DURHAM, N.C. - Biomedical engineers at Duke University have demonstrated that human muscle has an innate ability to ward off the damaging effects of chronic inflammation when exercised. The discovery was made possible through the use of lab-grown, engineered human muscle, demonstrating the potential power of the first-of-its-kind platform in such research endeavors. The results appear online on January 22 in the journal Science Advances. "Lots of processes are taking place throughout the human body during exercise, and it is difficult to tease apart which systems and cells are doing what inside an active person," said Nenad Bursac, professor of biomedical engineering at Duke. "Our engineered muscle ...

When tetrapods (four-limbed vertebrates) began to move from water to land roughly 390 million years ago it set in motion the rise of lizards, birds, mammals, and all land animals that exist today, including humans and some aquatic vertebrates such as whales and dolphins. The earliest tetrapods originated from their fish ancestors in the Devonian period and are more than twice as old as the oldest dinosaur fossils. They resembled a cross between a giant salamander and a crocodile and were about 1-2 meters long, had gills, webbed feet and tail fins, and ...

New research suggests the majority of people in the UK are willing to use privacy-encroaching tracking technology and support the introduction of 'immunity passports' to protect themselves and others in the COVID-19 pandemic. The study, published today in the journal PLOS ONE, found more than two thirds of respondents overall would accept some form of smartphone tracking app to help manage social distancing and the relaxation of a full public lockdown. However, its findings are not reflected in the number of people who have downloaded the NHS Test and Trace app, prompting calls for this issue to be addressed. Lead author Professor Stephan Lewandowsky, Chair in Cognitive Psychology at the University of Bristol, said: "Attitudes were surprisingly permissive and this ...

Predictions of future climate change require a clear and nuanced understanding of Earth's past climate. In a study published today in Science Advances, University of Hawai'i (UH) at Mānoa oceanographers fully reconciled climate and carbon cycle trends of the past 50 million years--solving a controversy debated in the scientific literature for decades. Throughout Earth's history, global climate and the global carbon cycle have undergone significant changes, some of which challenge the current understanding of carbon cycle dynamics. Less carbon dioxide in the atmosphere cools Earth and decreases weathering of rocks and minerals on land over long time scales. Less weathering should lead to a shallower calcite compensation depth (CCD), which is the depth in the ocean where ...

Laser beams can be used to change the properties of materials in an extremely precise way. This principle is already widely used in technologies such as rewritable DVDs. However, the underlying processes generally take place at such unimaginably fast speeds and at such a small scale that they have so far eluded direct observation. Researchers at the University of Göttingen and the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen have now managed to film, for the first time, the laser transformation of a crystal structure with nanometre resolution and in slow motion in an electron microscope. The results have been published in the journal Science. The ...

Head and neck cancer is the sixth most common cancer worldwide, and while effective treatments exist, sadly, the cancer often returns. Researchers at the University of Cincinnati have tested a new combination therapy in animal models to see if they could find a way to make an already effective treatment even better. Since they're using a Food and Drug Administration-approved drug to do it, this could help humans sooner than later. These findings are published in the journal END ...

Washington, DC - January 22, 2021 - New research shows that non-steroidal anti-inflammatory drugs (NSAIDs) reduced both antibody and inflammatory responses to SARS-CoV-2 infection in mice. The study appears this week in the Journal of Virology, a publication of the American Society for Microbiology. The research is important because "NSAIDs are arguably the most commonly used anti-inflammatory medications," said principal investigator Craig B. Wilen, Assistant Professor of Laboratory Medicine and Immunology, Yale University School of Medicine. In addition to taking NSAIDs for chronic conditions such as arthritis, people take them "for shorter periods of time during infections, and [during] ...

UPTON, NY - New results from an atmospheric study over the Eastern North Atlantic reveal that tiny aerosol particles that seed the formation of clouds can form out of next to nothingness over the open ocean. This "new particle formation" occurs when sunlight reacts with molecules of trace gases in the marine boundary layer, the atmosphere within about the first kilometer above Earth's surface. The findings, published in the journal Nature Communications, will improve how aerosols and clouds are represented in models that describe Earth's climate so scientists can understand how the particles--and the processes that control them--might ...

Millions of students around the world could benefit if their educators adopted a more flexible and practical approach, say Swansea University experts. After analysing the techniques current being used in higher education, the researchers are calling for a pragmatic and evidence-based approach instead. Professor Phil Newton, director of learning and teaching at of Swansea University Medical School, said: "Higher education is how we train those who carry out important professional roles in our society. There are now more than 200 million students in HE worldwide and this number is likely to double again over the next decade. "Given the size, impact, importance and cost of ...

Researchers at the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) in Argentina have found that, since the 1990s, up to 25% of reported bee species are no longer being reported in global records, despite a large increase in the number of records available. While this does not mean that these species are all extinct, it might indicate that these species have become rare enough that no one is observing them in nature. The findings appear January 22 in the journal One Earth. "With citizen science and the ability to share data, records are going up exponentially, but the number of species reported in these records is going down," says first ...

Although electric vehicles that reduce greenhouse gas emissions attract many drivers, the lack of confidence in charging services deters others. Building a reliable network of charging stations is difficult in part because it's challenging to aggregate data from independent station operators. But now, researchers reporting January 22 in the journal Patterns have developed an AI that can analyze user reviews of these stations, allowing it to accurately identify places where there are insufficient or out-of-service stations. "We're spending billions ...

On January 22 in Current Biology, a team of Harvard-led researchers presented the most complete genome yet assembled of one of the major Rafflesiaceae lineages, Sapria himalayana. The species is found in Southeast Asia and its mottled red and white flower is about the size of a dinner plate. (It's more famous cousin, Rafflesia arnoldii, produces blossoms nearly three feet in diameter, the largest in the world.) The genetic analysis revealed an astonishing degree of gene loss and surprising amounts of gene theft from its ancient and modern hosts. These findings bring unique perspectives into the number and kind of genes it takes to be an endoparasite (an organism that is completely dependent on its host for all nutrients), along ...

What The Study Did: In this observational study, the spread of SARS-CoV-2 infection during a period of lockdown in southwest Germany was particularly low in children ages 1 to 10 years old. Overall, this large SARS-CoV-2 prevalence study in children is instructive for how ad hoc mass testing provides the basis for rational political decision-making in a pandemic setting. Authors: Burkhard Tönshoff, M.D., of the University Children's Hospital in Heidelberg, Germany, and Klaus-Michael Debatin, M.D., of Ulm University Medical Center in Ulm, Germany, are the corresponding authors. To ...

A new international study led by astrophysicist Eric Agol from the University of Washington has measured the densities of the seven planets of the exoplanetary system TRAPPIST-1 with extreme precision, the values obtained indicating very similar compositions for all the planets. This fact makes the system even more remarkable and helps to better understand the nature of these fascinating worlds. This study has just been published in the Planetary Science Journal. The TRAPPIST-1 system is home to the largest number of planets similar in size to our Earth ever found outside our solar system. Discovered in 2016 by a research team led by Michaël Gillon, astrophysicist at the University of Liège, the system offers an insight into the immense ...

ITHACA, NY - Biologists have long wondered how complex organisms contain a variety of dramatically different types of cells with specialized functions, even though all of those cells are genetically identical. New research reveals how proteins, called "pioneer transcription factors," help turn on key genes that give cell types their unique properties and functions. These pioneer factors, it turns out, help unspool tightly wound coils of DNA so that genetic blueprints in genes can be read and proteins that play roles in biological processes can be made. The study in fruit flies, "Pioneer-like Factor GAF Cooperates with PBAP (SWI/SNF) and NURF (ISWI) to Regulate Transcription," was published Dec. 10 in the journal Genes & Development. "We know pretty ...

January 22, 2021 - Patients with substance use disorders (SUDs) being treated for serious medical conditions are more likely to leave the hospital against medical advice (AMA) than those without addiction. A special type of contract with healthcare providers might enable patients to consent in advance to life-saving medical care - even if they later refuse treatment, according to a commentary in the Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine (ASAM). The journal is published in the Lippincott portfolio by Wolters Kluwer. The Substance Use Advance Directive (SUAD) "has the potential to greatly improve the current state of treatment for life-threatening comorbid conditions in SUD patients through ...

Human activities might have shifted the movement of caribou in and near the Arctic National Wildlife Refuge, according to scientists with the University of Cincinnati. Each year caribou take on one of nature's longest land migrations, trekking hundreds of miles across Alaska and Canada to find food and give birth in their preferred calving grounds. A UC study published today in the journal Frontiers in Ecology and Evolution identified a shift in one herd's movements after the 1970s that coincided with changes in herd size and climate, and the construction of new roads and other energy infrastructure. Researchers used isotope analysis of antlers shed by female caribou to track their historical patterns of movement over the landscape. Female caribou are unique among deer for growing ...

COLUMBUS, Ohio - A new study suggests that a lot of people might be going through life with symptoms that resemble concussion - a finding supporting researchers' argument that athletes recovering from a brain injury should be assessed and treated on a highly individualized basis. In the national study, between 11% and 27% of healthy college athletes with no history of a recent concussion reported combinations of symptoms that met criteria for post-concussion syndrome (PCS) as defined by an international classification system. Among the nearly 31,000 student-athletes surveyed, three factors stood out as the most likely to predict ...

Alongside Dennis vanEngelsdorp, associate professor at the University of Maryland (UMD) in Entomology named for the fifth year in a row for his work in honey bee and pollinator health, Yiping Qi, associate professor in Plant Science, represented the College of Agriculture & Natural Resources on the Web of Science 2020 list of Highly Cited Researchers for the first time. This list includes influential scientists based on the impact of their academic publications over the course of the year. In addition to this honor, Qi is already making waves in 2021 with a new high-profile publication in Nature Plants introducing SpRY, a newly engineered variant ...

Researchers at the Paul Scherrer Institute PSI have put forward a detailed plan of how faster and better defined quantum bits - qubits - can be created. The central elements are magnetic atoms from the class of so-called rare-earth metals, which would be selectively implanted into the crystal lattice of a material. Each of these atoms represents one qubit. The researchers have demonstrated how these qubits can be activated, entangled, used as memory bits, and read out. They have now published their design concept and supporting calculations in the journal PRX Quantum. On the way to quantum computers, an initial requirement is to create so-called quantum ...

In June 1991, Mount Pinatubo, a volcanic peak on the Philippine Island of Luzon, literally blew its top. It was the second-most powerful volcanic eruption of the 20th century, ten times stronger than Mount Saint Helens, and its effects were devastating. Lava and ash spewed into the surrounding environment in the Zambales Mountains, pooling in layers up to 600 feet thick in the valleys. Following the eruption, powerful typhoons and monsoon rains triggered landslides and ash flows that continued for many months. Eight hundred people lost their lives, and the lush forests that covered the mountain prior to the eruption were destroyed or severely damaged. In recent years, scientists returned to the region to survey the surviving mammal populations, and in a new paper in the ...

Human papillomavirus (HPV) is the most common sexually transmitted infection, with an estimated 79 million Americans currently infected with the virus, according to the Centers for Disease Control and Prevention. If a high-risk HPV infection does not go away, it can lead to the development of a variety of cancers, including 91% of all cervical cancers, 70% of oropharyngeal cancers and cancers of the vulva, vagina, penis and anus. HPV vaccination can significantly reduce the number of new cancer diagnoses linked to the virus, in addition to preventing a number of other health complications. "Given ...

Patients with acute myeloid leukemia (AML), the most common form of acute leukemia in adults, that has gone into remission following initial chemotherapy remain in remission longer and have improved overall survival when they are given a pill form of the cancer drug azacitidine as a maintenance treatment, according to a randomized, international phase 3 clinical trial for which Weill Cornell Medicine and NewYork-Presbyterian are trial sites. This is the first time a maintenance treatment for AML has shown such a strong benefit for patients, and it is already being adopted as part of standard care. The results, which were published Dec. 24 in the New England Journal of Medicine, led to the U.S. Food and Drug Administration's approval in September 2020 of oral ...

Many college students fully recover from infectious mononucleosis (which is almost always caused by Epstein-Barr virus) within 1-6 weeks, but some go on to develop chronic fatigue syndrome, also called myalgic encephalomyelitis (ME/CFS). A longitudinal study from DePaul University and Northwestern University followed 4,501 college students to examine risk factors that may trigger longer illness. The research appears in the journal Clinical Infectious Diseases and was funded by the National Institute of Allergy and Infectious Diseases. Previous retrospective studies found that risk factors ...

By 2050, most people on Earth will live downstream of tens of thousands of large dams built in the 20th century, many of them already operating at or beyond their design life, according to a UN University analysis. The report, "Ageing water infrastructure: An emerging global risk," by UNU's Canadian-based Institute for Water, Environment and Health, says most of the 58,700 large dams worldwide were constructed between 1930 and 1970 with a design life of 50 to 100 years, adding that at 50 years a large concrete dam "would most probably begin to express signs of aging." Ageing ...