Philadelphia, March 25, 2021 - Anabolic androgenic steroids (AAS), a synthetic version of the male sex hormone testosterone, are sometimes used as a medical treatment for hormone imbalance. But the vast majority of AAS is used to enhance athletic performance or build muscle because when paired with strength training. AAS use increases muscle mass and strength, and its use is known to have many side effects, ranging from acne to heart problems to increased aggression. A new study now suggests that AAS can also have deleterious effects on the brain, causing it to age prematurely. The report appears in Biological Psychiatry: Cognitive Neuroscience and ...

WEST LAFAYETTE, Ind. - A Purdue University innovator has developed a new approach to creating popular thin films used for devices across a broad range of fields, including optics, acoustics and electronics. Epitaxial lithium niobate (LNO) thin films are an attractive material for electronics and other devices. These films offer flexibility and other properties that are important to manufacturers. The challenge is that these devices demand high-quality thin films that can be difficult to grow and produce. Haiyan Wang, a Purdue materials engineer, developed a new approach to creating these films. The work is published in Advanced Photonics Research. "We created an approach ...

PLYMOUTH MEETING, PA [March 25, 2021] -- New recommendations to advance racial equity, ways to mitigate the impacts of the COVID-19 pandemic on cancer care, and ongoing strategies for preventing and controlling HPV-associated cancers led the conversation at the National Comprehensive Cancer Network® (NCCN®) 2021 Virtual Annual Conference March 18-20. More than 1,300 attendees from across the United States and more than 40 countries met online to learn about updates to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) and new research in the field. Sessions explored supportive care and ways to help survivors return to work, updates on best ...

For the first time, scientists have succeeded in continuous monitoring of a subglacial discharge plume, providing a deeper understanding of the glacier-fjord environment. As marine-terminating glaciers melt, the fresh water from the glacier interacts with the seawater to form subglacial discharge plumes, or convective water flows. These turbulent plumes are known to accelerate the melting and breakup (calving) of glaciers, drive fjord-scale circulation and mixing, and create foraging hotspots for birds. Currently, the scientific understanding of the dynamics of subglacial plumes based on direct measurements is limited to isolated instances. A team of scientists consisting of Hokkaido University's Assistant Professor Evgeny A. Podolskiy and Professor Shin Sugiyama, and the ...

URBANA, Ill. - Pumpkin growers dread the tiny tan scabs that form on their fruit, each lesion a telltale sign of bacterial spot disease. The specks don't just mar the fruit's flesh, they provide entry points for rot-inducing fungus and other pathogens that can destroy pumpkins and other cucurbits from the inside out. Either way, farmers pay the price, with marketable yields reduced by as much as 90%. Despite the disease's severity, scientists don't know much about the genetics of the pathogen that causes it; nearly all the molecular information required for accurate diagnostic testing and targeted treatments is lacking for the disease. In a new study, University of Illinois scientists, with the help of two undergraduate students, have assembled the first complete ...

Cambridge, MA - Astronomers have now obtained a new view of the supermassive black hole at the center of galaxy M87. Images released today by the Event Horizon Telescope (EHT) collaboration reveal how the black hole, some 55 million light-years away, appears in polarized light. The image marks the first time astronomers have captured and mapped polarization, a sign of magnetic fields, so close to the edge of a black hole. Scientists still don't understand how magnetic fields -- areas where magnetism affects how matter moves -- influence black hole activity. Do they help direct matter into the hungry mouths of black holes? Can ...

When clinical trials were conducted to determine the immunogenicity -- the ability to elicit an immune response -- for the first two vaccines marshaled against SARS-CoV-2the virus that causes COVID-19, one group was not among those included: people who have received solid organ transplants and others (such as those with autoimmune disorders) who are immunocompromised. Now, Johns Hopkins Medicine researchers have tried to rectify that inequity, taking one of the first looks at how people who are immunocompromised respond to their first dose of one of the two mRNA vaccines -- Moderna and Pfizer-BioNTech -- currently being administered worldwide. Their findings, as published March 15, 2021, in a research letter in the END ...

DANVILLE, Pa. - A survey of Geisinger employees conducted over two weeks in December 2020 found a steady increase in intent among healthcare workers to receive the COVID-19 vaccine. On Dec. 4, 2020, an announcement about anticipated vaccine availability was emailed to all 23,784 Geisinger employees. Recipients were asked to indicate their intention to receive a vaccine when one was available to them and the reasons for any hesitation they might have. More than two-thirds of employees responded to the survey. Of those who completed the survey before Dec. 10, when an independent FDA advisory committee ...

News coverage of expert scientific evidence on vaccine safety is effective at increasing public acceptance of vaccines, but the positive effect is diminished when the expert message is juxtaposed with a personal narrative about real side effects, new research has found. The study, by researchers affiliated with the Annenberg Public Policy Center (APPC) of the University of Pennsylvania and the University of Illinois, tested the effects of messages about vaccination in televised news reports. These included video clips of Dr. Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases, talking about evidence supporting the value and safety of the MMR (measles, mumps and rubella) vaccine, and a mother who's refusing to vaccinate ...

Scientists make pivotal discovery of method for wireless modulation of neurons with X-rays that could improve the lives of patients with brain disorders. The X-ray source only requires a machine like that found in a dentist's office. Many people worldwide suffer from movement-related brain disorders. Epilepsy accounts for more than 50 million; essential tremor, 40 million; and Parkinson's disease, 10 million. Relief for some brain disorder sufferers may one day be on the way in the form of a new treatment invented by researchers from the U.S. Department of Energy's (DOE) Argonne National Laboratory and ...

Researchers Mario Guarracino the HSE Laboratory of Algorithms and Technologies for Networks Analysis in Nizhny Novgorod and Julius ?ilinskas and Algirdas Lančinskas from Vilnius University, have proposed a new method of testing for COVID-19. This group method allows results to be obtained 13 times faster as compared to individual testing of each sample. The research paper was published in the journal Scientific Reports. The COVID-19 pandemic has already affected millions of people from over 200 countries. The rapid virus expansion demonstrated how fast such infections can spread in today's globalized world. At the beginning of the pandemic, when little was known about the virus and vaccines had not yet ...

WASHINGTON--Residents of South Asia already periodically experience heat waves at the current level of warming. But a new study projecting the amount of heat stress residents of the region will experience in the future finds with 2 degrees Celsius of warming, the population's exposure to heat stress will nearly triple. Limiting warming to 1.5 degrees Celsius will likely reduce that impact by half, but deadly heat stress will become commonplace across South Asia, according to the new study in Geophysical Research Letters, AGU's journal publishing high-impact, short-format reports with immediate implications spanning all Earth and space sciences. With ...

An old technique flexes its muscles Sarcomeres are small repeating subunits of myofibrils, the long cylinders that bundle together to make the muscle fibres. Inside the sarcomeres, filaments of the proteins myosin and actin interact to generate muscle contraction and relaxation. So far, traditional experimental approaches to investigate the structure and function of muscle tissue were performed on reconstructed protein complexes or suffered from low resolution. "Electron cryo-tomography, instead, allows us to obtain detailed and artefact-free 3D images of the frozen muscle", says Raunser. Cryo-ET was for a long time an established yet niche methodology. But recent technical advances in electron cryo-microscopy (cryo-EM) as well as the new development of ...

In the heart of black cherry's native range, including a part of the Allegheny Hardwoods that bills itself as the "Black Cherry Capital of the World," the tree's regeneration, growth and survival have all been declining for more than a decade. In a new analysis, a team of USDA Forest Service and University of Missouri scientists identify likely factors behind the tree's decline and, more significantly, conclude that black cherry may be the tip of the iceberg in terms of change in eastern deciduous forests. Scientists used a combination of synthesis of existing research and new analyses to examine the leading hypotheses for black cherry's regeneration failure. They conclude that the two factors that are ...

Family-centered prevention programs that foster protective caregiving can buffer the negative effects of racial discrimination on young Black people, according to a study published by University of Georgia researchers. Research shows that Black youth exposed to various levels of racial discrimination--including slurs, threats and false accusations--are at a high risk for poor mental health outcomes such as hopelessness, conduct problems, drug use and depression. After participating in family-oriented programs, high school-age adolescents who encountered high levels of racial discrimination and received supportive caregiving evinced fewer increases in conduct problems and depression/anxiety symptoms two years later. "This research shows that ...

The high temperatures and pressures of the Earth's mantle forge carbon-rich minerals known as carbonates into diamond. But less is known about the fate of carbonates that travel even deeper underground -- depths from which no sample has ever been recovered. Now, Michigan State University's Susannah Dorfman and her team are unearthing an answer with lab tools that mimic these extreme conditions. "What we were interested in is, when is carbon not diamond?" added Dorfman. In a paper recently published in Nature Communications, scientists in Dorfman's Experimental ...

Researchers at the Paul Scherrer Institute PSI have studied for the first time how chemical reactions in clouds can influence the global climate. They found that isoprene, the dominant non-methane organic compound emitted into the atmosphere, can strongly contribute to the formation of organic aerosols in clouds. They published their results today in the journal Science Advances. Aerosols, a mixture of solid or liquid particles suspended in the air, play an important role in Earth's climate. Aerosols originate either from natural or human sources. They influence Earth's radiation balance by interacting with sunlight and forming clouds. However, their effect remains the single most significant uncertainty ...

CHICAGO -- Immunotherapy, which recruits the body's own immune system to attack cancer, has given many cancer patients a new avenue to treat the disease. But many cancer immunotherapy treatments can be expensive, have devastating side effects, and only work in a fraction of patients. Researchers at the Pritzker School of Molecular Engineering at the University of Chicago have developed a new therapeutic vaccine that uses a patient's own tumor cells to train their immune system to find and kill cancer. The vaccine, which is injected into the skin just like a traditional vaccine, stopped ...

Addressing uncertainties about where large earthquakes are most likely to occur along the southern San Andreas fault, which splits into multiple strands east of Los Angeles, a new study identifies a strand that has largely flown under the radar of public concern as the region's greatest earthquake threat. The study determines that the Mission Creek strand, which passes through major water and power infrastructure for the greater Los Angeles region, may account for almost the entire slip rate of this portion of the fault, suggesting it may actually be the primary Pacific-North American plate boundary fault at this latitude. The San Andreas fault threatens large future earthquakes, since its southernmost section has not ruptured in almost 300 years ...

A 12-centimetre-thick sample of a deposit from a cave in the northeast of Greenland offers unique insights into the High Arctic's climate more than 500,000 years ago. The geologist and cave scientist Prof. Gina Moseley collected it during an exploratory expedition in 2015 for her palaeoclimatic research in one of the most sensitive areas of the world to climate change. The cave is located at 80° North 35 km from the coast and 60 km from the Greenland Ice Sheet margin. It was part of the Greenland Caves Project, funded by 59 different sponsors including the National Geographic Society. Moseley and her team are interested in the climate and environmental history captured by the unique cave deposit. "Mineral deposits formed ...

A study of 49 patients reveals that toxins from the bacterial pathogen Staphylococcus aureus can destroy the body's blood-clotting platelets, raising the risk of death during bacterial blood infections. Further experiments in mice also showed that the approved drugs ticagrelor and oseltamivir protected platelets and helped treat infections, suggesting these compounds could be repurposed into badly needed therapies for blood infections. Bacterial blood infections have mortality rates as high as 20% to 30% even with supportive care, and these rates have remained high for decades. Blood infections can also cause complications such as sepsis and endocarditis, and the rise of multidrug resistance has only compounded what was already a serious ...

Immunotherapy, which recruits the body's own immune system to attack cancer, has given many cancer patients a new avenue to treat the disease. But many cancer immunotherapy treatments can be expensive, have devastating side effects, and only work in a fraction of patients. Researchers at the Pritzker School of Molecular Engineering at the University of Chicago have developed a new therapeutic vaccine that uses a patient's own tumor cells to train their immune system to find and kill cancer. The vaccine, which is injected into the skin just like a traditional vaccine, stopped melanoma tumor growth in mouse models. It even worked long-term, destroying new tumors long after the therapy was given. The results were published ...

Eating just one cup of leafy green vegetables every day could boost muscle function, according to new Edith Cowan University (ECU) research. The study, published today in the Journal of Nutrition, found that people who consumed a nitrate-rich diet, predominantly from vegetables, had significantly better muscle function of their lower limb. Poor muscle function is linked to greater risk of falls and fractures and is considered a key indicator of general health and wellbeing. Researchers examined data from 3,759 Australians taking part in Melbourne's Baker Heart and Diabetes Institute AusDiab study over a 12-year ...

Sight is by far the sense that we humans use the most when navigating an environment. When those who are blind or visually impaired walk alone, they put themselves at great risk of falling or colliding with obstacles, especially when traversing new places. Unfortunately, the number of visually impaired people throughout the world is likely to increase in the near future because of the rapidly aging population. Thus, there is an urgent need for innovative and cost-effective solutions to help visually impaired people navigate safely. A promising strategy that was first implemented in Japan and then replicated throughout the world is called tactile paving. Inspired by Braille, the reading system of the blind, tactile paving essentially consists of ...

When invaded by a virus, our body cells launch an alert to neighboring cells to increase their antiviral defenses to prevent the infection from spreading. Some viruses, however, manage to bypass this system by mimicking the host's RNA, preventing them from being detected by the infected cell and avoiding this alert. In the case of SARS-CoV-2, this mimicking uses a protein known as nsp14. This protein is also very important for virus multiplication, a task which is facilitated by its binding to the nsp10 protein, resulting in a protein complex. Interfering with nsp14 binding and with the nsp10-nsp14 protein complex is the aim of the most recent ITQB NOVA research in COVID-19, led by researchers Margarida Saramago, Rute Matos and Cecília Arraiano. The researchers ...