yang have discovered a novel pathway through which marijuana can suppress the body's immune functions. Their research has been published online in the Journal of Biological Chemistry. Marijuana is the most frequently used illicit drug in the United States, but as more states legalize the drug for medical and even recreational purposes, research studies like this one are discovering new and innovative potential health applications for the federal Schedule I drug. ...
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Science 2014-06-02

Shape matters...

Which look bigger, packages of complicated shape or packages of simple shape? Some prior research shows that complex packages appear larger than simple packages of equal volume, while other research has shown the opposite - that simple packages look bigger than the more complex. US researchers, writing in the International Journal of Management Practice believe they have resolved this dilemma. Lawrence Garber of Elon University in North Carolina and Eva Hyatt and Ünal Boya of Appalachian State University report that human beings are just not very good at estimating the ...
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