A multidisciplinary team of University of Cincinnati Cancer Center researchers have opened a Phase 2 clinical trial to test a new combination treatment for glioblastomas (GBM), the most deadly form of brain tumors.  The team, led by UC’s Pankaj Desai, PhD, and Trisha Wise-Draper, MD, PhD, has been awarded a Catalyst Research Award from the Dr. Ralph and Marian Falk Medical Research Trust to move the trial forward.  Study background  Difficult to diagnose at early stages, GBMs are aggressive brain tumors that become symptomatic once the tumor is substantial. Current treatments include ...

An international research team led by RMIT University has designed and manufactured a virus-killing surface that could help control disease spread in hospitals, labs and other high-risk environments.  The surface made of silicon is covered in tiny nanospikes that skewer viruses on contact.  Lab tests with the hPIV-3 virus – which causes bronchitis, pneumonia and croup – showed 96% of the viruses were either ripped apart or damaged to the point where they could no longer replicate to cause infection.  These impressive results, featured on the cover of top nanoscience journal ACS Nano, show the material’s promise ...

Diving deep into quantum biology or cognitive science alone is challenging enough. That being said, a research team recently wrote a review article highlighting molecular quantum computing, a newly emerged research area that is likely to push the research boundaries of both. The review was published Feb. 21 in Intelligent Computing, a Science Partner Journal. Future theoretical breakthroughs may be achieved by connecting molecular quantum computing, the bridge research area, with cognitive science and quantum ...

One of the features of the deaf community is that it is highly diverse. As well as including people of different ages and genders, the members of the community do not all share the same type of deafness or form of communication. Firstly, the time of onset of deafness and the degree of hearing loss vary greatly. And secondly, not everybody uses sign and oral language in the same way. All these aspects have a bearing on the well-being of deaf people. However, few studies specifically analyse the effect of each one. The PhD thesis, defended by Amaia Jauregi-Orbe at the Faculty ...

Named for its ropy-looking long branches, Aplysina cauliformis, a coral reef sponge, provides a critical 3D habitat for marine organisms and helps to stabilize the foundation of coral reefs. However, these upright branching sponges are highly susceptible to breaking during storms, which increases sponge fragmentation and contributes to population clonality and inbreeding. Many sponges can survive severe damage and undergo frequent fragmentation, which is considered a mechanism for asexual reproduction. While fragmentation is a commonly utilized reproductive strategy in rope sponges, they also can reproduce sexually by producing larvae. How and whether they recolonize following ...

LOS ANGELES – (3/26/24) - In a landmark move for biomedical progress, the Terasaki Institute for Biomedical Innovation (TIBI) today unveiled the launch of four pioneering startup companies. These ventures represent a strategic leap forward in TIBI's commitment to transforming healthcare through innovation. By harnessing the institute's groundbreaking research in biomaterials, micro-needles, organoids, tissue engineering, and advanced biosensing, these startups are poised to tackle some of the most pressing health challenges ...

Engineers have designed a modular artificial reef that can dissipate wave energy far better than natural coral reefs, according to a study. Sixty percent of the world’s coral reefs are under threat from rising ocean temperatures, overfishing, or coastal development. At the same time, climate change is leading to sea level rise, frequent high-tide flooding, and powerful storm surges. Artificial reefs can help protect coastal infrastructure from storms as well as provide habitat for marine organisms. Michael Triantafyllou and colleagues proposed and tested an architected cellular reef structure ...

A Medicare policy requiring primary care providers (PCPs) to share in the decision-making with patients on whether to proceed with lung cancer screening is fraught with confusion and lack of evidence-based information, and may actually be undermining the purpose for which it was created, Mount Sinai researchers say. In their study, published in Annals of Family Medicine, the team reported that the policy, enacted nearly 10 years ago to encourage the use of lung cancer screening, is in urgent need of new ...

Nasopharyngeal carcinoma (or NPC) is a rare type of cancer affecting the epithelial tissue of the nasopharynx, the upper part of the throat behind the nasal cavity. Among the three main subtypes of NPC, non-keratinizing undifferentiated squamous carcinoma is endemic to the regions of Southern China and Southeast Asia, with a strong association with Epstein-Barr virus (or EBV) infection. EBV, also known as human tumor virus, is a double-stranded DNA virus that is associated with various cancers, such as Burkitt lymphoma, T-cell lymphoma, and gastric cancer. EBV genomes mostly survive autonomously as episomes or extrachromosomal ...

Entropy, the amount of molecular disorder, is produced in several systems but cannot be measured directly. An equation developed by researchers at Chalmers University of Technology and Heinrich Heine University Düsseldorf, now sheds new light on how entropy is produced on a very short time scale in laser excited materials. “New computational models give us new research opportunities. Extending thermodynamics for ultrashort excitations will provide novel insights into how materials function on the nanoscale,” says Matthias Geilhufe, Assistant Professor ...

Scientists on the hunt for evidence of quantum gravity’s existence at the South Pole University of Copenhagen team contributes to an Antarctic large-scale experiment striving to find out if gravity also exists at the quantum level. An extraordinary particle able to travel undisturbed through space seems to hold the answer. Several thousand sensors distributed over a square kilometer near the South Pole are tasked with answering one of the large outstanding questions in physics: does quantum gravity exist? ...

ITHACA, N.Y. – An international team of 25 scientists has proposed a roadmap for how to prevent the next pandemic by conserving natural areas and promoting biodiversity, thereby providing animals with enough food, safe havens and distance to limit contact and the transfer of pathogens to humans. Pandemics begin when disease-harboring animals, such as bats, come in close proximity with people, livestock or other animals and pass on new pathogens. Viruses such as SARS-CoV-2, SARS-CoV-1, Nipah, Hendra and possibly Ebola have all fatally spilled over from bats to humans, ...

Arlington, VA – As efforts to restore tree cover accelerate to help avoid runaway climate change, a new study highlights how restoring tree cover can, in some locations, heat up the Earth rather than cool it by affecting how much sunlight the surface reflects (i.e. “the albedo").    This new study by researchers at Clark University in the United States alongside scientists from The Nature Conservancy (TNC) and ETH-Zurich, published today in the journal Nature Communications, provides a global analysis of where restoration of tree cover is most effective at cooling the global climate system, considering ...

In a world inundated with a constant stream of new information—notifications, ads, emails, news—we often struggle to prevent our attention from being constantly hijacked by external events. But is it truly within our power to filter and select our perceptions? And why do we find ourselves so easily distracted? “Exogenous attention, the cognitive process that allows a salient visual stimulus to impose itself on us, is automatic. When a colleague walks past our desk, our attention is diverted from our computer screen despite ourselves,” explains Tal Seidel Malkinson (University of Lorraine), ...

Actually, the team from Naturalis Biodiversity Center in the Netherlands was looking for a Tyrannosaurus, that summer of 2013 in Wyoming. Instead, they found a Triceratops: the famous dinosaur with the three horns and the large neck frill. And then they found another one. And another one. And more. The dig turned into a project that would last for more than ten years.  All in all, they dug up 1200 bones and bone fragments, of at least five individuals. A team of professional and volunteer paleontologists ...

Research Highlights: Nontraditional risk factors for stroke were significantly associated with the development of strokes in adults younger than ages 35 to 45. Migraine was the most important nontraditional risk factor for stroke among both men and women, according to the study of adults in Colorado. Embargoed until 4 a.m. CT/5 a.m. ET Tuesday, March 26, 2024 DALLAS, March 26, 2024 — Adults younger than 35- to 45-years old may have a higher risk of developing a stroke from nontraditional risk factors ...

Bethesda, MD (March 26, 2024) – Modeling studies and expert consensus published today in the journals Gastroenterology and Clinical Gastroenterology and Hepatology shed new light on the promise and peril of liquid biopsy (blood tests) for colorectal cancer (CRC) screening that are currently in development.   “Based on their current characteristics, blood tests should not be recommended to replace established colorectal cancer screening tests, since blood tests are neither as effective or cost-effective, ...

One in three birders experiences accessibility challenges to participation in birding, according to Virginia Tech researchers Emily Sinkular and Ashley Dayer. “I like to think of our research as blending together two previously unconnected fields: disability studies and wildlife recreation,” said Sinkular, a Ph.D. student and lead author of the study published March 26 in the journal Human Dimensions and Wildlife. “There’s been quite a lot of research on disability and lots of research on birding, but very few researchers have combined these two topics together.” The ...

A global collaborative research group comprising 131 researchers from 105 laboratories across seven countries announces a groundbreaking research paper submitted to eLife. Titled "Large-scale Animal Model Study Uncovers Altered Brain pH and Lactate Levels as a Transdiagnostic Endophenotype of Neuropsychiatric Disorders Involving Cognitive Impairment," the study identifies brain energy metabolism dysfunction leading to altered pH and lactate levels as common hallmarks in numerous animal models of neuropsychiatric and neurodegenerative disorders, such as intellectual disability, autism spectrum disorders, schizophrenia, bipolar disorder, depressive disorders, and Alzheimer’s ...

An orange dwarf star has yielded the tiniest ‘starquakes’ ever recorded, measured by an international team of scientists. Named Epsilon Indi, the star is the smallest and coolest dwarf star yet observed with solar-like oscillations – “starquakes” like those shown by the Sun. These oscillations provide indirect glimpses of stellar interiors – just as earthquakes tell us about Earth's interior – and so are important sources of information about the makeup of the star. The measurements ...

When we talk, we often use our hands in addition to words. Gesturing is a phenomenon that has been observed across languages and cultures. Some cultures are typically thought to use more gestures than others. To find out if the deeply rooted stereotype of Italians gesturing more than other cultures is true, researchers in Sweden have examined the differences in gesture rate and function between Italians and Swedes who were telling a story to a friend. “We show that Italians do gesture more than Swedes, which was expected,” ...

Researchers at the University of Leeds and Lancaster University in the UK have identified a new potential target for the treatment of Alzheimer’s disease – PDE4B. Alzheimer's disease is the leading cause of dementia and disability in old age. As the number of people diagnosed with Alzheimer’s disease is on the increase, new treatments are urgently needed to improve the quality of life for people living with the disease. PDE4B is an enzyme inside cells that breaks down a molecule known as cyclic AMP, which regulates a range of cellular processes. Based on an Australian study that identified the ...

Scientists from Nagoya University have discovered a novel regulatory mechanism that controls the opening of stomata in plants, which is crucial for harnessing solar energy through photosynthesis. The team uncovered the role of phosphorylation at the 881st threonine residue (Thr881) of the plasma membrane proton pump in response to red and blue light in this process. This research opens up possibilities for manipulating plant physiology in specific ways, benefiting agriculture and the environment. The researchers reported their findings in Nature Communications. “This phosphorylation event, ...

As authorities crack down on illicit drugs, University of South Australia experts have issued an alert on the use of the synthetic stimulant pentylone, as new research finds a 75% increase in detections across Australia.   In a new study as part of the Australian Criminal Intelligence Commission’s National Wastewater Drug Monitoring Program, researchers identified 20 different novel psychoactive substances (NPS) in wastewater treatment plants across Australia (between Feb 22-23) with pentylone detected at every collection site. Other NPS, eutylone and phenibut were also commonly detected.   Pentylone, (street name ‘bath salts’), ...

It’s taboo to consume seaweed soup before exams in Korea since it can lead to failing the exam. The belief is rooted in the idea that the slippery nature of seaweed may cause people to slip and falter during the test. The slick surface of seaweeds such as seaweed and kelp is attributed to alginate, a mucilaginous substance. Notably, an intriguing study exploring the use of alginate for the treatment of retinal detachment has been recently published.   A collaborative effort between Professor Hyung Joon Cha from the Department of Chemical Engineering and the School of Convergence Science and Technology and Dr. Geunho Choi from ...