In a new scientific investigation headed by the German Leibniz Institute for Zoo and Wildlife Research (Leibniz-IZW), water from African and Mongolian waterholes as well as bloodmeals from Southeast Asian leeches were assessed for the ability to retrieve mammalian viruses without the need to find and catch the mammals. The scientists analysed the samples using high throughput sequencing to identify known viruses as well as viruses new to science. Both approaches proved to be suitable tools for pandemic prevention research as they allow finding and monitoring reservoirs of wildlife viruses. For example, a novel coronavirus most likely associated with Southeast Asian deer species was identified. The results are ...

An international research team led by HKUST has developed a simple but robust blood test from Chinese patient data for early detection and screening of Alzheimer's disease (AD) for the first time, with an accuracy level of over 96%. Currently, doctors mainly rely on cognitive tests to diagnose a person with AD. Besides clinical assessment, brain imaging and lumbar puncture are the two most commonly used medical procedures to detect changes in the brain caused by AD. However, these methods are expensive, invasive, and frequently unavailable in many countries. Now, a team led by Prof. Nancy IP, Vice-President for Research and Development at HKUST, has identified 19 out of the 429 plasma proteins associated with AD to form ...

University of Otago, New Zealand, and UK researchers have developed a world-first weight-loss device to help fight the global obesity epidemic. DentalSlim Diet Control is an intra-oral device fitted by a dental professional to the upper and lower back teeth. It uses magnetic devices with unique custom-manufactured locking bolts. It allows the wearer to open their mouths only about 2mm, restricting them to a liquid diet, but it allows free speech and doesn't restrict breathing. Participants in a Dunedin-based trial lost an average of 6.36kg in two weeks and were motivated to continue with their weight loss ...

Coral bleaching and the ecological degradation of coral reefs have become increasingly severe due to the global warming and human activities. As "mixotrophic" organisms, scleractinian coral can not only obtain energy through photosynthesis of symbiotic zooxanthellae (autotrophy), but also ingest nutrients in seawater through the coral host (heterotrophy). However, the influence of coral's trophic flexibility on environmental adaptability remains unclear. Coral reefs are widely distributed in the South China Sea (SCS), spanning about 20 latitudes from north to south. The environmental conditions of coral reef areas at different latitudes are significantly different. ...

Thousands of scientific papers describing the inner workings of the brain and its dysfunction have been published using resting state functional magnetic resonance imaging (RS-fMRI). This powerful tool allows researchers to look at each cubic millimeter of the brain, in voxels - the 3D version of a pixel. The average brain is well over 1,000,000 cubic mm, so researchers need to perform multiple comparisons correction (MCC) to reduce the possibility of making false claims, i.e., reduce the false positive rates. As part of this MCC, a smaller p value threshold is widely recommended for declaring ...

Multi-photon approaches provide printing rates of up to about ten million voxels per second. And, multi-photon-based 3D approaches structure matter with a resolution approaching sub-micrometer and nanometer feature sizes. Such spatial resolution is crucial for many applications in photonics and electronics and is inaccessible to most other 3D additive manufacturing approaches. However, the vast majority of 3D printed objects and devices made along these lines has been composed of only a single polymeric material. Multi-material architectures are much less investigated ...

The most significant feature of global land surface wind speed (SWS) recently is the long-term weakening trend since the 1960s, that is, the phenomenon known as global terrestrial stilling. Many studies have found that stilling is widespread worldwide. It has seriously affected the ecological environment and social economy, especially restricted the sustainable development of the wind energy industry. It is found that the stilling reversed around 2010 and global SWS is strengthening; then, has the stilling of surface wind speed ended in China? A recent study systematically answered this question. The related paper titled "Has the stilling of the surface wind ...

In the 1970s, Fleischmann, the scientist in British, discovered that on noble metallic nanostructure, the Raman scattering of pyridine was enhanced hundreds-hold. Then, the scientists attributed the enhancement to the localized electric field highly amplified near the surface of specific noble metallic nanostructures. Thus, this phenomenon was termed surface-enhanced Raman scattering (SERS). Currently, although the enhancement mechanism of SERS is still in the debate, the SERS exhibits incomparable abilities of monitoring and sensing with high sensitivity in diverse fields ...

Human's understanding of the oceans is still limited. The oceans are rich of various kinds of resource which have great exploitation potential and are far away from fully development. Marine biosafety also needs to be noticed. There are not only many animal and plant species undiscovered, but also a much larger and diverse number of microorganisms such as viruses. Traditional studies of marine viruses have focused on bacteriophage represented DNA viruses, and little is known about the genetic diversity, distribution characteristics and transmission patterns of marine invertebrate RNA viruses. Here, CUI Jie's team have collected a total of 58 marine invertebrate samples from 3 phyla and 6 classes and ...

The research team led by Prof. XIONG Wei and Prof. CANG Chunlei from Life Science and Medicine of University of Science and Technology of China, realized lysosome typing based on single lysosome metabonomic information for the first time by stablishing a single lysosome metabonomic mass spectrometry detection technology. A deeply explore to the heterogeneity changes of lysosome metabonomics in the process of cellular senescence has been achieved. The result was published on Nature Methods. Lysosomes are organelles present in almost all eukaryotic cells. Lysosomes are essential for maintaining energy and metabolic homeostasis, signal transduction, and recovery of damaged proteins and organelles. Previous reports indicate that cellular senescence is closely related to lysosomes and their ...

As the average life expectancy of residents increases, there are more and more cases of human bone tissue disease. With the upgrading of treatment methods, more and more bone tissue lesions can be treated with artificial implants for replacement. Due to the huge demand in the field of biophysical therapy, biomedical materials have very broad market prospects. In the past 10 years, the market growth rate of biomedical materials has remained at 20-25%, and the world population is nearly 6.5 billion. Statistics show that there are close to 400 million disabled people, 60 million physically disabled, and about 2 billion dental patients. At present, there are only 35 million implanters of biomaterial devices, and the annual joint replacement volume is about 1.5 million, ...

Research team, led by academician GUO Guangcan from University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS), collaborating with researchers from Sun Yat-sen University and Zhejiang University, realized two-photon quantum interference in the structure of valley-dependent topological insulators based on the valley Hall effect. The study was published in Physical Review Letters on June 11st, 2021. Topological photonics has a practical application prospect in the research of photonic chips due to its robust energy transport prosperities. The key to topological phase transition is to generate an energy gap at certain degenerate points by breaking either the time-reversal ...

Saturated fatty acid levels unexpectedly rise in the brain during memory formation, according to END ...

Newly-available scientific evidence, which could prove critical to the success of climate-related lawsuits, is often not produced in court, according to a new study published today by the Oxford Sustainable Law Programme and Environmental Change Institute. Filling the evidentiary gap in climate litigation in Nature Climate Change, a leading interdisciplinary science journal, is the first global study on the use and interpretation of climate-science evidence in lawsuits. The study reveals evidence submitted by litigants in 73 lawsuits across 14 jurisdictions is significantly behind state-of-the-art ...

(Boston)--Amyloid diseases, including Alzheimer's, Parkinson's, type-2 diabetes and other life-threatening diseases, involve pathologic deposits of normally soluble proteins or peptides as insoluble amyloid fibrils. When this happens in vital organs, such as the brain, kidney, liver and heart, it causes organ damage and, if left untreated, death. Unfortunately, the available treatment options are very limited. Now a new study from researchers at Boston University School of Medicine (BUSM) improves our understanding of how heparan sulfate and related biopolymers such as heparin, which is perhaps best known as a blood thinner, can promote amyloid deposition in various organs. The researchers ...

(COLUMBUS, Ohio) - While little research exists on how and why the rates of Black youth suicide are rising, research does show the rate of suicide in Black youth younger than 13 years of age is approximately two times higher compared to white peers. From 2009 to 2019, the percentages of Black youth who considered suicide, made a suicide plan and attempted suicide all increased. In a statement published in JAMA Pediatrics, researchers at the Nationwide Children's Hospital, the University of North Carolina at Chapel Hill and the nonprofit research institute RTI International ...

What The Study Did: The rates, duration and dosages of opioids prescribed to children, adolescents and young adults from 2006 to 2018 were examined in this study. Authors: Madeline H. Renny, M.D., of the New York University Grossman School of Medicine, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamapediatrics.2021.1832) Editor's Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media advisory: ...

What The Study Did: Researchers compared health care access and quality scores for the United States with high-income countries with universal health insurance coverage and compared scores among U.S. states with varying insurance coverage. Authors: Marcia R. Weaver, Ph.D., of the University of Washington in Seattle, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.14730) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other ...

What The Study Did: High school students in Austria were surveyed about their well-being, sleep quality, eating and symptoms of depression and anxiety during the COVID-19 pandemic. Authors: Christoph Pieh, M.D., of Danube University in Krems, Austria, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.14866) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media advisory: The full study ...

A gene variant that lowers white blood cell levels and is common in individuals with African ancestry contributes to unnecessary bone marrow biopsies, according to a study published June 28 in JAMA Internal Medicine. The findings from three institutions, led by investigators at Vanderbilt University Medical Center, provide an example of how using genetic data could reduce a health disparity. "We've essentially created this racial health disparity by not fully considering how genetic variation affects white blood cell levels," said Jonathan Mosley, MD, PhD, assistant professor of Medicine and Biomedical Informatics at VUMC. "Our study supports genotyping African Americans before ...

Most people associate the term "wearable" with a fitness tracker, smartwatch, or wireless earbuds. But what if you could wear cutting-edge biotechnology in your clothing, and it could warn you when you were exposed to something dangerous? A team of researchers from the Wyss Institute for Biologically Inspired Engineering at Harvard University and the Massachusetts Institute of Technology has found a way to embed synthetic biology reactions into fabrics, creating wearable biosensors that can be customized to detect pathogens and toxins and alert the wearer. The team has integrated this technology into standard face masks to detect the presence of the SARS-CoV-2 virus in a patient's breath. The button-activated mask ...

Researchers at Northwestern and George Washington (GW) universities have developed the first-ever transient pacemaker -- a wireless, battery-free, fully implantable pacing device that disappears after it's no longer needed. The thin, flexible, lightweight device could be used in patients who need temporary pacing after cardiac surgery or while waiting for a permanent pacemaker. All components of the pacemaker are biocompatible and naturally absorb into the body's biofluids over the course of five to seven weeks, without needing surgical extraction. The device wirelessly harvests energy from an external, remote antenna using near-field ...

A worldwide team led by UC Santa Barbara scientists at Las Cumbres Observatory has discovered the first convincing evidence for a new type of stellar explosion -- an electron-capture supernova. While they have been theorized for 40 years, real-world examples have been elusive. They are thought to arise from the explosions of massive super-asymptotic giant branch (SAGB) stars, for which there has also been scant evidence. The discovery, published in Nature Astronomy, also sheds new light on the thousand-year mystery of the supernova from A.D. 1054 that was visible all over the world in the daytime, before eventually becoming the Crab Nebula. Historically, supernovae have ...

A worldwide team led by scientists at Las Cumbres Observatory has discovered the first convincing evidence for a new type of stellar explosion -- an electron-capture supernova. While they have been theorized for 40 years, real-world examples have been elusive. They are thought to arise from the explosions of massive super-asymptotic giant branch (SAGB) stars, for which there has also been scant evidence. The discovery also sheds new light on the thousand-year mystery of the supernova from A.D. 1054 that was seen all over the world in the daytime, before eventually becoming the Crab Nebula. Historically, there have been two main supernova types. One is a thermonuclear supernova -- the explosion of a white dwarf star after it gains matter in a binary star system. These white ...

Engineers at MIT and Harvard University have designed a novel face mask that can diagnose the wearer with Covid-19 within about 90 minutes. The masks are embedded with tiny, disposable sensors that can be fitted into other face masks and could also be adapted to detect other viruses. The sensors are based on freeze-dried cellular machinery that the research team has previously developed for use in paper diagnostics for viruses such as Ebola and Zika. In a new study, the researchers showed that the sensors could be incorporated into not only face masks but also clothing such as lab coats, potentially offering a new way to ...