Researchers at the Centre for Genomic Regulation in Barcelona and the University of Cologne in Germany have developed a new experimental strategy to tackle scarring and fibrosis. Experiments with patient-derived human cells and animal models showed the strategy was effective, non-toxic and its effects reversible. The findings are published today in the journal Nature Communications. Scarring occurs from the secretion and accumulation of various components – primarily proteins known as collagens – into the space between individual cells, usually occurring as a response to injury or damage. Excessive collagen secretion can also cause the buildup of fibrotic ...

A new collaboration brings together a world-leading interdisciplinary team with skills across quantum computing, genomics, and advanced algorithms. They aim to tackle one of the most challenging computational problems in genomic science: building, augmenting and analysing pangenomic datasets for large population samples. Their project sits at frontiers of research in both biomedical science and quantum computing.   The project, which involves researchers based at the University of Cambridge, the Wellcome Sanger Institute and EMBL’s European ...

When pathogens invade the body, the immune system must react immediately to prevent or contain an infection. But how do our defence cells stay ready when no attacker is in sight? Scientists from Vienna have found a surprising explanation: They are constantly stimulated by healthy tissue. This keeps them active and ready to respond to pathogens. Based on this insight, future medications could be devised to selectively enhance our immune system’s attention. The study has been published in the journal Nature Immunology (DOI: 10.1038/s41590-024-01804-1). Communication is crucial in immune defence. When ...

“Our new study shows that renewable-scarce countries like parts of the EU, Japan and South Korea could save between 18 to 38 percent in production costs”, explains Philipp Verpoort, scientist at the Potsdam Institute for Climate Impact Research (PIK) and lead author of the study published in Nature Energy. “They could do so by relocating their production of industrial basic materials like green steel and chemicals based on green hydrogen to countries where renewable energy is cheap.” The use of renewable electricity and green hydrogen is ...

HOUSTON – (April 24, 2024) – Researchers at Texas Children’s Cancer Center and the Center for Cell and Gene Therapy at Baylor College of Medicine, Texas Children’s Hospital and Houston Methodist published results of a phase I clinical trial of a novel immunotherapy for high-risk sarcomas in the journal Nature Cancer.  The therapy uses chimeric antigen receptor (CAR) T cells engineered to target the HER2 protein, which is overexpressed on the surface of sarcoma cells. The HEROS 2.0 trial showed that this therapeutic approach is safe and is associated with clinical benefit. “CAR T cell therapy has been a highly successful strategy for recurrent ...

The emergence in the Neolithic of patrilineal1 social systems, in which children are affiliated with their father's lineage, may explain a spectacular decline in the genetic diversity of the Y chromosome2 observed worldwide between 3,000 and 5,000 years ago. In a study to be published on 24 April in Nature Communications, a team of scientists from the CNRS, MNHN and Université Paris Cité3 suggest that these patrilineal organisations had a greater impact on the Y chromosome than mortality during conflict. This ...

The research team asked one group of participants to follow healthy eating accounts and another to follow interior design accounts After just two weeks, participants following healthy eating accounts ate more fruit and vegetables and less junk food Even minor tweaks to social media accounts could result in substantial diet improvements in young adults. Researchers from Aston University have found that people following healthy eating accounts on social media for as little as two weeks ate more fruit and vegetables and less junk food. Previous ...

Driven by the overuse of antimicrobials, pathogens are quickly building up resistances to once-successful treatments. It’s estimated that antimicrobial-resistant infections killed more than 1 million people worldwide in 2019, according to the World Health Organization.    “There are worries that at the rate things are going, in perhaps 20 or 30 years, few of our drugs will be effective at all,” said Xuefei Huang, a Michigan State University Research Foundation Professor in the departments ...

European Hormone Day 2024: Endocrine community unites to raise public awareness and push for policy action on hormone health European Hormone Day returns for the third year today, 24 April 2024, putting a spotlight on the vital role of hormones in chronic diseases such as diabetes, thyroid disorders, cancer and obesity, as well as many rare diseases. The European Society of Endocrinology (ESE), the European Hormone and Metabolism Foundation (ESE Foundation), and partners from key groups and organisations across Europe and beyond will join forces to highlight simple steps we can all take towards better hormone health. This builds on the success of the previous ...

Research Highlights: Middle-aged Black women with better heart health were less likely to show a decline in mental function compared with middle-aged Black women with worse heart health. In this study, heart health was unrelated to cognitive decline among middle-aged white women. A clinical trial is required to confirm if improving heart health among middle-aged Black women may slow cognitive decline and decrease the risk of dementia. Embargoed until 2 a.m. CT/3 a.m. ET Wednesday, April 24, 2024 DALLAS, April 24, 2024 ...

Sleep and sleep disturbances have consequences for the development of adolescents and young adults. In a new article, researchers examine sleep during these periods, focusing on the effects of ethnic and racial discrimination. They conclude that improving sleep may boost health for all youth, but especially for those affected by racism. The article, by researchers at Fordham University and the University of Illinois at Urbana-Champaign, appears in Child Development Perspectives, a journal of the Society for Research in Child Development. “Discrimination ...

Why do some young children struggle to sit through a story one day but not the next? Why do they rush impulsively into one activity but not another? Parents and teachers often focus on individual differences as they prepare children for formal schooling, but traditional measurement approaches make it difficult to study fluctuations in children’s behavior. In a new study, researchers sought to understand children’s impulsive and inattentive behaviors in early education classrooms by having students use wearable devices called accelerometers to collect an intensive time series of their movement at school. The study found that children modulated their ...

Nature-based climate solutions can help mitigate climate change, especially in forested regions capable of storing and sequestering vast amounts of carbon. New research published in Global Change Biology indicates that a single hurricane in New England, one of the most heavily forested regions in the United States, can down 4.6–9.4% of the total aboveground forest carbon, an amount much greater than the carbon sequestered annually by New England’s forests. The work revealed that emissions from hurricanes are not instantaneous—it takes approximately 19 years for downed carbon to become a net emission, and 100 years for 90% of the downed carbon ...

Essential tremor, a nervous system disorder that causes rhythmic shaking, is one of the most common movement disorders. A new study published in the Annals of Neurology reveals details on the increased risk of mild cognitive impairment (MCI) and dementia that individuals with essential tremor may face. The research represents the longest available longitudinal prospective study of rates of MCI and dementia in people with essential tremor. The study enrolled 222 patients, 177 of whom participated in periodic evaluations over an average follow-up of 5 years. Investigators observed ...

A new study has found that Black women with poor cardiovascular health may face an elevated risk of early signs of cognitive decline in midlife. The study, which is published in the Journal of the American Heart Association, included 363 Black and 402 white women who enrolled in the Chicago site of the Study of Women’s Health Across the Nation when they were 42–52 years old. Cognition (measured as processing speed and working memory) was assessed annually or biennially over a maximum of 20 years, with an average follow-up of 9.8 years. A composite index of cardiovascular health (Life’s Essential 8) was calculated ...

The beginning of life is shrouded in mystery. While the intricate dynamics of mitosis is well-studied in the so-called somatic cells – the cells that have a specialized function, like skin and muscle cells – they remain elusive in the first cells of our bodies, the embryonic cells. Embryonic mitosis is notoriously difficult to study in vertebrates, as live functional analyses and -imaging of experimental embryos are technically limited, which makes it hard to track cells during embryogenesis. However, researchers from the Cell Division Dynamics Unit at the Okinawa Institute of Science and Technology ...

COLUMBUS, OHIO – A new national survey conducted by The Ohio State University Wexner Medical Center finds a broad majority of parents experience isolation, loneliness and burnout from the demands of parenthood, with many feeling a lack of support in fulfilling that role. The survey of parents conducted this month found: About two-thirds (66%) felt the demands of parenthood sometimes or frequently feel isolating and lonely.      About 62% feel burned out by their responsibilities ...

Traditional non-aqueous lithium-ion batteries have a high energy density, but their safety is compromised due to the flammable organic electrolytes they utilize. Aqueous batteries use water as the solvent for electrolytes, significantly enhancing the safety of the batteries. However, due to the limited solubility of the electrolyte and low battery voltage, aqueous batteries typically have a lower energy density. This means that the amount of electricity stored per unit volume of aqueous battery is relatively low. In a new study published in Nature Energy, a research group led by Prof. LI Xianfeng from the Dalian Institute of Chemical Physics (DICP) ...

Contemporary food systems were originally developed to tackle challenges of the mid-20th century, aiming to supply abundant, efficient, non-perishable starchy calories to accommodate the expanding global population. Although substantial progress has been made in global food security over the past several decades, there still exist large populations experiencing hunger worldwide. Currently, global hunger primarily refers to insufficient calorie intake. Hidden hunger is the presence of multiple micronutrient in the absence of an energy-deficit diet. Hidden hunger, particularly the inadequate consumption of high-quality protein, ...

An international team of researchers, led by Danielle DeLeo from the Smithsonian Institution, has identified eight organisms with previously unknown luminosity. Using genetic findings from these organisms and previous studies, they estimated that coral bioluminescence originated about 540 million years ago in the Cambrian period, making them the earliest bioluminescent organisms. During this period, they shared the oceans with invertebrates with light-sensitive eyes, hinting that interspecies interactions occurred involving light. They published their findings in Proceedings of the Royal Society B.  While shallow-water ...

SRI announced today that it has been selected by the Defense Advanced Research Projects Agency (DARPA) to deliver advanced technology for its recently launched Multiobjective Engineering and Testing of ALloy Structures (METALS) program. DARPA METALS aims to break today’s one-material-per-part paradigm, which can lead to vulnerabilities and reduced life when highly engineered components experience austere environments. The goal of the four-year program is to develop technologies that treat material selection – particularly metallic alloys – as a continuous ...

Vaccines remain the gold standard of protection against dangerous pathogens, but take considerable time and vast resources to develop. Rapidly mutating viruses such as SARS-CoV-2 can blunt their effectiveness and even render them obsolete. To address these gaps, a multi-university team led by New Jersey Institute of Technology’s Vivek Kumar is developing a hydrogel therapy that acts as a first line of defense against viruses and other biological threats. The peptides that make up this gel prevent viruses ...

WASHINGTON –Perinatal transmission of HIV to newborns is associated with serious cognitive deficits as children grow older, according to a detailed analysis of 35 studies conducted by Georgetown University Medical Center neuroscientists. The finding helps pinpoint the geographic regions and factors that may be important for brain development outcomes related to perinatal HIV infection: mother-to-child HIV transmission during pregnancy, labor and delivery, or breastfeeding. The findings appeared in eClinicalMedicine on April 23, 2024. Mostly because of advances in antiretroviral therapies, AIDS, which is caused by HIV infection, has ...

In Europe and North America, 30 to 60% of dietary energy intake in adults comes from ultra-processed foods. An increasing number of epidemiological studies suggest a link between higher consumption levels of ultra-processed foods with higher risks of diabetes and other metabolic disorders. Emulsifiers are among the most commonly used additives. They are often added to processed and packaged foods such as certain industrial cakes, biscuits and desserts, as well as yoghurts, ice creams, chocolate bars, industrial breads, margarines and ready-to-eat or ready-to-heat meals, in order to improve their appearance, taste and texture and lengthen ...

Imagine being able to look inside a single cancer cell and see how it communicates with its neighbours.  Scientists are celebrating a new technique that lets them study the fatty contents of cancer cells, one by one.   A study led by the University of Surrey has sampled single live cancer cells and measured the fatty lipid compounds inside them. Working with partners at GSK and UCL, and developing new equipment with Yokogawa, the team saw how those cells transformed in response to changes in their environment.   Dr ...