PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Representation of racial/ethnic minorities, women in clinical trials of managing hearing loss

2021-04-22
(Press-News.org) What The Study Did: This review of 125 U.S.-based clinical trials that investigated the management of hearing loss assessed representation in the trials by race/ethnicity and sex.

Authors: Carrie Nieman M.D., M.P.H., of the Johns Hopkins University Bloomberg School of Public Health in Baltimore, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ 

(doi:10.1001/jamaoto.2021.0550)

Editor's Note: The article includes conflicts of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

#  #  #

Media advisory: The full article is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/10.1001/jamaoto.2021.0550?guestAccessKey=4a6d3f17-01d3-4d8d-99c0-925e28e69efa&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=042221

INFORMATION:



ELSE PRESS RELEASES FROM THIS DATE:

Opioid use following first prescription among adolescents, young adults

2021-04-22
What The Study Did: Claims data were used to look at opioid use among young people (ages 10 to 21) who had been prescribed opioids for the first time. Authors: J. Deanna Wilson, M.D., M.P.H., of the University of Pittsburgh School of Medicine, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.4552) Editor's Note: The article includes conflicts of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. #  ...

Racial/ethnic disparities in ophthalmology clinical trials of FDA-approved drugs

2021-04-22
What The Study Did: Researchers investigated racial/ethnic representation in clinical trials that led to U.S. Food and Drug Administration approval of ophthalmology drugs from 2000 to 2020. Authors: Shriji Patel, M.D., of Vanderbilt University Medical Center in Nashville, Tennessee, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamaophthalmol.2021.0857) Editor's Note: The article includes conflicts of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. #  #  ...

Salad or cheeseburger? Your co-workers shape your food choices

2021-04-22
BOSTON -- The foods people buy at a workplace cafeteria may not always be chosen to satisfy an individual craving or taste for a particular food. When co-workers are eating together, individuals are more likely to select foods that are as healthy--or unhealthy--as the food selections on their fellow employees' trays. "We found that individuals tend to mirror the food choices of others in their social circles, which may explain one way obesity spreads through social networks," says Douglas Levy, PhD, an investigator at the Mongan Institute Health Policy Research Center at Massachusetts General Hospital (MGH) ...

Study finds stereotactic body radiotherapy is safe for treating multiple metastases

2021-04-22
A phase 1 clinical trial led by investigators at the University of Chicago Medicine testing the effects of stereotactic body radiotherapy for treating multiple metastases has determined that treatments used for single tumors can also be safely used for treating patients with multiple metastases. The study was run through NRG Oncology and sponsored by the National Cancer Institute. The results were published on April 22 in JAMA Oncology. Cancer is traditionally treated with a combined approach, with clinicians using surgery, chemotherapy and radiation therapy to kill and remove cancerous tumors. Systemic ...

Less is more for the next generation of CAR T cells

2021-04-22
PHILADELPHIA--When researchers from Penn Medicine found that many patients with B-cell acute lymphoblastic leukemia (ALL) treated with the investigational chimeric antigen receptor (CAR) T cell therapy targeting the CD22 antigen didn't respond, they went back to the drawing board to determine why. They discovered that less is more when it comes to the length of what is known as the single-chain variable fragment -- the linker that bridges the two halves of the receptor that allows CAR T cells to latch onto tumor cells and attack them. The findings are reported online today in Nature Medicine. "A little difference of a few amino acids can make a huge difference for patients," said co-senior author Marco Ruella, MD, an ...

'Stickiness' key to better diagnostics and pharmaceuticals

Stickiness key to better diagnostics and pharmaceuticals
2021-04-22
The 'stickiness', or viscosity, of microscopic liquids can now be measured thousands of times faster than ever before, potentially leading to better understanding of living cells, disease diagnostics and pharmaceutical testing. University of Queensland's Professor Warwick Bowen and his colleagues at the Queensland Quantum Optics Lab developed the world-leading technology, technology that uses lasers to track microscale particles with world-record precision. "The stickiness, or viscosity, of liquids is incredibly important in biology," Professor Bowen said. "In living cells, viscosity fluctuations control shape and structure, modulate chemical reactions, and signal whether a cell is healthy or cancerous. "However, ...

Urgent shortage of evidence for safe withdrawal from antidepressants

2021-04-22
A new study has highlighted that while much is known about the ever increasing uptake of antidepressant medications around the world, there is very little evidence on safe and effective approaches to discontinuing treatment. In 2020 there were 78 million prescriptions for antidepressants in England and about half of patients treated have taken them for at least two years. Guidelines typically recommend that antidepressants be taken for up to 6 to 12 months after improvement, or for up to two years in people at risk of relapse, but many people take antidepressants for much longer. Surveys of antidepressant users suggest that up to a half of people on long-term antidepressant prescriptions have no clear medical ...

Miniaturized models of neuron-muscle interactions give insight in ALS

Miniaturized models of neuron-muscle interactions give insight in ALS
2021-04-22
Skeletal muscles enable voluntary movements and are controlled by a special type of neurons called motor neurons, which make direct contact with skeletal muscles through so-called neuromuscular junctions (NMJs). It is through NMJs that skeletal muscles receive signals making them contract or relax. In certain neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), NMJs are destroyed, leading to progressive muscle weakness and ultimately death. Treatments for ALS mainly focus on alleviating symptoms but cannot stop or reverse its disease progression. To find more effective treatments, researchers require accurate and easily accessible lab-based models for ALS to understand its causes and to develop and test new therapies. One step in this ...

Transport phenomena at the nanoscale

Transport phenomena at the nanoscale
2021-04-22
Transient grating spectroscopy is an elegant method that uses two laser pulses to activate a medium by creating an interference pattern made of parallel stripes of excitations that can be thermal, electronic, magnetic or even structural. The modulation depth of the pattern and its evolution can be measured by diffracting a third, time-delayed probe beam on the transient grating. The modulation depth decays as the initial excitation propagates through the material. The distance between the stripes is determined by the wavelength of the pulses used to create the grating, which ...

Uniquely sharp X-ray view

Uniquely sharp X-ray view
2021-04-22
Researchers at the Paul Scherrer Institute PSI have succeeded for the first time in looking inside materials using the method of transient grating spectroscopy with ultrafast X-rays at SwissFEL. The experiment at PSI is a milestone in observing processes in the world of atoms. The researchers are publishing their research results today in the journal Nature Photonics. The structures on microchips are becoming ever tinier; hard disks write entire encyclopedias on magnetic disks the size of a fingernail. Many technologies are currently breaking through the boundaries of ...

LAST 30 PRESS RELEASES:

Study challenges assumptions about how tuberculosis bacteria grow

NASA Goddard Lidar team receives Center Innovation Award for Advancements

Can AI improve plant-based meats?

How microbes create the most toxic form of mercury

‘Walk this Way’: FSU researchers’ model explains how ants create trails to multiple food sources

A new CNIC study describes a mechanism whereby cells respond to mechanical signals from their surroundings

Study uncovers earliest evidence of humans using fire to shape the landscape of Tasmania

Researchers uncover Achilles heel of antibiotic-resistant bacteria

Scientists uncover earliest evidence of fire use to manage Tasmanian landscape

Interpreting population mean treatment effects in the Kansas City Cardiomyopathy Questionnaire

Targeting carbohydrate metabolism in colorectal cancer: Synergy of therapies

Stress makes mice’s memories less specific

Research finds no significant negative impact of repealing a Depression-era law allowing companies to pay workers with disabilities below minimum wage

Resilience index needed to keep us within planet’s ‘safe operating space’

How stress is fundamentally changing our memories

Time in nature benefits children with mental health difficulties: study

In vitro model enables study of age-specific responses to COVID mRNA vaccines

Sitting too long can harm heart health, even for active people

International cancer organizations present collaborative work during oncology event in China

One or many? Exploring the population groups of the largest animal on Earth

ETRI-F&U Credit Information Co., Ltd., opens a new path for AI-based professional consultation

New evidence links gut microbiome to chronic disease outcomes

Family Heart Foundation appoints Dr. Seth Baum as Chairman of the Board of Directors

New route to ‘quantum spin liquid’ materials discovered for first time

Chang’e-6 basalts offer insights on lunar farside volcanism

Chang’e-6 lunar samples reveal 2.83-billion-year-old basalt with depleted mantle source

Zinc deficiency promotes Acinetobacter lung infection: study

How optogenetics can put the brakes on epilepsy seizures

Children exposed to antiseizure meds during pregnancy face neurodevelopmental risks, Drexel study finds

Adding immunotherapy to neoadjuvant chemoradiation may improve outcomes in esophageal cancer

[Press-News.org] Representation of racial/ethnic minorities, women in clinical trials of managing hearing loss