About The Study: In this secondary analysis of a randomized clinical trial, a telephone-based weight loss intervention induced significant weight loss in patients with breast cancer with overweight and obesity across demographic and treatment factors. Further follow-up of the Breast Cancer Weight Loss trial will evaluate whether the weight loss intervention improves disease outcomes. Corresponding Author: To contact the corresponding author, Jennifer A. Ligibel, MD, email jennifer_ligibel@dfci.harvard.edu. To access the embargoed ...

Researchers developed the first genome-wide CRISPR screening tool for primary human natural killer (NK) cells Study revealed critical regulators of NK cell activity that can be targeted to improve chimeric antigen receptor (CAR) NK cell therapies Findings open new avenues for developing more effective CAR NK cell therapies for many cancers HOUSTON, AUGUST 21, 2025 ― Natural killer (NK) cells became markedly better at killing cancer cells after scientists removed key gene targets identified through a new genome-wide CRISPR screening tool, according to new research from The University of Texas MD Anderson ...

A recent study published in Current Pharmaceutical Analysis introduces a robust and validated reverse-phase high-performance liquid chromatography (RP-HPLC) method for the analysis of orlistat, a widely used anti-obesity drug. The method, developed by researchers from KIET School of Pharmacy in India, ensures accurate quantification and is fully compliant with International Council for Harmonisation (ICH) guidelines. The research team, led by Kandasamy Nagarajan, optimized the chromatographic conditions to achieve high sensitivity and precision. "Our method uses an XBridge C8 column and acetonitrile as the mobile phase, providing sharp peaks ...

From virtual counselors that can hear depression creeping into a person’s voice to smart watches that can detect stress, artificial intelligence is poised to revolutionize mental health care for patients with breast cancer. In a new paper, UVA Cancer Center’s J. Kim Penberthy, PhD, and colleagues detail the many ways artificial intelligence could help ensure patients receive the support they need. AI, they say, can identify patients at risk for mental-health struggles, get them treatment earlier, provide continuous psychological monitoring and even ...

1. Summary The National Institute for Environmental Studies (NIES), in cooperation with the Ministry of the Environment of Japan (MOE) and the Japan Aerospace Exploration Agency (JAXA), has been observing atmospheric carbon dioxide, methane, and other gases by utilizing the Greenhouse Gases Observing Satellite (GOSAT) Series, with the aim of advancing climate change science and contributing to the evaluation of climate change policies and initiatives. The Global Observing SATellite for Greenhouse gases and Water cycle “IBUKI GW” (GOSAT-GW)1, developed jointly by MOE, NIES, ...

Key Takeaways Harvard physicists have developed a computational method that can uncover the rules that cells use to self-organize, translating the complex process of cell growth into an optimization problem a computer can solve. The technique they use is automatic differentiation, originally built for training neural networks, but used in this context for predicting how small changes in genes or cellular signals affect the final design.   Scientists could someday use such predictive models in real biological experiments to design living tissues with specific functions or shapes. One of the most fundamental processes in all of biology ...

“[…]age estimation on blood stains from cancer patients might not result in significantly higher estimation errors, except for very aggressive forms of cancer.” BUFFALO, NY — August 21, 2025 — A new research paper was published in Volume 17, Issue 7 of Aging (Aging-US) on July 17, 2025, titled “The influence of cancer on a forensic age estimation tool.” In this study by Charlotte Sutter, Daniel Helbling, Cordula Haas and Jacqueline Neubauer from the Zurich Institute of Forensic Medicine, University ...

WASHINGTON — Researchers have developed a technique to fold glass sheets into microscopic 3D photonic structures directly on a chip — a process they call photonic origami. The method could enable tiny, yet complex optical devices for data processing sensing and experimental physics. “Existing 3D printers produce rough 3D structures that aren’t optically uniform and thus can’t be used for high-performance optics,” said research team leader Tal Carmon from Tel Aviv University in Israel. “Mimicking the way a pinecone’s scales bend outward to release ...

Dr. Matthew Greenblatt will receive the prestigious Paul-Gallin Trailblazer Prize for Physician-Scientists in recognition of his discovery of distinct types of bone-building stem cells in different parts of the body. These unique cells have the ability to create copies of themselves as well as develop into specialized cells that perform distinct functions in the body. Each year, the Foundation for the National Institutes of Health awards the Paul-Gallin Trailblazer Prize to an early- to mid-career physician-scientist who is translating their basic science discoveries into new ways to diagnose, prevent, treat, or cure disease ...

Infection control is paramount in prosthodontics and oral implantology to prevent complications like denture stomatitis and peri-implantitis. While synthetic disinfectants (e.g., chlorhexidine) are widely used, their side effects—including mucosal irritation, toxicity, and antimicrobial resistance—drive the search for safer alternatives. Natural products derived from plants, animals, and minerals offer promising solutions due to their antimicrobial efficacy, biocompatibility, and environmental sustainability. Key Natural Agents and Mechanisms Plant-Based Products: Clove oil (eugenol), tea tree oil (terpinen-4-ol), neem (azadirachtin), ...

Snow water equivalent (SWE) measurements are critical for water resource management, yet existing remote sensing methods struggle to provide accurate, large-scale estimates. This study introduces a multisensor approach combining optical snow cover data and L-band interferometric synthetic aperture radar (InSAR) to enhance SWE retrievals. By analyzing multiple optical snow cover datasets in conjunction with UAVSAR L-band InSAR data, the researchers demonstrate how these combined technologies can effectively address the uncertainties in snow measurement, improving the accuracy of SWE change estimations over snow-covered regions. Current snow monitoring techniques, particularly those ...

PULLMAN, Wash. – Washington State University researchers have developed a mathematical model and a set of recommendations to improve liquid hydrogen storage tank operations that could someday make hydrogen a more viable alternative for powering vehicles and other industrial processes. The researchers used real-world tank data to identify operational regimes in which hydrogen boils off and is lost, which can be as much as 25% of the hydrogen delivered to storage tanks. The work is published in the journal Cryogenics. “If we want to reduce reliance on fossil fuels and come up with fuel that is clean and produced from renewable energy sources, then liquid hydrogen ...

Transthyretin amyloidosis (ATTR) is caused by the misfolding and aggregation of the transthyretin (TTR) protein, leading to multi-organ damage. Two main forms exist: hereditary ATTR (ATTRv), linked to TTR gene mutations, and wild-type ATTR (ATTRwt), associated with aging. Historically underdiagnosed, ATTR carried poor prognoses, particularly in advanced cardiac or neuropathic disease. However, the past decade has seen unprecedented therapeutic advances. Diagnostic Advances Enable Earlier Intervention Improved detection ...

Background and Aims Patients with chronic hepatitis B virus (HBV) infection in the immune-tolerant phase may still experience hepatic inflammation and disease progression, and could benefit from early antiviral treatment. This study aimed to investigate changes in the cumulative hepatitis B surface antigen (HBsAg)/HBV DNA ratio in immune-tolerant patients during the transition to the immune-active phase, and to evaluate its potential in predicting the risk of disease progression. Methods This longitudinal study included 127 untreated immune-tolerant patients, who were followed for up to 10 years. An independent cohort of 109 subjects ...

Miami (August 21, 2025) – Prioritizing communications between patients and health care providers and increasing patient education about chronic obstructive pulmonary disease (COPD) could help improve patient care, according to a new study. The study is published in the July 2025 issue of Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation, a peer-reviewed, open-access journal. COPD is an inflammatory lung disease, comprising several conditions, including chronic bronchitis and emphysema, and can be caused ...

News Release * Physicians Committee for Responsible Medicine * August 20, 2025 Media contact: Leslie Raabe lraabe@pcrm.org 443 534 5803   Nation’s Leading Breast Health Advocate Receives Benjamin Spock Award for Compassion in Medicine   WASHINGTON, D.C.— Santa Monica Breast Surgeon and Founder of the Pink Lotus Breast Center Kristi Funk, MD, FACS, received the Benjamin Spock Award for Compassion in Medicine at the International Conference on Nutrition and Medicine (ICNM) on Aug. 15. The award was presented by Neal Barnard, MD, president of the Physicians Committee ...

Biological systems have inspired the development of next-generation soft robotic systems with diverse motions and functions. Such versatility in soft robots—in terms of rapid and efficient crawling—can be achieved via asymmetric bending through bilayer-type actuators that combine responsive liquid crystal elastomers (LCEs) with flexible substrates. This, in turn, requires temperature-responsive LCEs with accurate temperature regulation via elaborate Joule heating configurations. However, it is a complicated task owing to the difficulty in generating asymmetric motions using isotropic thermal distributions, necessitating simple temperature ...

A preclinical evaluation of a new ’dual-mode’ tracer agent shows promise in not only helping surgeons image and plan prostate cancer procedures, but also provide them with much more consistent and targeted guidance during surgery. The agent uses a single tracer molecule labeled with Fluorine-18—a common isotope used in Positron Emission Tomography (PET) scans—for diagnostic imaging. It also provides a one-step, widely accessible solution that would enable combined fluorescence-guided and radio-guided surgery. “Precision ...

Most of the drugs, plastics, and industrial materials widely used today are produced through chemical reactions. In general, most high-performance and sophisticated substances have complex structures, and their assembly involves multiple chemical reaction steps carried out one after another. This creates significant overhead, as each step requires specific conditions, reagents, and catalysts, as well as considerable energy and labor. Tandem reactions offer a promising solution to this issue. The ...

A new critical review, published in the journal CABI Agriculture and Bioscience, highlights the emergence and scientific basis of regenerative agriculture – proposing a working definition centred on ecological cycles and farm system outcomes. Dr Nicholas Bardsley, author of the paper from the Department of Agri-Food Economics and Marketing at the University of Reading, suggests that as global agriculture faces intensifying soil degradation, climate disruption, and ecological breakdown, there ...

Oak Brook, IL – Volume 33 of SLAS Technology, includes one literature highlights column, eight original research articles and four Special Issue (SI) features. Literature Highlights Literature highlights column: From the literature life sciences discovery and technology highlights SLAS Technology Section Editors Jamien Lim, PhD (TDK Electronics, Inc.) and Tal Murthy, PhD (Strain LLC) review noteworthy research articles pertaining to advances in biotechnology, artificial intelligence in science and ...

Researchers at the Complexity Science Hub (CSH) analyzed 13 million inpatient hospital stays involving around 4 million individuals in Austria: Although about 20% of the population in Austria does not hold Austrian citizenship, this group accounts for only 9.4% of hospital patients and 9.8% of total hospital nights. An estimated 300 million people – about 3.6 percent of the global population – are international migrants. Yet studies consistently show that migrants access healthcare services less frequently ...

PITTSBURGH, Aug. 21, 2025 – New research from the University of Pittsburgh School of Medicine and Cambridge University upends a long-standing belief about brain plasticity. A study published today in Nature Neuroscience shows that the brain’s built-in “body map” remains stable even when the body undergoes drastic changes, such as the loss of a limb. The findings have implications for the treatment of “phantom limb” pain and suggest that achieving reliable restoration of sensation and controlling robotic replacement limbs via brain-computer interfaces may be more viable in the long term than previously thought. “This study is a powerful ...

Research Highlights: Hormone replacement therapy using vaginal estrogen tablets was not associated with an increased risk of ischemic stroke for postmenopausal women who have already had a stroke, according to a data analysis from a health registry in Denmark. This is one of the first studies to analyze the risk of recurrent stroke for postmenopausal women using vaginal estrogen. Embargoed until 4 a.m. CT/5 a.m. ET, Thursday, August 21, 2025 DALLAS, August 21, 2025 — Using vaginal estrogen ...

GLOBAL: Australian researchers have used an innovative genome-wide screening approach to identify genes, and their encoded proteins, that play critical roles in the prevention of lymphoma development, revealing new potential treatment targets for these blood cancers.  The study, published in Nature Communications today, has identified a group of proteins known as the GATOR1 complex as essential tumour suppressors.   The GATOR1 complex normally functions as a ‘brake’ on cellular growth by regulating pathways that control cell growth and metabolism.1 When GATOR1 components are lost or defective, this protective mechanism ...