(Press-News.org) New Rochelle, NY, November 24, 2014--Genetically engineered pigs, minipigs, and microminipigs are valuable tools for biomedical research, as their lifespan, anatomy, physiology, genetic make-up, and disease mechanisms are more similar to humans than the rodent models typically used in drug discovery research. A Comprehensive Review article entitled "Current Progress of Genetically Engineered Pig Models for Biomedical Research," describing advances in techniques to create and use pig models and their impact on the development of novel drugs and cell and gene therapies, is published in BioResearch Open Access, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available on the BioResearch Open Access website at http://online.liebertpub.com/doi/full/10.1089/biores.2014.0039.
Gökhan Gün and Wilfried Kues, Friedrich-Loeffler-Institute (Neustadt, Germany), Istanbul Technical University, and Istanbul University Faculty of Veterinary Medicine (Turkey), discuss the technologies that have made it possible to develop transgenic pig models of human diseases, such as targeted gene transfer and genome sequencing. The authors review current progress in creating transgenic pig models for cancer, cardiovascular diseases, diabetes, neurodegenerative diseases, ophthalmology, and xenotransplantation. These models will enable researchers to study disease processes, identify new drug targets, test novel cell therapies to restore diseased tissues and organs, and assess methods to correct or replace mutated genes.
"This review provides an excellent update of recent progress in the field of pig transgenics for biomedical research," says BioResearch Open Access Editor Jane Taylor, PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, Scotland.
INFORMATION:
About the Journal
BioResearch Open Access is a bimonthly peer-reviewed open access journal led by Editor-in-Chief Robert Lanza, MD, Chief Scientific Officer, Advanced Cell Technology, Inc. and Editor Jane Taylor, PhD. The Journal provides a new rapid-publication forum for a broad range of scientific topics including molecular and cellular biology, tissue engineering and biomaterials, bioengineering, regenerative medicine, stem cells, gene therapy, systems biology, genetics, biochemistry, virology, microbiology, and neuroscience. All articles are published within 4 weeks of acceptance and are fully open access and posted on PubMed Central. All journal content is available on the BioResearch Open Access website at http://www.liebertpub.com/biores.
About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many areas of science and biomedical research, including DNA and Cell Biology, Tissue Engineering, Stem Cells and Development, Human Gene Therapy, HGT Methods, and HGT Clinical Development, and AIDS Research and Human Retroviruses. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website at http://www.liebertpub.com.
DENVER--Nov. 24, 2014-- Four years ago, a bulldozer operator turned over some bones during construction at Ziegler Reservoir near Snowmass Village, Colorado. Scientists from the Denver Museum of Nature & Science were called to the scene and confirmed the bones were those of a juvenile Columbian mammoth, setting off a frenzy of excavation, scientific analysis, and international media attention. This dramatic and unexpected discovery culminates this month with the publication of the Snowmastodon Project Science Volume in the international journal Quaternary Research.
Fourteen ...
Conventional treatment seeks to eradicate cancer cells by drugs and therapy delivered from outside the cell, which may also affect (and potentially harm) nearby normal cells.
In contrast to conventional cancer therapy, a University of Cincinnati team has developed several novel designs for iron-oxide based nanoparticles that detect, diagnose and destroy cancer cells using photo-thermal therapy (PTT). PTT uses the nanoparticles to focus light-induced heat energy only within the tumor, harming no adjacent normal cells.
The results of the UC work will be presented at the ...
Scientists from the US Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have learned new details about how an important tumor-suppressing protein, called p53, binds to the human genome. As with many things in life, they found that context makes a big difference.
The researchers mapped the places where p53 binds to the genome in a human cancer cell line. They compared this map to a previously obtained map of p53 binding sites in a normal human cell line. These binding patterns indicate how the protein mobilizes a network of genes that quell tumor ...
Researchers at UC San Francisco have identified patterns of genetic activity that can be used to diagnose endometriosis and its severity, a finding that may offer millions of women an alternative to surgery through a simple noninvasive procedure.
The study is online in the journal Endocrinology.
"This promising molecular diagnostic approach would not have been possible without advances in genomics and bioinformatics," said senior author Linda Giudice, MD, PhD, distinguished professor and chair of obstetrics, gynecology and reproductive sciences at UCSF.
"Importantly, ...
A protein that stimulates the brain to awaken from sleep may be a target for preventing Alzheimer's disease, a study by researchers at Washington University School of Medicine in St. Louis suggests.
In recent years, scientists at Washington University have established links between sleep problems and Alzheimer's. For example, they have shown in people and in mice that sleep loss contributes to the growth of brain plaques characteristic of Alzheimer's, and increases the risk of dementia.
The new research, in mice, demonstrates that eliminating that protein - called orexin ...
WASHINGTON, Nov. 24, 2014 -- The season of giving is often also the season of over-indulging at the dinner table. As Thanksgiving approaches, Reactions takes a look down at our stomachs to find out what happens when you overeat. Put on your "eating pants" and enjoy the video here:
Subscribe to the series at Reactions YouTube, and follow us on Twitter @ACSreactions to be the first to see our latest videos.
INFORMATION:The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 161,000 members, ACS is the world's largest scientific ...
How does glass transition from a liquid to its familiar solid state? How does this common material transport heat and sound? And what microscopic changes occur when a glass gains rigidity as it cools?
A team of researchers at NYU's Center for Soft Matter Research offers a theoretical explanation for these processes in Proceedings of the National Academy of Sciences.
Our understanding of glasses as they change state is relatively limited. This is because, unlike other materials such as metals, their constituent particles--which can be as small as a billionth of a meter ...
People who see their group as more homogenous - for instance, the more one thinks Americans are similar to each other - are less likely to be influenced by external terrorist threat alerts, according to research from NYU's Steinhardt School of Culture, Education, and Human Development.
"Among people who viewed their group to be homogeneous, external threat did not translate to higher perceived threat, and they did not influence beliefs about the legitimacy of the U.S. military intervention in Iraq," said study author Rezarta Bilali, assistant professor of psychology and ...
ANN ARBOR--The medical community may be inadvertently creating a new generation of illegal, recreational drug users by prescribing anti-anxiety or sleep medications to teenagers, say University of Michigan researchers.
Teens prescribed anxiety or sleep medications are up to 12 times more likely to abuse those drugs than those who had never had a prescription, either by using someone else's prescription pills or to get high or experiment, according to a study from the U-M School of Nursing.
Nearly 9 percent of the 2,745 adolescent study participants had received ...
A team of scientists from Arizona State University's Biodesign Institute and IBM's T.J. Watson Research Center have developed a prototype DNA reader that could make whole genome profiling an everyday practice in medicine.
"Our goal is to put cheap, simple and powerful DNA and protein diagnostic devices into every single doctor's office," said Stuart Lindsay, an ASU physics professor and director of Biodesign's Center for Single Molecule Biophysics. Such technology could help usher in the age of personalized medicine, where information from an individual's complete DNA ...
