Treating advanced small-cell lung cancer (SCLC) with thoracic (or chest) radiation therapy in addition to standard treatment significantly prolongs long-term survival and reduces cancer recurrence in the chest by almost 50%, according to new research published in The Lancet and being presented simultaneously at ASTRO's 2014 Annual Meeting in San Francisco. The authors say that as the thoracic radiotherapy is well tolerated, it should to be routinely offered to all SCLC patients with extensive disease whose cancer responds to chemotherapy. SCLC is an aggressive cancer ...

Researchers have determined that African Americans and Caribbean blacks who experience discrimination of multiple types are at substantially greater risk for a variety of mental disorders including anxiety, depression and substance abuse. The research — co-authored by professor Christopher Salas-Wright at The University of Texas at Austin's School of Social Work and published in the August 2014 edition of Addictive Behaviors — suggests that experiences of discrimination in the form of disrespect and condescension do not alone appear to increase risk for most mental disorders. ...

WASHINGTON, DC – September 13, 2014 – New data from a landmark clinical trial found that after five years, transcatheter aortic valve replacement (TAVR) demonstrated a persistent mortality benefit, improved functional status, and resulted in a lower rate of repeat hospitalizations when compared with standard therapy for patients with severe aortic stenosis who are not candidates for surgery. Findings were reported today at the 26th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT ...

WASHINGTON, DC – September 13, 2014 – According to a new study, transcatheter aortic valve replacement (TAVR) provided meaningful clinical benefits relative to surgical aortic valve replacement (SAVR) in high risk patients with incremental costs considered acceptable from a US perspective. Findings from the cost-effectiveness analysis of the US CoreValve High Risk Trial were reported today at the 26th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational ...

WASHINGTON, DC – September 13, 2014 – A first-of-its kind study found that using a cerebral protection device during transcatheter aortic valve replacement (TAVR) can significantly reduce the number and volume of cerebral lesions in high risk patients with severe aortic stenosis. Findings were reported today at the 26th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine. Stroke remains ...

WASHINGTON, DC – September 13, 2014 – In extended follow-up from a clinical trial, a self-expanding transcatheter aortic valve was shown to have low rates of all-cause mortality and major stroke. Findings were reported today at the 26th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine. Degenerative aortic stenosis is a progressive disease with a poor prognosis in the absence of surgical ...

WASHINGTON, DC – September 13, 2014 – A new clinical trial found that vascular closure devices (VCD) are non-inferior to manual compression in patients undergoing transfemoral coronary angiography. Findings were reported today at the 26th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine. Vascular closure devices help achieve more rapid hemostasis after coronary angiography, however ...

An international study co-led by Keck School of Medicine of the University of Southern California (USC) scientists and researchers in the United Kingdom has revealed 23 new genetic susceptibility locations indicating risk for prostate cancer. The data study, analyzing more than 87,000 individuals of European, African, Japanese and Latino ancestry, is the largest of its kind and is the first that combines multiple studies across different ethnic populations. "The goal of this research is to identify regions of the genome that contribute susceptibility to prostate cancer ...

DURHAM, N.C. -- Faulty well integrity, not hydraulic fracturing deep underground, is the primary cause of drinking water contamination from shale gas extraction in parts of Pennsylvania and Texas, according to a new study by researchers from five universities. The scientists from Duke, Ohio State, Stanford, Dartmouth and the University of Rochester published their peer-reviewed study Sept. 15 in the Proceedings of the National Academy of Sciences. Using noble gas and hydrocarbon tracers, they analyzed the gas content of more than 130 drinking water wells in the two ...

Leaky intestines may cripple bacteria-fighting immune cells in patients with a rare hereditary disease, according to a study by researchers in Lausanne, Switzerland. The study, published in The Journal of Experimental Medicine on September 15, may explain why these patients suffer from recurrent bacterial infections. Patients with a disease called common variable immunodeficiency (CVID) suffer from recurrent bacterial infections as a result of faulty immune cells. But despite these immune defects, CVID patients rarely contract viral infections. New data from Matthieu ...

A single protein may tip the balance between ridding the body of a dangerous virus and enduring life-long chronic infection, according to a report appearing in The Journal of Experimental Medicine. Hepatitis B and C viruses cause chronic infections in roughly three-quarters of infected people, putting these individuals at risk for developing liver diseases including cirrhosis and cancer. A few patients successfully eliminate infection, thanks primarily to virus-fighting immune cells called CD8+ T cells. The protective effects of CD8+ T cells depend on a cellular protein ...

COLUMBUS, Ohio—A study has pinpointed the likely source of most natural gas contamination in drinking-water wells associated with hydraulic fracturing, and it's not the source many people may have feared. What's more, the problem may be fixable: improved construction standards for cement well linings and casings at hydraulic fracturing sites. A team led by a researcher at The Ohio State University and composed of researchers at Duke, Stanford, Dartmouth, and the University of Rochester devised a new method of geochemical forensics to trace how methane migrates under ...

The very idea of fibers made of carbon nanotubes is neat, but Rice University scientists are making them neat -- literally. The single-walled carbon nanotubes in new fibers created at Rice line up like a fistful of uncooked spaghetti through a process designed by chemist Angel Martí and his colleagues. The tricky bit, according to Martí, whose lab reported its results this month in the journal ACS Nano, is keeping the densely packed nanotubes apart before they're drawn together into a fiber. Left to their own devices, carbon nanotubes form clumps that are perfectly ...

ANN ARBOR, Mich. —One in five men in the U.S. reports violence towards their spouse or significant other, says a new nationally-representative study by the University of Michigan. The analysis also found that male aggression toward a partner is associated with warning signs that could come up during routine health care visits, including irritable bowel syndrome (IBS) and insomnia, in addition to better known risks like substance abuse and a history of either experiencing or witnessing violence as a child. The findings appear in the Journal of the American Board of Family ...

CHICAGO, IL—When an adolescent wants to terminate a pregnancy, how does she decide whether to talk to a parent? A recent study from the Section of Family Planning and Contraceptive Research at the University of Chicago found that pregnant teens will turn to parents and adults who are engaged in their lives and who will offer support, regardless of her pregnancy decision. Young women will avoid talking with parents who are less involved or may try to prevent them from seeking care. The study, published online ahead of print in the American Journal of Public Health, explored ...

Doctors have discovered that patients with a particular genetic variation are four times more likely to develop pancreatitis if they are prescribed a widely used group of drugs. Clinicians at the Royal Devon and Exeter NHS Foundation Trust and the University of Exeter Medical School have discovered that 17 per cent of patients who have two copies of a particular genetic marker are likely to go on to develop pancreatitis if they are prescribed thiopurine drugs. The drugs, which include azathioprine and mercaptopurine, are some of the most effective and most commonly used ...

Researchers from Moscow Institute of Physics and Technology, Technological Institute for Superhard and Novel Carbon Materials in Troitsk, MISiS, and MSU have developed anew method for the synthesis of an ultrahard material that exceeds diamond in hardness. An article recently published in the journal Carbon describes in detail a method that allows for the synthesis of ultrahard fullerite, a polymer composed of fullerenes, or spherical molecules made of carbon atoms. In their work, the scientists note that diamond hasn't been the hardest material for some time now. Natural ...

September 15, 2014 – An educational program for nurses can help address knowledge gaps related to advance health care directives (AHCDs)—thus helping to ensure that patients' wishes for care at the end of life are known and respected, reports a paper in the October/December Journal of Christian Nursing, official journal of the Nurses Christian Fellowship. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. Maureen Kroning, EdD, RN, of Nyack (N.Y.) College and Good Samaritan Hospital presents her hospital's experience with developing ...

Soldiers deployed to tropical and sunny climates are coming home with increased risk factors for a threat far from the battlefield: skin cancer. In a retrospective study of about 200 veterans seen at the post-deployment clinic of the Tennessee Valley Healthcare System of the U.S. Department of Veterans Affairs, researchers from Vanderbilt University Medical Center and the Tennessee Valley Healthcare System found that 62 percent of military personnel reported getting sunburned while deployed abroad, including cases of skin blistering. In addition, 29 percent noted a change ...

At nearly 100 feet long and weighing as much as 170 tons, the blue whale is the largest creature on the planet, and by far the heaviest living thing ever seen on Earth. So there's no way it could have anything in common with the tiniest fish larvae, which measure millimeters in length and tip the scales at a fraction of a gram, right? Not so fast, says L. Mahadevan, the Lola England de Valpine Professor of Applied Mathematics, of Organismic and Evolutionary Biology, and of Physics. Using simple hydrodynamics, a team of researchers led by Mahadevan was able to show ...

Philadelphia, PA, September 15, 2014 – Schizophrenia is generally considered to be a disorder of brain development and it shares many risk factors, both genetic and environmental, with other neurodevelopmental disorders such as autism and intellectual disability. The normal path for brain development is determined by the combined effects of a complex network of genes and a wide range of environmental factors. However, longitudinal brain imaging studies in both healthy and patient populations are required in order to map the disturbances in brain structures as they emerge, ...

(SACRAMENTO, Calif.) —In what may be the largest study of sleep problems among individuals with multiple sclerosis (MS), researchers at UC Davis have found that widely undiagnosed sleep disorders may be at the root of the most common and disabling symptom of the disease: fatigue. Conducted in over 2,300 individuals in Northern California with multiple sclerosis, the large, population-based study found that, overall, more than 70 percent of participants screened positive for one or more sleep disorders. The research highlights the importance of diagnosing the root causes ...

The age of the Anthropocene--the scientific name given to our current geologic age--is dominated by human impacts on our environment. A warming climate. Increased resistance of pathogens and pests. A swelling population. Coping with these modern global challenges requires application of what one might call a more-ancient principle: evolution. That's the recommendation of a diverse group of researchers, in a paper published today in the online version of the journal Science. A majority of the nine authors on the paper have received funding from the National Science Foundation ...

EAST LANSING, Mich. – A microbe developed to clean up nuclear waste and patented by a Michigan State University researcher has just been improved. In earlier research, Gemma Reguera, MSU microbiologist, identified that Geobacter bacteria's tiny conductive hair-like appendages, or pili, did the yeoman's share of remediation. By increasing the strength of the pili nanowires, she improved their ability to clean up uranium and other toxic wastes. In new research, published in the current issue of Applied and Environmental Microbiology, Reguera has added an additional layer ...

Two fires are seen burning in this satellite image taken by the Aqua satellite on September 11, 2014. The Selway complex of fires had been previously reported located 30 miles west of Darby, MT. It appears a new fire may have started again in this complex. Currently the size of the complex is 1,659 fires. The fire is mostly contained and there will be no additional reporting on this fire unless activity increases. It is, for the most part, contained. The Johnson Bar fire started with a lightning strike on August 03, 2014. To date, 8,867 acres have been affected. ...