Under the tutelage of Junior Professor Dr Simon Ebbinghaus, researchers from Bochum have demonstrated that the water surrounding the dissolved substances inside the cell plays a crucial role with regard to protein stability, which has frequently been neglected in the past. The researchers have published the results of their study, gained by means of simple model systems and thermodynamic analyses, in the Journal of the American Chemical Society (JACS). The results have been obtained following a collaboration under the umbrella of the Excellence Cluster RESOLV. The researchers ...

Researchers at the Royal Veterinary College have identified a highly specialised ligament structure that is thought to prevent giraffes' legs from collapsing under the immense weight of these animals. "Giraffes are heavy animals (around 1000 kg), but have unusually skinny limb bones for an animal of this size" explained lead investigator Christ Basu, a PhD student in the Structure & Motion Lab. "This means their leg bones are under high levels of mechanical stress." In giraffes, the equivalents to our metatarsal bone (in the foot) and metacarpal bone (in the hand) are ...

Contrary to what was thought, sequences of DNA called enhancers – which control a gene's output – find their targets long before they are activated during embryonic development, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have found. Their study, published online today in Nature, also reveals that, surprisingly, the degree of complexity of enhancers' interactions in the 'simple' fruit fly Drosophila is comparable to what is seen in vertebrates. "As an embryo develops, there are huge changes in transcription, much of which drives ...

An international team of researchers identified a pathogenic mechanism that is common to several neurodegenerative diseases. The findings suggest that it may be possible to slow the progression of dementia even after the onset of symptoms. The relentless increase in the incidence of dementia in aging societies poses an enormous challenge to health-care systems. An international team of researchers led by Professor Christian Haass and Gernot Kleinberger at the LMU's Adolf-Butenandt-Institute and the German Center for Neurodegenerative Diseases (DZNE), has now elucidated ...

Paleontologists of Ludwig-Maximilians-Universitaet (LMU) in Munich are currently studying a new specimen of Archaeopteryx, which reveals previously unknown features of the plumage. The initial findings shed light on the original function of feathers and their recruitment for flight. A century and a half after its discovery and a mere 150 million years or so since it took to the air, Archaeopteryx still has surprises in store: The eleventh specimen of the iconic "basal bird" so far discovered turns out to have the best preserved plumage of all, permitting detailed comparisons ...

Researchers from the Cochrane Infectious Diseases Group, hosted at LSTM, conducted an independent review of the effects of adding a single dose of primaquine (PQ) to malaria treatment to prevent the transmission of the disease. Mosquitoes become infected with Plasmodium falciparum when they ingest gametocyte-stage parasites from an infected person's blood. PQ is an antimalarial drug that does not cure malaria illness, but is known to kill the gametocyte stage of the P falciparum parasite, thus potentially limiting transmission to further humans. PQ is known to have potentially ...

Various manual tasks in everyday life require the use of the right hand or are optimized for right-handers. Around 90 percent of the general population is right-handed, only about 10 percent is left-handed. The study of Ulrich Tran, Stefan Stieger, and Martin Voracek comprised two large and independent samples of nearly 13000 adults from Austria and Germany. As in modern genetic studies, where a discovery-and-replication-sample design is standard, the use of two samples allowed testing the replicability and robustness of findings within one-and-the-same study. Overall, ...

Let us imagine, for a moment, the arm of a robot that lifts a cup of coffee to its "lips" over and over again. The joint of this robotic arm needs a certain flexibility plus an electric motor to drive the upward and downward movements. So orders have to be sent to the motor so that the joint can perform the corresponding movements. "The motors need to receive orders constantly. In fact, the motor has to know at all times what angle its axis has to be at. However, current digital controllers only issue orders at specific moments (in discrete time); they can be described ...

WEST LAFAYETTE, Ind. — A tool to help brain surgeons test and more precisely remove cancerous tissue was successfully used during surgery, according to a Purdue University and Brigham and Women's Hospital study. The Purdue-designed tool sprays a microscopic stream of charged solvent onto the tissue surface to gather information about its molecular makeup and produces a color-coded image that reveals the location, nature and concentration of tumor cells. "In a matter of seconds this technique offers molecular information that can detect residual tumor that otherwise ...

In a cluster of articles released today in the peer reviewed European Journal of Psychotraumatology, researchers provide new insights into the treatment of children and youth exposed to acts of terror. The work is drawn from studies examining the mass shooting at Utoya, Norway in 2011, and two school shootings in Finland – Jokela in 2007 and Kauhajoki in 2008. A lead researcher in the cluster is noted Norwegian child psychiatrist and terror expert Dr. Grete Dyb of the University of Oslo and the Norwegian Center for Violence and Traumatic Stress Studies. "Terror ...

DARIEN, IL – A new study is the first to identify specific coping behaviors through which stress exposure leads to the development of insomnia. Results show that coping with a stressful event through behavioral disengagement – giving up on dealing with the stress – or by using alcohol or drugs each significantly mediated the relationship between stress exposure and insomnia development. Surprisingly, the coping technique of self-distraction – such as going to the movies or watching TV – also was a significant mediator between stress and incident insomnia. Furthermore, ...

Angiogenesis, the sprouting of new blood vessels from pre-existing ones, is essential to the body's development. As organs grow, vascular networks must grow with them to feed new cells and remove their waste. The same process, however, also plays a critical role in the onset and progression of many cancers, as it allows the rapid growth of tumors. With lifesaving applications possible in both inhibiting and accelerating the creation of new blood vessels, a more fundamental understanding of what regulates angiogenesis is needed. Now, researchers at the University of Pennsylvania, ...

Adults who have dyslexia are much more likely to report they were physically abused before they turned 18 than their peers without dyslexia, according to a new study from researchers at the University of Toronto and the University of North Carolina School of Medicine in Chapel Hill. Thirty-five per cent of adults with dyslexia report they were physically abused before they turned 18. In contrast, seven per cent of those without dyslexia reported that they had experienced childhood physical abuse. "Even after accounting for age, race, sex and other early adversities ...

3 JULY 2014 | ROME, ITALY - The World Health Organization (WHO) today, together with the European Respiratory Society (ERS), presented a new framework to eliminate tuberculosis (TB) in countries with low levels of the disease. Today there are 33* countries and territories where there are fewer than 100 TB cases per million population. The framework outlines an initial "pre-elimination" phase, aiming to have fewer than 10 new TB cases per million people per year by 2035 in these countries. The goal is to then achieve full elimination of TB by 2050, defined as less than ...

New research shows that our brain displays a similar pattern of activity during dreams as it does during a mind-expanding drug trip. Psychedelic drugs such as LSD and magic mushrooms can profoundly alter the way we experience the world but little is known about what physically happens in the brain. New research, published in Human Brain Mapping, has examined the brain effects of the psychedelic chemical in magic mushrooms, called 'psilocybin,' using data from brain scans of volunteers who had been injected with the drug. The study found that under psilocybin, activity ...

THURSDAY, July 3, 2014, Las Vegas: Researchers at the Cleveland Clinic Lou Ruvo Center for Brain Health have conducted the first-ever analysis of clinical trials for Alzheimer's disease (AD), revealing an urgent need to increase the number of agents entering the AD drug development pipeline and progressing successfully towards new therapy treatments. The paper, "Alzheimer's Disease Drug Development Pipeline: Few Candidates, Frequent Failures," was published today in the journal Alzheimer's Research & Therapy. A comprehensive look at all clinical trials underway shows: There ...

As older adults typically have one or more chronic health conditions that can affect dietary intake, malnutrition has been identified as a serious problem in older adults. This has given rise to the recommendation that nutrition screenings be a mandatory part of the comprehensive geriatric analysis (CGA). The CGA, first developed in the 1930s, is a multidimensional diagnostic process that looks at a frail elderly person's medical, psychosocial, and functional capabilities in order to develop an overall plan for treatment and follow-up. While it has been used across health ...

Pediatric patients with intestinal failure often need gastrostomy tubes, or feeding tubes inserted into an opening created in the stomach, for long-term nutrition. The use of such tubes can lead to persistent gastrocutaneous fistulae, or the failure of the opening to close on its own, resulting in a need for surgical closure. The causes of gastrocutaneous fistulae in pediatric patients are largely unknown, but researchers at Boston Children's Hospital looked at possible risk factors, including nutrition. Their finds are published today in the OnlineFirst version of the ...

A new study gives hospitals overall good marks for conducting nutrition screenings within 24 hours of a patient's admission, but finds that many need to improve other practices to be more effective. The study, conducted by the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) and published today in A.S.P.E.N's Nutrition in Clinical Practice journal, found that while most respondents said that screening patients for malnutrition was being done in compliance with The Joint Commission mandate of 1995, fewer than half were familiar with the 2012 Consensus ...

Researchers at the University of Copenhagen and the Copenhagen University Hospital have identified a particular genetic mutation that may cause parkinsonism in young people. The mutation interferes with the brain's transport of the important signal substance dopamine and may also plays a role in mental diseases, e.g. ADHD. The findings have just been published in the scientific Journal of Clinical Investigation. Being one of the most important signal substances in the brain, dopamine is particularly important for the control of movements and reward mechanisms in the brain. ...

Bottom Line: Women with long-term high blood pressure (hypertension) appear to be at an increased risk for the skin condition psoriasis, and long-term use of beta (β)-blocker medication to treat hypertension may also increase the risk of psoriasis. Author: Shaowei Wu, M.D., Ph.D., of Brown University, Providence, Rhode Island, and colleagues. Background: Psoriasis is an immune-related chronic disease that affects about 3 percent of the U.S. population. The authors suggest prospective data on the risk of psoriasis associated with hypertension is lacking. Antihypertensive ...

Bottom Line: Full implementation of the Affordable Care Act's (ACA) national health insurance expansion could result in many more discretionary surgical procedures in the next few years based on how utilization changed after an earlier insurance reform in Massachusetts. Author: Chandy Ellimoottil, M.D., of the University of Michigan, Ann Arbor, and colleagues. Background: The potential effect of the ACA on surgical care is not well known. The authors examined its possible effect by analyzing the Massachusetts insurance expansion and utilization of discretionary and ...

Bottom Line: A clinical trial found a reduction in seizures and improvement in related symptoms, including depression and anxiety, in patients with psychogenic nonepileptic seizures (PNES) who were treated with cognitive behavioral therapy informed psychotherapy (CBT-ip) with and without the medication sertraline. Authors: W. Curt LaFrance, Jr., M.D., M.P.H., of Brown University, Rhode Island Hospital, Providence, R.I., and colleagues. Background: PNES is not responsive to standard treatment and can be made worse by antiepileptic medications. Up to 20 percent of civilians ...

A team including researchers from the U.S. Geological Survey (USGS) and the San Diego Zoo's Institute for Conservation Research has developed a novel methodology that for the first time combines 3D and advanced range estimator technologies to provide highly detailed data on the range and movements of terrestrial, aquatic, and avian wildlife species. A paper detailing the project, called 'Movement-based Estimation and Visualization of Space Use in 3D for Wildlife Ecology and Conservation', was published July 2 in the PLOS ONE online science journal. A video of the project ...

PHOENIX, Ariz. — July 2, 2014 — Lung cancer patients could receive more precise treatment, and their progress could be better tracked, using a new high-tech method of non-invasive medical imaging analysis, according to a study published today by the journal PLOS ONE. Genetic changes increasingly are recognized as driving cancer development. But obtaining evidence of these changes usually requires a biopsy, which can be problematic for sensitive regions of the body such as the lungs. Based on a review of 48 patients with non-small cell lung cancer (NSCLC), the study ...