Cleveland: Cleveland Clinic researchers have discovered for the first time that a metabolite of an FDA-approved drug for metastatic prostate cancer, abiraterone (Abi), has more anti-cancer properties than its precursor. The research will be published online June 1st in Nature. Cleveland Clinic researcher Nima Sharifi, M.D., found that abiraterone, a steroid inhibitor, is converted into the more physiologically active D4A (Δ4-abiraterone) in both patients and animal models with prostate cancer who take the drug. Furthermore, they found that D4A is more effective ...

For more than a decade, scientists have had a working map of the human genome, a complete picture of the DNA sequence that encodes human life. But new pages are still being added to that atlas: maps of chemical markers called methyl groups that stud strands of DNA and influence which genes are repressed and when. Now, Salk scientists have constructed the most comprehensive maps yet of these chemical patterns--collectively called the epigenome--in more than a dozen different human organs from individual donors (including a woman, man and child). While the methylation ...

CHAMPAIGN, Ill. -- New compounds that specifically attack fungal infections without attacking human cells could transform treatment for such infections and point the way to targeted medicines that evade antibiotic resistance. Led by University of Illinois chemistry professor Martin D. Burke, a team of chemists, microbiologists and immunologists developed and tested several derivatives of the antifungal drug amphotericin B (pronounced am-foe-TARE-uh-sin B). They published their findings in the journal Nature Chemical Biology. Amphotericin B is doctors' last, best defense ...

WASHINGTON, DC, June 1, 2015 -- Non-heterosexual women who feel a disconnect between who they are attracted to and how they identify themselves may have a higher risk of alcohol abuse, according to a new study led by Amelia E. Talley, an assistant professor in Texas Tech University's Department of Psychological Sciences. The study, titled "Longitudinal Associations among Discordant Sexual Orientation Dimensions and Hazardous Drinking in a Cohort of Sexual Minority Women," appears in the June issue of the Journal of Health and Social Behavior. It delves into the reasons ...

A new study links a commonly used household pesticide with attention deficit hyperactivity disorder (ADHD) in children and young teens. The study found an association between pyrethroid pesticide exposure and ADHD, particularly in terms of hyperactivity and impulsivity, rather than inattentiveness. The association was stronger in boys than in girls. The study, led by researchers at Cincinnati Children's Hospital Medical Center, is published online in the journal Environmental Health. "Given the growing use of pyrethroid pesticides and the perception that they may ...

WASHINGTON, D.C. - In northwestern Greenland, glaciers flow from the main ice sheet to the ocean in see-sawing seasonal patterns. The ice generally flows faster in the summer than in winter, and the ends of glaciers, jutting out into the ocean, also advance and retreat with the seasons. Now, a new analysis shows some important connections between these seasonal patterns, sea ice cover and longer-term trends. Glaciologists hope the findings, accepted for publication in the June issue of the American Geophysical Union's Journal of Geophysical Research-Earth Surface and ...

Washington, DC, June 1, 2015 - Tweets regarding the Ebola outbreak in West Africa last summer reached more than 60 million people in the three days prior to official outbreak announcements, according to a study published in the June issue of the American Journal of Infection Control, the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC). Researchers from the Columbia University School of Nursing in New York analyzed over 42,000 Ebola-related tweets posted to the social networking site Twitter, from July 24 - August ...

In the last 40 years, fructose, a simple carbohydrate derived from fruit and vegetables, has been on the increase in American diets. Because of the addition of high-fructose corn syrup to many soft drinks and processed baked goods, fructose currently accounts for 10 percent of caloric intake for U.S. citizens. Male adolescents are the top fructose consumers, deriving between 15 to 23 percent of their calories from fructose--three to four times more than the maximum levels recommended by the American Heart Association. A recent study at the Beckman Institute for Advanced ...

Biology isn't the only reason women eat less as they near ovulation, a time when they are at their peak fertility. Three new independent studies found that another part of the equation is a woman's desire to maintain her body's attractiveness, says social psychologist and assistant professor Andrea L. Meltzer, Southern Methodist University, Dallas. Women nearing ovulation who also reported an increase in their motivation to manage their body attractiveness reported eating fewer calories out of a desire to lose weight, said Meltzer, lead researcher on the study. When ...

Bethesda, MD (June 1, 2015) -- The antiviral drug telbivudine prevents perinatal transmission of hepatitis B virus (HBV), according to a study1 in the June issue of Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association. "If we are to decrease the global burden of hepatitis B, we need to start by addressing mother-to-infant transmission, which is the primary pathway of HBV infection," said study author Yuming Wang from Institute for Infectious Diseases, Southwest Hospital, Chongqing, China. "We ...

The following research will be presented at the American Physical Society's 2015 Division of Atomic, Molecular and Optical Physics (DAMOP) meeting that will take place June 8-12, 2015 at the Hyatt Regency Columbus and the Greater Columbus Convention Center in Columbus, Ohio. FINDING VENUS AND SEARCHING FOR EXOPLANETS Thursday, June 11, 8:48 AM, Room: Franklin CD Telescopes aren't the only way to detect the presence of Venus passing by. It's also now possible to measure the relative motion of the Earth and Sun so precisely that physicists can use the measurement to ...

Policy makers need to budget more than 288 million pounds over the next 40 years to adequately provide health care to all British soldiers who suffered amputations because of the Afghan war. This is the prediction of Major DS Edwards of the Royal Centre for Defence Medicine in the UK, in a new article appearing in the journal Clinical Orthopaedics and Related Research, published by Springer. He led a study into the scale and long-term economic cost of military amputees following Britain's involvement in Afghanistan between 2003 and 2014. The authors describe the traumatic ...

HOUSTON - (June 1, 2015) - The remains of tiny creatures found deep inside a mountaintop glacier in Peru are clues to the local landscape more than a millennium ago, according to a new study by Rice University, the University of Nebraska-Lincoln and Ohio State University. The unexpected discovery of diatoms, a type of algae, in ice cores pulled from the Quelccaya Summit Dome Glacier demonstrate that freshwater lakes or wetlands that currently exist at high elevations on or near the mountain were also there in earlier times. The abundant organisms would likely have been ...

Researchers from the University of Liverpool have found that approximately half of patients who have an eye removed because of a form of eye cancer experience `phantom eye syndrome.' Patients with the condition experience "seeing" and pain in the eye that is no longer there. Researchers assessed 179 patients whose eye had been removed as a result of a cancer, called intraocular melanoma. They found that more than a third of the patients experienced phantom eye symptoms every day. In most patients, the symptoms ceased spontaneously, but some patients reported that they ...

Understanding the volcanic activity on Earth is not only important in order to limit the impact of natural disasters, volcanic eruptions also have a large impact on the climate and evolution of life on our planet. However, many details in the history of volcanic activity are still unknown. Scientists from the GEOMAR Helmholtz Centre for Ocean Research Kiel, together with colleagues from the USA, Taiwan, Australia and Switzerland, now have been able to track the development of the Galapagos volcanoes in the time frame between eight and 16 million years ago. In the process ...

Insulin degludec (trade name: Tresiba) has been approved since January 2015 for adolescents and children from the age of one year with type 1 or type 2 diabetes mellitus. In an early benefit assessment pursuant to the Act on the Reform of the Market for Medicinal Products (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) has now examined whether this new drug, alone or in combination with other blood-glucose lowering drugs, offers an added benefit over the appropriate comparator therapy. No added benefit of insulin degludec for adolescents ...

The effort to identify new ways of fighting infections has taken a step forward now that scientists have identified a key protein involved in the host's response to strep infections. This protein, called "NFAT," appears to play a key role in the body's inflammatory response to an infection, which when uncontrolled, can be as bad, if not worse, than the infection itself. Furthermore, this discovery was made using streptococcal bacteria, which are responsible for a wide range of human illnesses, ranging from sore throat and pink eye to meningitis and bacterial pneumonia. ...

CAMBRIDGE, Mass--Most of the world's electricity-producing power plants -- whether powered by coal, natural gas, or nuclear fission -- make electricity by generating steam that turns a turbine. That steam then is condensed back to water, and the cycle begins again. But the condensers that collect the steam are quite inefficient, and improving them could make a big difference in overall power plant efficiency. Now, a team of researchers at MIT has developed a way of coating these condenser surfaces with a layer of graphene, just one atom thick, and found that this can ...

Chicago, IL, USA (30 May 2015) -- The benefits of adding liver-directed SIR-Spheres Y-90 resin microspheres to a current systemic chemotherapy for the first-line treatment of unresectable metastatic colorectal cancer (mCRC) reported in the SIRFLOX study, were presented at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago. The results of the 530-patient SIRFLOX randomized controlled study, which open new possibilities for combining radiation targeted at liver metastases with first-line systemic treatment of mCRC, were presented by Associate Professor ...

Chicago and Madrid, June 1st 2015: PharmaMar today announced data from a Phase 1b study of the transcriptional inhibitor PM1183 in combination with doxorubicin in second line therapy in patients with small cell lung cancer (SCLC) showing that the treatment induced objective responses in 67% of the patients, including 10% of them where all signs of cancer disappeared (complete responses). Every patient with SCLC denominated primary chemotherapy-sensitive (their chemotherapy-free interval (CTFI) is more than 90 days) responded to treatment, including 18% of complete responses. ...

Chicago and Madrid, June 1st 2015: PharmaMar today announced data from a Phase 2 study in patients with sarcomatoid/biphasic malignant pleural mesothelioma showing that 41.2% (95% CI: 18.4-67.1) of patients treated with the anticancer drug trabectedin in second line were alive and free of progression at 12 weeks. The median progression-free survival (PFS) in these 17 evaluated patients was 8.3 weeks. There were 5 patients who continue receiving trabectedin beyond 12 weeks. "Mesothelioma patients usually do not respond to second-line treatments so the preliminary data ...

PORTLAND, Ore., June 01, 2015 -- Women who took vitamin D and calcium supplements had the same number of menopausal symptoms as women who did not take the supplements, according to a study published today in Maturitas, the official journal of the European Menopause and Andropause Society. The study, which involved 34,157 women ages 50-79, is part of the Women's Health Initiative, one of the largest clinical trials ever undertaken to address the most common causes of death, disability and impaired quality of life in menopausal women. "Our study suggests that women ...

Aging is associated with significant decline in cognitive functions. But does this translate into poorer decision making? Psychologists from the University of Basel and the Max Planck Institute for Human Development report that in simple decision situations, older adults perform just as well as younger adults. However, according to their study published in the academic journal Cognition, aging may affect decision performance in more complex decision situations. Important decisions in politics and economics are often made by older people: According to Forbes magazine, ...

The NHS could achieve up to twice as much with the resources that the Government plans to spend introducing a full seven day service in the NHS in England, according to new research from The University of Manchester. Health economists, working with colleagues at the University of York, have used official data to suggest an extra 5,353 deaths each year occur when people are admitted to hospital at the weekend rather than mid-week, but that the £1.43 billion cost of removing this risk would be better spent on other priorities. Despite a seven day health service ...

Researchers have developed a new augmented reality display that allows the audience to explore 3D augmentations of digital musical performances in order to improve their understanding of electronic musicians' engagement. The diversity of digital musical instruments keeps increasing, especially with the emergence of software and hardware that musicians can modify. While this diversity creates novel artistic possibilities, it also makes it more difficult for the audience to appreciate what the musicians are doing during performances. Contrary to acoustic instruments, digital ...