Results of a multicenter phase II clinical trial led by the University of Chicago Medicine Comprehensive Cancer Center show that adding an immunomodulatory agent to treatment with the targeted tyrosine kinase inhibitor (TKI) cediranib did not make a difference in outcomes for treating patients with an advanced form of thyroid cancer that develops from thyroid follicular cells called differentiated thyroid cancer (DTC). The findings were published in Annals of Oncology on May 13, 2023. Most patients with DTC receive successful treatment. But a small group develops cancer that recurs or spreads to other parts of the body, making it hard to treat with traditional methods like ...

BOSTON – New research from Boston Medical Center found that providing pragmatic support, specifically rapid access to antiretroviral therapy, pharmacotherapy for opioid use disorder, and strengths-based case management, improved treatment outcomes for people with HIV who inject drugs in St. Petersburg, Russia. Published in The Lancet HIV, researchers from the Linking Infectious and Narcology Care – Part II (LINC-II) trial highlight that the odds of achieving viral load suppression at 12 months are 3 times higher for participants randomized to the intervention group. Russia ...

A study led by researchers at the UCLA Jonsson Comprehensive Cancer Center sheds new light on why tumors that have spread to the brain from other parts of the body respond to immunotherapy while glioblastoma, an aggressive cancer that originates in the brain, does not. In people with tumors that originated in other parts of the body but spread to the brain, treatment with a type of immunotherapy called immune checkpoint blockade appears to elicit a significant increase in both active and exhausted T cells — signs that the T cells have been triggered to fight the cancer. The ...

Red blood cells exposed to oxygen deficiency protect against myocardial infarction, according to a new KI study published in the Journal of Clinical Investigation. The study also shows that the protective effect is enhanced by a nitrate-rich vegetable diet. Red blood cells carry oxygen from the lungs to all of the body’s cells and carbon dioxide back to the lungs. A new study, conducted at Karolinska Institutet in collaboration with Karolinska University Hospital, now shows that red blood cells have an intrinsic function of protecting against ...

UMC Utrecht will lead an international consortium that will try to answer a key question that’s in the mind of many pediatricians, infectiologists, pulmonologists and other health professionals: “Why are children that had an RSV infection in early childhood at increased risk of developing asthma later in life?” The project - which will run for five years - is funded by a HORIZON HLTH 2023 grant from the European Commission of € 7 million. Chronic respiratory tract diseases such as asthma and COPD ...

Dozens of European cities could reach net zero carbon emissions over the next 10 years by incorporating nature into their infrastructure, according to a new study. Published recently in the journal, Nature Climate Change, the analysis shows the ways cities can orchestrate a wide range of green solutions like parks, streetscaping and roof gardens to not only capture carbon emissions, but help reduce them. The study was undertaken by researchers from Sweden, the U.S. and China. It recommends the most effective approaches for natural carbon sequestration in 54 cities in the EU. And it shows how blending these steps with other climate ...

COLUMBUS, Ohio – As global ice dams begin to weaken due to warming temperatures, a new study suggests that prior attempts to evaluate the mass of the huge floating ice shelves that line the Antarctic ice sheet may have overestimated their thickness. The research, recently published in the Journal of Glaciology, is the first large-scale study of its kind to compare ice shelf thickness data from ice-penetrating radar measurements to thickness data estimated from contemporary surface elevation measurements. By juxtaposing vast datasets of 20 of the 300 ...

We are constantly exposed to phthalates in our environment through plastic products such as storage containers, medical devices, packages, fabrics, and toys. Specifically, di-isononyl phthalate is inevitably becoming a part of our lives. Unfortunately, the impact of DiNP on the establishment and maintenance of pregnancy is largely unknown. In a new study, researchers used mice to understand how DiNP affects pregnancy. “Although we finally recognize that environmental chemicals impact women's health, most studies have focused on men’s reproductive health and very few studies have looked at how these chemicals affect women,” said Jodi Flaws (EIRH co-leader/MME), ...

A program designed to ensure fairness and that people living in the most disadvantaged U.S. neighborhoods would be offered a scarce, potentially life-saving medication proved feasible in a large health system. The approach can improve equity in receipt of the drug by people disproportionately affected by disease, according to a new analysis published today in JAMA Health Forum by University of Pittsburgh and UPMC scientist-clinicians. However, the study revealed that more work needs to be done in building trust with and improving the ability to contact Black patients to ensure they ultimately receive scarce medications and other health care resources ...

About The Study: The results of this study suggest that a weighted lottery to allocate scarce resources is feasible and may result in more drug allocation to individuals who reside in disadvantaged neighborhoods and who identify as Black; however, Black individuals allocated the drug may be less likely to accept allocation and receive it.  Authors: Erin K. McCreary, Pharm.D., of the University of Pittsburgh School of Medicine, is the corresponding author. To access the embargoed study: Visit ...

About The Study: The findings of this study suggest that telehealth medication abortion services (tele-MAB) facilitates abortion care access for those further from brick-and mortar abortion facilities and, thus, may mitigate the impacts of travel logistics and costs. Additionally, tele-MAB may better meet the needs of those with prior abortion experience, perhaps due to greater familiarity with the abortion process.  Authors: Anna E. Fiastro, M.P.H., M.E.M., Ph.D., of the University of Washington in Seattle, is the corresponding author.  To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamanetworkopen.2023.31900) Editor’s ...

Researchers worldwide are seeking visible indicators of what is going on inside our minds as we think about issues and take decisions. They are searching for the ability to probe the invisible workings of the mind by monitoring subtle signals from the body. New insights from experiments at Tohoku University have revealed a link between eye movements and certain types of decision-making. Kazumichi Matsumiya and Shota Furukawa at the university's Graduate School of Information Sciences reported their findings in the journal Communications Biology. "Our work has revealed that eye movements that are not ...

The Yangtze River Valley (YRV) is one of the most densely populated and economically developed regions in China. Summer precipitation over this region shows considerable intraseasonal variability with a period of 10–90 days, which can induce extreme precipitation events and lead to massive economic losses and human casualties.   The Boreal Summer Intraseasonal Oscillation (BSISO) is the intraseasonal variability active in the tropical Indian Ocean and western Pacific region. Over the last three decades, scientists have studied the influence of the BSISO, because it is an essential predictability source in extended-range forecasts.   A new study published in Atmospheric ...

Metal organic frameworks (MOFs) could deliver a major efficiency boost to the photocatalytic production of clean hydrogen. Chemical engineers have drafted a comprehensive overview of the state of their field and a plan for where it needs to focus.   Clean hydrogen production remains an energy-intensive and therefore costly proposition, inhibiting the battle against global warming. Metal organic frameworks—in effect tiny molecular ‘sponges’—look set to radically improve the efficiency of photocatalytic production of hydrogen due to their unique structural ...

The National Institutes of Health has provided $3.5 million for a large-scale clinical trial testing a radical new approach to managing type 2 diabetes that, in an earlier study, put almost 70% of participants in remission without weight loss or medication. The approach was developed by UVA Health’s Daniel J. Cox, PhD. It is built on the notion that educating people about how to make wise dietary and exercise choices can allow them to control their blood sugar and possibly even alter the course of the disease. “Instead of focusing on reducing weight with diets ...

A breakthrough in satellite observations has allowed scientists to obtain high spatial resolution ozone profiles, enhancing our understanding of ozone distribution and its impact on the atmosphere. The research, conducted by the research team led by Cheng Liu and Fei Zhao at the University of Science and Technology of China, utilized data from the Environmental Trace Gases Monitoring Instrument (EMI) on the Gaofen-5 satellite, the first Chinese ultraviolet-visible hyperspectral spectrometer. Ozone plays a crucial role in the atmosphere, and understanding its vertical distribution is key to comprehending its horizontal and vertical transport, as well as its physical and chemical ...

A long-lived monocarpic species of bamboo, Phyllostachys nigra var. henonis, only flowers once every 120 years before it dies. The upcoming flowering event for this species does not bode well for its continued long-term survival, as most flowers are not producing viable seeds. Flowering for some plants is a yearly occurrence, for others, it is a once-in-a-lifetime event. A widespread species of bamboo in Japan, Phyllostachys nigra var. henonis, takes this one-time flowering event and pushes it to the extreme: they flower once every 120 years before dying to make way for the next ...

Since its inception in 2009 with 13 founding institutions, the National Academy of Inventors (NAI) has grown to more than 4,600 individual members worldwide from more than 300 U.S. and international colleges and universities, government agencies and non-profit research institutes. That growth continued recently when the Texas Tech University Health Sciences Center (TTUHSC) added its name to the NAI membership roster. Lance R. McMahon, Ph.D., TTUHSC senior vice president for research and innovation, said the university’s new NAI membership and the appointment of several faculty members as senior members ...

80% of all patient data is unstructured. Notes from a conversation with a GP, the evaluation of a specialist in a university medical centre or even a recommendation from a pharmacist. While this 'unstructured’ data is no problem for the human eye, it presents an unsurmountable challenge to an AI-algorithm. One that is "preventing AI from reaching its full potential," in the view of Amsterdam UMC, Assistant Professor Iacer Calixto. To give AI the helping hand that it needs, Calixto is set to lead a project that will "tackle the important challenges ...

Fusion is the process of combining two light atomic nuclei to form a single heavier one while releasing massive amounts of energy. The Sun and all stars are powered through fusion, which makes it the universe's preferred method of producing energy. Recent breakthroughs in fusion research have led to the US government's Bold Vision for Commercial Fusion Energy and the remarkable growth of the global fusion industry. To accelerate the development of fusion-powered reactors on Earth, the US Department ...

‘Let us remember the lessons of the coronavirus to usher in a new era on a global scale with different personal and collective behaviour so that everyone, not just a few, enjoys the dignified life that is their due. We have to remember that we cannot go back to “pre-COVID”. We have to keep in mind that the circumstances before the pandemic most likely contributed in some way to the situation as have had to live it. A radical change of course is indispensable and urgent…” ~Federico Mayor Zaragoza, Former Director-General of UNESCO and Former Member of the European Parliament. Where did COVID-19 originate? Prof Angus Dalgleish ...

AUGUSTA, Ga. (Sept. 1, 2023) – A nationwide assessment of Obstetrics and Gynecology residency programs reveals the need for more training in how to provide the best care for women going through menopause, according to investigators at the Medical College of Georgia. “When you look at projections over the next few decades, by 2060, there will be around 90 million women in the US alone, who will be in the post-menopausal range,” says  Jennifer Allen, MD, associate professor and director of the Obstetrics and Gynecology Residency Program ...

Disadvantaged teenagers are at greater risk of email scams and need better protection, according to an international study published in the peer-reviewed British Journal of Educational Studies.    Findings based on more than 170,000 students aged 15 show that one in five from low-income families or deprived areas could fall victim to phishing. This is much higher than the probability for the age group overall. Email scams leave people vulnerable to identity theft, putting young people at risk of financial fraud and having their savings stripped.     The most vulnerable are those who also have poor learning skills according to the data from 38 countries including ...

Aqueous rechargeable zinc ion batteries are promising in electric grid storage due to their low cost and intrinsic safety. However, their practical implementation is hindered by poor reversibility of the zinc anode, primarily caused by the chaotic Zn deposition present as dendrite and side reactions. Recently, a research group led by Prof. YANG Weishen and Dr. ZHU Kaiyue from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS) has proposed a strategy of "ion ...

Simple strategies to strengthen your bones, implemented by the whole community not just those at higher risk, could lead to a substantial decrease in hip fractures, a new Australian study suggests. A hip fracture, particularly in the elderly, dramatically increases the risk of death. Around 37 per cent of men and 20 per cent of women die within one year of a hip fracture. It also causes significant pain and suffering, loss of mobility and independence, and increased healthcare costs. Distinguished Professor Tuan Nguyen, ...