At its annual assembly in Geneva last week, the World Health Organization approved a radical and far-reaching plan to slow the rapid, extensive spread of antibiotic resistance around the world. The plan hopes to curb the rise caused by an unchecked use of antibiotics and lack of new antibiotics on the market. New Tel Aviv University research published in PNAS introduces a promising new tool: a two-pronged system to combat this dangerous situation. It nukes antibiotic resistance in selected bacteria, and renders other bacteria more sensitive to antibiotics. The research, ...

La Jolla, Calif., June 4 -- In a scientific discovery that has significant implications for preventing HIV infections, researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have identified a protein that could improve the body's immune response to HIV vaccines and prevent transmission of the virus. The study shows how a protein called polyglutamine-binding protein 1 (PQBP1) acts as a front-line sensor and is critical to initiating an immune response to HIV. When the PQBP1 encounters the virus, it starts a program that triggers an overall protective ...

ANN ARBOR--African-American women are equally, if not more, likely to experience infertility than their white counterparts, but they often cope with this traumatic issue in silence and isolation, according to a new University of Michigan study. African-American women also more often feel that infertility hinders their sense of self and gender identity. The U-M study may be among the first known to focus exclusively on African-American women and infertility. Most research has been conducted on affluent white couples seeking advanced medical interventions. "Infertile ...

ATLANTA--The ability to delay gratification in chimpanzees is linked to how specific structures of the brain are connected and communicate with each other, according to researchers at Georgia State University and Kennesaw State University. Their findings were published June 3 in the Proceedings of the Royal Society B: Biological Sciences. This study provides the first evidence in primates, including humans, of an association between delay of gratification performance and white matter connectivity between the caudate and the dorsal prefrontal cortex in the right hemisphere, ...

A tougher federal standard for ozone pollution, under consideration to improve public health, would ramp up the importance of scientific measurements and models, according to a new commentary published in the June 5 edition of Science by researchers at NOAA and its cooperative institute at the University of Colorado Boulder. The commentary, led by Owen Cooper of the Cooperative Institute for Research in Environmental Sciences and NOAA's Earth System Research Laboratory, looks at how a new, stricter ozone standard would pose challenges for air quality managers at state ...

Modern mountain climbers typically carry tanks of oxygen to help them reach the summit. It's the combination of physical exertion and lack of oxygen at high altitudes that creates one of the biggest challenges for mountaineers. University of Washington researchers and collaborators have found that the same principle will apply to marine species under global warming. The warmer water temperatures will speed up the animals' metabolic need for oxygen, as also happens during exercise, but the warmer water will hold less of the oxygen needed to fuel their bodies, similar to ...

If you want to live, you need to breathe and muster enough energy to move, find nourishment and reproduce. This basic tenet is just as valid for us human beings as it is for the animals inhabiting our oceans. Unfortunately, most marine animals will find it harder to satisfy these criteria, which are vital to their survival, in the future. That was the key message of a new study recently published in the journal Science, in which American and German biologists defined the first universal principle on the combined effects of ocean warming and oxygen loss on the productivity ...

From a single drop of blood, researchers can now simultaneously test for more than 1,000 different strains of viruses that currently or have previously infected a person. Using a new method known as VirScan, researchers from Brigham and Women's Hospital (BWH) and Harvard Medical School tested for evidence of past viral infections, detecting on average 10 viral species per person. The new work sheds light on the interplay between a person's immunity and the human virome -- the vast array of viruses that can infect humans - with implications both for the clinic and for the ...

PHILADELPHIA - Around-the-clock rhythms guide nearly all physiological processes in animals and plants. Each cell in the body contains special proteins that act on one another in interlocking feedback loops to generate near-24 hour oscillations called circadian rhythms. These dictate behaviors controlled by the brain, such as sleeping and eating, as well as metabolic, hormonal, and other rhythms that are intrinsic to the organs of the body. For example, when you eat may have affects on rhythms controlling fat or sugar metabolism, illustrating how circadian and metabolic ...

This news release is available in Japanese. An analysis using updated global surface temperature data disputes the existence of a 21st century global warming slowdown described in studies including the latest Intergovernmental Panel on Climate Change (IPCC) assessment. The new analysis suggests no discernable decrease in the rate of warming between the second half of the 20th century, a period marked by manmade warming, and the first fifteen years of the 21st century, a period dubbed a global warming "hiatus." Numerous studies have been done to explain the possible ...

This news release is available in Japanese. Many species are migrating toward Earth's poles in response to climate change, and their habitats are shrinking in the process, researchers say. Two new reports focusing on marine organisms, which have been moving pole-ward at higher rates than terrestrial creatures, show how factors, including those not directly related to climate change, are limiting the ranges of corals and fish. Paul Muir and colleagues investigated 104 species of reef corals -- collectively known as the staghorn corals -- and confirmed the hypothesis ...

This news release is available in Japanese. With less than a drop of blood, a new technology called VirScan can identify all of the viruses that individuals have been exposed to over the course of their lives. Researchers used the screening technique with 569 people from around the world and found that, on average, their participants had been exposed to about 10 viral species over their lifetimes. VirScan provides a powerful and inexpensive tool for studying interactions between the human virome -- the collection of viruses known to infect humans, some of which don't ...

This news release is available in Japanese. Some of the world's last isolated tribes are emerging from the Amazon rainforest, forcing scientists and policymakers in South America to reconsider their policies regarding contact with such people. In this special package of news, Science correspondents Andrew Lawler and Heather Pringle report from Peru and Brazil, respectively -- two countries that are dealing with a spate of first encounters. Lawler describes contact between isolated tribespeople emerging from the forest and indigenous Peruvian villagers, who themselves ...

New technology developed by Howard Hughes Medical Institute (HHMI) researchers makes it possible to test for current and past infections with any known human virus by analyzing a single drop of a person's blood. The method, called VirScan, is an efficient alternative to existing diagnostics that test for specific viruses one at a time. With VirScan, scientists can run a single test to determine which viruses have infected an individual, rather than limiting their analysis to particular viruses. That unbiased approach could uncover unexpected factors affecting individual ...

Friction is all around us, working against the motion of tires on pavement, the scrawl of a pen across paper, and even the flow of proteins through the bloodstream. Whenever two surfaces come in contact, there is friction, except in very special cases where friction essentially vanishes -- a phenomenon, known as "superlubricity," in which surfaces simply slide over each other without resistance. Now physicists at MIT have developed an experimental technique to simulate friction at the nanoscale. Using their technique, the researchers are able to directly observe individual ...

A revolutionary power shift from internet giants such as Google to ordinary consumers is critically overdue, according to new research from a University of East Anglia (UEA) online privacy expert. In a manifesto that ranges from "the right to be treated fairly on the internet" to finding a better, more nuanced approach to using the internet as an archive, Dr Paul Bernal of UEA's School of Law delves deeper into his research on the so-called 'right to be forgotten.' His paper, called 'A right to be remembered? Or the internet, warts and all,' will be presented today at ...

The red, itchy rash caused by varicella-zoster - the virus that causes chickenpox - usually disappears within a week or two. But once infection occurs, the varicella-zoster virus, or VZV, remains dormant in the nervous system, awaiting a signal that causes this "sleeper" virus to be re-activated in the form of an extremely unpleasant but common disease: herpes zoster, or shingles. In a study recently published in PLOS Pathogens, scientists at Bar-Ilan University report on a novel experimental model that, for the first time, successfully mimics the "sleeping" and "waking" ...

Washington, DC-Unreliable estrogen measurements have had a negative impact on the treatment of and research into many hormone-related cancers and chronic conditions. To improve patient care, a panel of medical experts has called for accurate, standardized estrogen testing methods in a statement published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). The panel's recommendations are the first to address how improved testing methods can affect clinical care, and were developed based on discussions at an estrogen measurement workshop hosted ...

Women who exercise during pregnancy are less likely to have gestational diabetes, and the exercise also helps to reduce maternal weight gain, finds a study published on 3 June 2015 in BJOG: an International Journal of Obstetrics and Gynaecology. Gestational diabetes is one of the most frequent complications of pregnancy. It is associated with an increased risk of serious disorders such as pre-eclampsia, hypertension, preterm birth, and with induced or caesarean birth. It can have long term effects on the mother including long term impaired glucose tolerance and type ...

CAMBRIDGE, Mass. (June 4, 2015) - Leveraging a novel system designed to examine the double-strand DNA breaks that occur as a consequence of gene amplification during DNA replication, Whitehead Institute scientists are bringing new clarity to the causes of such genomic damage. Moreover, because errors arising during DNA replication and gene amplification result in chromosomal abnormalities often found in malignant cells, these new findings may bolster our understandings of certain drivers of cancer progression. At the core of system, developed in the lab of Whitehead ...

About 10 years ago, Peter Hews stumbled across some bones sticking out of a cliff along the Oldman River in southeastern Alberta, Canada. Now, scientists describe in the Cell Press journal Current Biology on June 4 that those bones belonged to a nearly intact skull of a very unusual horned dinosaur--a close relative of the familiar Triceratops that had been unknown to science until now. "The specimen comes from a geographic region of Alberta where we have not found horned dinosaurs before, so from the onset we knew it was important," says Dr. Caleb Brown of the Royal ...

Infectious diseases kill more people worldwide than any other single cause, but treatment often fails because a small fraction of bacterial cells can transiently survive antibiotics and recolonize the body. A study published June 4 in Molecular Cell reveals that these so-called persisters form in response to adverse conditions through the action of a molecule called Obg, which plays an important role in all major cellular processes in multiple bacterial species. By revealing a shared genetic mechanism underlying bacterial persistence, the study paves the way for novel diagnostic ...

A team of researchers led by the University of Cambridge has described for the first time in humans how the epigenome - the suite of molecules attached to our DNA that switch our genes on and off - is comprehensively erased in early primordial germ cells prior to the generation of egg and sperm. However, the study, published today in the journal Cell, shows some regions of our DNA - including those associated with conditions such as obesity and schizophrenia - resist complete reprogramming. Although our genetic information - the 'code of life' - is written in our DNA, ...

Our social connections and social compass define us to a large degree as human. Indeed, our tendency to act to benefit others without benefit to ourselves is regarded by some as the epitome of human nature and culture. But is it truly a quality unique to humans, or is this apparent virtue common to other species such as rats? "We would not hesitate about helping an older person trying to cross the road", says Dr. Cristina Márquez, who conducted this study with Scott Rennie and Diana Costa from the Behavioural Neuroscience Lab, led by Dr. Marta Moita. "This type of ...

CAMBRIDGE, MA -- The process that allows our brains to learn and generate new memories also leads to degeneration as we age, according to a new study by researchers at MIT. The finding, reported in a paper published today in the journal Cell, could ultimately help researchers develop new approaches to preventing cognitive decline in disorders such as Alzheimer's disease. Each time we learn something new, our brain cells break their DNA, creating damage that the neurons must immediately repair, according to Li-Huei Tsai, the Picower Professor of Neuroscience and director ...