A common antihistamine may offer hope for patients with a rare genetic disease that can lead to severe liver damage and ultimately require transplantation, according to new research from Rutgers Health. The study in Cellular and Molecular Gastroenterology and Hepatology found that chlorcyclizine, a decades-old allergy medication, could potentially treat erythropoietic protoporphyria (EPP), a condition that creates extreme skin light sensitivity and can produce toxic levels of protoporphyrin in the liver, bone marrow, red cells, and plasma. "There is an unmet need for these patients," said Bishr Omary, senior ...

In patients with high-risk HER2-positive breast cancer, post-surgery, or adjuvant, treatment with trastuzumab emtansine (T-DM1) reduced the long-term risk of death or invasive disease by 46% and improved survival compared to trastuzumab alone, according to the final results of the phase 3 KATHERINE clinical trial led by researchers from the University of Pittsburgh and UPMC Hillman Cancer Center.  The findings, published today in the New England Journal of Medicine (NEJM), provide long-term evidence that T-DM1 is an effective adjuvant treatment for this population of breast ...

MINNEAPOLIS — People who eat more red meat, especially processed red meat like bacon, sausage and bologna, are more likely to have a higher risk of cognitive decline and dementia when compared to those who eat very little red meat, according to a study published in the January 15, 2025, online issue of Neurology®, the medical journal of the American Academy of Neurology. “Red meat is high in saturated fat and has been shown in previous studies to increase the risk of type 2 diabetes and heart disease, which are both linked to reduced brain health,” said ...

MINNEAPOLIS — Tourette syndrome is currently diagnosed about three times more frequently in males than in females. A new study finds that female individuals are less likely to be diagnosed with the syndrome, take longer to receive a diagnosis and are older when they are diagnosed than male individuals. The study is published in the January 15, 2025, online issue of Neurology®, the medical journal of the American Academy of Neurology. Tourette syndrome is a neurodevelopmental disorder defined by ...

Red meat consumption is an established risk factor for chronic conditions, including cardiovascular disease and type 2 diabetes. A new study by investigators from Mass General Brigham, Harvard T.H. Chan School of Public Health, and the Broad Institute of MIT and Harvard found that eating greater quantities of red meat, especially in processed forms, increased risk for dementia, too. Results, published online on January 15, 2025, in Neurology®, the medical journal of the American Academy of Neurology, highlight that replacing processed red meat with protein sources like nuts and legumes or fish may decrease dementia risk by approximately 20 percent. “Dietary ...

Racial disparities decreased slightly, but sex disparities increased significantly over 20-year period Fewer Black people and men underwent weight loss surgery than other racial groups and women, respectively A new study by Mass General Brigham investigators shows persistent racial disparities and growing sex disparities between patients who discussed and received weight loss surgery between 2000 and 2020. Using artificial intelligence to analyze the medical records of more than 120,000 patients with obesity, researchers found that Black people ...

A new paper by a team of Concordia researchers from the departments of Biology and Physics proposes a novel method of fighting cancer tumours that uses ultrasound-guided microbubbles — a technology already widely used in medical imaging and drug delivery. Writing in the journal Frontiers in Immunology, the researchers describe a process that uses ultrasound to modify the behaviour of cancer-fighting T cells by increasing their cell permeability. They examined how this can influence the release of more than 90 kinds of cytokines, a type of signalling molecule crucial for immune response. The researchers targeted freshly isolated human immune cells with tightly ...

In small preliminary study, fearful pet dogs exhibited significantly different microbiomes and metabolic molecules to non-fearful dogs, suggesting the gut-brain axis might be involved in fear behaviors     Article URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0315374 Article title: Altered microbiome and metabolome profiling in fearful companion dogs: An exploratory study  Author countries: Italy Funding: The author(s) received no specific funding for this work. END ...

Examination of Large Language Model "red-teaming" defines it as a non-malicious team-effort activity to seek LLMs' limits and identifies 35 different techniques used to test them     Article URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0314658 Article title: Summon a demon and bind it: A grounded theory of LLM red teaming Author countries: US, Denmark Funding: VILLUM Foundation, grant No. 37176: ATTiKA: Adaptive Tools for Technical Knowledge Acquisition. The funders had no role in study design, data collection ...

Most microplastics in French bottled and tap water are smaller than 20 µm - fine enough to pass into blood and organs, but below the EU-recommended detection limit for water quality assessments.  #### Article URL: https://journals.plos.org/water/article?id=10.1371/journal.pwat.0000250 Article Title: Majority of potable water microplastics are smaller than the 20 μm EU methodology limit for consumable water quality Author Countries: Denmark, France Funding: This work and the PhD fellowship of O.H. is funded by an 80Prime CNRS grant «4DμPlast» (G.L.R, J.E.S.). This publication was supported by ANR-20-CE34-0014 ATMO-PLASTIC (G.L.R, J.E.S.) and the Plasticopyr ...

An analysis of the nine top players in the U.S. fossil fuel-derived hydrocarbon industries (oil/gas, plastics, and agrichemicals) shows tight linkages across the three different sectors, with news media, other petrochemical industry players, and politicians also frequently tagged, according to a study published January 15, 2025 in the open-access journal PLOS Climate by Alaina Kinol from Northeastern University, United States, and colleagues. Previous research on connections between the fossil fuel and plastics sectors and ...

CAMBRIDGE, MA — With a more efficient method for artificial pollination, farmers in the future could grow fruits and vegetables inside multilevel warehouses, boosting yields while mitigating some of agriculture’s harmful impacts on the environment. To help make this idea a reality, MIT researchers are developing robotic insects that could someday swarm out of mechanical hives to rapidly perform precise pollination. However, even the best bug-sized robots are no match for natural pollinators like bees when it comes to endurance, speed, and maneuverability. Now, inspired by the anatomy of these natural pollinators, the researchers ...

Hamilton, ON (January 15, 2025) – Researchers at McMaster University have made an important discovery in the field of asthma research, identifying a new population of immune cells that may play a crucial role in the severity of asthma symptoms.   The study, published in Science Translational Medicine on Jan. 15, 2025, sheds light on the complex mechanisms behind severe asthma and opens new avenues for potential treatments.  Asthma is a chronic respiratory condition characterized by inflammation and narrowing of the airways, leading to difficulty breathing. Severe ...

The study, published in Science Advances, was led by researchers Qigao Jiangzuo, from Peking University, and Joan Madurell Malapeira, from the Universitat Autònoma de Barcelona (UAB). Snow leopards (Panthera uncia) are in serious danger of extinction, with only about 4,000 specimens remaining. They are medium to large felids that live at high altitudes, over 2,000 meters above sea level, mainly in the Himalayas. Although their distinctive traits have long been recognized, the correlation between these ...

Researchers have demonstrated new wearable technologies that both generate electricity from human movement and improve the comfort of the technology for the people wearing them. The work stems from an advanced understanding of materials that increase comfort in textiles and produce electricity when they rub against another surface. At issue are molecules called amphiphiles, which are often used in consumer products to reduce friction against human skin. For example, amphiphiles are often incorporated into diapers to prevent chafing. “We set out to develop a model that would give us ...

Most treatments being pursued today to protect against Alzheimer’s disease focus on amyloid plaques and tau tangles that accumulate in the brain, but new research from Mass General Brigham and Washington University School of Medicine in St. Louis points to a novel—and noble—approach: using Xenon gas. The study found that Xenon gas inhalation suppressed neuroinflammation, reduced brain atrophy, and increased protective neuronal states in mouse models of Alzheimer’s disease. Results are published in Science Translational Medicine, and a phase 1 clinical trial of the treatment in healthy volunteers will begin in early 2025.   “It ...

A small helper for big tasks: an oxygen sensor protein protects the enzymatic machinery of biological nitrogen fixation from serious damage. Its use in biotechnology could help to reduce the use of synthetic fertiliser in agriculture in the future. A research team led by biochemist Prof. Dr Oliver Einsle from the Faculty of Chemistry and Pharmacy and the Centre for Biological Signalling Studies (BIOSS) at the University of Freiburg has discovered exactly how the so-called Shethna protein II works. The scientists used the newly established cryo-electron microscopy in Freiburg. ...

Three-quarters of medical facilities in Mariupol sustained damage during Russia’s siege of 2022, with some evidence that the attacks may have been intentionally targeted, per study using satellite imagery. #### Article URL: https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0003950 Article Title: The effect of conflict on damage to medical facilities in Mariupol, Ukraine: a quasi-experimental study Author Countries: Germany, United States Funding: This work was supported ...

The snow leopard (Panthera uncia) is a large feline unique to the Qinghai-Tibet Plateau and its surrounding areas. As the apex predator in the region, the snow leopard plays a crucial role in maintaining ecological stability. Its unique characteristics, coupled with its striking appearance, have made it a flagship species for conservation efforts aimed at protecting the ecosystem of the Qinghai-Tibet Plateau. Unfortunately, few snow leopard fossils have been found in the Qinghai-Tibet Plateau region, particularly fossils from the Quaternary period. As a result, it’s unclear how snow leopards evolved their specialized adaptations to this environment. On the one hand, molecular ...

Researchers from the National Institute of Health Data Science at Peking University and the Department of Clinical Epidemiology and Biostatistics at Peking University People's Hospital have conducted a comprehensive systematic review evaluating strategies for addressing missing data in electronic health records (EHRs). Published in Health Data Science, the study highlights the growing importance of machine learning methods over traditional statistical approaches in managing missing data scenarios effectively​​. Electronic health records have become a cornerstone in modern healthcare research, enabling analysis across clinical trials, treatment effectiveness studies, and ...

About The Study: In this multicenter validation study, trained health care professionals with artificial intelligence (AI) assistance achieved lung ultrasound images meeting diagnostic standards compared with lung ultrasound experts without AI. This technology could extend access to lung ultrasound to underserved areas lacking expert personnel.  Corresponding Author: To contact the corresponding author, Cristiana Baloescu, MD, MPH, email cristiana.baloescu@yale.edu. To access the embargoed ...

About The Study: This survey study documents increasingly prevalent poor mental health from 2011 to 2022 across multiple U.S. health surveys, with notable prevalence differences in Behavioral Risk Factor Surveillance System and National Survey on Drug Use and Health vs National Health Interview Survey. Inequities in these outcomes by age, sex, and racial and ethnic group were often sizeable and changed over time in distinct ways, consistent with findings in prior literature.  Corresponding Author: To contact the corresponding ...

About The Study: In this cohort study including 38 attending surgeons and 793 patients, increased surgeon stress at the beginning of a procedure was associated with improved clinical patient outcomes. The results are illustrative of the complex relationship between physiological stress and performance, identify a novel association between measurable surgeon human factors and patient outcomes, and may highlight opportunities to improve patient care.  Corresponding Author: To contact the corresponding author, Jake Awtry, MD, email jawtry@bwh.harvard.edu. To access the embargoed study: Visit our For The Media ...

According to the United Nations, soil salinization affects between 20% and 40% of arable land globally, with human activity and climate change – especially rising sea levels – largely responsible for this process. While the human body needs sodium to function, this is not the case for most plants. In fact, excess salt around plants’ roots gradually blocks their access to water, stunting their growth, poisoning them and hastening their death. Ten million hectares of farmland are destroyed by soil salinization every year, posing a threat to global food security. Scientists at EPFL, ...

While most known types of DNA damage are fixed by our cells’ in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that the damage has multiple chances to generate harmful mutations, which can lead to cancer. Scientists from the Wellcome Sanger Institute and their collaborators analysed family trees of hundreds of single cells from several individuals. The team pieced together these family trees from patterns of shared mutations between the cells, indicating common ancestors. Researchers uncovered unexpected ...