WASHINGTON, January 21, 2021 -- Despite cancer being a leading cause of death worldwide, treatment options for many types of cancers remain limited. This is partly due to the in vitro tools used to model cancers, which cannot adequately predict the behavior of a cancer or its sensitivity to drugs. Further, animal models, like mice, biologically differ from humans in ways that play a critical role in immunotherapy, and results from animal studies do not always translate well to human disease. These shortcomings point to a clear need for a better, patient-specific model to improve the understanding of cancer cells and their impacts. Researchers from the University of Wisconsin and the University ...

Medicated drops may help close small macular holes over a two- to eight-week period, allowing some people to avoid surgery to fix the vision problem, a new study suggests. The findings, based on a retrospective multicenter case series published Dec. 15, 2020, in Ophthalmology Retina, could lead to a better understanding of which patients may benefit from the treatment, as well as the timeline of the treatment's effectiveness. "For certain patients, medicated drops may heal their macular hole by decreasing inflammation and increasing fluid absorption in the retina," said ophthalmologist and retinal surgeon Dimitra Skondra, MD, PhD, senior author of the study. Skondra is an associate professor of ophthalmology and visual ...

WASHINGTON, January 21, 2021 -- Cancer is a major, worldwide challenge, and its impact is projected to escalate due to aging and growth of the population. Researchers recognize that new approaches to diagnose and treat deadly cancers, including identifying new drugs to treat cancer, will be essential to curbing the growing impact of the disease. While decades of investment in research have resulted in substantial improvements in surviving cancer, a key challenge remains in identifying new drugs that improve outcomes for cancer patients, particularly for cancers when tumors have spread throughout the body. In APL Bioengineering, by AIP Publishing, researchers suggest a major hurdle to identifying new drugs is the paucity of models -- organisms ...

EUGENE, Ore. -- Jan. 21, 2021 -- Developing economies suffer from a paradox: they don't receive investment flows from developed economies because they lack stability and high-quality financial and lawmaking institutions, but they can't develop those institutions without foreign funds. A study co-authored by Brandon Julio, a professor in the Department of Finance at the University of Oregon's Lundquist College of Business, found that bilateral investment treaties, commonly known as BITs, can help developing economies overcome this paradox, but only as long as those ...

Researchers at Vanderbilt University Medical Center and colleagues have identified genetic factors that increase the risk for developing pneumonia and its severe, life-threatening consequences. Their findings, published recently in the American Journal of Human Genetics, may aid efforts to identify patients with COVID-19 at greatest risk for pneumonia, and enable earlier interventions to prevent severe illness and death. Despite the increasing availability of COVID-19 vaccines, it will take months to inoculate enough people to bring the pandemic under control, experts predict. In the meantime, thousands of Americans are hospitalized and die from COVID-19 each ...

A new study from researchers at MIT uncovers the kinds of infrastructure improvements that would make the biggest difference in increasing the number of electric cars on the road, a key step toward reducing greenhouse gas emissions from transportation. The researchers found that installing charging stations on residential streets, rather than just in central locations such as shopping malls, could have an outsized benefit. They also found that adding on high-speed charging stations along highways and making supplementary vehicles more easily available to people who need to travel beyond the single-charge range of their electric vehicles could greatly increase the vehicle electrification potential. The findings are reported today in the journal Nature Energy, in a paper by MIT associate ...

DAVIS, Calif., January 21, 2020 - A new peer-reviewed study reveals that the vast majority of U.S. infants may be suffering from a substantial deficiency in an important bacterium key to breast milk utilization and immune system development, as well as protection against gut pathogens linked to common newborn conditions such as colic and diaper rash. According to the study published today in END ...

Sex-specific chromosomes are a dangerous place to be, if you're a gene. Because these chromosomes -- Y chromosomes, in humans -- do not have a matching chromosome with which to exchange genetic information, they are prone to losing non-essential genes left and right in a process called genetic decay. Now, a new study from research scientist Daniel Winston Bellott in the lab of Whitehead Institute Member David Page broadens our understanding of what makes a gene able to survive on a sex-specific chromosome by looking at one especially slithery branch of the evolutionary tree: snakes. Comparing surviving genes on snake ...

PHILADELPHIA -- (Jan. 21, 2021) -- Researchers at The Wistar Institute have discovered a new enzymatic function of the Epstein-Barr Virus (EBV) protein EBNA1, a critical factor in EBV's ability to transform human cells and cause cancer. Published in Cell, this study provides new indications for inhibiting EBNA1 function, opening up fresh avenues for development of therapies to treat EBV-associated cancers. EBV establishes life-long, latent infection in B lymphocytes, which can contribute to development of different cancer types, including Burkitt's lymphoma, nasopharyngeal carcinoma (NPC) and Hodgkin's lymphoma. The Epstein-Barr Nuclear Antigen 1 (EBNA1) serves as an attractive therapeutic ...

Two out of five individuals delayed or missed medical care in the early phase of the pandemic--from March through mid-July 2020--according to a new survey from researchers at the Johns Hopkins Bloomberg School of Public Health. The survey of 1,337 U.S. adults found that 544, or 41 percent, delayed or missed medical care during the survey period. Among the 1,055 individuals who reported needing medical care, 29 percent (307 respondents), indicated fear of transmission of COVID-19 as the main reason. Seven percent (75 respondents) reported financial concerns as the main reason for delaying ...

Researchers from the University Hospitals in Zurich and Basel, ETH Zurich, University of Zurich and the pharmaceutical company Roche have set out to improve cancer diagnostics by developing a platform of state-of-the-art molecular biology methods. The "Tumor Profiler" project aims to derive the comprehensive molecular profile of tumours in cancer patients, which has the potential to predict the efficacy of a host of new cancer medications. It will therefore make it possible to offer treating physicians personalised and improved therapy recommendations. Three years ago, the researchers began a large-scale clinical study involving ...

PROVIDENCE, R.I. [Brown University] -- When sheets of two-dimensional nanomaterials like graphene are stacked on top of each other, tiny gaps form between the sheets that have a wide variety of potential uses. In research published in the journal Nature Communications, a team of Brown University researchers has found a way to orient those gaps, called nanochannels, in a way that makes them more useful for filtering water and other liquids of nanoscale contaminants. "In the last decade, a whole field has sprung up to study these spaces that form between 2-D nanomaterials," said Robert Hurt, a professor in Brown's School of Engineering and coauthor of the ...

TROY, N.Y. -- Warnings about misinformation are now regularly posted on Twitter, Facebook, and other social media platforms, but not all of these cautions are created equal. New research from Rensselaer Polytechnic Institute shows that artificial intelligence can help form accurate news assessments -- but only when a news story is first emerging. These findings were recently published in Computers in Human Behavior Reports by an interdisciplinary team of Rensselaer researchers. They found that AI-driven interventions are generally ineffective when used to flag issues with stories on frequently covered ...

Among the materials known as perovskites, one of the most exciting is a material that can convert sunlight to electricity as efficiently as today's commercial silicon solar cells and has the potential for being much cheaper and easier to manufacture. There's just one problem: Of the four possible atomic configurations, or phases, this material can take, three are efficient but unstable at room temperature and in ordinary environments, and they quickly revert to the fourth phase, which is completely useless for solar applications. Now scientists at Stanford ...

Delivering a minor electric shock into a stream to reveal any fish lurking nearby may be the gold standard for detecting fish populations, but it's not much fun for the trout. Scientists at Oregon State University have found that sampling stream water for evidence of the presence of various species using environmental DNA, known as eDNA, can be more accurate than electrofishing, without disrupting the fish. "It's revolutionizing the way we do fish ecology work," said Brooke Penaluna, a research fish biologist with the U.S. Department of Agriculture Forest Service who also has an appointment in OSU's Department ...

If you believe you are capable of becoming the healthy, engaged person you want to be in old age, you are much more likely to experience that outcome, a recent Oregon State University study shows. "How we think about who we're going to be in old age is very predictive of exactly how we will be," said Shelbie Turner, a doctoral student in OSU's College of Public Health and Human Sciences and co-author on the study. Previous studies on aging have found that how people thought about themselves at age 50 predicted a wide range of future health outcomes up to 40 years later -- cardiovascular events, memory, balance, will to live, hospitalizations; even mortality. "Previous ...

BIRMINGHAM, Ala. - A 72-year-old woman was hospitalized with severe COVID-19 disease, 33 days after the onset of symptoms. She was suffering a prolonged deteriorating illness, with severe pneumonia and a high risk of death, and she was unable to mount her own immune defense against the SARS-CoV-2 virus because of chronic lymphocytic leukemia, which compromises normal immunoglobulin production. But when physicians at the University of Alabama at Birmingham recommended a single intravenous infusion of convalescent blood plasma from her son-in-law -- who had recovered from COVID-19 disease ...

Microscopy is the workhorse of contemporary life science research, enabling morphological and chemical inspection of living tissue with ever-increasing spatial and temporal resolution. Even though modern microscopes are genuine marvels of engineering, minute deviations from ideal imaging conditions will still lead to optical aberrations that rapidly degrade imaging quality. A mismatch between the refractive indices of the sample and its immersion medium, deviations in the thickness of sample holders or cover glasses, the effects of aging on the instrument--such deviations ...

Contemporary robots can move quickly. "The motors are fast, and they're powerful," says Sabrina Neuman. Yet in complex situations, like interactions with people, robots often don't move quickly. "The hang up is what's going on in the robot's head," she adds. Perceiving stimuli and calculating a response takes a "boatload of computation," which limits reaction time, says Neuman, who recently graduated with a PhD from the MIT Computer Science and Artificial Intelligence Laboratory (CSAIL). Neuman has found a way to fight this mismatch between a robot's "mind" and body. The method, called robomorphic computing, uses a robot's physical layout and intended applications ...

BOSTON - Regular aspirin use has clear benefits in reducing colorectal cancer incidence among middle-aged adults, but also comes with some risk, such as gastrointestinal bleeding. And when should adults start taking regular aspirin and for how long? There is substantial evidence that a daily aspirin can reduce risk of colorectal cancer in adults up to age 70. But until now there was little evidence about whether older adults should start taking aspirin. A team of scientists set out to study this question. They were led by Andrew T. Chan MD, MPH, a gastroenterologist and chief of the Clinical and Translational Epidemiology Unit at ...

Diamond, like graphite, is a special form of carbon. Its cubic crystal structure and its strong chemical bonds give it its unique hardness. For thousands of years, it has also been sought after as both a tool and as a thing of beauty. Only in the 1950s did it become possible to produce diamonds artificially for the first time. Most natural diamonds form in the Earth's mantle at depths of at least 150 kilometres, where temperatures in excess of 1500 degrees Celsius and enormously high pressures of several gigapascals prevail - more than 10.000 times that of a well-inflated bicycle tyre. There are different theories for the exact mechanisms ...

The liquid electrolytes in flow batteries provide a bridge to help carry electrons into electrodes, and that changes how chemical engineers think about efficiency. The way to boost electron transfer in grid-scale batteries is different than researchers had believed, a new study from the University of Michigan has shown. The findings are a step toward being able to store renewable energy more efficiently. As governments and utilities around the world roll out intermittent renewable energy sources such as wind and solar, we remain reliant on coal, natural gas and nuclear power plants to provide energy when the wind isn't blowing and the sun isn't shining. Grid-scale "flow" batteries are one proposed solution, storing energy for later use. But because they aren't very efficient, ...

New Rochelle, NY, January 20, 2020--SARS-CoV-2, the virus that causes COVID-19, blocks the processes of innate immune activation that normally direct the production and/or signaling of type I interferon (IFN-I) by the infected cell and tissues. IFN-I is a key component of host innate immunity that is responsible for eliminating the virus at the early stage of infection, as summarized in a recent review article in Journal of Interferon & Cytokine Research (JICR). By suppressing innate immunity, the virus replicates and spreads in the body unchecked, leading to the disease known as COVID-19. Click here to read the article now. "SARS-CoV-2 utilizes various approaches to evade host IFN-I response, including suppression of IFN-I ...

Even a modest sea level rise, triggered by increasing global temperatures, would place 100 airports below mean sea level by 2100, a new study has found. Scientists from Newcastle University modelled the risk of disruption to flight routes as a result of increasing flood risk from sea level rise. Publishing the findings in the journal Climate Risk Management, Professor Richard Dawson and Aaron Yesudian of Newcastle University's School of Engineering analysed the location of more than 14,000 airports around the world and their exposure to storm surges for current and future sea level. The researchers also studied airports' pre-COVID-19 connectivity and aircraft traffic, and their current level of flood protection. They ...

A brain pressure disorder that especially affects women, causing severe headaches and sometimes permanent sight loss, has risen six-fold in 15 years, and is linked to obesity and deprivation, a new study by Swansea University researchers has shown. Rates of emergency hospital admissions in Wales for people with the disorder were also five times higher than for those without. The condition is called idiopathic intracranial hypertension (IIH). It causes increased pressure in the fluid surrounding in the brain. This can lead to severely disabling headaches as well as vision loss, which ...