Early access to testosterone therapy in transgender and gender-diverse adults seeking masculinization

JAMA Network Open

2023-09-07

(Press-News.org) About The Study: In this randomized clinical trial including 64 transgender and gender-diverse adults, immediate testosterone therapy compared with no treatment significantly reduced gender dysphoria, depression, and suicidality in transgender and gender-diverse individuals desiring testosterone therapy.

Authors: Ada S. Cheung, M.B.B.S., Ph.D., of Austin Health in Heidelberg, Victoria, Australia, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2023.31919)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.31919?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=090723

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END

ELSE PRESS RELEASES FROM THIS DATE:

Analysis of heat exposure during pregnancy and severe maternal morbidity

2023-09-07

About The Study: Long- and short-term heat exposure during pregnancy was associated with higher risk of severe maternal morbidity in this study with 403,000 pregnancies from 2008 to 2018 in Southern California. These results might have important implications for severe maternal morbidity prevention, particularly in a changing climate. Authors: Jun Wu, Ph.D., of the University of California, Irvine, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2023.32780) Editor’s Note: Please ...

Calcium channel blocker use and associated glaucoma and related traits

2023-09-07

About The Study: Calcium channel blocker use was adversely associated with glaucoma prevalence in this study of 427,000 adult UK Biobank participants, suggesting that calcium channel blockers may represent an important modifiable risk factor for glaucoma, potentially through an intraocular pressure–independent mechanism. Authors: Alan Kastner, M.D., M.Sc., of the Moorfields Eye Hospital National Health Service Foundation Trust and University College London Institute of Ophthalmology in London, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamaophthalmol.2023.3877) Editor’s ...

Phase I clinical trial shows treatment designed to clear senescent cells in Alzheimer’s disease is safe

2023-09-07

WINSTON-SALEM, N.C. – Sept. 7, 2023 – Alzheimer’s disease is the most common cause of dementia that affects more than 6.5 million Americans, according to the Alzheimer’s Association. To find effective treatments and slow the progression of this debilitating disease, researchers have made much progress in developing new drugs that target beta-amyloid plaques, one of the hallmarks of Alzheimer’s disease. Beta-amyloid plaques are accumulations of brain protein fragments, which can impact cognition. However, these recent drugs have only yielded modest results. Now, ...

Ravenous black hole consumes three Earths’-worth of star every time it passes

2023-09-07

A star like our own Sun in a nearby galaxy is gradually being eaten away by a small but ravenous black hole, losing the equivalent mass of three Earths every time it passes close. The discovery by University of Leicester astronomers is reported today (7 September) in Nature Astronomy and provides a ‘missing link’ in our knowledge of black holes disrupting orbiting stars. It suggests a whole menagerie of stars in the process of being consumed that still lie undiscovered. The team was supported by the UK Space Agency and the UK Science and technology Facilities Council (STFC). The astronomers were alerted to ...

MIT engineers design more powerful RNA vaccines

2023-09-07

CAMBRIDGE, MA -- RNA vaccines against Covid-19 have proven effective at reducing the severity of disease. However, a team of researchers at MIT is working on making them even better. By tweaking the design of the vaccines, the researchers showed that they could generate Covid-19 RNA vaccines that produce a stronger immune response, at a lower dose, in mice. Adjuvants are molecules commonly used to increase the immune response to vaccines, but they haven’t yet been used in RNA vaccines. In this study, the MIT researchers engineered both the nanoparticles used to deliver the Covid-19 antigen, and the antigen itself, to boost the immune response, ...

Genetic tools probe microbial dark matter

2023-09-07

Patescibacteria are a group of puzzling, tiny microbes whose manner of staying alive has been difficult to fathom. Scientists can cultivate only a few types, yet these bacteria are a diverse group found in many environments. The few types of Patescibacteria that researchers can grow in the lab reside on the cell surfaces of another, larger host microbe. Patescibacteria in general lack the genes required to make many molecules necessary for life, such as the amino acids that make up proteins, the fatty acids that form membranes, and the nucleotides in DNA. This has led researchers ...

Revolutionizing lithium production on a string

2023-09-07

A vital component of the batteries at the heart of electric vehicles and grid energy storage, lithium is key to a clean energy future. But producing the silvery-white metal comes with significant environmental costs. Among them is the vast amount of land and time needed to extract lithium from briny water, with large operations running into the dozens of square miles and often requiring over a year to begin production. Now, researchers at Princeton have developed an extraction technique that slashes the amount of land and time needed for lithium production. The researchers say their system ...

Genetic study of blood glucose levels calls for stratified treatment with GLP-1R agonists in type 2 diabetes, reveals the role of the intestine, and impact on lung function

2023-09-07

New research highlights that genetic background can affect individual responses to GLP-1R agonist drugs. Researchers reveal for the first time that high blood sugar levels in type 2 diabetes can play a causal role in lung disorders. The study sheds light on the role of the digestive system, including the small intestine, ileum, and colon, in controlling blood sugar levels. This is the largest-ever study into the genetic basis of random "round-the-clock" blood sugar levels. Groundbreaking research published today in Nature Genetics describes the largest-ever study into the genetics of random "round-the-clock" ...

Bursting air bubbles may play a key role in how glacier ice melts, Oregon State research suggests

2023-09-07

CORVALLIS, Ore. – Oregon State University research has uncovered a possible clue as to why glaciers that terminate at the sea are retreating at unprecedented rates: the bursting of tiny, pressurized bubbles in underwater ice. Published today in Nature Geoscience, the study shows that glacier ice, characterized by pockets of pressurized air, melts much more quickly than the bubble-free sea ice or manufactured ice typically used to research melt rates at the ocean-ice interface of tidewater glaciers. Tidewater glaciers are rapidly retreating, the authors say, resulting in ice mass loss in Greenland, the Antarctic Peninsula and other glacierized regions around the globe. “We ...

A secret passage for mutant protein to invade the brain

2023-09-07

Researchers from Tokyo Medical and Dental University (TMDU) show that the protein involved in Parkinson’s disease, α-synuclein, can propagate through the lymphatic system of the brain before it aggregates Tokyo, Japan – In many neurodegenerative disorders, abnormal proteins progressively aggregate and propagate in the brain. But what comes first, aggregation or propagation? Researchers from Japan share some new insights about the mechanism involved in Parkinson’s disease. In a study published ...

Ox-eye daisy, bellis and yarrow: Flower strips with at least two sown species provide 70 percent more natural enemies of pests

How modern dog ownership has redefined family and parenting

Green ammonia powered by sunlight

[Press-News.org] Early access to testosterone therapy in transgender and gender-diverse adults seeking masculinization
JAMA Network Open

Early access to testosterone therapy in transgender and gender-diverse adults seeking masculinization

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: