(Press-News.org) Optic nerve transection increased the expression of heat shock protein 72 (HSP72) in the lateral geniculate body, indicating that this protein is involved in the prevention of neuronal injury. Zinc sulfate and quercetin induced and inhibited the expression of HSP72, respectively. In a study reported by Dr. Ning Li and co-workers from the First Affiliated Hospital of Anhui Medical University, China, intraperitoneal injections of zinc sulfate, SP600125 (c-Jun N-terminal kinase inhibitor), or quercetin were performed on retinal ganglion cells in a Wistar rat model of chronic ocular hypertension. Researchers found that HSP72 protects retinal ganglion cells and lateral geniculate body in a rat model of chronic ocular hypertension from injury by blocking the activation of the stress-activated kinase/c-Jun N-terminal kinase apoptotic pathway. This study has been published in the Neural Regeneration Research (Vol. 9, No. 14, 2014).
INFORMATION:
Article: " HSP72 confers protection in RGCs and LGN neurons via blockade of the SAPK/JNK pathway in a chronic ocular-hypertensive rat model," by Ning Li 1, Yuehua Li 2, Xuanchu Duan 2 (1 Department of Ophthalmology, The First Affliated Hospital of Anhui Medical University, Hefei, Anhui Province, China; 2 Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China)
Li N, Li YH, Duan XC. Heat shock protein 72 confers protection in retinal ganglion cells and lateral geniculate nucleus neurons via blockade of the SAPK/JNK pathway in a chronic ocular-hypertensive rat model. Neural Regen Res. 2014;9(14):1395-1401.
Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
http://www.nrronline.org/
HSP72 confers protection in retinal ganglion cells and lateral geniculate nucleus neurons
2014-08-18
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