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Poor QOL doesn't predict low survival in high-risk lung cancer patients undergoing surgery

2014-04-29
Toronto, ON, Canada, April 29, 2014 – Quality of life (QOL) is rarely reported in surgical publications, yet it can be an important metric that can be of use to physicians and patients when making treatment decisions. Prior studies of average-risk patients undergoing lobectomy suggested that low baseline QOL scores predict worse survival in patients undergoing non-small cell lung cancer surgery. The results of a multi-center, longitudinal study of high-risk lung cancer patients who underwent sublobar resection counters this idea, finding that poor baseline global QOL scores ...

Mother's diet affects the 'silencing' of her child's genes

Mothers diet affects the silencing of her childs genes
2014-04-29
A mother's diet before conception can permanently affect how her child's genes function, according to a study published in Nature Communications. The first such evidence of the effect in humans opens up the possibility that a mother's diet before pregnancy could permanently affect many aspects of her children's lifelong health. Researchers from the MRC International Nutrition Group, based at the London School of Hygiene & Tropical Medicine and MRC Unit, The Gambia, utilised a unique 'experiment of nature' in rural Gambia, where the population's dependence on own grown ...

Genealogy and biogeography meet personalized medicine

Genealogy and biogeography meet personalized medicine
2014-04-29
Biogeographical data is useful in screening for disease risk and drug sensitivity associated with certain ethnic groups. A team of researchers, including an investigator from Children's Hospital Los Angeles, has developed a tool to accurately identify the biogeography of worldwide individuals. Previous tools were accurate in identifying place of origin within homogeneous European populations but highly inaccurate for places with significant immigration, such as the U.S. Tatiana Tatarinova, PhD, of The Saban Research Institute of Children's Hospital Los Angeles, Eran ...

Screening out: What are parents doing to limit screen time for young children?

2014-04-29
ANN ARBOR, Mich. – About 25 percent of parents who have children aged two to five say their children get three or more hours of entertainment screen time a day, well beyond recommended limits, according to a new poll from the University of Michigan. In the latest University of Michigan Mott Children's Hospital National Poll on Children's Health, a little more than half of those parents do try to set some limits by location: banning media devices from places like the bedroom or at mealtime. In 2013, the American Academy of Pediatrics issued updated guidelines to recommend ...

People rely on what they hear to know what they're saying

2014-04-29
You know what you're going to say before you say it, right? Not necessarily, research suggests. A study from researchers at Lund University in Sweden shows that auditory feedback plays an important role in helping us determine what we're saying as we speak. The study is published in Psychological Science, a journal of the Association for Psychological Science. "Our results indicate that speakers listen to their own voices to help specify the meaning of what they are saying," says researcher Andreas Lind of Lund University, lead author of the study. Theories about how ...

NOAA reports show strong economic gains from fishing, continued improvement in fish stocks

2014-04-29
U.S. commercial and recreational saltwater fishing generated more than $199 billion in sales in 2012, a gain of seven percent over the previous year, with the economic impact of fishing jobs increasing three percent from 2011 to 2012, according to a new NOAA Fisheries economics report. Further, two more fish stocks were rebuilt to target levels in 2013, bringing the number of rebuilt U.S. marine fish stocks to 34 since 2000, according to another NOAA Fisheries report also released today. Taken together, the two reports, Fisheries Economics of the United States 2012 ...

RI Hospital: Medicare patients with dementia 20 percent more likely to be readmitted

2014-04-29
PROVIDENCE, R.I. – A review of more than 25,000 admissions of Medicare beneficiaries to Rhode Island hospitals has found that patients with a documented diagnosis of dementia are nearly 20 percent more likely to be readmitted within 30 days than those without dementia. The study by Rhode Island Hospital researchers is published online in advance of print in the journal Archives of Gerontology and Geriatrics. "Persons with dementia may have difficulties comprehending and following important discharge instructions, (e.g. medication changes, decision making, self care)," ...

Model sheds new light on sports-related brain injuries

2014-04-29
A new study has provided insight into the behavioral damage caused by repeated blows to the head. The research provides a foundation for scientists to better understand and potentially develop new ways to detect and prevent the repetitive sports injuries that can lead to the condition known as chronic traumatic encephalopathy (CTE). The research – which appears online this week in the Journal of Neurotrauma – shows that mice with mild, repetitive traumatic brain injury (TBI) develop many of the same behavioral problems, such as difficultly sleeping, memory problems, ...

A risk management framework improves health systems' resilience to high-impact weather

2014-04-29
WASHINGTON — April 29, 2014 - According to a new study by the American Meteorological Society (AMS) Policy Program, a risk management framework can improve the resilience of healthcare facilities and services to high-impact weather such as tornadoes and hurricanes. The report is based on a recent AMS Policy Program workshop, A Prescription for the 21st Century: Improving Resilience to High-Impact Weather for Healthcare Facilities and Services, held in Washington, DC in October 2013. The purpose of the study was to explore methods for improving the resilience of the health ...

Brain tumor cells penetrated by tiny, degradable particles carrying genetic instructions

Brain tumor cells penetrated by tiny, degradable particles carrying genetic instructions
2014-04-29
Working together, Johns Hopkins biomedical engineers and neurosurgeons report that they have created tiny, biodegradable "nanoparticles" able to carry DNA to brain cancer cells in mice. The team says the results of their proof of principle experiment suggest that such particles loaded with "death genes" might one day be given to brain cancer patients during neurosurgery to selectively kill off any remaining tumor cells without damaging normal brain tissue. A summary of the research results appeared online on April 26 in the journal ACS Nano. "In our experiments, ...

Major lung resection safer than ever, especially at the busiest hospitals

2014-04-29
Toronto, ON, Canada, April 29, 2014 – A major new study using data from the National Cancer Data Base details the impact of annual hospital volume on 30- and 90-day mortality rates. Investigators found that major lung surgery has become progressively safer over the last few decades, although higher death rates at low-volume hospitals and an unexpected increase in mortality at 90 days compared to 30 days were observed. The study further suggests that choosing a center that performs major lung surgery regularly can have a strong impact on survival. Lung cancer is the leading ...

'Tell-tail' MRI image diagnosis for Parkinson's disease

Tell-tail MRI image diagnosis for Parkinsons disease
2014-04-29
An image similar in shape to a Swallow's tail has been identified as a new and accurate test for Parkinson's disease. The image, which depicts the healthy state of a group of cells in the sub-region of the human brain, was singled out using 3T MRI scanning technology – standard equipment in clinical settings today. The research was led by Dr Stefan Schwarz and Professor Dorothee Auer, experts in neuroradiology in the School of Medicine at The University of Nottingham and was carried out at the Queen's Medical Centre in collaboration with Dr Nin Bajaj, an expert in Movement ...

CWRU researchers profile women's employment, caregiving workloads, effort and health

2014-04-29
A study from the Case Western Reserve University nursing school provides a profile of women with the dual responsibilities of full-time paid work and unpaid care for an elderly family member. "We often hear caregivers talk about 'how much time and effort it takes' to provide care for their family members or neighbors," said Evanne Juratovac, PhD, RN (GCNS-BC), assistant professor of nursing at the Frances Payne Bolton School of Nursing and the study's lead researcher, "so we examined the experience of doing the workload on these women caregivers as the 'workers." She ...

NAI Fellows paper on patents and commercialization for tenure, career advancement in PNAS

NAI Fellows paper on patents and commercialization for tenure, career advancement in PNAS
2014-04-29
TAMPA, Fla. (April 29, 2014) – When six university leaders took the stage at the 2013 Annual Conference of the National Academy of Inventors (NAI), held just over a year ago at the University of South Florida, they began a national conversation on changing the academic culture to recognize faculty patents and commercialization activity toward tenure and promotion. That conversation, according to NAI president Paul R. Sanberg, was long overdue. The question posed to the panel, "Would Thomas Edison Receive Tenure," was answered with a clear "yes" and the paper that resulted, ...

Girls make higher grades than boys in all school subjects, analysis finds

2014-04-29
WASHINGTON -- Despite the stereotype that boys do better in math and science, girls have made higher grades than boys throughout their school years for nearly a century, according to a new analysis published by the American Psychological Association. "Although gender differences follow essentially stereotypical patterns on achievement tests in which boys typically score higher on math and science, females have the advantage on school grades regardless of the material," said lead study author Daniel Voyer, PhD, of the University of New Brunswick, Fredericton, Canada. ...

Experiment on Earth demonstrates effect observed in space

2014-04-29
Streaming jets of high-speed matter produce some of the most stunning objects seen in space. Astronomers have seen them shooting out of young stars just being formed, X-ray binary stars and even the supermassive black holes at the centers of large galaxies. Theoretical explanations for what causes those beam-like jets have been around for years, but now an experiment by French and American researchers using extremely high-powered lasers offers experimental verification of one proposed mechanism for creating them. "This research is an example of how laboratory experiments ...

Newly identified 'universal' property of metamagnets may lead to everyday uses

2014-04-29
A new physics discovery made by a University of Virginia-led team may lead to more efficient refrigerators, heat pumps and airport scanners, among many possible uses –perhaps within a decade. The team of physicists and materials scientists have discovered a universal law governing the magnetic properties of metamagnets – metal alloys that can undergo dramatic increases in magnetization when a small external magnetic field is applied, such as from a permanent magnet or an electromagnet. The scientists have discovered that the magnetic effect of apparently all metamagnets ...

Anti-bullying policy must focus on all of society

2014-04-29
Policy to reduce bullying in the schoolyard needs to span all levels of society, say researchers from the University of Warwick, who warn that socioeconomic status is not a reliable indicator of whether a child is likely to become a bully. Up to one third of children are involved in bullying, and a growing body of evidence has shown that bullying is a significant public health concern, which can cause long lasting health and social problems. The new review, published in the American Journal of Public Health, advises that policy makers should be wary of assuming that ...

Higher calcium intake may reduce body fat, mitigating genetic risk for diabetes

2014-04-29
SAN DIEGO (April 29, 2014) – As the number of people with type 2 diabetes continues to rise and its toll increases, scientists are scrambling to unravel the complex genetic and lifestyle factors behind the disease. A new study finds that African American children with a genetic predisposition to diabetes may be able to reduce their risk by getting the USDA-recommended dose of calcium. "Even though life expectancy for people with diabetes has gone up, the disease has a significant impact on quality of life, so finding ways to prevent people from developing diabetes is ...

More coral babies staying at home on future reefs

2014-04-29
Researchers have found that increasing ocean temperatures due to climate change will soon see reefs retaining and nurturing more of their own coral larvae, leaving large reef systems less interconnected and potentially more vulnerable. "We found that at higher temperatures more coral larvae will tend to stay on their birth reef," says the lead author of the study published today, Dr Joana Figueiredo from the ARC Centre of Excellence for Coral Reef Studies (Coral CoE) at James Cook University. "This is good news in an otherwise cloudy picture for isolated reefs, because ...

Stem cell therapies look promising for heart disease

2014-04-29
Stem cell therapies work as a complement to standard treatments, potentially cutting the number of deaths after a year, suggests evidence from the latest Cochrane review: Stem cell therapy for chronic ischaemic heart disease and congestive heart failure. Taking stem cells from a patient's bone marrow and injecting them into their damaged heart may be an effective way to treat heart disease. The new review, published today in The Cochrane Library, uses data involving 1,255 people from 23 randomised controlled trials, where all participants received standard treatments. ...

Microfluidic technology reveals potential biomarker for early pancreatic cancer

Microfluidic technology reveals potential biomarker for early pancreatic cancer
2014-04-29
ANN ARBOR, Mich. – Cancer cells are on the move in the bloodstream in the very early stage of pancreatic cancer, and can be detected before cancer is diagnosed, according to research by the University of Michigan Health System. In a study of 51 patients, researchers used a state-of-the art microfluidic device to capture circulating pancreas epithelial cells in 33 percent of patients with early pancreatic lesions and no clinical diagnosis of cancer. The findings, published in Gastroenterology, suggest that circulating pancreas cells (CPCs) seed the bloodstream before ...

Coral reefs provide potent new anti-HIV proteins

2014-04-29
SAN DIEGO (April 29, 2014) – Researchers have discovered a new class of proteins capable of blocking the HIV virus from penetrating T-cells, raising hope that the proteins could be adapted for use in gels or sexual lubricants to provide a potent barrier against HIV infection. The proteins, called cnidarins, were found in a feathery coral collected in waters off Australia's northern coast. Researchers zeroed in on the proteins after screening thousands of natural product extracts in a biorepository maintained by the National Cancer Institute. "It's always thrilling when ...

NCI, NCRI and EORTC outline risk-assessment approach for biomarker-driven cancer clinical trials

2014-04-29
In an article published in The Lancet Oncology, an NCI (US National Cancer Institute), NCRI (UK National Cancer Research Institute), and EORTC (European Organisation for Research and Treatment of Cancer) working group outline a practical risk-management approach for effective integration of biomarkers into cancer clinical trials. Their work provides the international community with a set of common principles by which biomarkers can be integrated into clinical trials, exchange of data can be facilitated, quality promoted, and research accelerated while simultaneously respecting ...

Mobile users may not buy into instant gratification cues

2014-04-29
Gimmicky contest ads and flashy free-prize messages may be an instant turnoff for mobile users, according to Penn State researchers. In a study, a tempting offer of a free prize drawing for registering on a mobile website led users to distrust the site, said S. Shyam Sundar, Distinguished Professor of Communications and co-director of the Media Effects Research Laboratory. Sundar said that in an increasingly information-loaded world, people tend to lean on cues, such as icons and messages, for decision-making shortcuts, called heuristics. However, some cues may elicit ...
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