Large weight gain raises risk for recurrence among breast cancer survivors

(Press-News.org) Oakland, Calif., April 5, 2011 — Breast cancer survivors who experience large weight gain have an increased risk of death after diagnosis, according to research scientists at the Kaiser Permanente Division of Research in Oakland, Calif.

Breast cancer survivors who experienced large weight gain (10 percent or more over their pre-diagnosis weight) were 14 percent more likely to experience a cancer recurrence compared to women whose weight remained stable (within 5 percent of pre-diagnosis weight) following diagnosis.

The study results are being presented at the American Association of Cancer Research 102nd meeting, to be held April 2-6 in Orlando, Fla.

"Most women are not gaining a large amount of weight following breast cancer diagnosis," said lead researcher Bette Caan, DrPH, a senior research scientist at the Kaiser Permanente Division of Research. "However, our analysis showed an association with poorer outcomes overall for those who do." She explained that moderate weight gain did not affect breast cancer outcomes.

"Women tend to worry about gaining weight after a breast cancer diagnosis," said Caan. "But it's actually only the larger weight gains that increase the risk of poor outcomes."

Researchers also found that women who have large weight gains after diagnosis tend to be within normal weight ranges to begin with. In addition, the post-diagnosis effect of the weight gain tends to be greater for women who were originally thinner, they explained.

Women who were leaner to begin with at diagnosis (body mass index less than 25) and who later gained 10 percent or more, had a 25 percent higher risk of cancer death and also had a higher risk of recurrence compared to women whose weight remained stable (within 5 percent of pre-diagnosis weight) following diagnosis.

Large weight gain occurred in 16 percent of women overall. Just over 19 percent of women with a BMI less than 25 fell into the large weight gain category, but only 11.1 percent of women with a BMI greater than 30 fell into that category.

Data for the study came from the After Breast Cancer Pooling Project, which includes 18,336 breast cancer survivors from four prospective cohorts — three in the United States and one in Shanghai.

Caan explained that more research is needed to identify those women most at risk for extreme weight gain and those whose weight gain puts them at risk for poor cancer outcomes.

### About the Kaiser Permanente Division of Research (http://www.dor.kaiser.org/) The Kaiser Permanente Division of Research conducts, publishes, and disseminates epidemiologic and health services research to improve the health and medical care of Kaiser Permanente members and the society at large. It seeks to understand the determinants of illness and well-being and to improve the quality and cost-effectiveness of health care. Currently, DOR's 500-plus staff is working on more than 250 epidemiological and health services research projects. About Kaiser Permanente

Kaiser Permanente is committed to helping shape the future of health care. We are recognized as one of America's leading health care providers and not-for-profit health plans. Founded in 1945, our mission is to provide high-quality, affordable health care services and to improve the health of our members and the communities we serve. We currently serve 8.7 million members in nine states and the District of Columbia. Care for members and patients is focused on their total health and guided by their personal physicians, specialists and team of caregivers. Our expert and caring medical teams are empowered and supported by industry-leading technology advances and tools for health promotion, disease prevention, state-of-the art care delivery and world-class chronic disease management. Kaiser Permanente is dedicated to care innovations, clinical research, health education and the support of community health. For more information, go to: www.kp.org/newscenter.