PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Better healthcare management can reduce the risk of delirium among older adults

New research outlines how those admitted on Sunday and Tuesday are more likely to develop delirium, a hospital complication

2021-07-23
(Press-News.org) Elderly patients with neurological conditions are significantly more likely to develop delirium shortly after they are hospitalised.

A new study has discovered that a delayed transfer to a hospital floor is associated with greater short-term risk of delirium among patients aged 65 and over, and for those who arrive to the Emergency Department (ED) on days with higher risk of prolonged lengths of stay - found to be Sunday and Tuesday.

Delirium is an acute cognitive disorder characterised by altered awareness, attentional deficits, confusion, and disorientation. Current estimates of new-onset delirium highlight the fact that delirium overwhelmingly develops in medical settings (as high as 82 per cent in intensive care settings) compared to the community at large (between one per cent and two per cent). Research has shown that between 30 per cent and 40 per cent of all delirium cases are preventable.

Authored by Valdery Moura Junior, an Executive PhD Research student at the Business School (formerly Cass), the study explores whether a combination of the care experienced at the ED and the delayed implementation of delirium prevention measures contribute to an increased risk of the disorder. For example, it is possible that the bright lights and high ambient noise level of the ED for 24 hours a day will contribute to increased short-term risk.

The findings showed that of the 858 patients who presented to the ED with a neurological emergency, delirium was documented in 234 (30 per cent) patients within the first 72 hours from ED arrival.

This study also found that there was a connection between the onset of delirium and the day in which the patient arrived in the ED. Those arriving on Sundays and Tuesdays were more likely to demonstrate symptoms in a shorter time. Casual factors suggested include fewer hospital beds, delayed floor admission - a waiting time greater than 13 hours - and a greater proportion of elective pre-surgical admissions.

Mr. Moura has outlined several measures which can be taken to help prevent the likelihood of the onset of delirium in these settings, as well as reduce spending. These include an earlier initiation of delirium prevention measures; a quicker transfer from the ED to the hospital bed; and improving communication across healthcare managers in primary care, emergency rooms, operating rooms, and post-acute services.

Valdery Moura Junior, who is also computer scientist and technical leader at the Mass General Brigham, a Boston-based non-profit hospital and physicians network that includes Brigham and Women's Hospital (BWH) and Massachusetts General Hospital (MGH), two of the Harvard Medical School's most prestigious teaching hospitals, said:

"New-onset delirium in older patients alone will mean a high price for the health care system and poses a global challenge for healthcare managers, providers, and payors. Managing hospital capacity has been an enormous challenge throughout the pandemic, with many admission processes reviewed as a result with the goal of improving patient outcomes. Our study may help to identify feasible targets to improve processes between ED and the rest of the hospital."

Professor Feng Li, Chair of Information Management at the Business School, said: "This is an excellent example where routine operational data in a hospital can be used to identify anomaly and improve patient outcomes. Valdery's research demonstrated that more systematic use of such data can lead to significant improvement in the management of hospital capacity and operational processes, and most of all, quality of patient care."

INFORMATION:

‘Hospital complications among older adults: Better processes could reduce the risk of delirium’ by Valdery Moura Junior, M Brandon Westover, Feng Li, Eyal Kimchi, Maura Kennedy, Nicole M Benson, Lidia Maria Moura, John Hsu, is published in Health Services Management Research journal.

Notes to Editors

1. Although delirium reverberates through all age populations, adults over 65 are at greater risk of developing delirium during an acute illness, as are individuals with an underlying neurocognitive disorder (mild cognitive impairment and dementia)

2. ED arrival on Sundays was associated with delayed floor admission and with the lowest proportion of hospital to skilled nursing facility discharges. Similarly, ED arrival on Tuesdays was associated with delayed floor admission and with greater proportion of elective pre-surgical admissions on Wednesday morning

3. The research examined the time to delirium onset among 858 patients: 2/3 were admitted for stroke, with the remaining admitted for another acute neurologic event. Among all patients, 81.2 per cent had at least one delirium risk factor in addition to age. All eligible patients received delirium prevention protocols upon admission to the floor and received at least one delirium screening event

4. Of the 858 patients aged 65+, 697 (81 per cent) had at least one delirium risk factor (e.g., stroke, visual impairment, fall, dementia)



ELSE PRESS RELEASES FROM THIS DATE:

Cascaded metasurfaces for dynamic control of THz wavefronts

Cascaded metasurfaces for dynamic control of THz wavefronts
2021-07-23
Electromagnetic (EM) waves in the terahertz (THz) regime contribute to important applications in communications, security imaging, and bio- and chemical sensing. Such wide applicability has resulted in significant technological progress. However, due to weak interactions between natural materials and THz waves, conventional THz devices are typically bulky and inefficient. Although ultracompact active THz devices do exist, current electronic and photonic approaches to dynamic control have lacked efficiency. Recently, rapid developments in metasurfaces have opened new possibilities for the creation of high-efficiency, ultracompact THz ...

"Noisy" gene expression may help improve stem cell therapies

2021-07-23
SAN FRANCISCO, CA--July 22, 2021--To speed up a chemical reaction, a chemist might place the reactants over a Bunsen burner. Adding heat increases the degree of random movements and collisions of particles, accelerating the reaction. In cell biology, one important "reaction" is the transformation of stem cells into all the other cells in the body, a process known as differentiation. Gladstone Institutes researchers have now discovered a molecular mechanism that acts like a Bunsen burner to "turn up the heat" and accelerate differentiation. However, instead of boosting temperature, this process amplifies random fluctuations ...

Mount Sinai researchers develop novel therapy that could be effective in many cancers

2021-07-23
New York, NY (July 23, 2021) -- Mount Sinai researchers have developed a therapeutic agent that shows high effectiveness in vitro at disrupting a biological pathway that helps cancer survive, according to a paper published in Cancer Discovery, a journal of the American Association for Cancer Research, in July. The therapy is an engineered molecule, named MS21, that causes the degradation of AKT, an enzyme that is overly active in many cancers. This study laid out evidence that pharmacological degradation of AKT is a viable treatment for cancers with mutations in certain genes. AKT is a cancer gene that encodes an enzyme that is frequently abnormally activated in cancer cells to stimulate tumor growth. Degradation of ...

New insights into immune responses to malaria

New insights into immune responses to malaria
2021-07-23
Advanced technologies have been used to solve a long-standing mystery about why some people develop serious illness when they are infected with the malaria parasite, while others carry the infection asymptomatically. An international team used mass cytometry - an in-depth way of characterising individual cells - and machine learning to discover 'immune signatures' associated with symptomatic or asymptomatic infections in people infected with the Plasmodium vivax parasite. This uncovered an unexpected role for immune T cells in protection against malaria, ...

How the brain paints the beauty of a landscape

How the brain paints the beauty of a landscape
2021-07-23
How does a view of nature gain its gloss of beauty? We know that the sight of beautiful landscapes engages the brain's reward systems. But how does the brain transform visual signals into aesthetic ones? Why do we perceive a mountain vista or passing clouds as beautiful? A research team from the Max Planck Institute for Empirical Aesthetics has taken up this question and investigated how our brains proceed from merely seeing a landscape to feeling its aesthetic impact. In their study, the research team presented artistic landscape videos to 24 participants. Using functional magnetic resonance imaging (fMRI), they measured the participants' brain activity as they viewed and rated the videos. Their findings have just been published in the ...

Researchers uncover fatal flaw in green pigmented concrete

2021-07-23
As Xi'an Jiaotong-Liverpool University researchers completed their research on coloured architectural concrete, they found a surprising result--green pigmented cement had impurities that produced porous, poor quality concrete. Meanwhile, red and blue pigments had little effect. The research was conducted by Mehreen Heerah, a graduate of XJTLU's Department of Civil Engineering, Dr Graham Dawson of XJTLU's Department of Chemistry, and Isaac Galobardes of Mohammed VI Polytechnic University. Pigmented architectural concrete is used as a visually appealing alternative to grey concrete, such as in Barcelona's Ciutat de la Justícia, explains Dr Dawson. As the demand for pigmented architectural concrete grows, so does the importance of this research. Not easy ...

Research 'final nail in the coffin' of Paranthropus as hard object feeders

2021-07-23
New research from the University of Otago debunks a long-held belief about our ancestors' eating habits. For more than 60 years, researchers have believed Paranthropus, a close fossil relative of ours which lived about one to three million years ago, evolved massive back teeth to consume hard food items such as seeds and nuts, while our own direct ancestors, the genus Homo, is thought to have evolved smaller teeth due to eating softer food such as cooked food and meats. However, after travelling to several large institutes and museums in South Africa, Japan and the ...

China's carbon-monitoring satellite reports global carbon net of six gigatons

Chinas carbon-monitoring satellite reports global carbon net of six gigatons
2021-07-23
About six gigatons -- roughly 12 times the mass of all living humans -- of carbon appears to be emitted over land every year, according to data from the Chinese Global Carbon Dioxide Monitoring Scientific Experimental Satellite (TanSat). Using data on how carbon mixes with dry air collected from May 2017 to April 2018, researchers developed the first global carbon flux dataset and map. They published their results in Advances in Atmospheric Sciences. The map was developed by applying TanSat's satellite observations to models of how greenhouse gasses are exchanged among Earth's atmosphere, land, ...

Novel imaging agent identifies biomarker for iron-targeted cancer therapies

Novel imaging agent identifies biomarker for iron-targeted cancer therapies
2021-07-23
Reston, VA--A new radiotracer that detects iron in cancer cells has proven effective, opening the door for the advancement of iron-targeted therapies for cancer patients. The radiotracer, 18F-TRX, can be used to measure iron concentration in tumors, which can help predict whether a not the cancer will respond to treatment. This research was published in the July issue of the Journal of Nuclear Medicine. All cancer cells have an insatiable appetite for iron, which provides them the energy they need to multiply. As a result, tumors have higher levels of iron than normal tissues. Recent advances in chemistry have led scientists to take advantage of this altered state, targeting the expanded cytosolic ...

Phase two CD19-antibody-drug conjugate trial demonstrates promise for aggressive lymphoma

Phase two CD19-antibody-drug conjugate trial demonstrates promise for aggressive lymphoma
2021-07-23
MUSC Hollings Cancer Center was one of 28 clinical sites around the world that participated in the LOTIS-2 trial to test the efficacy of Loncastuximab tesirine, a promising new treatment for aggressive B-cell lymphoma. The results of the single-arm, phase 2 trial were published online in May 2021 in Lancet Oncology. Brian Hess, M.D., a Hollings researcher and lymphoma specialist at MUSC Health, was instrumental in bringing the phase 2 trial to Hollings. The manufacturer of Loncastuximab tesirine, ADC Therapeutics S.A., sponsored the trial. B-cell non-Hodgkin lymphoma (NHL) is a blood cancer that begins in the lymph nodes, spleen or bone marrow. Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of aggressive NHL. New treatment options are vital for patients with DLBCL. ...

LAST 30 PRESS RELEASES:

Drug candidate eliminates breast cancer tumors in mice in a single dose

WSU study shows travelers are dreaming forward, not looking back

Black immigrants attract white residents to neighborhoods

Hot or cold? How the brain deciphers thermal sensations

Green tea-based adhesive films show promise as a novel treatment for oral mucositis

Single-cell elemental analysis using Inductively Coupled Plasma Mass Spectrometry (ICP-MS)

BioChatter: making large language models accessible for biomedical research

Grass surfaces drastically reduce drone noise making the way for soundless city skies

Extent of microfibre pollution from textiles to be explored at new research hub

Many Roads Lead to… the embryo

Dining out with San Francisco’s coyotes

What’s the mechanism behind behavioral side effects of popular weight loss drugs?

How employee trust in AI drives performance and adoption

Does sleep apnea treatment influence patients’ risk of getting into car accidents?

Do minimum wage hikes negatively impact students’ summer employment?

Exposure to stress during early pregnancy affects offspring into adulthood

Curious blue rings in trees and shrubs reveal cold summers of the past — potentially caused by volcanic eruptions

New frontiers in organic chemistry: Synthesis of a promising mushroom-derived compound

Biodegradable nylon precursor produced through artificial photosynthesis

GenEditScan: novel k-mer analysis tool based on next-generation sequencing for foreign DNA detection in genome-edited products

Survey: While most Americans use a device to monitor their heart, few share that data with their doctor

Dolphins use a 'fat taste' system to get their mother’s milk

Clarifying the mechanism of coupled plasma fluctuations using simulations

Here’s what’s causing the Great Salt Lake to shrink, according to PSU study

Can DNA-nanoparticle motors get up to speed with motor proteins?

Childhood poverty and/or parental mental illness may double teens’ risk of violence and police contact

Fizzy water might aid weight loss by boosting glucose uptake and metabolism

Muscular strength and good physical fitness linked to lower risk of death in people with cancer

Recommendations for studying the impact of AI on young people's mental health  proposed by Oxford researchers

Trump clusters: How an English lit graduate used AI to make sense of Twitter bios

[Press-News.org] Better healthcare management can reduce the risk of delirium among older adults
New research outlines how those admitted on Sunday and Tuesday are more likely to develop delirium, a hospital complication