Scientists are reporting results of the first frontline clinical trial to use targeted therapy to treat high-risk pediatric Hodgkin lymphoma. The study showed that the addition of brentuximab vedotin achieved excellent outcomes, reduced side effects, and allowed for reduced radiation exposures. The study was the result of work by a multi-site consortium dedicated to pediatric Hodgkin-lymphoma. Collaborating institutions include St. Jude Children's Research Hospital, Stanford University School of Medicine, Dana-Farber Cancer Institute, Massachusetts General Hospital, Maine Children's Cancer Program and OSF Children's Hospital of Illinois. A paper detailing the findings was published today in ...

The Mfd protein repairs bacterial DNA, but can also, to scientists' surprise, promote mutation. Bacterial mutations can lead to antibiotic resistance. Understanding this second "role" of the Mfd protein opens up opportunities for combating antibiotic resistance, and also the resistance of tumours to anti-cancer drugs and therapies. Using a specialized protein, all bacteria are capable of rapidly and effectively repairing damage to their DNA from UV. However, this mutation frequency decline (Mfd) protein plays another role and causes mutations. A team involving ...

In cancer, personalised medicine takes advantage of the unique genetic changes in an individual tumour to find its vulnerabilities and fight it. Many tumours have a higher number of mutations due to a antiviral defence mechanism, the APOBEC system, which can accidentally damage DNA and cause mutations. Researchers at IRB Barcelona led by Dr. Travis Stracker and Dr. Fran Supek have found the HMCES enzyme to be the Achilles heel of some lung tumours, specifically those with a higher number of mutations caused by the APOBEC system. "We have discovered that blocking HMCES is very damaging to cells with an activated ...

Hispanic immigrants of working age -- 20 to 54 years old -- are over 11 times more likely to die of COVID-19 than U.S.-born men and women who are not Hispanic, according to a USC study of California death certificate data from 2020. The study, published Monday in the END ...

QUT researchers have used carbon dots, created from human hair waste sourced from a Brisbane barbershop, to create a kind of "armour" to improve the performance of cutting-edge solar technology. In a study published in the Journal of Materials Chemistry A, the researchers led by Professor Hongxia Wang in collaboration with Associate Professor Prashant Sonar of QUT's Centre for Materials Science showed the carbon nanodots could be used to improve the performance of perovskites solar cells. Perovskites solar cells, a relatively new photovoltaic technology, are seen as the best PV candidate to deliver low-cost, highly efficient solar electricity in coming years. ...

EUGENE, Ore. -- April 8, 2021 -- Researchers exploring the developing central nervous system of fruit flies have identified nonelectrical cells that transition the brain from highly plastic into a less moldable, mature state. The cells, known as astrocytes for their star-like shapes, and associated genes eventually could become therapeutic targets, said University of Oregon postdoctoral researcher Sarah Ackerman, who led the research. "All of the cell types and signaling pathways I looked at are present in humans," Ackerman said. "Two of the genes that I ...

More than a third of the Antarctic's ice shelf area could be at risk of collapsing into the sea if global temperatures reach 4°C above pre-industrial levels, new research has shown. The University of Reading led the most detailed ever study forecasting how vulnerable the vast floating platforms of ice surrounding Antarctica will become to dramatic collapse events caused by melting and runoff, as climate change forces temperatures to rise. It found that 34% of the area of all Antarctic ice shelves - around half a million square kilometres - including 67% of ice shelf area on the Antarctic Peninsula, would be at risk of destabilisation under 4°C of warming. Limiting temperature ...

INDIANAPOLIS--Worldwide, 1 in 4 people will suffer from a depressive episode in their lifetime. While current diagnosis and treatment approaches are largely trial and error, a breakthrough study by Indiana University School of Medicine researchers sheds new light on the biological basis of mood disorders, and offers a promising blood test aimed at a precision medicine approach to treatment. Led by Alexander B. Niculescu, MD, PhD, Professor of Psychiatry at IU School of Medicine, the study was published today in the high impact journal Molecular Psychiatry . The work builds on previous research conducted by Niculescu and his colleagues into blood biomarkers that track suicidality as well as pain, post-traumatic stress ...

The almost 15-million-year-old Nördlinger Ries is an asteroid impact crater filled with lake sediments. Its structure is comparable to the craters currently being explored on Mars. In addition to various other deposits on the rim of the basin, the crater fill is mainly formed by stratified clay deposits. Unexpectedly, a research team led by the University of Göttingen has now discovered a volcanic ash layer in the asteroid crater. In addition, the team was able to show that the ground under the crater is sinking in the long term, which provides important ...

LOUISVILLE, Ky. - When a new drug is being developed, the first question is, "Does it work?" The second question is, "Does it do harm?" No matter how effective a therapy is, if it harms the patient in the process, it has little value. Doctoral student Robert Skolik and Associate Professor Michael Menze, Ph.D., in the Department of Biology at the University of Louisville, have found a way to make cell cultures respond more closely to normal cells, allowing drugs to be screened for toxicity earlier in the research timeline. The vast majority of cells used for biomedical research are derived from cancer tissues stored in biorepositories. They are cheap to maintain, easy to grow and multiply quickly. Specifically, ...

PISCATAWAY, NJ - Adolescents who frequently see billboard or storefront advertisements for recreational cannabis are more likely to use the drug weekly and to have symptoms of a cannabis use disorder, according to a new study in the Journal of Studies on Alcohol and Drugs. Despite use being illegal for those below age 21 even in states that have approved recreational marijuana, "legalization may alter the ways that youth use cannabis," write the study authors, led by Pamela J. Trangenstein, Ph.D., M.P.H., of the University of North Carolina at Chapel Hill. An increasing number of states have legalized or are considering legalizing recreational marijuana, and public concern over the risks of cannabis use has declined in recent ...

A horse's gut microbiome communicates with its host by sending chemical signals to its cells, which has the effect of helping the horse to extend its energy output, finds a new study published in Frontiers in Molecular Biosciences. This exciting discovery paves the way for dietary supplements that could enhance equine athletic performance. "We are one of the first to demonstrate that certain types of equine gut bacteria produce chemical signals that communicate with the mitochondria in the horse's cells that regulate and generate energy," says Eric Barrey, author of this study and the Integrative Biology and Equine Genetics team leader at the National Research Institute for Agriculture, Food and Environment, France. "We believe that metabolites - small molecules created ...

Eliminating racist and anti-LGBTQ policies is essential to improving the health of Black gay, bisexual and other sexual minority men, according to a Rutgers-led research team. The study, published in the American Journal of Preventive Medicine, examined the impact that U.S. state-level structural racism and anti-LGBTQ policies have on the psychological and behavioral health of Black and white sexual minority men. "Our results illuminate the compounding effects of racist and anti-LGBTQ policies and their implementation for Black gay, bisexual, and queer men. To improve mental and physical health and support their human rights, these oppressive policies must be changed," said lead author Devin English, an assistant professor at Rutgers School of Public Health. The researchers ...

WEST LAFAYETTE, Ind. - An invention from Purdue University innovators may provide a new option to use directed energy for biomedical and defense applications. The Purdue invention uses composite based nonlinear transmission lines (NLTLs) for a complete high-power microwave system, eliminating the need for multiple auxiliary systems. The interest in NLTLs has increased in the past few decades because they offer an effective solid-state alternative to conventional vacuum-based, high-power microwave generators that require large and expensive external systems, such as cryogenic electromagnets and high-voltage nanosecond pulse generators. NLTLs have proven ...

Doublespeak, or the use of euphemisms to sway opinion, lets leaders avoid the reputational costs of lying while still bringing people around to their way of thinking, a new study has found. Researchers at the University of Waterloo found that the use of agreeable euphemistic terms biases people's evaluations of actions to be more favourable. For example, replacing a disagreeable term, "torture," with something more innocuous and semantically agreeable, like "enhanced interrogation." "Like the much-studied phenomenon of 'fake news,' manipulative language can serve as a tool for misleading the public, doing so not with falsehoods but rather with the strategic use of euphemistic language," said Alexander Walker, lead author of the study and a PhD candidate in cognitive ...

Single-cell transcriptomic methods allow scientists to study thousands of individual cells from living organisms, one-by-one, and sequence each cell's genetic material. Genes are activated differently in each cell type, giving rise to cell types such as neurons, skin cells and muscle cells. Single-cell transcriptomics allows scientists to identify the genes that are active in each individual cell type, and discover how these genetic differences change cellular identity and function. Careful study of this data can allow new cell types to be discovered, ...

WHAT: Researchers funded by the National Institutes of Health have developed a test to evaluate the expressive language skills of people with Down syndrome, a condition resulting from an extra copy or piece of chromosome 21. Expressive language is the use of words to convey meaning to others. Language delays are common in people with Down syndrome, and the study authors believe their test provides a more effective way to evaluate prospective language interventions, compared to current evaluation methods. The study was conducted by Angela Thurman, Ph.D., of the University of California, Davis, and ...

Cancer doctors may soon have a new tool for treating melanoma and other types of cancer, thanks to work being done by researchers at the University of Colorado Cancer Center. In a paper published in the journal PNAS last month, CU Cancer Center members Mayumi Fujita, MD, PhD, Angelo D'Alessandro, PhD, Morkos Henen, PhD, MS, Beat Vogeli, PhD, Eric Pietras, PhD, James DeGregori, PhD, Carlo Marchetti, PhD, and Charles Dinarello, MD, along with Isak Tengesdal, MS, a graduate student in the Division of Infectious Diseases at the University of Colorado School of Medicine, detail their work on NLRP3, an intracellular complex that has been found to participate in melanoma-mediated inflammation, leading to tumor growth and progression. By ...

ZANZIBAR CITY (April 7, 2021) - A new study revealed that a drastic reduction of deaths of one of Africa's rarest primates, the Zanzibar red colobus (Piliocolobus kirkii), followed the installation of four speedbumps along a stretch of road where the species frequently crossed. Zanzibar red colobus are found only in the Zanzibar archipelago and classified as Endangered by the IUCN Red List. Reliant on Unguja Island's forests for their survival, around half of the species population is found in Jozani-Chwaka Bay National Park. In the study, published ...

Eight months after mild COVID-19, one in ten people still has at least one moderate to severe symptom that is perceived as having a negative impact on their work, social or home life. The most common long-term symptoms are a loss of smell and taste and fatigue. This is according to a study published in the journal JAMA, conducted by researchers at Danderyd Hospital and Karolinska Institutet in Sweden. Since spring 2020, researchers at Danderyd Hospital and Karolinska Institutet have conducted the so-called COMMUNITY study, with the main purpose of examining immunity after COVID-19. In the first phase of the study in spring 2020, blood samples were collected from 2,149 employees at Danderyd Hospital, of whom about 19 percent had antibodies against SARS-CoV-2. Blood samples have since ...

With a lethal, airborne virus spreading fast, hospitals had to change how they treated patients and policies for how caregivers provided that treatment. But for maternity patients and nurses some of those changes had negative outcomes, according to a new University of Washington study. "We found that visitor restrictions and separation policies were harming families and nurses. The effects for patients included loneliness, isolation and mistrust, while nurses described mistrust and low morale," said Molly Altman, lead author of the study and assistant professor in the UW School of Nursing. Importantly, Altman added, both nurses and patients described how COVID "amplified existing ...

LA JOLLA--(April 7, 2021) When cells are stressed, chemical alarms go off, setting in motion a flurry of activity that protects the cell's most important players. During the rush, a protein called Parkin hurries to protect the mitochondria, the power stations that generate energy for the cell. Now Salk researchers have discovered a direct link between a master sensor of cell stress and Parkin itself. The same pathway is also tied to type 2 diabetes and cancer, which could open a new avenue for treating all three diseases. "Our findings represent the earliest step in Parkin's alarm response that anyone's ever found by a long shot. ...

New medicines for people who have diabetes seem to pop up all the time. Drugs that help the body break down carbohydrates, drugs that increase excretion of glucose in the urine, drugs that help muscles respond to insulin and drugs that stimulate the pancreas to produce it -- the list of pharmaceutical options to treat diabetes gets longer and longer. The downside of this wealth of treatment options is that it can be difficult for health care providers to stay on top of the latest research and standards of care. Which medication is best for which patients? And what are the best medicines to prescribe that both lower blood glucose and reduce risk for cardiovascular disease? Johns Hopkins Medicine endocrinologist ...

How many species of birds are there in the world? It depends on whose count you go by. The number could be as low as 10,000 or as high as 18,000. It's tough to standardize lists of species because the concept of a "species" itself is a little bit fuzzy. That matters because conserving biodiversity requires knowing what diversity exists in the first place. So biologists, led by University of Utah doctoral candidate Monte Neate-Clegg of the School of Biological Sciences, set out to compare four main lists of bird species worldwide to find out how the lists differ--and why. They found that although the lists agree on most birds, disagreements in some regions ...

A new analysis of lung epithelial cells from COVID-19 patients reveals how the protective complement branch of the immune system, which usually plays roles in both innate and adaptive immunity, can convert to a harmful system during COVID-19. Blocking excessive complement activity in lung epithelial cells with a combination of existing chemotherapy and antiviral medications - ruxolitinib and remdesivir, respectively - helped normalize the production of complement proteins by infected lung epithelial cells in human cell culture experiments, the researchers found. Thus, the drug duo could serve as a promising strategy to treat damaging inflammation during severe COVID-19, the authors say. Overactivation of complement proteins can contribute to diseases such as acute respiratory distress ...