Biological organisms (such as elephant trunks, octopus tentacles, and human tongues) show remarkable dexterity and self-adaptation in unstructured environments, relying on the multiple-mode actuations of the skeleton-free muscular hydrostats. In general, muscular hydrostats mainly consist of well-ranged active 3D muscle-fiber arrays bundled by passive connective tissues (Fig. 1A). By selectively actuating the active 3D muscle-fiber arrays, muscular hydrostats can generate elongation, bending, contraction and twisting. Producing such multiple-mode actuation of muscular hydrostats is an interesting but long-lasting challenge in the field of robotics. During past decades, many artificial muscles (such ...

A Pediatric Policy Council state of the art plenary session during the Pediatric Academic Societies (PAS) 2021 Virtual Meeting explored the role of public health research in iterative policymaking to reduce gun violence in America. The toll of gun violence on young people represents one of the most significant public health challenges facing contemporary America. In recent years, firearm-related injury and death has made headlines routinely, including mass shootings at schools, public festivals, and places of worship, while daily occurrences of gun violence affect local communities. Gun ...

Originally formulated in the context of condensed matter physics, the Haldane model is an influential model of a two-dimensional topological insulator. It has also been realized in classical-wave metamaterial analogues of topological insulator, such as photonic crystals, acoustic crystals, and electric LC circuits. Recently, theorists have shown that a modification to the Haldane model exhibits the novel phenomenon of antichiral edge sates, according to E. Colomés and M. Franz, scholars at Department of Physics and Astronomy and Quantum Matter Institute, University of British Columbia. Unlike the chiral edge states associated with the standard Haldane model, antichiral edge states possess the same propagation direction on opposite edges of a sample; the current carried by the edge ...

Researchers at University of California San Diego School of Medicine, with colleagues elsewhere, have used gene therapy to prevent learning and memory loss in a mouse model of Alzheimer's disease (AD), a key step toward eventually testing the approach in humans with the neurodegenerative disease. The findings are published online in advance of the June 11, 2021 issue of Molecular Therapy-Methods & Clinical Development. AD is characterized by the accumulation of clumps of misfolded proteins called amyloid plaques and neurofibrillary tau tangles, both of which impair cell signaling and promote neuronal death. Current AD treatments targeting plaques and tangles address ...

Polarization-sensitive photodetectors, based on anisotropic semiconductors, have exhibited wide advantages in specialized applications, such as astronomy, remote sensing, and polarization-division multiplexing. For the active layer of polarization-sensitive photodetectors, recent researches focus on two-dimensional (2D) organic-inorganic hybrid perovskites, where inorganic slabs and organic spacers are alternatively arranged in parallel layered structures. Compared with inorganic 2D materials, importantly, the solution accessibility of hybrid perovskites makes it possible to obtain their large crystals at low cost, offering exciting opportunities to incorporate crystal out-of-plane anisotropy for polarization-sensitive photodetection. However, limited by ...

During the next 10 years, an estimated half-million individuals in the U.S. with autism spectrum disorder (ASD) are expected to transition from adolescence to adulthood, according to the Centers for Disease Control and Prevention. That means thousands of these young adults will likely fall into a widening and potentially devastating gap in a variety of services--because they're too old for high school, but may not qualify for Medicaid-funded services, social work researchers at Case Western Reserve University predict in a new study. The team of researchers from the Jack, Joseph and Morton Mandel School of Applied Social Sciences interviewed 174 families from Northeast Ohio to examine the use of health, medical and social services for youth with autism--from 16 to 30 years old--and ...

HOUSTON - (May 4, 2021) - Private equity investment in hospitals has grown substantially in the 21st century, and it accelerated in the years leading up the COVID-19 pandemic. Now a new study of short-term acute care hospitals acquired by private equity firms finds they not only have higher markups and profit margins, they're also slower to expand their staffs. In a study published in Health Affairs, a multi-institutional team of investigators led by Dr. Anaeze C. Offodile II, a nonresident scholar in the Center for Health and Biosciences at Rice University's Baker Institute for Public Policy, the Gilbert Omenn Fellow at the National Academy of Medicine and an assistant professor of plastic and reconstructive surgery at The University of Texas MD Anderson Cancer Center, examined ...

ORLANDO, Fla. (May 3, 2021) - Researchers have identified a gene expressed in children with acute myeloid leukemia (AML) that could serve as a new immunotherapy treatment target, according to a new study published today in Blood Advances, a journal of the American Society of Hematology. The study, co-authored by researchers with Nemours Children's Health System, outlines the process and potential path for new immunotherapy drugs that improve survival and reduce treatment-related toxicity in children with AML. Leukemia is the most common cancer in children and teens, and AML accounts for nearly one-fourth of those cases. AML is a fast-growing cancer that typically starts in immature bone marrow cells. "Using ...

Coronavirus (CoVs) infection in animals and humans is not new. The earliest papers in the scientific literature of coronavirus infection date to 1966. However, prior to SARS-CoV, MERS-CoV, and SARS-CoV-2, very little attention had been paid to coronaviruses. Suddenly, coronaviruses changed everything we know about personal and public health, and societal and economic well-being. The change led to rushed analyses to understand the origins of coronaviruses in humans. This rush has led to a thus far fruitless search for intermediate hosts (e.g., civet in SARS-CoV and pangolin in SARS-CoV-2) rather than focusing on the important work, which has always been surveillance of ...

When was the last time you repainted your car? Redesigned your coffee mug collection? Gave your shoes a colorful facelift? You likely answered: never, never, and never. You might consider these arduous tasks not worth the effort. But a new color-shifting "programmable matter" system could change that with a zap of light. MIT researchers have developed a way to rapidly update imagery on object surfaces. The system, dubbed "ChromoUpdate" pairs an ultraviolet (UV) light projector with items coated in light-activated dye. The projected light alters the reflective properties of the dye, creating colorful new images in just a few minutes. The advance could accelerate product development, enabling product designers to churn through ...

Since it was first introduced in 2016, transparent wood has been developed by researchers at KTH Royal Institute of Technology as an innovative structural material for building construction. It lets natural light through and can even store thermal energy. The key to making wood into a transparent composite material is to strip out its lignin, the major light-absorbing component in wood. But the empty pores left behind by the absence of lignin need to be filled with something that restores the wood's strength and allows light to permeate. In earlier versions of the composite, researchers at KTH's Wallenberg Wood Science Centre used fossil-based polymers. Now, the researchers have successfully tested an eco-friendly alternative: limonene acrylate, a monomer made ...

Cancer has been recently shown to be affected by protein clusters, particularly by the aggregation of mutant variants of the tumor suppressor protein p53, which are present in more than half of malignant tumors. However, how the aggregates are formed is not yet fully understood. The understanding of this process is expected to provide new therapeutic tools able to prevent proteins to clump and cancer progression. In Brazil, researchers at the Federal University of Rio de Janeiro have identified a key mechanism behind the mutant p53 aggregation process, linked to cancer pathology, opening new paths for the development of novels ...

BAR HARBOR, MAINE — Our kidneys are charged with the extraordinary task of filtering about 53 gallons of fluid a day, a process that depends on podocytes, tiny, highly specialized cells in the cluster of blood vessels in the kidney where waste is filtered that are highly vulnerable to damage. In research at the MDI Biological Laboratory in Bar Harbor, Maine, a team led by Iain Drummond, Ph.D., director of the Kathryn W. Davis Center for Regenerative Biology and Aging, has identified the signaling mechanisms underlying podocyte formation, or morphogenesis. The discovery opens the door to ...

A team of University of Alberta researchers has discovered a way to use 3-D bioprinting technology to create custom-shaped cartilage for use in surgical procedures. The work aims to make it easier for surgeons to safely restore the features of skin cancer patients living with nasal cartilage defects after surgery. The researchers used a specially designed hydrogel--a material similar to Jell-O--that could be mixed with cells harvested from a patient and then printed in a specific shape captured through 3-D imaging. Over a matter of weeks, the material is cultured in a lab to become functional cartilage. "It takes a lifetime to make cartilage in an individual, while this method takes about four weeks. So you still expect ...

Metallacages prepared via coordination-driven self-assembly have received extensive attention because of their three-dimensional layout and cavity-cored nature. The construction of light-emitting materials employing metallacages as a platform has also gained significant interest due to their good modularity in photophysical properties, which bring emerging applications in fields as diverse as sensing, biomedicine, and catalysis. However, the luminescence efficiency of conventional luminophores significantly decreases in the aggregate state because they encounter unfavorable aggregation-caused quenching (ACQ). Therefore, it was quite a challenge to fabricate light-emitting metallacages with high luminescence efficiency in various physical states. In 2001, Tang's group ...

The most complete picture yet is coming into focus of how antibodies produced in people who effectively fight off SARS-CoV-2 work to neutralize the part of the virus responsible for causing infection. In the journal Science, researchers at The University of Texas at Austin describe the finding, which represents good news for designing the next generation of vaccines to protect against variants of the virus or future emerging coronaviruses. Previous research focused on one group of antibodies that target the most obvious part of the coronavirus's spike protein, called the receptor-binding domain (RBD). Because the RBD is the part of the spike that attaches directly to human cells and enables the virus to infect them, ...

New York, NY (May 4, 2021) - A powerful, long-term study from WCS adds scientific backing for global calls for conserving 30 percent of the world's ocean. The studied no-take marine protected areas (MPAs) increased the growth of fish populations by 42 percent when fishing was unsustainable in surrounding areas, achieving the benefits of stable and high production of fish populations for fishers, while protecting threatened ecosystems. The study recorded fish catches for 24-years across a dozen fish landing sites within two counties in Kenya, which allowed scientists to evaluate the long-term impacts of two different fisheries management methods. While one county ...

Harsh prison sentences for juvenile crimes do not reduce the probability of conviction for violent crimes as an adult, and actually increase the propensity for conviction of drug-related crimes, finds a new study by economists at UC Riverside and the University of Louisiana. Harsh juvenile sentences do reduce the likelihood of conviction for property crimes as an adult. But the increase in drug-related crimes cancels out any benefit harsh sentences might offer, researchers found. "Juvenile incarceration is a double-edged sword which deters future property crimes but makes drug convictions more likely in adulthood. Thus, it's hard to make firm policy recommendations ...

Scientists believe a stomach-specific protein plays a major role in the progression of obesity, according to new research in Scientific Reports. The study co-authored by an Indiana University School of Medicine researcher, could help with development of therapeutics that would help individuals struggling with achieving and maintaining weight loss. Researchers focused on Gastrokine-1 (GKN1) -- a protein produced exclusively and abundantly in the stomach. Previous research has suggested GKN1 is resistant to digestion, allowing it to pass into the intestine and interact with microbes in the gut. In the Scientific Reports study, researchers show that inhibiting GKN1 produced significant differences in weight and levels of body fat in comparison to when the protein was expressed. "While ...

Next-generation gene sequencing (NGS) technologies --in which millions of DNA molecules are simultaneously but individually analyzed-- theoretically provides researchers and clinicians the ability to noninvasively identify mutations in the blood stream. Identifying such mutations enables earlier diagnosis of cancer and can inform treatment decisions. Johns Hopkins Kimmel Cancer Center researchers developed a new technology to overcome the inefficiencies and high error rates common among next-generation sequencing techniques that have previously limited their clinical application. To correct for these sequencing errors, the research team from the Ludwig Center and Lustgarten Laboratory at the Johns Hopkins ...

ROCHESTER, Minn. -- A pair of Mayo Clinic studies shed light on something that is typically difficult to see with the eye: respiratory aerosols. Such aerosol particles of varying sizes are a common component of breath, and they are a typical mode of transmission for respiratory viruses like COVID-19 to spread to other people and surfaces. Researchers who conduct exercise stress tests for heart patients at Mayo Clinic found that exercising at increasing levels of exertion increased the aerosol concentration in the surrounding room. Then also found that a high-efficiency particulate air (HEPA) device effectively filtered out the aerosols and decreased the time needed to ...

Reston, VA--For patients with brain metastases, amino acid positron emission tomography (PET) can provide valuable information about the effectiveness of state-of-the-art treatments. When treatment monitoring with contrast-enhanced magnetic resonance imaging (MRI) is unclear, adding 18F-FET PET can help to accurately diagnose recurring brain metastases and reliably assess patient response. This research was published in The Journal of Nuclear Medicine. Newer treatment options for patients with brain metastases--such as immune checkpoint inhibitors and targeted therapies--are effective, but can cause a variety of side effects. ...

The human immune system doesn't just protect our health, it reflects it. Each encounter with a potential disease-causing agent causes the body to produce specific immune agents -- proteins known as antibodies and T-cell receptors -- tailor-made to recognize and destroy the invader. Tasked with preventing re-infection, antibodies and T-cell receptors (TCR) from your previous encounters circulate throughout the body indefinitely, like a record of your personal medical history that you carry inside of you. Clinical pathologist Ramy Arnaout, MD, DPhil, ...

WASHINGTON, DC -- A new case report, detailed in Annals of Emergency Medicine, is the first known case of a patient with VITT (vaccine-induced thrombotic thrombocytopenia) treated with a heparin alternative following the Centers for Disease Control and Prevention (CDC) guidance. An otherwise healthy female patient in her 40s came to the emergency department at UCHealth University of Colorado Hospital twelve days after receiving the Johnson & Johnson vaccine with a headache, dizziness, and vision changes. The patient was treated on April 13, 2021, the same day that the Centers for Disease Control and Prevention (CDC) announced a pause in the administration of the Johnson & Johnson vaccine. CDC guidance recommended ...

You know that raw overwhelm people have been reporting after months of a pandemic, compounded by economic issues and social unrest? Does fatigue and compulsive social media scrolling strike a familiar chord? Those brittle feelings offer us a glimpse into what regular life can be like for individuals with sensory processing sensitivity (SPS), a biological trait possessed by roughly a third of the population. In a world of constant information overload and stress, it's a characteristic that can result in a variety of behaviors, from emotional outbursts to withdrawal, overwhelm and procrastination. "Behaviorally, we observe it as being more careful and cautious when approaching new things," said Bianca Acevedo, a researcher ...