(Press-News.org) About The Study: In this cohort study, non-Hispanic Black race was associated with increased odds of not receiving guideline-concordant care (GCC) and less timely treatment initiation. Non-Hispanic Black race was associated with increased all-cause mortality, which was reduced after adjusting for GCC and clinical and sociodemographic factors. These findings suggest that optimizing timely receipt of GCC may represent a modifiable pathway to improving inferior survival outcomes among older non-Hispanic Black patients with breast cancer.
Corresponding Author: To contact the corresponding author, Yehoda M. Martei, MD, MSCE, email yehoda.martei@pennmedicine.upenn.edu.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamanetworkopen.2024.41056)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.41056?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=102424
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
END
Racial disparities in receipt of guideline-concordant care in older adults with early breast cancer
JAMA Network Open
2024-10-24
ELSE PRESS RELEASES FROM THIS DATE:
Fentanyl, heroin, methamphetamine, and cocaine analyte concentrations in urine drug testing specimens
2024-10-24
About The Study: This cross-sectional study found that absolute concentrations of fentanyl, methamphetamine, and cocaine in urine specimens increased from 2013 to 2023, with a decrease in heroin concentration during that period. The findings suggest that exposure to these substances, as well as the illicit drug supply, has fundamentally changed in many parts of the U.S., highlighting the need to reinforce surveillance initiatives and accelerate efforts to treat individuals with illicitly manufactured fentanyl and/or stimulant exposure.
Corresponding Author: To ...
UCLA researchers engineer experimental drug for preventing heart failure after heart attacks
2024-10-24
Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have developed a first-of-its-kind experimental therapy that has the potential to enhance heart repair following a heart attack, preventing the onset of heart failure.
Cardiovascular disease continues to be the world’s leading cause of death, contributing to one-third of deaths annually. After a heart attack, the heart’s innate ability to regenerate is limited, causing the muscle to develop scars to maintain its structural integrity. ...
Combining targeted therapy and immunotherapy improves overall survival in patients with anaplastic thyroid cancer
2024-10-24
HOUSTON ― Researchers from The University of Texas MD Anderson Cancer Center demonstrated that anti-PD-L1 immunotherapy in combination with mutation-directed targeted therapy extended overall survival (OS) in patients with anaplastic thyroid carcinoma (ATC). Findings from the Phase II single center study published today in JAMA Oncology.
The trial enrolled 42 patients across three cohorts to evaluate mutation-matched targeted therapy and the immune checkpoint inhibitor atezolizumab. The median OS across all cohorts was 19 months, which compares favorably to historical OS of five months for patients with ATC. ...
Assessing the real climate costs of manufacturing
2024-10-24
Producing materials such as steel, plastics and cement in the United States alone inflicts $79 billion a year in climate-related damage around the world, according to a new study by engineers and economists at the University of California, Davis. Accounting for these costs in market prices could encourage progress toward climate-friendly alternatives.
“We wanted to look at the cost to society to produce these materials,” said Elisabeth Van Roijen, a recent Ph.D. graduate from the UC Davis Department of Civil and Environmental Engineering ...
A multi-functional simulation platform for on-demand ride service operations
2024-10-24
On-demand ride services or ride-sourcing services have been experiencing fast development and steadily reshaping the way people travel in the past decade. Various optimization algorithms, including reinforcement learning approaches, have been developed to help ride-sourcing platforms design better operational strategies to achieve higher efficiency. However, due to cost and reliability issues, it is commonly infeasible to validate these models and train/test these optimization algorithms within real-world ride-sourcing platforms. Acting as a proper test bed, a simulation platform for ride-sourcing systems will thus be essential for both ...
Research team undertakes review of carbon anodes for lithium-ion batteries
2024-10-24
A team of researchers has undertaken a study of the future of carbon anodes for lithium-ion batteries. Their review provides a comprehensive overview of the progression in carbon anode development and the current status of their industrialization. This study underscores the critical role of interphase regulation engineering in advancing lithium-ion battery technology.
Their research is published in the journal Carbon Future on September 24, 2024.
Today, graphite is the most commonly used material for anodes in lithium-ion batteries. Graphite can operate at a low voltage, is readily available, and cost effective. While graphite materials ...
Researchers improve speed and accuracy of 3D surface measurements
2024-10-24
WASHINGTON — Researchers have developed a faster and more accurate method for acquiring and reconstructing high-quality 3D surface measurements. The approach could greatly improve the speed and accuracy of surface measurements used for industrial inspection, medical applications, robotic vision and more.
“Traditional 3D imaging works by comparing two viewpoints, similar to how our eyes work together to judge depth,” said research team leader Ce Zhu from the University of Electronic Science and Technology of China. “In contrast, our new approach ‘feels’ the surface by projecting light ...
GPX4 promoter hypermethylation induced by ischemia/reperfusion injury regulates hepatocytic ferroptosis
2024-10-24
Background and Aims
Glutathione peroxidase 4 (GPX4) is a key factor in ferroptosis, which is involved in ischemia-reperfusion injury. However, little is known about its role in hepatic ischemia-reperfusion injury (HIRI). This study aimed to investigate the role of GPX4 methylation in ferroptosis during HIRI.
Methods
For the in vivo experiments, an ischemia-reperfusion model was created by subjecting mice to simulated HIRI. Ferroptosis occurrence, GPX4 promoter methylation, and global methylation levels were then assessed.
Results
Ferroptosis ...
Advances in biointegrated wearable and implantable optoelectronic devices for cardiac healthcare
2024-10-24
A review paper by scientists at Institute of Chemistry, Chinese Academy of Sciences summarized the progress of biointegrated flexible and stretchable optoelectronics for wearable and implantable cardiac healthcare.
The new review paper, published on Oct. 18 in the journal Cyborg and Bionic Systems, focuses on the advances in biointegrated flexible and stretchable optoelectronics for wearable and implantable cardiac healthcare systems.
With the prevalence of cardiovascular disease, it is imperative that medical monitoring and treatment become more instantaneous and comfortable for ...
Science/Science Careers’ survey ranks top biotech, biopharma, and pharma employers
2024-10-24
The Science and Science Careers’ 2024 Top Employers Survey polled employees in biotechnology, biopharmaceutical, pharmaceutical, and related industries to determine the 20 best employers as well as their driving characteristics. Respondents to the web-based survey were asked to rate companies based on 24 characteristics, including innovative leadership, respect for employees, and social responsibility.
Insmed, Bridgewater, New Jersey, receives the top honor this year in a ranking of the world’s most respected employers. The rankings, determined from a study conducted by an independent research firm commissioned by the Science/AAAS Office of Publishing, ...
LAST 30 PRESS RELEASES:
Exploring factors affecting workers' acquisition of exercise habits using machine learning approaches
Nano-patterned copper oxide sensor for ultra-low hydrogen detection
Maintaining bridge safer; Digital sensing-based monitoring system
A novel approach for the composition design of high-entropy fluorite oxides with low thermal conductivity
A groundbreaking new approach to treating chronic abdominal pain
ECOG-ACRIN appoints seven researchers to scientific committee leadership positions
New model of neuronal circuit provides insight on eye movement
Cooking up a breakthrough: Penn engineers refine lipid nanoparticles for better mRNA therapies
CD Laboratory at Graz University of Technology researches new semiconductor materials
Animal characters can boost young children’s psychological development, study suggests
South Korea completes delivery of ITER vacuum vessel sectors
Global research team develops advanced H5N1 detection kit to tackle avian flu
From food crops to cancer clinics: Lessons in extermination resistance
Scientists develop novel high-fidelity quantum computing gate
Novel detection technology alerts health risks from TNT metabolites
New XR simulator improves pediatric nursing education
New copper metal-organic framework nanozymes enable intelligent food detection
The Lancet: Deeply entrenched racial and geographic health disparities in the USA have increased over the last two decades—as life expectancy gap widens to 20 years
2 MILLION mph galaxy smash-up seen in unprecedented detail
Scientists find a region of the mouse gut tightly regulated by the immune system
How school eligibility influences the spread of infectious diseases: Insights for future outbreaks
UM School of Medicine researchers link snoring to behavioral problems in adolescents without declines in cognition
The Parasaurolophus’ pipes: Modeling the dinosaur’s crest to study its sound #ASA187
St. Jude appoints leading scientist to create groundbreaking Center of Excellence for Structural Cell Biology
Hear this! Transforming health care with speech-to-text technology #ASA187
Exploring the impact of offshore wind on whale deaths #ASA187
Mass General Brigham and BIDMC researchers unveil an AI protein engineer capable of making proteins ‘better, faster, stronger’
Metabolic and bariatric surgery safe and effective for patients with severe obesity
Smarter city planning: MSU researchers use brain activity to predict visits to urban areas
Using the world’s fastest exascale computer, ACM Gordon Bell Prize-winning team presents record-breaking algorithm to advance understanding of chemistry and biology
[Press-News.org] Racial disparities in receipt of guideline-concordant care in older adults with early breast cancerJAMA Network Open