PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Women with endometriosis at greater associated risk of heart attack and stroke

2024-08-29
(Press-News.org) London, United Kingdom – 29 Aug 2024: According to research presented at ESC Congress 2024,1 women with endometriosis have a 20% greater risk of significant cardiac outcomes compared with women without endometriosis.  

“For decades, cardiovascular disease (CVD) has been thought of as a man’s disease and risk factors have been considered from the male perspective, for example, including erectile dysfunction in guidelines on CVD risk assessment.2 Yet, 1 in 3 women die from CVD and 1 in 10 women suffer from endometriosis.3 Our results suggest that it may be time to routinely consider the risk of CVD in women with endometriosis,” said lead study author, Dr. Eva Havers-Borgersen from Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark. 

The study used Danish nationwide registries of all women with a diagnosis of endometriosis between 1977 and 2021. They were matched with women from the background population without endometriosis in a 1:4 ratio based on year of birth. The primary outcome was a composite of acute myocardial infarction and ischaemic stroke. The secondary outcomes were the individual components of the primary outcome, as well as arrhythmias, heart failure and mortality.   

There were 60,508 women with endometriosis and 242,032 matched controls included in the analysis (median age, 37.3 years) who were followed for a median of 16 years and a maximum of 45 years.  

Women with endometriosis had around a 20% increased risk of the composite endpoint of acute myocardial infarction and ischaemic stroke compared with those without endometriosis (unadjusted hazard ratio [HR] 1.18; 95% confidence interval [CI] 1.14−1.23; adjusted HR 1.15; 95% CI 1.11−1.20). The 40-year cumulative incidence of the composite of acute myocardial infarction and ischaemic stroke was 17.5% (95% CI 16.6−18.2%) and 15.3% (95% CI 15.0−15.7%) in women with and without endometriosis, respectively (p<0.0001).  

When this was broken down to the individual components, women with endometriosis had around a 20% increased risk of ischaemic stroke (adjusted HR 1.18; 95% CI 1.12−1.23) and around 35% increased risk of acute myocardial infarction (adjusted HR 1.35; 95% CI 1.31−1.40) compared with those without endometriosis. Moreover, women with endometriosis also had increased risk of arrhythmias (adjusted HR 1.21; 95% CI 1.17−1.25) and heart failure (adjusted HR 1.11; 95% CI 1.05−1.18) compared with those without endometriosis. 

Growing evidence suggests there is a close relationship between endometriosis and the cardiovascular system and that they may share common disease pathways.3 Dr. Havers-Borgersen concluded: “Although the absolute differences were small, the relative differences were 20%, and with the high prevalence of endometriosis, these results provide more evidence that female-specific risk factors and CVD in women need greater attention. We suggest that women with endometriosis undergo CVD risk assessment, and it is now time for female-specific risk factors – such as endometriosis, but also gestational diabetes and pre-eclampsia – to be considered in cardiovascular risk prediction models. Further research is needed to confirm our findings and integrate these factors into effective risk prediction models.”  

ENDS 

Notes to editors 

 

Funding: None. 

  

Disclosures: None. 

 

References and notes 

1The abstract “Endometriosis, a prevalent disease, is associated with significant cardiac disease” will be presented at the session ‘Cardiovascular disease in women (5)’, which takes place on 2 September 2024, Station 6 in the Research Gateway.  

2Visseren FLJ, Mach F, Smulders YM, et al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021;42:3227–3337. 

3Marchandot B, Curtiaud A, Matsushita K, et al. Endometriosis and cardiovascular disease. Eur Heart J Open. 2022;2:oeac001. 

CVD is the leading cause of death in women, both in Europe and worldwide.  Yet, compared with men, women with CVD are typically underdiagnosed and undertreated. The ESC supports measures to reduce the gap in the prevention, diagnosis and treatment between women and men as integral to reducing the overall burden of CVD. 

 

ESC Press Office 
Tel: +33 6 61 40 18 84  

Email: press@escardio.org 

The hashtag for ESC Congress 2024 is #ESCCongress 

Follow us on X @ESCardioNews  

Journalists are invited to become accredited and register here. 

Check out the ESC Media and Embargo Policy. 

 

About ESC Congress 2024 

It is the world’s largest gathering of cardiovascular professionals, disseminating ground-breaking science both onsite in London and online – from 30 August to 2 September. Explore the scientific programme. More information is available from the ESC Press Office at press@escardio.org. 

About the European Society of Cardiology  

The European Society of Cardiology brings together health care professionals from more than 150 countries, working to advance cardiovascular medicine and help people lead longer, healthier lives. 

END


ELSE PRESS RELEASES FROM THIS DATE:

Catching up on sleep on weekends may lower heart disease risk by up to 20%

2024-08-29
London, United Kingdom – 29 August 2024: The demands of the working week, often influenced by school or work schedules, can lead to sleep disruption and deprivation. However, new research presented at ESC Congress 2024 shows that people that ‘catch up’ on their sleep by sleeping in at weekends may see their risk of heart disease fall by one-fifth.   “Sufficient compensatory sleep is linked to a lower risk of heart disease,” said study co-author Mr Yanjun Song of the State Key Laboratory ...

Quitting smoking nearly halves heart attack risk, cutting down does little

2024-08-29
London, United Kingdom – 29 August 2024: According to research presented today at ESC Congress 2024,1 patients with stable coronary artery disease who quit smoking at any timepoint after their diagnosis reduced their risk of a major event by almost 50%. In contrast, there was minimal impact on cardiovascular risk in patients who reduced their smoking habits.   The international CLARIFY registry (prospeCtive observational LongitudinAl RegIstry oF patients with stable coronary arterY ...

Children contribute to group projects when there are clear and common goals

2024-08-29
Children can work together to reach a target that benefits a whole group even if it is at a personal cost to themselves, a new study has shown. Researchers invited groups of six to 10-year-olds to take part in a game where they were each given containers of water and could decide how much of it to offer into a common pool. If the group contributed a certain amount of water it resulted in benefits for the whole group, but children also obtained benefits for any water they kept.  At the same time, the ...

Dine on DNA: Compounds from nucleic acids in food show anticancer effects

Dine on DNA: Compounds from nucleic acids in food show anticancer effects
2024-08-29
When people eat, they ingest the nucleic acids that reside in all living things. The compounds in these acids could inhibit the growth of cancer cells, according to findings published in PLOS ONE by Osaka Metropolitan University Associate Professor Akiko Kojima-Yuasa of the Graduate School of Human Life and Ecology and colleagues. Consuming nucleic acids found in food has been shown to boost the immune system and prevent some diseases. The nucleotides and nucleosides that result from digesting the acids are largely responsible for these beneficial effects. Professor ...

MCG scientists working to understand why men with prostate cancer are at higher risk of Alzheimer’s

MCG scientists working to understand why men with prostate cancer are at higher risk of Alzheimer’s
2024-08-29
AUGUSTA, Ga. (Aug. 29, 2024) – Researchers at the Medical College of Georgia at Augusta University are searching for a better way to understand why many men with prostate cancer end up with Alzheimer’s disease, and whether it’s the standard hormone therapy treatment or an overactive immune response that actually contributes to the problem. The hormone therapy, androgen deprivation therapy, known as ADT, treats the cancer by reducing testosterone, which the cancer needs to grow. But androgen is a key regulator of amyloid metabolism and when it’s removed from the equation, more amyloid is left to form the plaques that are a hallmark of Alzheimer’s. “We ...

Ancient sea cow attacked by a crocodile and sharks sheds new light on prehistoric food chains

2024-08-29
A new study describing how a prehistoric sea cow was preyed upon by not one, but two different carnivores – a crocodilian and a shark – is revealing clues into both the predation patterns of ancient creatures and the wider food chain millions of years ago. Published in the peer-reviewed Journal of Vertebrate Paleontology, the findings mark one of the few examples of a creature being preyed upon by different animals during the Early to Middle Miocene epoch (23 million to 11.6 million years ago). Predation marks in the skull indicate that the dugongine sea cow, ...

Georgia Tech neuroscientists explore the intersection of music and memory

Georgia Tech neuroscientists explore the intersection of music and memory
2024-08-29
By Jerry Grillo The soundtrack of this story begins with a vaguely recognizable and pleasant groove. But if I stop writing and just listen for a second, the music reveals itself completely. In Freddie Hubbard’s comfortable, lilting trumpet solo over Herbie Hancock’s melodic, repetitive piano vamping, I recognize “Cantaloupe Island.” Then, with my fingers again poised at the keyboard, Freddie and Herbie fade into the background, followed by other instrumental music: captivating — but not distracting — sonic nutrition, feeding my concentration and productivity.  Somewhere, I think, Yiren Ren is studying, focused on her ...

Waging war on ‘superbugs’ in aged care

2024-08-29
There’s an urgent need for more careful antibiotic management to protect older people living in residential aged care from the dangerous spread of antibiotic resistant bacteria or ‘superbugs’, researchers from Flinders University and SAHMRI warn. A new study published in the well-respected Journal of Infection, explores the link between the widespread use of antibiotics in residential aged care and the resulting antibiotic resistant bacteria in the gut that can be passed on to other residents. “Commonly ...

Increasing risk of synthetic opioid drug overdoses in Australia

2024-08-29
A recent study has uncovered alarming insights into the dangers posed by fentanyl-contaminated drug supplies in Australia, including a heightened risk of lethal overdose. The study, titled ‘The gear could be cut with fentanyl which is starting to happen more in Australia’: Exploring Overdose Survivors’ Perspectives on Toxic Supply and Safe Consumption, aimed to explore the role of synthetic opioids in overdoses among Queenslanders. Led by Griffith University’s Dr Timothy Piatkowski, Emma Kill and Steph Reeve in partnership with the Queensland ...

Protein mutant stability can be inferred from AI-predicted structures

Protein mutant stability can be inferred from AI-predicted structures
2024-08-29
Researchers at the Center for Algorithmic and Robotized Synthesis within the Institute for Basic Science have taken a significant step forward in understanding the stability of proteins by leveraging the power of AI. The research team used AlphaFold2 to explore how mutations affect protein stability—a crucial factor in ensuring proteins function correctly and do not cause diseases like Alzheimer's. DeepMind’s AlphaFold algorithm, which can accurately predict a protein’s structure from ...

LAST 30 PRESS RELEASES:

Reality check: making indoor smartphone-based augmented reality work

Overthinking what you said? It’s your ‘lizard brain’ talking to newer, advanced parts of your brain

Black men — including transit workers — are targets for aggression on public transportation, study shows

Troubling spike in severe pregnancy-related complications for all ages in Illinois

Alcohol use identified by UTHealth Houston researchers as most common predictor of escalated cannabis vaping among youths in Texas

Need a landing pad for helicopter parenting? Frame tasks as learning

New MUSC Hollings Cancer Center research shows how Golgi stress affects T-cells' tumor-fighting ability

#16to365: New resources for year-round activism to end gender-based violence and strengthen bodily autonomy for all

Earliest fish-trapping facility in Central America discovered in Maya lowlands

São Paulo to host School on Disordered Systems

New insights into sleep uncover key mechanisms related to cognitive function

USC announces strategic collaboration with Autobahn Labs to accelerate drug discovery

Detroit health professionals urge the community to act and address the dangers of antimicrobial resistance

3D-printing advance mitigates three defects simultaneously for failure-free metal parts 

Ancient hot water on Mars points to habitable past: Curtin study

In Patagonia, more snow could protect glaciers from melt — but only if we curb greenhouse gas emissions soon

Simplicity is key to understanding and achieving goals

Caste differentiation in ants

Nutrition that aligns with guidelines during pregnancy may be associated with better infant growth outcomes, NIH study finds

New technology points to unexpected uses for snoRNA

Racial and ethnic variation in survival in early-onset colorectal cancer

Disparities by race and urbanicity in online health care facility reviews

Exploring factors affecting workers' acquisition of exercise habits using machine learning approaches

Nano-patterned copper oxide sensor for ultra-low hydrogen detection

Maintaining bridge safer; Digital sensing-based monitoring system

A novel approach for the composition design of high-entropy fluorite oxides with low thermal conductivity

A groundbreaking new approach to treating chronic abdominal pain

ECOG-ACRIN appoints seven researchers to scientific committee leadership positions

New model of neuronal circuit provides insight on eye movement

Cooking up a breakthrough: Penn engineers refine lipid nanoparticles for better mRNA therapies

[Press-News.org] Women with endometriosis at greater associated risk of heart attack and stroke