A recent study has uncovered alarming insights into the dangers posed by fentanyl-contaminated drug supplies in Australia, including a heightened risk of lethal overdose. The study, titled ‘The gear could be cut with fentanyl which is starting to happen more in Australia’: Exploring Overdose Survivors’ Perspectives on Toxic Supply and Safe Consumption, aimed to explore the role of synthetic opioids in overdoses among Queenslanders. Led by Griffith University’s Dr Timothy Piatkowski, Emma Kill and Steph Reeve in partnership with the Queensland ...

Researchers at the Center for Algorithmic and Robotized Synthesis within the Institute for Basic Science have taken a significant step forward in understanding the stability of proteins by leveraging the power of AI. The research team used AlphaFold2 to explore how mutations affect protein stability—a crucial factor in ensuring proteins function correctly and do not cause diseases like Alzheimer's. DeepMind’s AlphaFold algorithm, which can accurately predict a protein’s structure from ...

DNA damage is a cellular phenomenon that introduces structural abnormalities in double-stranded DNA. External factors, such as radiation or chemical agents, as well as internal factors, such as blocked DNA replication, can generate double-strand breaks (DSBs) in DNA. To counteract DNA damage, cells engage in DNA repair to preserve genetic integrity and ensure cell survival as failure to repair DSBs has serious health complications like increased risk of cancer. DSBs are repaired by two mechanisms called non-homologous end joining (NHEJ) and homologous recombination (HR). NHEJ is the predominant DNA repair mechanism in human somatic cells and is ...

Fuel cells offer a promising solution for clean energy with advantages over traditional electric power systems, including extended driving range and higher energy density. Despite these benefits, the high costs and durability concerns associated with fuel cell stacks have limited their commercialization. The durability of membrane electrode assemblies (MEAs), a key component of proton exchange membrane fuel cells (PEMFCs), is particularly affected by the frame sealing structure, which is often overlooked in research. The study, conducted by Tiankuo Chu ...

An international group of researchers has developed a novel approach that enhances the efficiency of the oxygen evolution reaction (OER), a key process in renewable energy technologies. By introducing rare earth single atoms into manganese oxide (MnO2), the group successfully modulated oxygen electronic states, leading to unprecedented improvements in OER performance. Their findings were published in the journal Nano Energy on June 10, 2024. Transition-metal-based oxides have been widely explored for their potential as active OER catalysts. However, the capacity of these catalysts is hindered by the adsorbate evolution mechanism, which ...

The concurrency control in deterministic databases, i.e., deterministic concurrency control, ensures that each transaction batch produces a unique result. In this way, replicas can process transactions in batches without communicating with each other to ensure consistency, which is simpler and more efficient than non-deterministic databases in achieving high availability through replication. Early deterministic concurrency control protocols, e.g. Calvin, Bohm, PWV, rely on the prior knowledge of the read-write set, which is impractical in most scenarios. The state-of-the-art Ari breaks this limitation. However, Aria has three issues. First, ...

The National Science Foundation has announced a $22 million grant to establish a “BioFoundry” laboratory for the study of extreme microorganisms with collaborating facilities at UC Riverside, UC Santa Barbara, and Cal Poly Pomona. The BioFoundry for Extreme and Exceptional Fungi, Archaea, and Bacteria, or ExFAB, will focus on developing techniques to learn from nature’s more unusual microorganisms. These microbes are considered “extreme” because they have unusual nutritional requirements, grow at extremely high or low temperatures, or grow without ...

(Santa Barbara, Calif.) — This week, the National Science Foundation announced the award of a six-year, $22M grant to UC Santa Barbara under its biofoundries program for the establishment of the BioFoundry for Extreme and Exceptional Fungi, Archaea and Bacteria (ExFAB), a collaboration led by UC Santa Barbara (UCSB), together with UC Riverside (UCR), and Cal Poly Pomona (CPP). ExFAB establishes the nation’s first biofoundry that focuses on largely untapped and unexplored extreme microbes. UCSB's award is one of only five grants made under NSF's BioFoundry program during this funding cycle, which awarded ...

Misconceptions about dyslexia are held by professionals who assess children for the learning difficulty, according to a new study which calls for evidence-based standardised assessment procedures. The research, led by Durham University, found that almost half of dyslexia professionals in the study believed at least one unproven indicator for dyslexia, which could lead to children being misdiagnosed. In a survey of 275 dyslexia professionals, the most common myth – which is not backed up by solid evidence – was that people with dyslexia read letters in reverse order, believed by 61 per cent of specialists. Just over 30 per cent of professionals also ...

A recently developed block copolymer could help push the limits of integration and miniaturization in semiconductor manufacturing, report scientists in Tokyo Tech and TOK. Chemically tailored for reliable directed self-assembly, the proposed compound can arrange itself into perpendicular lamellar structures whose half-pitch width is less than 10 nanometers, outperforming conventional and widely used block copolymers. Miniaturization is one of the fundamental qualities of modern electronics and is largely responsible for the incredible increments in performance witnessed ...

Researchers at Macquarie University have developed a new way to produce ultraviolet (UV) light sensors, which could lead to more efficient and flexible wearable devices. The study, published in the journal Small in July, shows how acetic acid vapour – essentially vinegar fumes – can rapidly improve the performance of zinc oxide nanoparticle-based sensors without using high-temperatures for processing. Co-author Professor Shujuan Huang, from the School of Engineering at Macquarie University, says: “We found by briefly exposing the sensor to vinegar vapour, adjoining ...

Sodium-glucose cotransporter-2 (SGLT-2) inhibitors used to treat type 2 diabetes might prevent dementia, providing greater benefits with longer treatment, suggests a large study from Korea published by The BMJ today.  As this study was observational, the researchers note that the effect size could have been overestimated and say randomised controlled trials are now needed to confirm these findings. According to the World Health Organization, the number of people with dementia globally is expected to reach 78 million ...

Girls with mental illness or neurodevelopmental conditions are less likely than their peers to be vaccinated with the HPV vaccine that protects against future cervical cancer. This is according to a new registry study from Karolinska Institutet in Sweden published in The Lancet Public Health. The study involved more than 115,000 girls covered by the Swedish school-based human papillomavirus (HPV) vaccination programme. The vaccine, which prevents cervical cancer, among other things, is offered to all children in Sweden and given by school health services. Significant ...

Scientists are on the verge of a cancer breakthrough after working out how the body’s immune system targets cells devastated by the disease. A new study has discovered that our natural killer cells, from the immune system which protect against disease and infections, instinctively recognise and attack a protein that drives cancer growth. The experts say that by hijacking this protein, known as XPO1, they may be able to activate more killer cells to destroy the disease. Scientists from the University of Southampton, working with experts worldwide, led the study and now believe it could offer new ...

Geriatrics experts have long known that collaboration is key to delivering quality, patient-centered care to older adults. That’s why USC’s Interprofessional Education and Collaboration for Geriatrics (IECG) trains up to 150 students annually from seven health professions to teach the importance of teamwork in meeting the complex needs of the elderly. Now, a study published in the Journal of Interprofessional Care highlights the long-term impact of IECG on USC health sciences graduates. Researchers surveyed graduates one to three years after completing IECG to assess how the program influenced their practice. The findings were significant: 81% ...

New Haven, Conn. — More than two decades ago, a research team in the lab of David Hafler, a Yale researcher who at the time was at Harvard, discovered a type of T cell in humans that suppresses the immune system; they later found that these so-called regulatory T cells, when defective, are an underlying cause of autoimmune disease, specifically multiple sclerosis (MS). For many years, however, the mechanism behind this dysfunction has remained unclear. In a new Yale-led study, a team of researchers finds that this loss of immune regulation is triggered by an increase in PRDM1-S, a protein involved in immune function, ...

When it comes to purchasing and using electric vehicles (EVs), housing- and income-related factors significantly shape perceptions and preferences among potential buyers, finds a new study in Energy and Climate Change. This research, a collaboration between the Boston University Institute for Global Sustainability (IGS) and the U.S. Department of Energy’s National Renewable Energy Laboratory (NREL), is among the first to examine both EV adoption and charging infrastructure through an equity lens coupled with state-of-the-art original survey data. Understanding the barriers to widespread EV adoption ...

An external study of Twitter in 2022 estimated that between a third and two thirds of accounts on the social media site were bots. And many of these automatons flooding social media are dispatched to sow political polarization, hate, misinformation, propaganda and scams. The ability to sift them out of the online crowds is vital for a safer, more humane (or at least more human) internet. But the recent proliferation of large language models (known as "LLMs" for short), such as OpenAI’s ChatGPT and Meta’s Llama, ...

Rutgers University-New Brunswick scientists have discovered a virus that caused a nationwide die-off of superworms, a common food for birds, reptiles, other pets and, more and more so, even for humans as an alternative protein source. In doing so, they pioneered a different way to search for and identify emerging viruses and pathogens in humans, plants and animals. Using chopped up beetle carcasses forming a slurry and an electron microscope cooled by liquid nitrogen, the scientists reported today in Cell that they have discovered what they have titled Zophobas morio black wasting virus. The name is derived from ...

University of Maryland School of Medicine (UMSOM) Dean Mark T. Gladwin, MD, announced today the appointment of Elana J. Fertig, PhD, FAIMBE, as the new Director of the School’s Institute for Genome Sciences (IGS). She is  internationally-recognized for her work in integrating spatial multi-omics technologies with mathematical models to develop a new predictive medicine paradigm in cancer. Spatial technologies allow researchers to learn about any cell type inside of natural tissue, including gene activity ...

A multi-university research team co-led by University of Virginia engineering professor Gustavo K. Rohde has developed a system that can spot genetic markers of autism in brain images with 89 to 95% accuracy. Their findings suggest doctors may one day see, classify and treat autism and related neurological conditions with this method, without having to rely on, or wait for, behavioral cues. And that means this truly personalized medicine could result in earlier interventions. “Autism is traditionally diagnosed behaviorally but has a strong genetic basis. A genetics-first approach could ...

Zhili Feng, a distinguished R&D staff member, and Jian Chen, a senior R&D staff member, in Materials Science and Technology Division at the Department of Energy’s Oak Ridge National Laboratory, will receive the Elmer L. Hann Award at the Society of Naval Architects and Maritime Engineers, or SNAME, Convention on Oct. 15 in Norfolk, Virginia. SNAME plays a crucial role in promoting excellence in marine engineering and naval architecture, supporting professionals through education, research and collaboration. The award is presented to authors of the best paper on ship production delivered at a SNAME event. In September 2023, Feng and Chen presented “Develop ...

Chemical engineers at the University of British Columbia have developed a new treatment that traps and treats PFAS substances—widely known as “forever chemicals”—in a single, integrated system. Per- and polyfluoroalkyl substances (PFAS) are widely used in manufacturing consumer goods like waterproof clothing due to their resistance to heat, water and stains. However, they are also pollutants, often ending up in surface and groundwater worldwide, where they have been linked to cancer, liver damage and ...

WEST LAFAYETTE, Ind. — A researcher in Purdue University’s College of Science is developing a patent-pending platform technology that mimics the dual-layer structure of viruses to deliver nucleic acid (NA)-based therapies to targeted cancer cells. David Thompson leads a team developing the carrier system called LENN. He is a professor in the James Tarpo Jr. and Margaret Tarpo Department of Chemistry and on the faculty of the Purdue Institute for Cancer Research and the Purdue ...

With swing states playing a pivotal role in the 2024 presidential election, new reports from the Center for Inclusive Democracy (CID) at the USC Sol Price School of Public Policy have found significant voter turnout disparities between white, non-Latino voters and voters of color in all nine battleground states. The reports highlight the persistent “voter representation gap,” where voters of color remain underrepresented at the polls, despite substantial population growth. If narrowed by November, the research concludes, this gap could significantly influence election results, particularly in swing states that had particularly close ...