A type of cell derived from human stem cells that has been widely used for brain research and drug development may have been leading researchers astray for years, according to a study from scientists at Weill Cornell Medicine and Columbia University Irving Medical Center. The cell, known as an induced Brain Microvascular Endothelial Cell (iBMEC), was first described by other researchers in 2012, and has been used to model the special lining of capillaries in the brain that is called the "blood-brain barrier." Many brain diseases, including brain cancers as well as degenerative ...

Older adults who are classified as having "prediabetes" due to moderately elevated measures of blood sugar usually don't go on to develop full-blown diabetes, according to a study led by researchers at Johns Hopkins Bloomberg School of Public Health. Doctors still consider prediabetes a useful indicator of future diabetes risk in young and middle-aged adults. However, the study, which followed nearly 3,500 older adults, of median age 76, for about six and a half years, suggests that prediabetes is not a useful marker of diabetes risk in people of more advanced age. The results were published February 8 in JAMA ...

Ask anyone from an NFL quarterback scanning the field for open receivers, to an air traffic controller monitoring the positions of planes, to a mom watching her kids run around at the park: We depend on our brain to hold what we see in mind, even as we shift our gaze around and even temporarily look away. This capability of "visual working memory" feels effortless, but a new MIT study shows that the brain works hard to keep up. Whenever a key object shifts across our field of view--either because it moved or our eyes did--the brain immediately transfers a memory of it by re-encoding it among neurons in the opposite brain hemisphere. The finding, published in Neuron by neuroscientists at The Picower Institute for Learning and Memory, explains via experiments in animals how we can keep ...

The snapping claws of male amphipods--tiny, shrimplike crustaceans--are among the fastest and most energetic of any life on Earth. Researchers reporting in the journal Current Biology on February 8 find that the crustaceans can repeatedly close their claws in less than 0.01% of a second, generating high-energy water jets and audible pops. The snapping claws are so fast, they almost defy the laws of physics. "What's really amazing about these amphipods is that they're sitting right on the boundary of what we think is possible in terms of how small something can be and how fast it can move without self-destructing," says senior author Sheila Patek, a Professor of Biology at Duke University. "If they accelerated any faster, their bodies would break." While amphipods are ...

What The Study Did: The National Health Service in Italy provides universal coverage to citizens but because no approved drug was available for COVID-19, patients received potentially effective drugs, participated in clinical trials, accessed compassionate drug use programs or self-medicated. This study evaluated changes in drug demand during the early phase of the COVID-19 outbreak in Italy compared with the period before the outbreak. Authors: Adriana Ammassari, M.D., of the Italian Medicines Agency in Rome, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2020.37060) Editor's ...

Philadelphia, February 8, 2021--Adding to a growing body of research affirming the benefits of fetal surgery for spina bifida, new findings show prenatal repair of the spinal column confers physical gains that extend into childhood. The researchers found that children who had undergone fetal surgery for myelomeningocele, the most severe form of spina bifida, were more likely than those who received postnatal repair to walk independently, go up and down stairs, and perform self-care tasks like using a fork, washing hands and brushing teeth. They also had stronger leg muscles and walked faster than children who had their spina bifida surgery ...

What The Study Did: This observational study compared different measures of prediabetes and the risk of progression to diabetes among adults age 71 to 90. Authors: Mary R. Rooney, Ph.D., M.P.H., of the Johns Hopkins Bloomberg School of Public Health in Baltimore, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamainternmed.2020.8774) Editor's Note: The article includes conflicts of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and ...

What The Study Did: Researchers assessed what percentage of the Virginia population had been exposed to SARS-CoV-2 after the first wave of COVID-19 infections in the U.S. Authors: Eric R. Houpt, M.D., of the University of Virginia in Charlottesville, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2020.35234) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for ...

If temperature varies strongly from day to day, the economy grows less. Through these seemingly small variations climate change may have strong effects on economic growth. This shows data analyzed by researchers from the Potsdam Institute for Climate Impact Research (PIK), Columbia University and the Mercator Research Institute on Global Commons and Climate Change (MCC). In a new study in Nature Climate Change, they juxtapose observed daily temperature changes with economic data from more than 1,500 regions worldwide over 40 years - with startling results. "We ...

Negishi cross-coupling reactions have been widely used to form C-C bonds since the 1970s and are often perceived as the result of two metals (i.e zinc and palladium/nickel) working in synergy. But like all relationships, there is more under the surface than what we first expected. PhD student Craig Day and Dr. Rosie Somerville from the Martin group at ICIQ have delved into the Negishi cross-coupling of aryl esters using nickel catalysis to understand how this reaction works at the molecular level and how to improve it. The results have been published in Nature Catalysis. Compared to palladium, nickel has the advantage of being readily available transition metal, ...

It's clear that rising greenhouse gas emissions are the main driver of global warming. But on a regional level, several other factors are at play. That's especially true in the Arctic - a massive oceanic region around the North Pole which is warming two to three times faster than the rest of the planet. One consequence of the melting of the Arctic ice cap is a reduction in albedo, which is the capacity of surfaces to reflect a certain amount of solar radiation. Earth's bright surfaces like glaciers, snow and clouds have a high reflectivity. As snow and ice decrease, albedo decreases and more radiation is absorbed by the Earth, leading to a rise in ...

What The Study Did: Researchers investigated the association between the use of proton pump inhibitors among children and adolescents in Sweden and the risk of asthma. Authors: Yun-Han Wang, M.Sc., B.Pharm., of the Karolinska Institutet in Stockholm, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamapediatrics.2020.5710) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict ...

What The Article Says: In this essay, the authors describe a 97-year-old patient who learned to titrate condensed chicken soup like a medicine during the COVID-19 pandemic. Authors: Yuenting Diana Kwong, M.D., M.A.S., University of California, San Francisco, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamainternmed.2020.8897) Editor's Note: The article includes conflicts of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, ...

What The Study Did: Salary information from faculty at U.S. medical schools was used to examine the association between the percentage of female clinicians in a medical specialty and the average and median salaries for that specialty. Authors: Terrill Bravender, M.D., M.P.H., of the University of Michigan in Ann Arbor, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamapediatrics.2020.5683) Editor's Note: The article includes conflict of interest disclosures. Please see the article for additional information, including other authors, author ...

Coral reefs are beautiful and diverse ecosystems that power the economies of many coastal communities. They're also facing threats that are driving their decline, including the planet's warming waters. This threat hit extreme levels in 2015, when high temperatures were turning corals white around the globe. Kaneohe Bay in Hawaii was hit hard; nearly half of its corals bleached. Hidden in the aftermath of this extreme event, however, were biochemical clues as to why some corals bleached while others were resistant, information that could help reefs better weather warming waters in the future. These clues have now been uncovered by researchers at Michigan State University and the University of Hawaii at Manoa. "It was kind of horrifying," said coral biologist Crawford Drury, who witnessed ...

Researchers at the University of Massachusetts Amherst have gained new insight into the biological processes of a chytrid fungus responsible for a deadly skin infection devastating frog populations worldwide. Led by cell biologist Lillian Fritz-Laylin, the team describes in a paper published Feb. 8 in Current Biology how the actin networks of Batrachochytrium dendrobatidis (Bd) also serve as an "evolutionary Rosetta Stone," revealing the loss of cytoskeletal complexity in the fungal kingdom. "Fungi and animals seem so different, but they are actually pretty closely related," says Fritz-Laylin, whose lab studies how cells move, which is a central ...

The findings are published in the prestigious journal, Nature Climate Change, and calls on businesses, the financial services industry and regulators to work more closely with climate scientists. Regulators and governments - both domestic and international - are increasingly requiring that businesses assess and disclose their vulnerability to the physical effects of climate change, for example, increased drought, bushfires and sea level rise. "People are making strategically material decisions on a daily basis, and raising debt or capital to finance these, but the decisions may not have properly considered climate risk," said lead author Dr Tanya Fiedler from the University of Sydney Business School. ...

Under increasing global warming, tropical fish are escaping warmer seas by extending their habitat ranges towards more temperate waters. But a new study from the University of Adelaide, published in Nature Climate Change, shows that the ocean acidification predicted under continuing high CO2 emissions may make cooler, temperate waters less welcoming. "Every summer hundreds of tropical fish species extend their range to cooler and temperate regions as the waters of their natural habitat become a little too warm for comfort," says lead author Ericka Coni, PhD student in the University's School of Biological Sciences. "For at least two decades, Australian temperate reefs have been receiving new guests ...

Recycling cans and bottles is a good practice. It helps keep the planet clean. The same is true for recycling within cells in the body. Each cell has a way of cleaning out waste in order to regenerate newer, healthier cells. This "cell recycling" is called autophagy. Targeting and changing this process has been linked to helping control or diminish certain cancers. Now, University of Cincinnati researchers have shown that completely halting this process in a very aggressive form of breast cancer may improve outcomes for patients one day. These results are published in the Feb. 8 print edition of the journal Developmental Cell. "Autophagy is sort of like cell cannibalism," ...

BUFFALO, N.Y. -- In cells, numerous important biochemical functions take place within spherical chambers made from proteins and RNA. These compartments are akin to specialized rooms inside a house, but their architecture is radically different: They don't have walls. Instead, they take the form of liquid droplets that don't have a membrane, forming spontaneously, similar to oil droplets in water. Sometimes, the droplets are found alone. Other times, one droplet can be found nested inside of another. And these varying assemblies can regulate the functions the droplets perform. A study published on Feb. 8 in Nature Communications explores how these ...

Some coronaviruses can add to their genetic pool some genes belonging to the host they infected. In this way, they can blend in and be less detectable to the immune system. This discovery was published in the journal Viruses by an Italian research team from the IIS (Italian Healthcare Institute), ISPRA (Institute for Environmental Protection and Research), IZSLER (Italian health authority and research organization for animal health and food safety of Lombardy and Emilia-Romagna) and the University of Bologna. The outcome of this study demonstrates that coronaviruses encompass a sophisticated evolutionary mechanism ...

Electrons in materials have a property known as 'spin', which is responsible for a variety of properties, the most well-known of which is magnetism. Permanent magnets, like the ones used for refrigerator doors, have all the spins in their electrons aligned in the same direction. Scientists refer to this behaviour as ferromagnetism, and the research field of trying to manipulate spin as spintronics. Down in the quantum world, spins can arrange in more exotic ways, giving rise to frustrated states and entangled magnets. Interestingly, a property similar to spin, known as "the valley," appears in graphene materials. This unique feature has given rise to the field of valleytronics, which aims to exploit the ...

The lung is a complex organ whose main function is to exchange gases. It is the largest organ in the human body and plays a key role in the oxygenation of all the organs. Due to its structure, cellular composition and dynamic microenvironment, is difficult to mimic in vitro. A specialized laboratory of the ARTORG Center for Biomedical Engineering Research, University of Bern, headed by Olivier Guenat has developed a new generation of in-vitro models called organs-on-chip for over 10 years, focusing on modeling the lung and its diseases. After a first successful lung-on-chip system exhibiting essential features of the lung, the Organs-on-Chip (OOC) Technologies laboratory has now developed a purely ...

Researchers have identified a new form of magnetism in so-called magnetic graphene, which could point the way toward understanding superconductivity in this unusual type of material. The researchers, led by the University of Cambridge, were able to control the conductivity and magnetism of iron thiophosphate (FePS3), a two-dimensional material which undergoes a transition from an insulator to a metal when compressed. This class of magnetic materials offers new routes to understanding the physics of new magnetic states and superconductivity. Using new high-pressure techniques, the researchers have shown what happens to magnetic graphene during the transition from insulator to conductor and into ...

A Rochester Institute of Technology researcher has validated a tool measuring adherence to a popular child feeding approach used by pediatricians, nutritionists, social workers and child psychologists to assess parents' feeding practices and prevent feeding problems. The best-practice approach, known as the Satter Division of Responsibility in Feeding, has now been rigorously tested and peer reviewed, resulting in the quantifiable tool sDOR.2-6y. The questionnaire will become a standard parent survey for professionals and researchers working in the early childhood development field, predicts lead researcher ...