Ultra-processed foods are linked to reduced fertility and embryonic development
First study to look at combined impact of diet in both men and women
Eating large amounts of ultra-processed food (UPF) is linked not only to reduced fertility in men, but also to slower growth in early embryos, and smaller yolk sacs, which are essential for early embryonic development, according to new research.
The authors of the study, which is published today (Tuesday) in Human Reproduction [1], one of the world’s leading reproductive medicine journals, say their findings suggest that reducing the consumption of UPFs, especially around the time of conception and pregnancy, is better for both parents and embryos.
Although maternal and paternal health are known to influence reproductive success and the development and health of offspring, until now no study has investigated the combined impact of mothers’ and fathers’ UPF consumption on the length of time it takes to conceive and early embryonic development.
Consumption of UPFs has been growing rapidly. They are highly processed foods, typically high in added sugars, salt, saturated and trans fats, and additives, and low in fibre, whole foods and other essential nutrients; they are usually designed for convenience and mass production rather than nutritional value. In some high-income countries, UPF now account for up to 50-60% of food eaten each day.
“Even though UPFs are so common in our diets, very little is known about their potential relationship with fertility outcomes, and early human development,” said Dr Romy Gaillard, a paediatrician and associate professor of developmental epidemiology at Erasmus University Medical Center, Rotterdam, The Netherlands, who led the study.
Dr Gaillard and colleagues analysed findings from 831 women and 651 male partners enrolled in a population-based, prospective study that has been following parents from before conception onwards and into their offspring’s childhood – the Generation R Study Next Programme. Couples were included during the pre-conception period or during pregnancy between 2017 and 2021.
The researchers assessed the parents’ diet with a questionnaire during early pregnancy around 12 weeks. The different foods were classified as either non-UPFs or UPFs, and UPF intake was expressed as a percentage of total food intake in grams per day. All the women were pregnant at the time of this questionnaire. The average (median) consumption of UPF was 22% and 25%, respectively, of women’s and men’s total food intake. [2]
A questionnaire also provided information on time to pregnancy, fecundability (the probability of conceiving within one month) and subfertility (a time to pregnancy of 12 months or more, or the use of assisted reproductive technology).
The distance between the embryo’s head and its buttocks (crown rump length or CRL), which is an indication of its size and development, and the volume of the yolk sac were measured by transvaginal ultrasound at seven, nine and 11 weeks of gestation.
The first author of the study, Celine Lin, a Phd student at Erasmus University Medical Center, said: “We observed that UPFs consumption in women was not consistently related to the risk of subfertility and time to pregnancy, but was associated with slightly smaller embryonic growth and yolk sac size by the seventh week of pregnancy. These differences in early human development were small, but are important from a research perspective and at population level, as we showed for the first time that UPF consumption is not only important for health of the mother, but may also be related to development of the offspring.
“In men, we observed that higher UPF consumption was related to a higher risk of subfertility and a longer duration until pregnancy was achieved, but not with early embryo development. This association may be explained by the sensitivity of sperm to dietary composition, whereas maternal UPF consumption may directly influence the environment in the womb in which the embryo develops from the start of life onwards.”
Dr Gaillard said: “Our findings suggest that a diet low in UPFs would be best for both partners, not only for their own health, but also for their chances of pregnancy and the health of their unborn child.”
Other studies have shown that slower embryonic growth in the first trimester is associated with an increased risk of adverse birth outcomes, including premature birth (birth before 37 weeks), low birth weight, and an increased risk of heart and blood vessel problems in childhood. Impaired yolk sac development is associated with an increased risk of miscarriage and premature birth.
Dr Gaillard continued: “Our study shows for the first time that UPF consumption in men and women is associated with fertility outcomes and early human development, but also has limitations. Importantly, as this is an observational study, our study shows associations, but cannot prove direct causal effects of UPF consumption on these early life outcomes.
“More research is needed to replicate our findings, in diverse populations, and to study the potential biological mechanisms underlying this effect. For instance, are these differences driven by the low nutritional value of UPFs or by the increased exposure to additives or microplastics? We also want to study whether these early differences have consequences for birth outcomes, growth and development of offspring throughout childhood.
“Finally, our research shows that we should think more broadly about fertility and early pregnancy. We should move away from the idea that only the health and lifestyle of mothers-to-be is important for pregnancy and offspring outcomes, and recognise that the health and lifestyle of both the mother- and father-to-be play an important role. Our results highlight the need to pay more attention to male health in the preconception period, which has traditionally been overlooked.”
(ends)
[1] “Periconceptional ultra-processed food consumption in women and men, fertility, and early embryonic development.” Human Reproduction journal. doi:10.1093/humrep/deag023
[2] The most recent national survey shows that about 30% of the total intake in The Netherlands comes from UPFs (Vellinga et al. 2022). This is much lower than in countries like the United States or the United Kingdom, where these foods make up about half of what people eat. In southern European countries, such as Spain and Italy, the share is lower, usually around 15-20% (Marino et al. 2021).
END
The authors of the study, which is published today (Tuesday) in Human Reproduction [1], one of the world’s leading reproductive medicine journals, say their findings suggest that reducing the consumption of UPFs, especially around the time of conception and pregnancy, is better for both parents and embryos.
Although maternal and paternal health are known to influence reproductive success and the development and health of offspring, until now no study has investigated the combined impact of mothers’ and fathers’ UPF consumption on the length of time it takes to conceive and early embryonic development.
Consumption of UPFs has been growing rapidly. They are highly processed foods, typically high in added sugars, salt, saturated and trans fats, and additives, and low in fibre, whole foods and other essential nutrients; they are usually designed for convenience and mass production rather than nutritional value. In some high-income countries, UPF now account for up to 50-60% of food eaten each day.
“Even though UPFs are so common in our diets, very little is known about their potential relationship with fertility outcomes, and early human development,” said Dr Romy Gaillard, a paediatrician and associate professor of developmental epidemiology at Erasmus University Medical Center, Rotterdam, The Netherlands, who led the study.
Dr Gaillard and colleagues analysed findings from 831 women and 651 male partners enrolled in a population-based, prospective study that has been following parents from before conception onwards and into their offspring’s childhood – the Generation R Study Next Programme. Couples were included during the pre-conception period or during pregnancy between 2017 and 2021.
The researchers assessed the parents’ diet with a questionnaire during early pregnancy around 12 weeks. The different foods were classified as either non-UPFs or UPFs, and UPF intake was expressed as a percentage of total food intake in grams per day. All the women were pregnant at the time of this questionnaire. The average (median) consumption of UPF was 22% and 25%, respectively, of women’s and men’s total food intake. [2]
A questionnaire also provided information on time to pregnancy, fecundability (the probability of conceiving within one month) and subfertility (a time to pregnancy of 12 months or more, or the use of assisted reproductive technology).
The distance between the embryo’s head and its buttocks (crown rump length or CRL), which is an indication of its size and development, and the volume of the yolk sac were measured by transvaginal ultrasound at seven, nine and 11 weeks of gestation.
The first author of the study, Celine Lin, a Phd student at Erasmus University Medical Center, said: “We observed that UPFs consumption in women was not consistently related to the risk of subfertility and time to pregnancy, but was associated with slightly smaller embryonic growth and yolk sac size by the seventh week of pregnancy. These differences in early human development were small, but are important from a research perspective and at population level, as we showed for the first time that UPF consumption is not only important for health of the mother, but may also be related to development of the offspring.
“In men, we observed that higher UPF consumption was related to a higher risk of subfertility and a longer duration until pregnancy was achieved, but not with early embryo development. This association may be explained by the sensitivity of sperm to dietary composition, whereas maternal UPF consumption may directly influence the environment in the womb in which the embryo develops from the start of life onwards.”
Dr Gaillard said: “Our findings suggest that a diet low in UPFs would be best for both partners, not only for their own health, but also for their chances of pregnancy and the health of their unborn child.”
Other studies have shown that slower embryonic growth in the first trimester is associated with an increased risk of adverse birth outcomes, including premature birth (birth before 37 weeks), low birth weight, and an increased risk of heart and blood vessel problems in childhood. Impaired yolk sac development is associated with an increased risk of miscarriage and premature birth.
Dr Gaillard continued: “Our study shows for the first time that UPF consumption in men and women is associated with fertility outcomes and early human development, but also has limitations. Importantly, as this is an observational study, our study shows associations, but cannot prove direct causal effects of UPF consumption on these early life outcomes.
“More research is needed to replicate our findings, in diverse populations, and to study the potential biological mechanisms underlying this effect. For instance, are these differences driven by the low nutritional value of UPFs or by the increased exposure to additives or microplastics? We also want to study whether these early differences have consequences for birth outcomes, growth and development of offspring throughout childhood.
“Finally, our research shows that we should think more broadly about fertility and early pregnancy. We should move away from the idea that only the health and lifestyle of mothers-to-be is important for pregnancy and offspring outcomes, and recognise that the health and lifestyle of both the mother- and father-to-be play an important role. Our results highlight the need to pay more attention to male health in the preconception period, which has traditionally been overlooked.”
(ends)
[1] “Periconceptional ultra-processed food consumption in women and men, fertility, and early embryonic development.” Human Reproduction journal. doi:10.1093/humrep/deag023
[2] The most recent national survey shows that about 30% of the total intake in The Netherlands comes from UPFs (Vellinga et al. 2022). This is much lower than in countries like the United States or the United Kingdom, where these foods make up about half of what people eat. In southern European countries, such as Spain and Italy, the share is lower, usually around 15-20% (Marino et al. 2021).
END