Design, synthesis, molecular modeling, and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis Human dihydroorotate dehydrogenase (DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases, such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis (MS). The authors designed and synthesized a series of acrylamide-based novel DHODH inhibitors as potential RA treatment agents. 2-Acrylamidobenzoic acid analog 11 was identified as the lead compound for structure-activity ...

Orchids of the Boreal zone are rare species. Most of the 28,000 species of the Orchid family actually live in the tropics. In the Boreal zone, ground orchids can hardly tolerate competition from other plants -- mainly forbs or grasses. So they are often pushed into ecotones -- border areas between meadows and forests, or between forests and swamps. Furthermore, there has been a decline in wild orchids all over North America and Eurasia, caused in part by human-induced destruction of their habitats, the transformation of ecosystems, and the harvesting of flowers from the wild. In the Novosibirsk region, ...

Pioneering research led by experts from the University of Exeter's Living Systems Institute has provided new insight into formation of the human embryo. The team of researchers discovered an unique regenerative property of cells in the early human embryo. The first tissue to form in the embryo of mammals is the trophectoderm, which goes on to connect with the uterus and make the placenta. Previous research in mice found that trophectoderm is only made once. In the new study, however, the research team found that human early embryos are able to regenerate trophectoderm. They also showed that human embryonic stem cells grown in the laboratory can similarly ...

Every year, our planet encounters dust from comets and asteroids. These interplanetary dust particles pass through our atmosphere and give rise to shooting stars. Some of them reach the ground in the form of micrometeorites. An international program conducted for nearly 20 years by scientists from the CNRS, the Université Paris-Saclay and the National museum of natural history with the support of the French polar institute, has determined that 5,200 tons per year of these micrometeorites reach the ground. The study will be available in the journal Earth & Planetary Science Letters from April 15. Micrometeorites have always fallen on our planet. These interplanetary dust particles from comets or asteroids are particles of a few tenths to hundredths of a millimetre that have passed ...

Scientists have made a pivotal breakthrough in understanding the way in which cells communicate with each other. A team of international researchers, including experts from the University of Exeter's Living Systems Institute, has identified how signalling pathways of Wnt proteins - which orchestrate and control many cell developmental processes - operate on both molecular and cellular levels. Various mechanisms exist for cells to communicate with each other, and many are essential for development. This information exchange between cells is often based on signalling proteins that activate specific intracellular signalling cascades to control cell behaviour at a distance. Wnt proteins are produced by a relatively small group ...

The damaging effects of life under Nazi rule have long been known with many victims having experienced periods of protracted emotional and physical torture, malnutrition and mass exposure to disease. But recent research from the Hebrew University of Jerusalem show that even for those who survived, their health and mortality continued to be directly impacted long after the end of the Holocaust. The study, led by Drs. Iaroslav Youssim and Hagit Hochner from the School of Public Health at the Faculty of Medicine and published in the American Journal of Epidemiology, investigated mortality rates from ...

Short pieces of DNA--jumping genes--can bounce from one place to another in our genomes. When too many DNA fragments move around, cancer, infertility, and other problems can arise. Cold Spring Harbor Laboratory (CSHL) Professor & HHMI Investigator Leemor Joshua-Tor and a research investigator in her lab, Jonathan Ipsaro, study how cells safeguard the genome's integrity and immobilize these restless bits of DNA. They found that one of the jumping genes' most needed resources may also be their greatest vulnerability. The mammalian genome is full of genetic elements that have the potential to move from place to place. One type is an LTR retrotransposon (LTR). In normal cells, these elements don't ...

ITHACA, N.Y. - Research shows people turn to religion in times of fear and uncertainty - and March 2020 was one of those times. To find the impact of religion during the early days of the COVID-19 pandemic in the United States, Landon Schnabel, the Robert and Ann Rosenthal Assistant Professor of Sociology in the College of Arts and Sciences, analyzed responses from 11,537 Americans surveyed March 19-24, 2020, shortly after the World Health Organization declared COVID-19 a global health pandemic. Religion protected mental health of members of several ...

Image inpainting is a computer vision technique in which pixels missing from an image are filled in. It is often used to remove unwanted objects from an image or to recreate missing regions of occluded images. Inpainting is a common tool for predicting missing image data, but it's challenging to synthesize the missing pixels in a realistic and coherent way. Researchers at the University of Tokyo have presented a frequency-based inpainting method that enables the use of both frequency and spatial information to generate missing image portions. Publishing in the Journal of Electronic Imaging (JEI), Hiya Roy et al. detail the technique in " END ...

COLUMBUS, Ohio - It's one thing to decide among two or three snacks available at a friend's house. But what do people do when they're faced with a vending machine offering 36 different options? A new study using eye-tracking technology suggests that the amount of time people spend looking at individual items may actually help them decide. Findings showed that people tended to choose snacks they spent more time looking at, sometimes even over snacks that they rated more highly. "We could do pretty well predicting what people would choose based just ...

CHAMPAIGN, Ill. -- Avian brood parasites lay their eggs in the nests of other bird species, forcing the hosts to do the hard work of raising the unrelated young. A team of scientists wanted to simulate the task of piercing an egg - a tactic that only a minority of host birds use to help grasp and eject the foreign eggs. Their study offers insight into some of the physical challenges the discriminating host birds face. The new findings appear in the Journal of Experimental Biology. Take cowbirds, for example. Their eggs look nothing like the host birds' eggs, "yet most of their hosts do not reject the parasite eggs," said study co-author Mark Hauber, a professor of evolution, ecology and behavior at the ...

Natural disasters have a way of bringing people together to rebuild. Now, researchers reporting in the journal Current Biology on April 8 have found that the same is true for rhesus macaques. The study reports that after a major hurricane hit Puerto Rico, macaques living on Cayo Santiago Island became more tolerant of each other and sought new social connections. The findings are based on careful study of social connections among Cayo Santiago Island's macaques before and after Hurricane Maria, a devastating storm that left more than 3,000 people dead. "The macaques ...

Chest beating by mountain gorillas - rapidly beating their chests with their hands to produce a drumming sound - may convey information about their body size and allow identification of individuals, a study published in Scientific Reports suggests. These findings demonstrate how non-vocal behaviours may contribute to mountain gorilla communication. Although it had previously been suggested that gorillas may beat their chests to convey information, the exact nature of that information was unclear. Edward Wright and colleagues observed and recorded 25 wild, adult male silverback gorillas monitored by the Dian Fossey Gorilla Fund in Volcanoes National Park, Rwanda, between January 2014 and July 2016. Body size was determined from photographs ...

Along the Tian Shan and Alay mountain ranges of Central Asia, sheep and other domestic livestock form the core economy of contemporary life. Although it was here that the movements of their ancient predecessors helped to shape the great trade networks of the Silk Road, domestic animals were thought to have come relatively late to the region. A new study, published today in the journal Nature: Human Behavior, reveals that the roots of animal domestication in Central Asia stretch back at least 8,000 years - making the region one of the oldest continuously inhabited pastoral landscapes in the world. The domestication ...

Ageing and age-related brain disease do not affect women and men in the same way. The adult brain constantly generates new brain cells called neurons from stem cells, a process called neurogenesis. This process is important for learning and cognitive function which declines as the brain ages. Neurogenesis has been extensively studied in animals, but most studies have looked at male animals, raising the question of whether age-related decline in neurogenesis affects both sexes in the same way. To address this, researchers Sally Temple, PhD (sallytemple@neuralsci.org), Kristen Zuloga, PhD (zuloagk@amc.edu) and colleagues at the NY Neural Stem ...

Mutations in the DNA of the cell's energy 'factories' increases the chances of survival for people with bowel cancer, according to a study published today (Thursday) in Nature Metabolism. Scientists funded by Cancer Research UK have found that patients with colorectal cancer, a common form of bowel cancer, had a 57 to 93% decreased risk of death from their cancer, depending on the presence and type of mitochondrial DNA mutations in their tumours. The researchers hope that in the future, doctors could use this information to identify patients with more aggressive forms of bowel ...

What The Study Did: This analysis evaluated in-hospital mortality rates for patients with SARS-CoV-2 infection over time and factors associated with changes were examined Authors: Lyn Finelli, Dr.P.H., M.S., of Merck Research Labs in North Wales, Pennsylvania, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.6556) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions ...

Gorillas usually stand bipedally and rapidly beat their chests with cupped hands in rapid succession. Chest beating is a unique sound because is it not a vocalization, like frogs croaking, but rather it is a form of gestural communication that can be both heard and seen. The emanating drumming sound can be heard over one kilometre away. The presumed function of gorilla chest beats is to attract females and intimidate rival males. Researchers recorded chest beats and used a technique called photogrammetry to non-invasively measured body size of adult male wild mountain gorillas monitored by the Dian Fossey Gorilla Fund in Volcanoes National Park, Rwanda. They found that larger males emitted chest beats with lower peak frequencies than smaller ones. In other words, ...

The U.S. military veteran population is known to have abnormally high rates of suicide, so health officials have been concerned that the COVID-19 pandemic might elevate risk of psychiatric disorders, particularly among those suffering from post-traumatic stress and related disorders. A recent national study of more than 3,000 veterans participating in the National Health and Resilience in Veterans Study did find that 12.8% reported post-traumatic stress disorder (PTSD) symptoms related to COVID-19 and 8% said they had contemplated suicide during the pandemic. However, the same survey, published April 8 in JAMA Network Open, revealed another, startling finding. A full 43.3% ...

What The Study Did: This survey study uses self-reported data from a national study of veterans to assess the association of symptoms of posttraumatic stress disorder with posttraumatic psychological growth (these are positive psychological changes such as an appreciation of life and personal growth) among U.S. veterans during the COVID-19 pandemic. Authors: Robert H. Pietrzak, Ph.D., M.P.H., of the U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder and the VA Connecticut Healthcare System in West Haven, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.4972) Editor's ...

It may be possible in the future to use information technology where electron spin is used to store, process and transfer information in quantum computers. It has long been the goal of scientists to be able to use spin-based quantum information technology at room temperature. A team of researchers from Sweden, Finland and Japan have now constructed a semiconductor component in which information can be efficiently exchanged between electron spin and light at room temperature and above. The new method is described in an article published in Nature Photonics. ...

The millions of people who have chronic sinusitis deal not only with stuffy noses and headaches, they also commonly struggle to focus, and experience depression and other symptoms that implicate the brain's involvement in their illness. New research links sinus inflammation with alterations in brain activity, specifically with the neural networks that modulate cognition, introspection and response to external stimuli. The paper was published today in JAMA Otolaryngology-Head & Neck Surgery. "This is the first study that links chronic sinus inflammation with a neurobiological ...

Expressive language sampling (ELS) is a useful tool for measuring communication development in youth with Down syndrome, a END ...

Cyberbullying already accounts for one in four cases of bullying and, according to the latest UNICEF report issued on the occasion of 'Safer Internet Day', it affects at least two students per class in Spanish schools. In this regard, the Laboratory of Studies on Coexistence and Violence Prevention at the University of Cordoba, under the direction of professors Rosario Ortega-Ruiz and Eva M. Romera, has just published a study examining family communication and its impact on cyber-gossip and the excessive use of social media-two of the main factors with the greatest influence on cyber-bullying. Their results point in the same direction: an atmosphere of trust in the family is an antidote to this type of behaviour, reducing the risk of schoolchildren engaging inproblematic ...

Calibration and validation (CAL/VAL) is a key technology for quantitative application of space-borne remote sensing data. However, the complex space environment can cause many uncertainties and degrade the calibration accuracy. In-flight calibration is always needed. The thermal emission of the Moon is stable over hundreds of years because there is no atmosphere and no significant physical or chemical change on its surface. The deep space view of the Microwave Humidity Sounder onboard NOAA-18 has viewed the Moon many times every year. Under solar illumination, the lunar surface shows stable and periodical variation in microwave brightness temperature (TB). The Moon is a potential calibration source for thermal calibration The ...