Their study has shown that these malignant melanoma vesicles produced by CSCs have a different molecular composition from that of differentiated tumour cells. These molecules were also found to be detectable in exosomes present in the blood, and they presented differences in patients with malignant melanoma compared to healthy individuals. This makes them potentially suitable as biomarkers for the diagnosis and prognosis of this disease. The results have been published in the prestigious scientific journal Molecular Oncology. Malignant melanoma is one of the most aggressive types of skin cancer and its prevalence has been increasing worldwide in recent years. Among the factors that contribute to the life-threatening nature and ...

Dr. Rosario González-Férez, a researcher at the Department of Atomic, Molecular and Nuclear Physics and the "Carlos I" Institute of Theoretical and Computational Physics of the University of Granada, has published the article "Ultralong-Range Rydberg Bi-molecules" in the prestigious scientific journal Physical Review Letters. The results of the study show a new type of bi-molecule formed from two nitric oxide (NO) molecules, both in their ground state and in the Rydberg electronic state. The work was made possible thanks to the scientific collaboration between the researcher and the Institute for Theoretical Atomic, Molecular ...

The novel label-free assay uses unconventional L and inverse-L shaped pillars of deterministic lateral displacement (DLD) microfluidic technology to quantify and profile immune states of white blood cells (WBCs) by assessing biophysical properties of size, deformation, distribution, and cell count The assay requires only 20 microlitres (μl) of unprocessed blood and takes just 15 minutes - much faster than existing methods which require up to 15 millilitres (ml) of blood and take at least a few hours to produce results This new technology measures and profiles the often volatile host immune response, resulting in a more accurate assessment of patient pathophysiology Current methods for early diagnosis of infection focus on ...

For almost a century, physicists have been intrigued by the fundamental question: why are complex numbers so important in quantum mechanics, that is, numbers containing a component with the imaginary number i? Usually, it was assumed that they are only a mathematical trick to facilitate the description of phenomena, and only results expressed in real numbers have a physical meaning. However, a Polish-Chinese-Canadian team of researchers has proved that the imaginary part of quantum mechanics can be observed in action in the real world. We need to significantly reconstruct our naive ...

Researchers at Lund University in Sweden have investigated how the X and Y chromosomes evolve and adapt to each other within a population. The results show that breaking up coevolved sets of sex chromosomes could lead to lower survival rates among the offspring - something that could be of importance in species conservation, for example. The study is published in the journal PNAS. The results provide new clues on how species are formed, and suggest it could be harmful to bring together individuals from different populations that have been separated for a long time. The reason is that the offspring have lower survival rates. "This is something worth keeping in mind in conservation biology, where you want to see a population ...

By clearing forests, burning grasslands, plowing fields and harvesting crops, humans apply strong selective pressures on the plants that survive on the landscapes we use. Plants that evolved traits for long-distance seed-dispersal, including rapid annual growth, a lack of toxins and large seed generations, were more likely to survive on these dynamic anthropogenic landscapes. In the current article, researchers argue that these traits may have evolved as adaptations for megafaunal mutualisms, later allowing those plants to prosper among increasingly sedentary human populations. The new study hypothesizes that the presence of specific anthropophilic traits explains why a select few plant families came to dominate the crop and weed ...

The claim that old-growth forests play a significant role in climate mitigation, based upon the argument that even the oldest forests keep sucking CO2 out of the atmosphere, is being refuted by researchers at the University of Copenhagen. The researchers document that this argument is based upon incorrectly analysed data and that the climate mitigation effect of old and unmanaged forests has been greatly overestimated. Nevertheless, they reassert the importance of old-growth forest for biodiversity. Old and unmanaged forest has become the subject of much debate in ...

One big challenge for the production of synthetic cells is that they must be able to divide to have offspring. In the journal Angewandte Chemie, a team from Heidelberg has now introduced a reproducible division mechanism for synthetic vesicles. It is based on osmosis and can be controlled by an enzymatic reaction or light. Organisms cannot simply emerge from inanimate material ("abiogenesis"), cells always come from pre-existing cells. The prospect of synthetic cells newly built from the ground up is shifting this paradigm. However, one obstacle on this path is the question of controlled division--a requirement for having "progeny". A team from the Max Planck Institute for Medical Research in Heidelberg, Heidelberg ...

The team of researchers at Kaunas University of Technology (KTU), Lithuania applied artificial intelligence (AI) methods to evaluate data of human embryo development. The AI-based system photographs the embryos every five minutes, processes the data of their development and notifies any anomalies observed. This increases the likelihood of choosing the most viable and healthy early-stage embryo for IVF procedures. The innovation was developed in collaboration with Esco Medical Technologies, a manufacturer of medical equipment. Almost one in six couples face infertility; about 48.5 million couples, 186 million individuals worldwide are inflicted. Europe has one of the lowest birth rates in the world, with an average of just 1.55 children per woman. The most effective form of ...

By offering a microscopic "tightrope" to cells, Virginia Tech and Johns Hopkins University researchers have brought new insights to the way migrating cells interact in the body. The researchers changed their testing environment for observing cell-cell interaction to more closely mirror the body, resulting in new observations of cells interacting like cars on a highway -- pairing up, speeding up, and passing one another. Understanding the ways migrating cells react to one another is essential to predicting how cells change and evolve and how they react in applications, such as wound healing and drug delivery. In a study published in the Proceedings of the National Academy of Sciences, a team formed by Mechanical Engineering Associate ...

Scientists of Tomsk Polytechnic University jointly with colleagues from different countries have developed a new sensor with two layers of nanopores. In the conducted experiments, this sensor showed its efficiency as a sensor for one of the doping substances from chiral molecules. The research findings are published in Biosensors and Bioelectronics (IF: 10,257; Q1) academic journal. The material is a thick wafer with pores of 20-30 nm in diameter. The scientists grew a layer of metal-organic frameworks (MOF) from Zn ions and organic molecules on these thick wafers. The MOF has about 3 nm nanopores only. It plays the role of a trap for molecules, which must be detected. "This sensor can operate with chiral molecules. Such substances consisting of chiral molecules are a lot among medical ...

In the future, photovoltaic cells could be "worn" over clothes, placed on cars or even on beach umbrellas. These are just some of the possible developments from a study published in Nature Communications by researchers at the Physics Department of the Politecnico di Milano, working with colleagues at the University of Erlangen-Nuremberg and Imperial College London. The research includes among its authors the Institute of Photonics and Nanotechnology (IFN-CNR) researcher Franco V. A. Camargo and Professor Giulio Cerullo. It focused on photovoltaic cells made using flexible organic technology. Today's most popular photovoltaic cells, based on silicone technology, are rigid and ...

The Miscanthus genus of grasses, commonly used to add movement and texture to gardens, could quickly become the first choice for biofuel production. A new study shows these grasses can be grown in lower agricultural grade conditions - such as marginal land - due to their remarkable resilience and photosynthetic capacity at low temperatures. Miscanthus is a promising biofuel thanks to its high biomass yield and low input requirements, which means it can adapt to a wide range of climate zones and land types. It is seen as a viable commercial option for farmers but yields ...

Energy models are used to explore different options for the development of energy systems in virtual "laboratories". Scientists have been using energy models to provide policy advice for years. As a new study shows, energy models influence policymaking around the energy transition. Similarly, policymakers influence the work of modellers. Greater transparency is needed to ensure that political considerations do not set the agenda for future research or determine its findings, the researchers demand. Renewable energies bring many changes, including fluctuations in the energy supply and a more geographically distributed generation system. ...

A collaborative research project by team of undergraduate students from the University of Exeter's Natural Sciences department has been published in a prestigious academic journal. Lewis Howell, Eleanor Osborne and Alice Franklin have had their second-year research published in The Journal of Physical Chemistry B. Their paper, Pattern Recognition of Chemical Waves: Finding the Activation Energy of the Autocatalytic Step in the Belousov-Zhabotinsky Reaction, was a result of their extended experiment work in the Stage 2 module "Frontiers in Science 2". Their project involved the Belousov-Zhabotinsky chemical reaction - an ...

March 7, 2021, KAUST, Saudi Arabia - KAUST Assistant Professor of Computer Science Mohamed Elhoseiny has developed, in collaboration with Stanford University, CA, and École Polytechnique (LIX), France, a large-scale dataset to train AI to reproduce human emotions when presented with artwork. The resulting paper, "ArtEmis: Affective Language for Visual Art," will be presented at the Conference on Computer Vision and Pattern Recognition (CVPR), the premier annual computer science conference, which will be held June 19-25, 2021. Described as the "Affective Language for Visual Art," ArtEmis's user interface has seven emotional descriptions on average for each image, bringing the total count to over 439K emotional-explained attributions from humans on ...

While urban agriculture can play a role in supporting food supply chains for many major American cities -- contributing to food diversity, sustainability and localizing food systems -- it is unrealistic to expect rooftop gardens, community plots and the like to provide the majority of nutrition for the population of a metropolis. That's the conclusion of a team of researchers who analyzed the nutritional needs of the population of Chicago and calculated how much food could be produced in the city by maximizing urban agriculture, and how much crop land would be needed adjacent to the city to grow the rest. The study was the first to evaluate land required to meet ...

Scientists have shown that SARS-CoV-2, the virus that causes COVID-19, can infect specific cells in the salivary gland in the mouth. The study by researchers from the Wellcome Sanger Institute, National Institutes of Health and the University of North Carolina at Chapel Hill, and their collaborators within the Human Cell Atlas Oral & Craniofacial Network, also discovered that live cells from the mouth were found in saliva, and that the virus was able to reproduce within these infected cells. The study revealed that salivary gland cells could play a role in transmission ...

Göttingen, March 25, 2021. Testing and vaccination - these are the pillars on which humanity is trying to get a grip on the Coronavirus pandemic. Although it is taking longer than many had expected, it is believed that it is only a matter of time before we are all vaccinated and thus protected. However, time is also working for the virus, which has now mutated several times, with variants B.1.1.7 from the United Kingdom, B.1.351 from South Africa and P.1 from Brazil spreading rapidly. These viruses have mutations in the so-called spike protein, the structure on the surface of the virus that is responsible for attachment to host cells. At the same time, the spike protein is also the major target of the immune response. Antibodies generated in response to SARS-CoV-2 infection or vaccination ...

Supersized alcopops are ready-to-drink flavored alcoholic beverages with high alcohol content that are disproportionately consumed by underage drinkers. There can be up to 5.5 standard alcoholic drinks in a single 24 ounce can, so consuming only one can of supersized alcopop is considered binge drinking, and consuming two cans can cause alcohol poisoning. Still, these products remain under-regulated and are available inexpensively at gas stations and convenience stores, where they are more readily accessible by underage youth. New research led by George Mason University's College of Health and Human Services found that nearly ...

The burial field in Valsgärde outside Uppsala in central Sweden contains more than 90 graves from the Iron Age. "On a light note, we could say that Valsgärde is Scandinavia's answer to Sutton Hoo in England as portrayed in the film The Dig on Netflix," says Birgitta Berglund, professor emeritus of archaeology at the Norwegian University of Science and Technology's NTNU University Museum. Valsgärde is especially known for its spectacular boat graves from the 600s and 700s CE. This timeframe is in the middle of what Norway calls the Merovingian period, the era just before the Viking Age. Two of these spectacular boat graves are at the centre of this story -- or more specifically, the story is really about the down bedding that was found ...

Oncotarget published "Phase 1 study of Z-Endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors" which reported that Z-endoxifen administration was anticipated to bypass these variations, increasing active drug levels, and potentially benefiting patients responding sub-optimally to tamoxifen. Patients with treatment-refractory gynecologic malignancies, desmoid tumors, or hormone receptor-positive solid tumors took oral Z-endoxifen daily with a 3 3 phase 1 dose escalation format over 8 dose levels. Three patients had partial responses and 8 had prolonged stable disease; 44.4% of patients at dose levels 6–8 achieved one of these ...

UPTON, NY — Inspired by the mastery of artificial intelligence (AI) over games like Go and Super Mario, scientists at the National Synchrotron Light Source II (NSLS-II) trained an AI agent – an autonomous computational program that observes and acts – how to conduct research experiments at superhuman levels by using the same approach. The Brookhaven team published their findings in the journal Machine Learning: Science and Technology and implemented the AI agent as part of the research capabilities at NSLS-II. As a U.S. Department of Energy (DOE) Office of Science User Facility located at DOE’s Brookhaven National Laboratory, NSLS-II enables scientific studies by more than 2000 researchers each year, ...

Akito Kawahara was snapping pictures at a scenic outlook in Hawaii when he spotted the moth equivalent of a dodo. An entomologist, Kawahara recognized the squiggly patterns on nearby plants as trails carved by leaf-mining caterpillars and lowered his camera to take a closer look. To his astonishment, he saw a tiny moth most experts assumed was extinct. It belonged to a genus known as Philodoria, a type of moth found only in Hawaii and one that hadn’t been documented in the wild since 1976. “I thought, ‘Oh my God, there’s a Philodoria ...

New research shows that consumers judge 'activist brands' based on how morally competent they are perceived to be when challenging free speech. The report, co-authored by experts at the Business School (formerly Cass), Birkbeck, University of London and the University of Sussex Business School explains that stakeholders draw their conclusions on the biggest brands by measuring three moral skills: sensitivity, vision, and integration. Lacking these traits, a brand raising controversy is judged as transgressing, reproducing and manipulating the boundaries of free speech. Displaying these traits proves the brand is not merely 'woke-washing' ...