What The Study Did: This comparative effectiveness research study that included a high proportion of non-White individuals assesses whether remdesivir administered alone or with corticosteroids is associated with time to clinical improvement or time to death in patients hospitalized with confirmed COVID-19. Authors: Brian T. Garibaldi, M.D,. M.E.H.P., of the Johns Hopkins University School of Medicine in Baltimore, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.3071) Editor's Note: The article includes conflict of interest and funding/support disclosures. ...

What The Study Did: This survey study investigated the frequency and nature of sexist and racial/ethnic microaggressions against female and racial/ethnic-minority surgeons and anesthesiologists and the association with physician burnout. Authors: Neha T. Sudol, M.D., of the Southern California Permanente Medical Group in Irvine, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamasurg.2021.0265) Editor's Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial ...

Female adult sockeye from the Fraser River are dying at significantly higher rates than their male counterparts on the journey back to their spawning grounds, finds new UBC research. For every male salmon that doesn't make it to their natal stream, at least two, sometimes three female salmon die. "This is causing skewed sex ratios in their spawning grounds, something that has been observed in recent years," says lead researcher Dr. Scott Hinch, a professor in the faculty of forestry and head of the Pacific Salmon Ecology and Conservation Laboratory at UBC. "The implications on the health of Fraser River stocks are concerning, particularly as Pacific ...

Three-dimensional or "volumetric" images are widely used in medical imaging. These images faithfully represent the 3D spatial relationships present in the body. Yet 3D images are typically displayed on a two-dimensional monitor, which creates a dimensionality mismatch that must be resolved in a clinical setting where practitioners must search a 2D or a 3D image to find a particular trait or target of interest. To learn more about this problem, Craig K. Abbey, Miguel A. Lago, and Miguel P. Eckstein, of the Department of Psychological and Brain Sciences at University of California Santa Barbara, used techniques from the field of vision science to examine how the observers use information in images to perform a given task. Their research, published in the Journal of ...

Syracuse, N.Y. - As opioid use disorders and overdoses continue to skyrocket in the United States, a study by researchers from Syracuse University and Pennsylvania State University shows that unmarried young adults who do not have children are mostly likely to misuse opioids. The growing number of these "disconnected" young adults may also result in continued rises in substance use disorders and overdoses, the researchers say. The study, "Opioid misuse and family structure: Changes and continuities in the role of marriage and children over two decades," was published ...

Living tissue can heal itself from many injuries, but giving similar abilities to artificial systems, such as robots, has been extremely challenging. Now, researchers reporting in ACS' Nano Letters have developed small, swimming robots that can magnetically heal themselves on-the-fly after breaking into two or three pieces. The strategy could someday be used to make hardier devices for environmental or industrial clean up, the researchers say. Watch a video of the self-healing swimmers here. Scientists have developed small robots that can "swim" through fluids ...

Today, Cochrane, a global independent network that gathers and summarizes the best evidence from research to help informed health decision-making, publishes an updated systematic review assessing rapid tests for the detection of SARS-CoV-2 infection (COVID-19). The review shows that rapid antigen tests are better at correctly identifying cases of COVID-19 in people with symptoms than in people without symptoms. There are large differences in the accuracy of different brands of test, with very few meeting the World Health Organization (WHO) minimum acceptable performance standards. During the COVID-19 pandemic, swift diagnosis of people who are infected with SARS-CoV-2 is important. Then decisions ...

The more nitrate there is in mothers' drinking water, the smaller the babies they give birth to. But alarmingly, the declining birth weight can also be registered when the women are exposed to nitrate levels below the EU's threshold of 50 milligrams of nitrate per litre. This is shown by a register-based study of more than 850,000 births in Denmark carried out in a Danish-American partnership led by Professor Torben Sigsgaard from the Department of Public Health at Aarhus University and Professor Leslie Stayner and Dr. Vanessa Coffman from the Division of Epidemiology and Biostatistics at the University of Illinois at Chicago, School of Public Health. On the ...

March 24, 2021 - For premature infants who can't breastfeed on their own, "mother's own milk" (MOM) is by far the best nutrition. There's an urgent need for effective ways to increase the relatively low rates of MOM feeding for preterm infants born to Black and Hispanic mothers. But so far, research has offered little or no specific guidance, concludes an evidence-based review in Advances in Neonatal Care, official journal of the National Association of Neonatal Nurses. The journal is published in the Lippincott portfolio by Wolters Kluwer. Until studies of targeted, culturally appropriate interventions are performed, available evidence points to some promising approaches to overcoming obstacles and facilitating ...

COLUMBIA, Mo. - Nearly 2,000 active landfills are spread across the U.S., with the majority of garbage discarded by homes and businesses finding its way to a landfill. The resulting chemicals and toxins that build up at these sites can then leach into soil and groundwater, and this "leachate" can present serious hazards to the environment and to the people who live nearby. To help environmental agencies battle the toxic threats posed by landfills, researchers at the University of Missouri -- in partnership with the USDA Forest Service -- have developed a system ...

HOUSTON - (Mar 24, 2021) -The mammalian center for learning and memory, hippocampus, has a remarkable capacity to generate new neurons throughout life. Newborn neurons are produced by neural stem cells (NSCs) and they are crucial for forming neural circuits required for learning and memory, and mood control. During aging, the number of NSCs declines, leading to decreased neurogenesis and age-associated cognitive decline, anxiety, and depression. Thus, identifying the core molecular machinery responsible for NSC preservation is of fundamental importance if we are to use neurogenesis to halt or reverse hippocampal age-related pathology. While there are increasing number of tools available to study NSCs and neurogenesis in mouse models, one of the major ...

Sickle cell disease is the most prevalent inherited blood disorder in the world, affecting 70,000 to 100,000 Americans. However, it is considered an orphan disease, meaning it impacts less than 200,000 people nationally, and is therefore underrepresented in therapeutic research. A team led by Abhishek Jain from the Department of Biomedical Engineering at Texas A&M University is working to address this disease. "I'm trying to create these new types of disease models that can impact health care, with the long-term goal of emphasizing on applying these tools ...

> CATONSVILLE, MD, March 24, 2021 - COVID-19 has been shown to spread on airplanes by infected passengers, so minimizing the risk of secondary infections aboard aircraft may save lives. New research in the INFORMS journal Service Science uses two models to help solve the airplane seating assignment problem (ASAP). The models can lower the transmission risk of COVID-19 more so than the strategy of blocking the middle seats, given the same number of passengers. "Blocking the middle seat on an airplane may provide limited benefit in reducing the risk of transmission of COVID-19. Rather, other health protocols are better supported at preventing the transmission ...

SARS-CoV-2, the virus responsible for the COVID-19 pandemic, arrived one year ago and turned our lives upside-down. While worldwide vaccination programs are currently ongoing, we do not yet know for how long the vaccine will provide immune protection against infection, and if the currently approved vaccines can provide protection against the emerging virus variants. In addition, it appears that vaccines cannot prevent illness for people who have already been infected. In contrast to vaccines, there are currently no effective drugs that act against the virus SARS-CoV-2. New research by Associate Professor Jasmin Mecinovic and co-workers from the Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, now presents a compound that might provide a basis for the ...

Decarbonizing the economy and achieving the transition from fossil fuels to renewable energies is one of the most urgent global challenges of the 21st century. Hydrogen can play a key role in this process as a promising climate-neutral energy vehicle. Yet, the so-called green hydrogen economy requires that hydrogen production be based exclusively on renewable energy. In addition, it should ideally not use expensive and rare metal catalysts, whose production has severe environmental consequences. To address this challenge, ITQB NOVA researchers Inês Cardoso Pereira and Mónica Martins are working on an innovative technology to produce hydrogen from light using non-photosynthetic microorganisms. Hydrogen offers exciting new possibilities as an energy vehicle, ...

The Event Horizon Telescope (EHT) collaboration, a multinational team of over 300 scientists including two astrophysicists from the University of the Witwatersrand (Wits University), has revealed today a new view of the massive object at the centre of the M87 galaxy: how it looks in polarised light. This is the first time astronomers have been able to measure polarisation, a signature of magnetic fields, this close to the edge of a black hole. The observations are key to explaining how the M87 galaxy, located 55 million light-years away, is able to launch energetic jets from its core. "We are now seeing the next crucial piece of evidence to understand how magnetic fields behave around black holes, and how activity in this very compact region of space can drive powerful ...

The Event Horizon Telescope (EHT) collaboration, who produced the first ever image of a black hole, has today revealed a new view of the massive object at the centre of the Messier 87 (M87) galaxy: how it looks in polarised light. This is the first time astronomers have been able to measure polarisation, a signature of magnetic fields, this close to the edge of a black hole. The observations are key to explaining how the M87 galaxy, located 55 million light-years away, is able to launch energetic jets from its core. "We are now seeing the next crucial piece of evidence to understand ...

A new study from the University of Bergen (UiB) shows that the way young people view their bodies have a great impact on their BMI. In a two-year follow up study among 1225 Norwegian adolescents in their early teens, professor Eivind Meland and his team examined how body mass index, self-esteem and self-rated health were mutually impacted and influenced by body dissatisfaction. "We revealed that positive self-image and self-esteem protected against weight gain", professor emeritus Meland says. The girls had in general lower body confidence than boys, the study shows. Body dissatisfaction The eager to be thinner, dieting, and wanting to change something with the body all impaired self-rated health ...

A new study shows that when people replace their old couch with a new one that has no added flame retardants, levels of the harmful chemicals in household dust drop significantly. Replacing the foam inside the couch cushions is also just as effective. The findings confirm that choosing healthier furniture without flame retardants can make a big difference in people's--especially children's--everyday exposures to these toxic chemicals. "We've long suspected that couches are a major source of toxic chemicals in dust. Now, for the first time, we have evidence demonstrating the positive impacts of replacing old furniture containing flame retardants," ...

What is the world made of? This question, which goes back millennia, was revisited by theoretical physicist Steven Weinberg from the University of Texas in Austin, TX, USA in the first of an international seminar series, 'All Things EFT'. Weinberg's seminar has now been published as an article in the journal EPJ H. And Weinberg is well placed to discuss both Effective Field Theories (EFTs) and the nature of the Universe, as he shared the 1979 Nobel Prize for Physics for developing a theory to unify the weak and electromagnetic interactions between elementary particles. This fed into the development of the ...

Ruptures of the carotid artery (cervical artery dissection) are the most common cause of stroke in people under 50 years of age, with an annual incidence of 2-3 cases per 100,000 persons. Salicylic-acid preparations (acetylsalicylic acid: aspirin, Aspegic) and blood-thinning medication (anticoagulants) are used for treatment. The multicenter therapy study "Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection (TREAT-CAD, NCT02046460)" investigated whether dissections - tears in the wall of vessels supplying blood to the brain - can be treated with aspirin or whether more complex blood thinning (anticoagulation) ...

Copepods are tiny crustaceans about the size of a grain of rice, but they are one of the most important parts of the Earth's aquatic ecosystems. Their behavior and interaction with the environment, however, remains a relative mystery. Now, a recent paper published in the Journal of Experimental Biology sheds new light on how these miniature marvels move and cluster in the ocean. Researchers from Bigelow Laboratory of Ocean Sciences and the Georgia Institute of Technology found that the copepods gather around small vortexes in the ocean, a finding which could have significant implications for the food web. "We're getting at a mechanism that helps us understand how the ecosystem ...

Chemists from RUDN University found out that fluorine and fluoroalkyl groups increase the efficiency of catalysts in metathesis reactions that are used in the pharmaceutical industry and polymer chemistry. The team also identified fluorine-containing compounds that can simplify the purification of the catalyst from the reaction product, making it reusable. The results of the study were published in the Russian Chemical Reviews journal. Many medicinal drugs and polymers are based on olefins, organic compounds with a double bond between carbon atoms. To obtain useful substances from them, scientists used the metathesis reaction. In the course of metathesis, ...

New research from the University of Kent and Leeds Beckett University has found that feelings of shame and stigmatisation at the idea of contracting Covid-19 are linked to lower compliance of social distancing and the likelihood of reporting infection to authorities and potential contacts in Italy, South Korea and the USA. In contrast, the study found that individuals who trust their Government's response to the Covid-19 pandemic and feel a mutual solidarity are more likely to report Covid-19 contraction to authorities and acquaintances. In Italy and South Korea, individuals are also more likely to follow social distancing regulations if they trust their Government's response to the pandemic, while in the USA, trust does not lead to social distancing compliance. This could ...

The invisibility of dads who lose access to their children because of concerns about child neglect or their ability to provide safe care comes under the spotlight in new research. A research partnership between the University of East Anglia and Lancaster University provides new evidence ('Up Against It': Understanding Fathers' Repeat Appearance in Local Authority Care Proceedings) about fathers' involvement in care and recurrent care proceedings in England. A national conference today (Wednesday 24th March), co-hosted online by the two universities, will share key insights from this study, funded by the Nuffield ...