PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Generalizability of clinical trials of novel weight loss medications to the US adult population

JAMA Internal Medicine

2024-11-25
(Press-News.org) About The Study: This study estimates that approximately one-third of U.S. adults without diabetes who were eligible for weight loss treatment with glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GLP-1/GIP) were excluded from clinical trials supporting these medications’ safety and effectiveness. Until there is evidence from high-quality postmarketing studies, the FDA should consider updating labeling to advise caution on generalizing the safety and effectiveness of GLP-1 and GLP-1/GIP to populations excluded from pivotal trials.

Corresponding Author: To contact the corresponding author, Timothy S. Anderson, MD, MAS, email tsander@pitt.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamainternmed.2024.6340)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

#  #  #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2024.6340?guestAccessKey=f706964e-006e-4c93-9e47-75456cc57d5f&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=112524

 

END


ELSE PRESS RELEASES FROM THIS DATE:

Wildfire smoke exposure and incident dementia

2024-11-25
About The Study: In this cohort study, after adjusting for measured confounders, long-term exposure to wildfire and non-wildfire fine particulate matter (PM2.5) over a 3-year period was associated with dementia diagnoses. As the climate changes, interventions focused on reducing wildfire PM2.5 exposure may reduce dementia diagnoses and related inequities. Corresponding Author: To contact the corresponding author, Joan A. Casey, PhD, email jacasey@uw.edu. To access the embargoed study: Visit our For ...

Health co-benefits of China's carbon neutrality policies highlighted in new review

2024-11-25
Researchers from the National Institute of Health Data Science at Peking University have conducted a comprehensive review of the health impacts of China's carbon mitigation strategies. Published in Health Data Science, this review emphasizes the significant health co-benefits of environmental policies aimed at reducing greenhouse gas emissions in China, the world's largest carbon emitter. These benefits include reducing deaths and diseases related to air pollution, particularly from PM2.5 and ozone (O3), as well as mitigating climate-related ...

Key brain circuit for female sexual rejection uncovered

Key brain circuit for female sexual rejection uncovered
2024-11-25
A team from the Champalimaud Foundation (CF) has pinpointed a critical neural circuit for sexual rejection, identifying a set of brain cells that play a crucial role in determining whether a female accepts or rejects mating attempts based on her reproductive cycle. Their findings, published today in Neuron, deepen our understanding of how the brain regulates social and reproductive behaviours. Female mammals, such as rodents, accept mating attempts only during their fertile phase, and actively reject males outside this period. While the brain areas controlling sexual receptivity are well-studied, the mechanisms behind active rejection ...

Electrical nerve stimulation eases long COVID pain and fatigue

Electrical nerve stimulation eases long COVID pain and fatigue
2024-11-25
A wearable electrical nerve stimulation device can provide relief to people experiencing the persistent pain and fatigue linked to long COVID, a study co-led by UCLA and Baylor College of Medicine researchers suggests. Long-COVID, a complex and lingering condition following COVID-19 recovery, affects approximately 1 in 13 adults in the U.S. Symptoms such as widespread pain, fatigue, and muscle weakness often continue to disrupt daily activities, including walking and basic tasks. The study, published in the peer-reviewed Nature Scientific Reports, focused on a wearable Transcutaneous Electrical Nerve Stimulation ...

ASTRO issues update to clinical guideline on radiation therapy for rectal cancer

2024-11-25
ARLINGTON, Va., November 25, 2024 — The American Society for Radiation Oncology (ASTRO) issued today an updated clinical guideline for physicians who use radiation therapy to treat patients with locally advanced rectal cancer. This update incorporates new data on patient selection and best practices from several practice-changing clinical trials published since the prior guideline was issued in 2020. The updated ASTRO guideline is published in Practical Radiation Oncology. Colorectal cancer is the leading cause of cancer deaths for Americans aged 20 to 49 and the second most common cause of cancer-related death overall. In the U.S., the incidence of early ...

Mount Sinai opens the Hamilton and Amabel James Center for Artificial Intelligence and Human Health to transform health care by spearheading the AI revolution

Mount Sinai opens the Hamilton and Amabel James Center for Artificial Intelligence and Human Health to transform health care by spearheading the AI revolution
2024-11-25
See accompanying video here:  https://youtu.be/o-opCV6oe3o New York, NY [November 25, 2024]—Today, the Mount Sinai Health System, one of New York City’s largest academic medical systems, announced the opening of the Hamilton and Amabel James Center for Artificial Intelligence and Human Health, which is dedicated to enhancing health care delivery through the research, development, and application of innovative artificial intelligence (AI) tools and technologies. The state-of-the-art research center solidifies ...

Researchers develop tools to examine neighborhood economic effects on spinal cord injury outcomes

Researchers develop tools to examine neighborhood economic effects on spinal cord injury outcomes
2024-11-25
East Hanover, NJ – November 25, 2024 – Kessler Foundation researchers have developed robust measures of neighborhood economic factors to study how social determinants influence health outcomes after spinal cord injury (SCI). The study reveals that individuals in disadvantaged neighborhoods face higher risks of poor health, emphasizing the need for public policy to address environmental inequities. Research scientists developed and validated two composite measures – neighborhood socioeconomic ...

Case Western Reserve University awarded $1.5 million to study vaginal bacterial linked to serious health risks

Case Western Reserve University awarded $1.5 million to study vaginal bacterial linked to serious health risks
2024-11-25
CLEVELAND—Bacterial vaginosis (BV), the most prevalent condition affecting the female reproductive system in women aged 15 to 44, is linked to such serious health risks as preterm birth, gynecological malignancies and sexually transmitted diseases. But effective long-term treatments for BV are limited: More than half experience a recurrence within six months, according to several studies. With a $1.5 million grant from the National Institutes of Health (NIH), researchers at the Case Western Reserve School of Medicine will study the dynamics of BV in hopes of identifying a more effective approach. “We hope to gain insights into promoting ...

The next evolution of AI begins with ours

2024-11-25
In a sense, each of us begins life ready for action. Many animals perform amazing feats soon after they’re born. Spiders spin webs. Whales swim. But where do these innate abilities come from? Obviously, the brain plays a key role as it contains the trillions of neural connections needed to control complex behaviors. However, the genome has space for only a small fraction of that information. This paradox has stumped scientists for decades. Now, Cold Spring Harbor Laboratory (CSHL) Professors Anthony Zador and Alexei Koulakov have devised a potential solution using artificial intelligence. When Zador first encounters this problem, he puts a ...

Using sunlight to recycle black plastics

Using sunlight to recycle black plastics
2024-11-25
Not all plastics are equal — some types and colors are easier to recycle than others. For instance, black foam and black coffee lids, which are often made of polystyrene, usually end up in landfills because color additives lead to ineffective sorting. Now, researchers report in ACS Central Science the ability to leverage one additive in black plastics, with the help of sunlight or white LEDs, to convert black and colored polystyrene waste into reusable starting materials. “Simple, visible light irradiation holds the potential to ...

LAST 30 PRESS RELEASES:

Older teens who start vaping post-high school risk rapid progress to frequent use

Corpse flowers are threatened by spotty recordkeeping

Riding the AI wave toward rapid, precise ocean simulations

Are lifetimes of big appliances really shrinking?

Pink skies

Monkeys are world’s best yodellers - new research

Key differences between visual- and memory-led Alzheimer’s discovered

% weight loss targets in obesity management – is this the wrong objective?

An app can change how you see yourself at work

NYC speed cameras take six months to change driver behavior, effects vary by neighborhood, new study reveals

New research shows that propaganda is on the rise in China

Even the richest Americans face shorter lifespans than their European counterparts, study finds

Novel genes linked to rare childhood diarrhea

New computer model reveals how Bronze Age Scandinavians could have crossed the sea

Novel point-of-care technology delivers accurate HIV results in minutes

Researchers reveal key brain differences to explain why Ritalin helps improve focus in some more than others

Study finds nearly five-fold increase in hospitalizations for common cause of stroke

Study reveals how alcohol abuse damages cognition

Medicinal cannabis is linked to long-term benefits in health-related quality of life

Microplastics detected in cat placentas and fetuses during early pregnancy

Ancient amphibians as big as alligators died in mass mortality event in Triassic Wyoming

Scientists uncover the first clear evidence of air sacs in the fossilized bones of alvarezsaurian dinosaurs: the "hollow bones" which help modern day birds to fly

Alcohol makes male flies sexy

TB patients globally often incur "catastrophic costs" of up to $11,329 USD, despite many countries offering free treatment, with predominant drivers of cost being hospitalization and loss of income

Study links teen girls’ screen time to sleep disruptions and depression

Scientists unveil starfish-inspired wearable tech for heart monitoring

Footprints reveal prehistoric Scottish lagoons were stomping grounds for giant Jurassic dinosaurs

AI effectively predicts dementia risk in American Indian/Alaska Native elders

First guideline on newborn screening for cystic fibrosis calls for changes in practice to improve outcomes

Existing international law can help secure peace and security in outer space, study shows

[Press-News.org] Generalizability of clinical trials of novel weight loss medications to the US adult population
JAMA Internal Medicine