Endothelial cell loss 1 year after successful DMEK in the diabetes endothelial keratoplasty study

JAMA Ophthalmology

2025-10-17

(Press-News.org) About The Study: This randomized clinical trial found that endothelial cell loss and morphometry 1 year after Descemet membrane endothelial keratoplasty (DMEK) were not affected by cornea donor diabetes status. With comparable 1-year graft success with tissue from donors with and without diabetes demonstrated in this trial, these findings support the use of corneas from donors with diabetes for endothelial keratoplasty procedures.

Corresponding Author: To contact the corresponding author, Jonathan H. Lass, MD, email deks@case.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamaophthalmol.2025.4261)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Media advisory: This study is being presented at the Cornea and Eye Banking Forum and the American Academy of Ophthalmology’s annual meeting.

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Endothelial cell loss 1 year after successful DMEK in the diabetes endothelial keratoplasty study

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