PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Heart and kidney outcomes after canagliflozin treatment in older adults

2024-10-26
(Press-News.org)

San Diego, CA (October 25, 2024) — Sodium-glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of cardiovascular and kidney outcomes in patients with type 2 diabetes, but it is unclear whether their effects differ based on patients’ age. A recent analysis of clinical trial data reveals that the SGLT2 inhibitor canagliflozin benefited patients across all age categories. The findings will be presented at ASN Kidney Week 2024 October 23 – 27.

The analysis pooled individual participant data from the CANVAS Program and CREDENCE trial and assessed efficacy and safety according to baseline age. Among the 14,543 participants, 7,927 (54.5%) were <65 years, 5,281 (36.3%) were 65 to <75 years, and 1,335 (9.2%) were ≥75 years. 

Across age groups, canagliflozin reduced risks of major adverse cardiovascular events, hospitalization for heart failure or cardiovascular death, and chronic kidney disease progression.  

Although the overall incidence of adverse events increased with age, the effects of canagliflozin on safety outcomes including acute kidney injury, volume depletion, urinary tract infections and hypoglycemia, were not modified by age.

“The prevalence of diabetes among older adults aged ≥65 years in the United States is estimated at 29.2%, a prevalence rate more than double that for the overall adult population aged ≥18 years, and older individuals with diabetes have higher absolute risks of cardiovascular events and kidney complications. Despite this, real-world uptake of SGLT2 inhibitors in older age groups is among the lowest of all patient groups,” said corresponding authorAmanda Siriwardana, MBBS (Hon), GCert Public Health, FRACP, of The George Institute for Global Health in Australia. “The data presented in this analysis suggests clear extension of the cardiorenal benefits of SGLT2 therapy to older individuals and should engender confidence amongst clinicians and patients regarding the safety of canagliflozin in older adults.”

Study: “Cardiovascular, kidney and safety outcomes with canagliflozin in older adults: A pooled secondary analysis of the CANVAS Program and CREDENCE trial”

Join ASN and approximately 12,000 other kidney professionals from across the globe at Kidney Week 2024 in San Diego, CA. The world's premier nephrology meeting, Kidney Week, provides participants with exciting and challenging opportunities to exchange knowledge, learn the latest scientific and medical advances, and listen to engaging and provocative discussions with leading experts in the field. Early programs begin on October 23, followed by the Annual Meeting from October 24-27. Follow the conversation at #KidneyWk.

 

About ASN

Since 1966, ASN has been leading the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge and advocating for the highest quality care for patients. ASN has nearly 21,000 members representing 140 countries. For more information, visit www.asn-online.organd follow us on Facebook, X, LinkedIn, and Instagram.

 

# # #

 

 

 

 

END



ELSE PRESS RELEASES FROM THIS DATE:

Slowing ocean current could ease Arctic warming -- a little

Slowing ocean current could ease Arctic warming -- a little
2024-10-25
The Arctic is warming at three to four times the global average. However, new research suggests the slowing of a key ocean current could reduce projected Arctic warming by up to 2 degrees Celsius by the end of the century. For years, scientists have warned that unchecked Arctic warming could lead to devastating consequences, threatening wildlife and ushering in an era of more frequent and extreme weather events. Amid concerns for these types of outcomes, a study led by UC Riverside offers some limited relief. The study, published in the Proceedings of the National Academy of Sciences, examined ...

Global, national, and regional trends in the burden of chronic kidney disease among women

2024-10-25
San Diego, CA (October 25, 2024) — A recent analysis reveals that the number of chronic kidney disease (CKD) cases in women around the globe nearly tripled in the past three decades. Also, type 2 diabetes and hypertension were the leading causes of CKD-related deaths in women. The research will be presented at ASN Kidney Week 2024 October 23– 27. The analysis drew from the Global Burden of Disease study 2021, a comprehensive effort to quantify health loss across the world over time. The study includes information from 204 countries and territories. From 1990 to 2021, the average annual percentage ...

Scientific discovery scratching beneath the surface of itchiness

Scientific discovery scratching beneath the surface of itchiness
2024-10-25
Ever had an itchy nose or, worse, an unreachable spot on your back that drives you mad? Now imagine an itch that refuses to go away, no matter how hard or long you scratch. That persistent itch, or pruritus, may actually be one of the skin’s first lines of defense against harmful invaders, according to neuroimmunologist Juan Inclan-Rico of the University of Pennsylvania. “It’s inconvenient, it’s annoying, but sensations like pain and itch are crucial. They’re ever-present, especially when it comes to skin infections,” says Inclan-Rico, a postdoctoral researcher in the Herbert Lab at ...

SFSU psychologists develop tool to assess narcissism in job candidates

2024-10-25
It feels like narcissism is everywhere these days: politics, movies and TV, sports, social media. You might even see signs of it at work, where it can be particularly detrimental. Is it possible to keep a workplace free of destructive, manipulative egotists?  More and more organizations have come to San Francisco State University’s experts in organizational psychology asking for help doing just that. In response, University researchers developed a tool for job interviews to assess narcissistic grandiosity among potential job candidates. San Francisco State Psychology Professors Kevin Eschleman and Chris ...

Invisible anatomy in the fruit fly uterus

Invisible anatomy in the fruit fly uterus
2024-10-25
You have likely not spent much time thinking about the uterus of the fruit fly, Drosophila melanogaster. But then, neither have most scientists, even though Drosophila is one of the most thoroughly studied lab animals. Now a team of biologists at the University of California, Davis, has taken the first deep look at the Drosophila uterus and found some surprises, which could have implications not just for understanding insect reproduction and potentially, pest control, but also for understanding fertility in humans.  The work is published Oct. 25 in Proceedings of the National Academy of Sciences.  Drosophila have been a favorite subject for ...

Skeletal muscle health amid growing use of weight loss medications

2024-10-25
A recent commentary published in The Lancet journal highlights the critical importance of skeletal muscle mass in the context of medically induced weight loss, particularly with the widespread use of GLP-1 receptor agonists. These medications, celebrated for their effectiveness in treating obesity, have raised concerns regarding the potential for substantial muscle loss as part of the weight loss process. Dr. Steven Heymsfield, professor of metabolism and body composition, and Dr. M. Cristina Gonzalez, adjunct and visiting professor in metabolism-body composition, both of Pennington Biomedical Research Center, joined colleagues Dr. Carla Prado of the University ...

The Urban Future Prize Competition awards top prizes to Faura and Helix Earth Technologies and highlights climate adaptation solutions with the inaugural Future Resilience Prize

2024-10-25
NYU Tandon School of Engineering's Urban Future Lab named the winners of its 2024 Future Resilience and Future Solutions prizes, at its 8th annual Urban Future Summit on October 24, 2024 at the Brooklyn Navy Yard in New York City. Through the generous support of The New York Community Trust, MUFG Bank, Mitsubishi Corporation (Americas), the Urban Future Lab continues to catalyze groundbreaking solutions for the climate crisis and this year, they’ve expanded their focus to include adaptation as a critical piece of the puzzle. After an afternoon of pitches, the jury, comprised of industry experts and ...

Wayne State researcher secures two grants from the National Institute on Aging to address Alzheimer’s disease

Wayne State researcher secures two grants from the National Institute on Aging to address Alzheimer’s disease
2024-10-25
DETROIT – A Wayne State University School of Medicine faculty member has been awarded a total of $2.3 million by the National Institute on Aging of the National institutes of Health for two new, concurrent projects that both address questions related to Alzheimer’s disease, a progressive, age-related degenerative brain disease characterized by memory problems, impaired judgment, cognitive issues and changes in personality. Joongkyu Park, Ph.D., assistant professor of pharmacology and of neurology, is the principal investigator on “Local protein synthesis ...

NFL’s Bears add lifesavers to the chain of survival in Chicago

2024-10-25
CHICAGO, October 22, 2024— The American Heart Association and the Chicago Bears brought cardiopulmonary resuscitation (CPR) and automated external defibrillator (AED) training to the Illinois High School Association (IHSA) Girls Flag Football State Finals on Saturday, Oct. 19. More than 150 youth athletes, coaches and league administrators learned lifesaving skills building their confidence and capabilities to respond in the event of a cardiac emergency. According to American Heart Association data, 9 out of every 10 people who experience cardiac arrest outside of a hospital die, in part ...

High-impact clinical trials generate promising results for improving kidney health: Part 1

2024-10-25
The results of numerous high-impact phase 3 clinical trials that could affect kidney-related medical care will be presented in-person at ASN Kidney Week 2024 October 23–27. Finerenone—a selective non-steroidal mineralocorticoid receptor antagonist—has been shown to have kidney protective effects in individuals with chronic kidney disease (CKD) with type 2 diabetes, but its effects on kidney outcomes in patients with heart failure with and without diabetes and/or CKD are not known. To investigate, researchers analyzed data from 6,001 participants enrolled in the FINEARTS-HF trial, a global, randomized ...

LAST 30 PRESS RELEASES:

Do certain diabetes drugs increase the risk of acute kidney injury in patients taking anti-cancer therapies?

Researchers integrate multiple protein markers to predict health outcomes in individuals with chronic kidney disease

How the novel antibody felzartamab impacts IgA nephropathy

Heart and kidney outcomes after canagliflozin treatment in older adults

Slowing ocean current could ease Arctic warming -- a little

Global, national, and regional trends in the burden of chronic kidney disease among women

Scientific discovery scratching beneath the surface of itchiness

SFSU psychologists develop tool to assess narcissism in job candidates

Invisible anatomy in the fruit fly uterus

Skeletal muscle health amid growing use of weight loss medications

The Urban Future Prize Competition awards top prizes to Faura and Helix Earth Technologies and highlights climate adaptation solutions with the inaugural Future Resilience Prize

Wayne State researcher secures two grants from the National Institute on Aging to address Alzheimer’s disease

NFL’s Bears add lifesavers to the chain of survival in Chicago

High-impact clinical trials generate promising results for improving kidney health: Part 1

Early, individualized recommendations for hospitalized patients with acute kidney injury

How mammals got their stride

Cancer risk linked to p53 in ulcerative colitis

Mass General Brigham experts develop laboratory toolkit for patients with viral hemorrhagic fevers such as Marburg virus disease

Ripples of colonialism: Decarbonization strategies perpetuate inequalities in human rights

Christine Schmidt elected to prestigious National Academy of Medicine

Move along moose, SFU study reveals the ‘most Canadian’ animals

Diabetes drug Ozempic also has positive effect in chronic kidney disease and obesity

Report summarizes findings from a decade of unprecedented gambling research

New lung cancer screening model removes barriers for central Texas' most vulnerable

Applications now open for Department of Energy Computational Science Graduate Fellowship

Astronauts return to Earth following seven-month science expedition on International Space Station

Alliance Bioversity-CIAT inaugurates the most advanced respirometry chambers in Latin America to measure methane emissions from livestock

Study finds bariatric surgery declined with rise in GLP-1 drugs to treat obesity

UMD researcher trains AI to predict diarrheal outbreaks related to climate change

Researchers discover that errors in protein location are a common cause of disease

[Press-News.org] Heart and kidney outcomes after canagliflozin treatment in older adults