'This effort truly represents a "moonshot" in COVID-19 research' Scientists identify target to treat COVID pneumonia and reduce severity Clinical trials with new experimental drug to begin early in 2021 Goal is to develop treatments that make COVID-19 no worse than a common cold First comparison between immune mechanisms driving COVID-19 pneumonia with other pneumonias CHICAGO --- Bacteria or viruses like influenza that cause pneumonia can spread across large regions of the lung over the course of hours. In the modern intensive care unit, these bacteria or viruses are usually controlled either by antibiotics or by the body's immune system within ...

How are networks of neurons connected to make functional circuits? This has been a long standing question in neuroscience. To answer this fundamental question, researchers from Boston Children's Hospital and Harvard Medical School developed a new way to study these circuits and in the process learn more about the connections between them. "Neural networks are extensive, but the connections between them are really small," says Wei-Chung Allen Lee, PhD, of the F.M. Kirby Neurobiology Center at Boston Children's and Harvard Medical School. "So, we have had to develop techniques to see them in extremely high-resolution over really large areas and volumes." ...

ORLANDO, Jan. 11, 2021 - Data from Arecibo Observatory in Puerto Rico has been used to help detect the first possible hints of low-frequency disturbances in the curvature of space-time. The results were presented today at the 237th meeting of the American Astronomical Society, which was held virtually, and are published in The Astrophysical Journal Letters. Arecibo Observatory is managed by the University of Central Florida for the National Science Foundation under a cooperative agreement. The disturbances are known as gravitational waves, which ripple through space as a result of the movement of incredibly massive objects, such as black holes orbiting one another or the collision of neutron stars. It's important to understand these waves as they provide insight into the history ...

CAMBRIDGE, MA -- When we experience a new event, our brain records a memory of not only what happened, but also the context, including the time and location of the event. A new study from MIT neuroscientists sheds light on how the timing of a memory is encoded in the hippocampus, and suggests that time and space are encoded separately. In a study of mice, the researchers identified a hippocampal circuit that the animals used to store information about the timing of when they should turn left or right in a maze. When this circuit was blocked, the mice were unable to remember which way they were supposed to turn next. However, disrupting the circuit ...

North Carolina State University-led researchers have developed an analytical measurement "framework" which could allow organic solar cell researchers and manufacturers to determine which materials will produce the most stable solar cells prior to manufacture. Organic solar cells have increased in efficiency over the past decades, but researchers and manufacturers still struggle with determining which material combinations work best and why, as well as with achieving stable morphology and operation. "There is still a lot of 'trial and error' guesswork involved in identifying promising materials for these solar cells," says Harald Ade, Goodnight Innovation Distinguished Professor of Physics at NC State and co-corresponding author of the research. ...

Two studies in today's Nature Neuroscience, led by researchers at Boston Children's Hospital, Brigham and Women's Hospital (BWH), and Harvard Medical School (HMS), implicate mosaic mutations arising during embryonic development as a cause of autism spectrum disorder (ASD). The findings open new areas for exploring the genetics of ASD and could eventually inform diagnostic testing. Mosaic mutations affect only a portion of a person's cells. Rather than being inherited, they arise as a "mistake" introduced when a stem cell divides. A mutation in a stem cell will only be passed to the cells that descend from it, producing the mosaic pattern. ...

Reza Shahbazian-Yassar, professor of mechanical and industrial engineering at the University of Illinois Chicago. Shahbazian-Yassar and colleagues facilitated the development of a cutting edge "Swiss Army knife" catalyst made up of 10 different elements - each of which on its own has the ability to reduce the combustion temperature of methane - plus oxygen. This unique catalyst can bring the combustion temperature of methane down by about half - from above 1400 degrees Kelvin down to 600 to 700 degrees Kelvin. Their findings are reported in the journal Nature Catalysis. In previously-published research, ...

Tales of post-apocalyptic landscapes in which few survivors emerge into a new and much different world have long been popular tales woven by screenwriters and authors. While many enjoy these stories, thinking of them as nothing but a guilty pleasure, they may not realize that immersing themselves in fiction has prepared them for the reality of 2020, according to a team of researchers. John Johnson, professor emeritus of psychology at Penn State, recently conducted research with several colleagues revealing that an individual's enjoyment of horror films could have better prepared them for the COVID-19 pandemic as opposed to others who do not enjoy frightening entertainment. Their findings are documented in Personality and Individual Differences. "My latest ...

The first-ever study of the levels of the stress hormone cortisol in the saliva of newborn white-tailed deer fawns yielded thought-provoking results that have Penn State researchers suggesting predation is not the only thing in the wild killing fawns. "We think the hormone offers a way to evaluate factors in the environment that affect fawns, such as disease, but are difficult to evaluate when just looking at a carcass that has been picked over by predators," said researcher Duane Diefenbach, adjunct professor of wildlife ecology. "By then, it's impossible to be certain what ...

University of Wyoming researchers headed a study that shows nonnative birds in Oahu, Hawaii, have taken over the role of seed dispersal networks on the island, with most of the seeds coming from nonnative plants. "Hawaii is one of the most altered ecosystems in the world, and we are lucky enough to examine how these nonnative-dominated communities alter important processes, such as seed dispersal," says Corey Tarwater, an assistant professor in the UW Department of Zoology and Physiology. "What we have found is that not only do nonnative species dominate species ...

Boston, Mass. - As the number of COVID-19 infections continues to rise nationwide, more than 360,000 Americans have already died from the potentially deadly viral infection. But recent reports describe an increase in mortality during the pandemic that cannot be explained by COVID-19 deaths alone. In a new study from the Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology at Beth Israel Deaconess Medical Center (BIDMC), researchers analyzed data from the National Center for Health Statistics to compare the rate of cardiovascular-related deaths before and after the onset of the pandemic in ...

Mindfulness courses can reduce anxiety, depression and stress and increase mental wellbeing within most but not all non-clinical settings, say a team of researchers at the University of Cambridge. They also found that mindfulness may be no better than other practices aimed at improving mental health and wellbeing. Mindfulness is typically defined as 'the awareness that emerges through paying attention on purpose, in the present moment, and nonjudgmentally to the unfolding of experience moment by moment'. It has become increasingly popular in recent years as a way of increasing wellbeing and ...

Deaths from ischemic heart disease and hypertensive diseases in the United States increased during the COVID-19 pandemic over the prior year, while globally, COVID-19 was associated with significant disruptions in cardiovascular disease testing. These findings are from two papers publishing in the Journal of the American College of Cardiology that examined the indirect effects of the pandemic on cardiovascular disease patients and their care. The impact of the COVID-19 pandemic has been substantial, but there are concerns about the indirect impact of the pandemic as well, particularly for heart disease patients. Many reports have suggested that large mortality increases during the pandemic cannot be explained by COVID-19 alone. During the height of stay-at-home orders in the U.S., hospitals ...

HOUSTON - (Jan. 11, 2021) - An atypical two-dimensional sandwich has the tasty part on the outside for scientists and engineers developing multifunctional nanodevices. An atom-thin layer of semiconductor antimony paired with ferroelectric indium selenide would display unique properties depending on the side and polarization by an external electric field. The field could be used to stabilize indium selenide's polarization, a long-sought property that tends to be wrecked by internal fields in materials like perovskites but would be highly useful for solar energy applications. Calculations by Rice materials theorist Boris Yakobson, lead author and researcher Jun-Jie Zhang and graduate student Dongyang Zhu shows switching the material's polarization with an external electric field makes ...

MDC researchers have developed a new approach to CAR T-cell therapy. The team has shown in Nature Communications that the procedure is very effective, especially when it comes to fighting follicular lymphomas and chronic lymphocytic leukemia, the most common type of blood cancer in adults. The body's defense system generally does not recognize cancer cells as dangerous. To correct this sometimes fatal error, researchers are investigating a clever new idea, one that involves taking a handful of immune cells from cancer patients and "upgrading" them in the laboratory so that they recognize certain surface proteins in the malignant cells. The researchers then multiply ...

Stress on an expectant mother could affect her baby's chance of developing disease - perhaps even over the course of the child's life, UC researchers have found. Psychosocial factors creating stress -- such as lack of social support, loneliness, marriage status or bereavement -- may be mutating their child's mitochondrial DNA and could be a precursor to a host of diseases, according to a University of Cincinnati study. "There are a lot of conditions that start in childhood that have ties to mitochondrial dysfunction including asthma, obesity, attention deficit hyperactivity ...

BUFFALO, N.Y. -- University at Buffalo researchers are reporting an advancement of a chemical sensing chip that could lead to handheld devices that detect trace chemicals -- everything from illicit drugs to pollution -- as quickly as a breathalyzer identifies alcohol. The chip, which also may have uses in food safety monitoring, anti-counterfeiting and other fields where trace chemicals are analyzed, is described in a study that appears on the cover of the Dec. 17 edition of the journal Advanced Optical Materials. "There is a great need for portable and cost-effective chemical sensors ...

Pregnant women who exercise more during the first trimester of pregnancy may have a lower risk of developing gestational diabetes, according to a new study led by Samantha Ehrlich, an assistant professor in the Department of Public Health at the University of Tennessee, Knoxville, and adjunct investigator with the Kaiser Permanente Division of Research. The analysis found that lower risk was associated with at least 38 minutes of moderate intensity exercise each day--a bit more than current recommendations of at least 30 minutes a day five days a week. Gestational diabetes refers to diabetes diagnosed for the first time during pregnancy. It can pose serious health problems including pregnancy and delivery complications as well as increased future risk for diabetes ...

The cover for issue 45 of Oncotarget features Figure 3, "Representative images of whole tumor volume segmentation of the co-registered T1 post-contrast sequence and apparent diffusion coefficient (ADC) map, yielding the corresponding ADC histogram distribution utilized for data analysis," recently published in "Diffusion-weighted MR imaging histogram analysis in HIV positive and negative patients with primary central nervous system lymphoma as a predictor of outcome and tumor proliferation" by Khan, et al. This authors reported that the aim of this study is to investigate the correlation between ...

Face-sensitive neurons in humans employ distinct activity patterns to encode individual faces; those patterns reactivate when imagining the face, according to research recently published in JNeurosci. Human social interaction hinges on faces. In fact, faces are so important that the brain contains entire regions in the ventral temporal cortex devoted to facial recognition. In humans, the fusiform facial area activates in response to faces, and monkeys have single neurons that fire when shown a face. However, experimental limitations have prevented us from knowing how the human brain responds to and processes faces at the level of the single neuron. To close this gap, Khuvis et al. measured the electrical activity of neurons in the ventral temporal ...

HOUSTON - (Jan. 11, 2021) - Rice University engineers hope to make life better for those with replacement joints by modeling how artificial hips are likely to rub them the wrong way. The computational study by the Brown School of Engineering lab of mechanical engineer Fred Higgs simulates and tracks how hips evolve, uniquely incorporating fluid dynamics and roughness of the joint surfaces as well as factors clinicians typically use to predict how well implants will stand up over their expected 15-year lifetime. The team's immediate goal is to advance the design of more robust prostheses. Ultimately, they say the model could help clinicians personalize hip joints for patients depending on gender, ...

In most animal species, if a major artery is cut off from the heart, the animal will struggle to survive. The same can be said for many of our critical infrastructure systems, such as electric power, water and communications. They are networked systems with vulnerable connections. This vulnerability was on display in September 2017 when Hurricane Maria wrecked Puerto Rico's electric power grid, leaving almost all of the island's 3.3 million people without electricity. The months-long blackout that followed was the worst in U.S. history. Claire Trevisan, ...

Oncotarget recently published "PD-1/PD-L1 expression in anal squamous intraepithelial lesions" which reported that the presence and distribution of CD8 lymphocytes and the presence of PD-1 lymphocytes and PD-L1 epithelial cells were assessed. CD8 lymphocytes were observed more frequently in HSIL versus LSIL in the lamina propria or intra epithelial. PD-1 lymphocytes were observed more frequently in HSIL versus LSIL. There was no difference between HSIL and LSIL for PD-L1 epithelial cells. Anal dysplastic lesions are accompanied by an inflammatory lymphocytic infiltrate expressing CD8 and PD-1, more frequent in high-grade lesions. Dr. ...

A team led by University of Minnesota Twin Cities researchers has discovered a groundbreaking one-step process for creating materials with unique properties, called metamaterials. Their results show the realistic possibility of designing similar self-assembled structures with the potential of creating "built-to-order" nanostructures for wide application in electronics and optical devices. The research was published and featured on the cover of Nano Letters, a peer-reviewed scientific journal published by the American Chemical Society. In general, metamaterials are materials made in the lab so as to provide specific physical, chemical, electrical, and optical properties otherwise impossible to find in naturally occurring materials. These materials can ...

HOUSTON - (Jan. 11, 2021) - A sweet new process is making sour more practical. Rice University engineers are turning carbon monoxide directly into acetic acid -- the widely used chemical agent that gives vinegar its tang -- with a continuous catalytic reactor that can use renewable electricity efficiently to turn out a highly purified product. The electrochemical process by the labs of chemical and biomolecular engineers Haotian Wang and Thomas Senftle of Rice's Brown School of Engineering resolves issues with previous attempts to reduce carbon monoxide (CO) into acetic acid. Those processes required additional steps to purify ...