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Artificial reef designed by MIT engineers could protect marine life, reduce storm damage

Artificial reef designed by MIT engineers could protect marine life, reduce storm damage
2024-03-26
The beautiful, gnarled, nooked-and-crannied reefs that surround tropical islands serve as a marine refuge and natural buffer against stormy seas. But as the effects of climate change bleach and break down coral reefs around the world, and extreme weather events become more common, coastal communities are left increasingly vulnerable to frequent flooding and erosion.  An MIT team is now hoping to fortify coastlines with “architected” reefs — sustainable, offshore structures engineered to mimic the wave-buffering effects of natural reefs while also providing pockets for fish and other marine ...

Biotechnology CEO and inventor of SiriusXM Satellite Radio Martine Rothblatt to deliver graduation address to the University of Maryland School of Medicine’s 215th graduating class

Biotechnology CEO and inventor of SiriusXM Satellite Radio Martine Rothblatt to deliver graduation address to the University of Maryland School of Medicine’s 215th graduating class
2024-03-26
University of Maryland School of Medicine (UMSOM) Dean Mark T. Gladwin, MD, announced today that Martine Rothblatt PhD, JD, MBA, Chairperson and CEO of United Therapeutics, and inventor of SiriusXM Satellite Radio, will deliver the keynote address for this year’s graduating medical student class. The UMSOM MD graduation ceremony will take place at the Hippodrome Theatre on Thursday, May 16, 2024. The ceremony will begin at 1:00 pm. Details for faculty members are here. Details for students/guests are here. Dr. Rothblatt is a trailblazing pioneer of several innovations in biotechnology, pharmaceuticals, and satellite communications. After developing SiriusXM, ...

ORIGAMI: anticipating the future of more connected, efficient and sustainable telecommunication infrastructures

2024-03-26
The ORIGAMI (Optimized Resource Integration and Global Architecture for Mobile Infrastructure for 6G) project is now underway. The project, funded by the European Commission under the Horizon Europe program, will spearhead architectural innovations for the next generation of 6G mobile networks, to enable innovative applications, new business models, and substantial reductions in energy consumption. By proposing and developing three critical architecture innovations – Global Services Based Architecture (GSBA), Zero Trust Exposure Layer (ZTL), and Continuous Compute ...

Study says it’s time to highlight positive skills associated with neurodevelopmental conditions

2024-03-26
New research says the wide variety of skills displayed by people with conditions such as ADHD, dyslexia and autism should be celebrated to help reduce stigma and change society’s expectations. Creativity, resilience and problem-solving are just some of the strengths exhibited and a study is now calling for a change in the way we think about people with neurodevelopmental conditions. Dr Edwin Burns, senior lecturer from the School of Psychology at Swansea University, worked with academics from Edge Hill University on the study and their findings have just been published by ...

Corporations use government grants to lighten debt load

2024-03-26
Local and state governments have a variety of tools at their disposal to attract businesses or entice them to stay. One is tax relief. Austin, for example, helped lure electric automaker Tesla in part with property tax rebates worth $14 million over 10 years. In a study released today from Texas McCombs, Dean and Accounting Professor Lillian Mills finds that another kind of government aid — cash grants — has a different kind of impact. It helps companies lighten their balance sheets by borrowing less. Corporations ...

C-Path launches consortium for alpha-1 antitrypsin deficiency

2024-03-26
TUCSON, Ariz., March 26, 2024 — Critical Path Institute (C-Path) is excited to announce the launch of the Critical Path for Alpha-1 Antitrypsin Deficiency (CPA-1) Consortium. The CPA-1 consortium aims to accelerate drug development for alpha-1 antitrypsin deficiency (AATD), a rare disease that affects individuals and families worldwide. This will be achieved by integrating data through C-Path’s Rare Diseases Cures Accelerator–Data Analytics Platform (RDCA-DAP®) and leveraging those data for CPA-1 to collaboratively develop regulatory-grade solutions to continuously address unmet needs in drug development for this condition, including: Generating evidence to ...

In paleontology, correct names are keys to accurate study

2024-03-26
COLUMBUS, Ohio – When the skeletal remains of a giant ground sloth were first unearthed in 1796, the discovery marked one of the earliest paleontological finds in American history.  The animal, named Megalonyx by Thomas Jefferson in 1799, was the first genus of fossil named from the United States. Thought to have roamed North America during one of the last ice ages, the extinct giant ground sloth was an herbivorous mammal resembling a large bear — at full size, it likely reached nearly 10 feet tall (3 meters) and weighed about as much as a small elephant.  The report made by Jefferson, an avid fossil collector who was known to keep ...

Imaging deep brain activity with microprisms

Imaging deep brain activity with microprisms
2024-03-26
Organisms constantly face the challenge of adapting their behavior to survive in a world full of uncertainties. This ability relies on complex neural circuits in the brain that help them find resources while avoiding danger. Scientists study how these neural circuits change over time to understand better how behaviors emerge. One powerful way to study these changes is through optical imaging techniques that allow researchers to track the activity of individual brain cells. Traditional methods rely on observing the activity of cells directly, ...

Chlorogenic acid prevents ovariectomized-induced bone loss by facilitating osteoblast functions and suppressing osteoclast formation

Chlorogenic acid prevents ovariectomized-induced bone loss by facilitating osteoblast functions and suppressing osteoclast formation
2024-03-26
“[...] chlorogenic acid appears to be a promising candidate for the management of osteoporosis.” BUFFALO, NY- March 26, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 5, entitled, “Chlorogenic acid prevents ovariectomized-induced bone loss by facilitating osteoblast functions and suppressing osteoclast formation.” Osteoporosis is a common bone disease in ...

Researchers identify protein sensor that plays a role in lung fibrosis

Researchers identify protein sensor that plays a role in lung fibrosis
2024-03-26
Researchers at Weill Cornell Medicine have discovered a protein called SEL1L that plays a critical role in clearing collagen from tissue, and which may be a therapeutic target to help prevent fibrosis, scar tissue that interferes with organ function. The paper, published on Feb. 20 in Nature Communications, provides clues that could lead to drug development for diseases like lung fibrosis which have no therapeutic options currently. Corresponding author, Dr. Michael J. Podolsky, assistant professor of medicine at Weill Cornell Medicine, has led a team that searched the human genome for genes involved in the ...

Johns Hopkins Children’s Center study shows negative impact of COVID-19 pandemic on youth minority mental health

2024-03-26
FOR IMMEDIATE RELEASE Recent historical, political and public health events, most notably the COVID-19 pandemic, have collectively contributed to increased stress and mental health challenges among many groups of people — including adolescents in racial and ethnic minorities.  In a study published Feb. 1 in Academic Pediatrics, Johns Hopkins Children’s Center researchers investigated the pandemic’s effect on preexisting mental health disparities among youth, and found rates of depression, anxiety, and suicidal thoughts and behaviors ...

Researchers a step closer to a cure for HIV

Researchers a step closer to a cure for HIV
2024-03-26
By 2030, the World Health Organization (WHO), the Global Fund and UNAIDS are hoping to end the human immunodeficiency virus (HIV) and AIDS epidemic. An international team of researchers led by Eric Arts, professor at the Schulich School of Medicine & Dentistry, and Jamie Mann, senior lecturer at the University of Bristol (U.K.), has brought us another step closer to meeting this goal, by finding an effective and affordable targeted treatment strategy for an HIV cure.  In a first, the study published ...

AI predicts the taste and quality of beer

AI predicts the taste and quality of beer
2024-03-26
Leuven (Belgium) 26 March 2024 - Belgian scientists have developed AI models that can predict how a particular beer will be rated by consumers, and what aroma compounds brewers can add to improve it. The research was published today in the renowned scientific journal Nature Communications and may revolutionize how the food and beverage industry develops new products.  Tricky to compare Comparing and ranking flavor profiles of different beers is a challenge. There are a multitude of guides on the market describing ...

A global map of how climate change is changing winegrowing regions

A global map of how climate change is changing winegrowing regions
2024-03-26
Grapes grown to make wine are sensitive to climate conditions such as temperature and extreme drought. These effects are already visible worldwide on yields, the composition of grapes and the quality of wines, with already and soon-to-be-observed consequences on the geography of wine production. Understanding shifts in wine production potential due to climate change is a major scientific concern. Based on their expertise and a thorough analysis of the scientific literature — over 250 publications in the last 20 years – a research team has established a global map of evolving trends in the threats and potential benefits that climate change brings ...

SwRI’s Dr. Rohini Giles receives NASA Early Career Achievement Medal

SwRI’s Dr. Rohini Giles receives NASA Early Career Achievement Medal
2024-03-26
SAN ANTONIO — March 26, 2024 —Southwest Research Institute Senior Research Scientist Dr. Rohini Giles has received the NASA Early Career Achievement Medal. The medal recognizes unusual and significant performance supporting NASA’s mission during the first 10 years of their career. Giles was cited for “significant early career achievements in the analysis of Juno data to study Jovian Transient Luminous Events and the distribution of constituents in Jupiter’s atmosphere.” “It’s ...

Sodium intake and cause-specific mortality among predominantly low-income Black and white residents

2024-03-26
About The Study: In this cohort study of 64,000 low-income Americans, nearly 80% of study participants consumed sodium exceeding the current recommended daily amount, which was associated with 10% to 30% of cardiovascular disease mortality. Public health programs targeted to reduce sodium intake among this underserved population may be beneficial. Authors: Xiao-Ou Shu, M.D., Ph.D., of the Vanderbilt University School of Medicine in Nashville, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi: 10.1001/jamanetworkopen.2024.3802) Editor’s Note: Please see the ...

Exclusive breastfeeding duration and risk of childhood cancers

2024-03-26
About The Study: In this cohort study including 309,000 Danish children, longer duration of exclusive breastfeeding was associated with reduced risk of childhood B-cell precursor-acute lymphoblastic leukemia, corroborating results of previous case-control investigations in this field. To inform future preemptive interventions, continued research should focus on the potential biologic mechanisms underlying the observed association. Authors: Signe Holst Søegaard, Ph.D., of the Danish Cancer Society in Copenhagen, is the corresponding ...

Ancient DNA reveals origin of racial/ethnic disparity in a childhood cancer

2024-03-26
There are 40% more Hispanic/Latino kids diagnosed with acute lymphoblastic leukemia (ALL) than white non-Hispanic/Latino children; actually, Hispanic/Latino individuals have the highest risk of ALL in the United States.  However, the basis for this difference is not well understood. Researchers recently identified a genetic variant that accounts for the increased risk of B-cell ALL in Hispanic/Latino children, and using ancient DNA, they traced the mutation all the way back to the first migrants who ...

USC researchers find genetic variant contributing to disparities in childhood leukemia risk

2024-03-26
Acute lymphoblastic leukemia (ALL), the most common childhood cancer, disproportionately affects children of Hispanic/Latino origin in the United States. They are 30-40% more likely to get ALL than non-Hispanic white children, but the exact genetic basis and cause of that increased risk are unknown. Now, a study from the Keck School of Medicine of USC has revealed a key genetic variant contributing towards the increased risk, as well as details about the biological basis of ALL. The team used genetic fine-mapping analysis, a statistical method that allows researchers ...

Structural basis for the regulatory mechanism of mammalian mitochondrial respiratory chain megacomplex-I2III2IV2

Structural basis for the regulatory mechanism of mammalian mitochondrial respiratory chain megacomplex-I2III2IV2
2024-03-26
Mammalian mitochondrial electron transport chain complexes are the most important and complicated protein machinery in mitochondria. Although this system has been studied for more than a century, its composition and molecular mechanism are still largely unknown. Here, Yang’s group report the high-resolution cryo-electron microscopy (cryo-EM) structures of porcine respiratory chain megacomplex-I2III2IV2 (MCI2III2IV2) in five different conformations, including State 1, State 2, Mid 1, Mid 2, and Mid 3. High-resolution cryo-EM imaging, combined with super-resolution gated stimulated emission depletion microscopy (gSTED), strongly supports ...

Antifungal activity of a maleimide derivative: Disruption of cell membranes and interference with iron ion homoeostasis

Antifungal activity of a maleimide derivative: Disruption of cell membranes and interference with iron ion homoeostasis
2024-03-26
This study is led by Prof. Ying Li (Xuzhou Medical University), Prof. Zuobin Zhu (Xuzhou Medical University), and Prof. Wenqiang Chang (Shandong University). A small molecule library consisting of 40 compounds, specifically N-substituted maleimide and its derivatives were initially screened in the study. Among them, twelve maleimides, each with a distinct N-protection group, were synthesized using ring-opening and ring-closing reactions involving various amines and maleic anhydride. Additionally, a set of twenty-eight ...

Addressing global energy needs with ideal electrocatalysts 

Addressing global energy needs with ideal electrocatalysts 
2024-03-26
Researchers from the University of Tartu and the University of Copenhagen have proposed the theoretical description of an ideal electrocatalysis process, which, if implemented, could double the efficiency of energy conversion and storage devices.   As the world seeks sustainable solutions to meet escalating energy demands, a collaborative team of researchers from the Universities of Tartu and Copenhagen has proposed an innovative approach to overcome long-standing limitations in oxygen electrocatalysis. Oxygen electrocatalysis ...

Researchers identify new way to inhibit immune cells that drive allergic asthma

Researchers identify new way to inhibit immune cells that drive allergic asthma
2024-03-26
Researchers at the Keck School of Medicine, University of Southern California, have discovered that a protein called Piezo1 prevents a type of immune cell in the lung from becoming hyperactivated by allergens. The study, to be published March 26 in the Journal of Experimental Medicine (JEM), suggests that switching on Piezo1 could represent a new therapeutic approach to reducing lung inflammation and treating allergic asthma. Type 2 innate lymphoid cells (also known as ILC2s) are a type of immune cell that resides in the lungs, skin, and other tissues of the body. ILC2s in the lungs become activated in the presence of allergens and produce ...

JSCAI publishes special issue: Cardiac CT Angiography in Diagnosis, Treatment, and Prognosis of Cardiac Disease

2024-03-26
Cardiac computed tomography angiography (CCTA or CTA) has emerged as a first-line tool for diagnosing, treating, and evaluating the prognosis of various cardiac diseases. In this special issue of JSCAI, "The Role of Cardiac Computed Tomography Angiography in Diagnosis, Treatment, and Prognosis of Cardiac Disease", experts detail the broad spectrum of uses of this imaging modality, acknowledging the role of this test in current clinical and procedural practice, including: Risk stratification Ruling out coronary artery disease in patients with chest pain Assessing ...

Just ask: patients in the ER are willing to get a flu shot

2024-03-26
Simply asking patients to get the flu vaccine, and combining it with helpful video and print messages, is enough to persuade many who visit emergency departments to roll up their sleeves, according to a new study led by UC San Francisco.    Researchers found a 32% vaccine uptake in patients who were asked if they’d be interested in getting the flu shot and told their health providers would be informed. They saw a 41% uptake for those who were asked about receiving a flu shot and received a pamphlet, watched ...
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