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Low-dose ketamine shows promise for pain relief in emergency department patients

2024-11-19
Des Plaines, IL — A new study that investigates low-dose ketamine (LDK) as an adjunct to morphine for treating acute pain has been published in the October issue of Academic Emergency Medicine (AEM), the peer-reviewed journal of the Society for Academic Emergency Medicine (SAEM). The study, titled Low-dose ketamine as an adjunct to morphine: A randomized controlled trial among patients with and without current opioid use highlights the potential of low-dose ketamine as a valuable tool in pain management, providing a safe and effective option for emergency medicine physicians managing acute pain.  Pain remains one of the most common and challenging complaints ...

Lifestyle & risk factor changes improved AFib symptoms, not burden, over standard care

2024-11-19
Research Highlights: A clinical trial with adults who have atrial fibrillation (AFib) and an implanted heart device found similar improvements to the amount of time they experienced arrhythmia regardless of whether they received standard care (education pamphlets about healthy diet and exercise), followed a lifestyle/risk factor modification program, or took metformin and followed a lifestyle/risk factor modification program. AFib burden, a measure of how much time a patient experiences atrial arrhythmia, improved during the treatment period — particularly in the standard of care and lifestyle risk factor modification groups. Lifestyle and risk factor modification was associated ...

Researchers discover new cognitive blueprint for making and breaking habits

2024-11-19
Cognitive neuroscientists in Trinity College Dublin have published new research describing a brand new approach to making habit change achievable and lasting.  This innovative framework has the potential to significantly improve approaches to personal development, as well as the clinical treatment of compulsive disorders (for example obsessive compulsive disorder, addiction, and eating disorders). The research was led by Dr Eike Buabang, Postdoctoral Research Fellow in the lab of Professor Claire Gillan in the School of Psychology and has been published as a paper, Leveraging ...

In a small international trial, novel oral medication muvalaplin lowered Lp(a)

2024-11-19
Research Highlights: The oral medication muvalaplin may safely lower high levels of lipoprotein(a), also known as Lp(a), an independent, inherited risk factor for cardiovascular disease. Muvalaplin is a small molecule inhibitor that prevents the bonding of the two protein components that combine to make Lp(a). There are no currently FDA-approved medications to lower Lp(a) levels, though other medications are currently being evaluated in clinical trials. Muvalaplin is the first oral medication developed to lower Lp(a) levels. Results ...

Eradivir’s EV25 therapeutic proven to reduce advanced-stage influenza viral loads faster, more thoroughly in preclinical studies than current therapies

Eradivir’s EV25 therapeutic proven to reduce advanced-stage influenza viral loads faster, more thoroughly in preclinical studies than current therapies
2024-11-19
WEST LAFAYETTE, Ind. — Eradivir, a preclinical biotech company, has developed a patent-pending antiviral therapeutic that reduces lung viral loads of advanced-stage influenza in preclinical studies quicker and more effectively than currently available therapies. A single intranasal dose of EV25, a bispecific small molecule developed by Eradivir, acts faster than the current standard of care, eliminating the detectable virus within 24 hours. EV25 also has a window of efficacy of 96 hours postinfection, which is broader than the current standard of care. A ...

Most Medicare beneficiaries do not compare prescription drug plans – and may be sticking with bad plans

2024-11-19
Every fall, millions of Medicare beneficiaries have the chance to pick a new stand-alone prescription drug plan that may be better suited for them, but most stick with the same plan. A new study published today in Health Affairs Scholar suggests that 52% of Medicare beneficiaries with stand-alone Part D plans did not switch because they made no plan comparisons at all for 2024. Many of these beneficiaries (41%) also reported not knowing how to switch plans.   “Comparing these Medicare Part D plans is hard, so many beneficiaries just don’t do it. But beneficiaries who don’t compare plans may not notice if they are sticking with more expensive plans or ...

“What Would They Say?” video wins second place in international award for tobacco control advocacy

2024-11-19
DALLAS, Nov. 19, 2024 —“What Would They Say?” – the powerful spoken word poem produced on video by the American Heart Association, which is celebrating 100 years of lifesaving service as the world’s leading voluntary organization focused on heart and brain health, has taken second place in the 4th Annual Anthem Awards winning the Silver Award in the Education, Art & Culture Campaign - Non-Profit Community Engagement category. This international recognition celebrates the Association’s impactful work and historic commitment ...

Black Britons from top backgrounds up to three times more likely to be downwardly mobile

2024-11-19
Even when their parents are lawyers, doctors, or executives, Black Britons are substantially more likely to end up in working class jobs than their White peers, a new study from the University of Kent reveals.   Funded by the Leverhulme Trust, this research shows that Black men from the most advantaged families are three times more likely than White men from similar backgrounds to be in working class jobs beyond age 30. Black women are also twice as likely as White women to experience this kind of downward mobility. This is true even after removing ...

Developing an antibody to combat age-related muscle atrophy

Developing an antibody to combat age-related muscle atrophy
2024-11-19
Fukuoka, Japan—We all age. And while humanity’s life expectancy has increased dramatically in the modern era, we still struggle with the inevitable health issues our bodies face as we get up in the years. For example, the decrease of muscle mass and function, leading to weakness and atrophy. This is a pressing concern in a super-aging society like Japan where—while people live longer—without proper muscle strength, quality of life can be drastically diminished. In findings that may eventually lead to targeted ...

Brain aging and Alzheimer's: Insights from non-human primates

Brain aging and Alzheimer's: Insights from non-human primates
2024-11-19
“Brain aging is a biological process that comprehends degenerative, adaptive, and regenerative brain changes that elapse through maturity until the elderly.” BUFFALO, NY- November 19, 2024 – A new review was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), on October 29, 2024, Volume 16, Issue 20, titled, ”Brain aging and Alzheimer’s disease, a perspective from non-human primates.“ In the review, Ferrer Isidro from the University of Barcelona and Reial Acadèmia de Medicina de Catalunya, explores the differences in ...

Can cells ‘learn’ like brains?

Can cells ‘learn’ like brains?
2024-11-19
Individual cells appear capable of learning, a behaviour once deemed exclusive to animals with brains and complex nervous systems, according to the findings of a new study led by researchers at the Centre for Genomic Regulation (CRG) in Barcelona and Harvard Medical School in Boston.    The findings, published today in the journal Current Biology, could represent an important shift in how we view the fundamental units of life.   “Rather than following pre-programmed genetic instructions, cells are elevated to entities equipped ...

How cells get used to the familiar

2024-11-19
A dog learns to sit on command, a person hears and eventually tunes out the hum of a washing machine while reading … The capacity to learn and adapt is central to evolution and, indeed, survival. Habituation — adaptation’s less-glamorous sibling — involves the lessening response to a stimulus after repeated exposure. Think the need for a third espresso to maintain the same level of concentration you once achieved with a single shot. Up until recently, habituation — a simple form of learning — was deemed ...

Seemingly “broken” genes in coronaviruses may be essential for viral survival

Seemingly “broken” genes in coronaviruses may be essential for viral survival
2024-11-19
Viruses are lean, mean, infection machines. Their genomes are tiny, usually limited to a handful of absolutely essential genes, and they shed extra genomic deadweight extremely fast. Usually. Coronaviruses, including SARS-CoV-2 (the virus that causes COVID-19), appear at first glance to be an exception. They have some extra “accessory” genes in addition to the usual minimal viral set, and scientists don’t know what most of them do. Scientists believe these extra genes must be doing something important, though, or they would be rapidly lost as the viruses evolved. Now, University of Utah Health researchers have found that some of these viral genes have stuck around ...

Improving hurricane modeling with physics-informed machine learning

Improving hurricane modeling with physics-informed machine learning
2024-11-19
WASHINGTON, Nov. 19, 2024 – Hurricanes, or tropical cyclones, can be devastating natural disasters, leveling entire cities and claiming hundreds or thousands of lives. A key aspect of their destructive potential is their unpredictability. Hurricanes are complex weather phenomena, and how strong one will be or where it will make landfall is difficult to estimate. In a paper published this week in Physics of Fluids, by AIP Publishing, a pair of researchers from the City University of Hong Kong employed machine learning to more accurately model the boundary layer wind field of tropical cyclones. In atmospheric science, the boundary layer ...

Seed slippage: Champati cha-cha

Seed slippage: Champati cha-cha
2024-11-19
WASHINGTON, Nov 19, 2024 – Champatis, the seeds of the Lapsi tree, are valued in Nepal for their medical, economic, social, and cultural significance. They are also popular among children as simple playthings. But for a group of physicists, these unique seeds—and the way they bounce and roll down slopes—could help them better understand landslides and avalanches, leading to research that could save lives. In a study published this week in Physics of Fluids, by AIP Publishing, a team ...

Hospitalization following outpatient diagnosis of RSV in adults

2024-11-19
About The Study: In this cohort study of adults with outpatient medically attended-respiratory syncytial virus (RSV) infections from 3 large deidentified U.S. databases across 6 RSV seasons, approximately 1 in 20 adults experienced all-cause hospitalization within 28 days. The results of this study highlight the public health need for RSV prevention and treatment.  Corresponding Author: To contact the corresponding author, Joshua T. Swan, PharmD, MPH, email swan.joshua@gmail.com. To access the embargoed study: Visit our For The Media ...

Beyond backlash: how feeling threatened by diversity can trigger positive change

2024-11-19
In recent years, employers across North America have introduced or boosted equity, diversity and inclusion (EDI) programs in hopes of creating a more diverse and inclusive workplace culture. But studies have shown that fostering diversity can come with a steep cost, as employees from dominant groups often felt threatened, leading to a backlash against the very groups the employers are seeking to support. But could those feelings of threat also lead to learning and change, and eventually allyship? ...

Climate change exposure associated with increased emergency imaging

Climate change exposure associated with increased emergency imaging
2024-11-19
OAK BROOK, Ill. – Using data collected over a 10-year period from four emergency departments, researchers at the University of Toronto found that short-term exposure to ambient heat and air pollution levels was associated with increased utilization of X-rays and computed tomography (CT). Results of the study were published today in Radiology, a journal of the Radiological Society of North America (RSNA). “Extreme climate exposures are associated with higher demand for health care including emergency department visits,” ...

Incorrect AI advice influences diagnostic decisions

Incorrect AI advice influences diagnostic decisions
2024-11-19
OAK BROOK, Ill. – When making diagnostic decisions, radiologists and other physicians may rely too much on artificial intelligence (AI) when it points out a specific area of interest in an X-ray, according to a study published today in Radiology, a journal of the Radiological Society of North America (RSNA). “As of 2022, 190 radiology AI software programs were approved by the U.S. Food and Drug Administration,” said one of the study’s senior authors, Paul H. Yi, M.D., director of intelligent imaging informatics and associate member in ...

Building roots in glass, a bio-inspired approach to creating 3D microvascular networks using plants and fungi

Building roots in glass, a bio-inspired approach to creating 3D microvascular networks using plants and fungi
2024-11-19
Fukuoka, Japan— Microfluidic technology has become increasingly important in many scientific fields such as regenerative medicine, microelectronics, and environmental science. However, conventional microfabrication techniques face limitations in scale and in the construction of complex networks. These hurdles are compounded when it comes to building more intricate 3D microfluidic networks. Now, researchers from Kyushu University have developed a new and convenient technique for building such complex 3D microfluidic networks. Their tool? Plants and fungi. The team developed a ‘soil’ medium using nanoparticles of glass (silica) and a cellulose ...

Spinning fusion fuel for efficiency

Spinning fusion fuel for efficiency
2024-11-19
A different mix of fuels with enhanced properties could overcome some of the major barriers to making fusion a more practical energy source, according to a new study.  The proposed approach would still use deuterium and tritium, which are generally accepted as the most promising pair of fuels for fusion energy production. However, the quantum properties of the fuel would be adjusted for peak efficiency using an existing process known as spin polarization. In addition to spin polarizing half the fuels, the percentage of deuterium would be increased from the usual amount of roughly 60% or more.  Models created by scientists at the U.S. Department ...

The American Pediatric Society names Dr. Beth Tarini as the recipient of the 2025 Norman J. Siegel New Member Outstanding Science Award

The American Pediatric Society names Dr. Beth Tarini as the recipient of the 2025 Norman J. Siegel New Member Outstanding Science Award
2024-11-19
The American Pediatric Society (APS) is pleased to announce Beth A. Tarini, MD, MS, MBA, as the 2025 Norman J. Siegel New Member Outstanding Science Award recipient for her considerable contributions to pediatric science. The award will be presented to Dr. Tarini during the APS Presidential Plenary at the Pediatric Academic Societies 2025 Meeting in Honolulu, Hawaii, April 24 – April 28. The award was created in honor of one of the world’s leading nephrologists, Norman J. Siegel, MD, FASN. Dr. Siegel was an outstanding ...

New Clinical Study Confirms the Anti-Obesity Effects of Kimchi

New Clinical Study Confirms the Anti-Obesity Effects of Kimchi
2024-11-19
Approximately 16% of the global population, or about 890 million people, suffer from obesity. The World Health Organization (WHO) has recognized obesity as a significant health issue and highlighted its impact on the quality of life and overall health of individuals across the world. In response to this, the World Institute of Kimchi, South Korea, has been publishing a series of articles on the anti-obesity effects of kimchi in international journals. These articles, based on research studies on the subject, indicate that the regular consumption of kimchi, a traditional ...

Highly selective pathway for propyne semihydrogenation achieved via CoSb intermetallic catalyst

Highly selective pathway for propyne semihydrogenation achieved via CoSb intermetallic catalyst
2024-11-19
Researchers delved deep into the regulation of cobalt active sites to enhance the selectivity of propylene to improve scalability and affordability of the production of this important chemical.   Chemical reactions are not always naturally optimized to yield the products in the quantities needed, especially on the scale needed for the amount of industry in the world today. Researchers from East China University of Science and Technology explored the options available to develop a more cost-effective, scalable and straightforward ...

GERD linked to cardiovascular risk factors: New insights from Mendelian randomization study

GERD linked to cardiovascular risk factors: New insights from Mendelian randomization study
2024-11-19
A recent study published in the Journal of Translational Internal Medicine (https://doi.org/10.1515/jtim-2024-0017) reveals significant insights into the broader impact of gastroesophageal reflux disease (GERD) on cardiovascular health. By using a rigorous bidirectional Mendelian randomization (MR) approach, the research provides compelling evidence that GERD—a condition traditionally recognized as a digestive disorder characterized by acid reflux and heartburn—may influence key cardiovascular risk factors, including blood pressure, lipid ...
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