(WASHINGTON, May 17, 2024) – People who use metformin are less likely to develop a myeloproliferative neoplasm (MPN) over time, indicating that the treatment may help prevent the development of certain types of cancers, according to a study published in Blood Advances. Metformin is a therapy used to treat high blood sugar in people with type 2 diabetes that increases the effect of insulin, reduces how much glucose is released from the liver and helps the body absorb glucose. A meta-analysis of previous studies connected the therapy with ...

OTTAWA, Ontario, May 17, 2024 – Pickleball Legal Consultant is a job title that likely did not exist a decade ago, but as pickleball courts infiltrate neighborhoods to satiate an appetite for a sport whose namesake is a snack, communities take issue with the resulting influx of noise. Now homeowners’ associations and city councils face litigation by those whose lives are disrupted by pickleball’s din. Charles Leahy, an attorney, retired mechanical engineer, and former HOA board member became ...

LAWRENCE — More than 300 million years ago, all sorts of arachnids crawled around the Carboniferous coal forests of North America and Europe. These included familiar ones we’d recognize, such as spiders, harvestmen and scorpions — as well exotic animals that now occur in warmer regions like whip spiders and whip scorpions. But there were also quite bizarre arachnids in these habitats belonging to now extinct groups. Even among these stranger species now lost to time, one might have stood out for its up-armored legs. The ancient critter recently was described in a new paper published ...

By Ian Scheffler By now, the challenges posed by generative AI are no secret. Models like OpenAI’s ChatGPT, Anthropic’s Claude and Meta’s Llama have been known to “hallucinate,” inventing potentially misleading responses, as well as divulge sensitive information, like copyrighted materials.  One potential solution to some of these issues is “model disgorgement,” a set of techniques that force models to purge themselves of content that leads to copyright infringement or biased responses.  In ...

Stroke is the leading cause of disability worldwide and the second leading cause of death, but the right early intervention can prevent severe consequences. A new study led by investigators from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, and collaborators developed a new test by combining blood-based biomarkers with a clinical score to identify patients experiencing large vessel occlusion (LVO) stroke with high accuracy. Their results are published in the journal Stroke: Vascular and Interventional Neurology. “We have developed a game-changing, accessible tool that could help ensure that more people suffering from ...

Bethesda, MD (May 17, 2024) — The American Gastroenterological Association’s (AGA) new evidence-based Clinical Practice Guideline on Endoscopic Eradication Therapy of Barrett's Esophagus and Related Neoplasia, published today in Gastroenterology, establishes updated guidance for Barrett’s esophagus patients.  A precursor to esophageal cancer, Barrett’s esophagus is a condition in which the cells in the esophagus have been replaced with non-cancerous abnormal cells. These cells can progress to a condition called dysplasia, which may in turn become cancer. Dysplasia is considered low-grade or ...

A team of researchers from the Instituto Gulbenkian de Ciência (IGC) in Portugal, together with Åbo Akademi University in Finland, the AI4Life consortium, and other collaborators, have developed an innovative open-source platform called DL4MicEverywhere published today in the journal Nature Methods*. This platform provides life scientists with easy access to advanced artificial intelligence (AI) for the analysis of microscopy images. Itenables other researchers, ...

A ruined building in the middle of the Pyrenees records a tragedy for the people who lived there — a devastating fire which burned a settlement to the ground, destroying everything down to a hidden gold earring. Now archaeologists’ excavation of Building G, in the strategically placed Iron Age site of Tossal de Baltarga, reveals a way of life derailed by violence: potentially, a forgotten episode of the war between Carthage and Rome. “The destruction was dated around the end of the third century BCE, the moment where the Pyrenees were involved in the Second Punic War and the passage of Hannibal’s troops,” ...

This study investigates the cononsolvency mechanism of poly(N-isopropylacrylamide) (PNIPAM), which is soluble in pure methanol (MeOH) and water but insoluble in aqueous MeOH solutions. Combining oxygen K-edge X-ray absorption spectroscopy (XAS) with theoretical calculations executed in molecular dynamics (MD) simulations and inner-shell calculations, it was found that hydrophobic interactions between PNIPAM and MeOH clusters play a key role in PNIPAM aggregation and cononsolvency emergence. PNIPAM is ...

Genome editing is making inroads into biomedical research and medicine. By employing biomolecule modeling tools, a Japanese research team is accelerating the pace and cutting the cost of zinc finger nuclease (ZFN) technology, a primary gene editing tool. In a recently published study, researchers from Hiroshima University and the Japanese National Institute of Advanced Industrial Science and Technology demonstrated how machine learning-driven modular assembly systems can improve gene editing. The study was published on April 10 in the journal Advanced Science. “Genome editing is ...

It has long been understood that pregnant women with diabetes are more likely to have children with obesity than women who do not have diabetes during pregnancy. But scientists have not fully understood the cause or why babies born to mothers with diabetes are also more likely to develop obesity and associated metabolic disorders later in life. To help find answers, Keck School of Medicine of USC researcher Shan Luo, PhD, has been awarded $3.1 million in funding from the National Institutes of Health and the National Institute of Diabetes ...

Men are at greater risk than women of the major health effects of diabetes (types 1 and 2), suggests a long term study published online in the Journal of Epidemiology & Community Health.   Rates of cardiovascular disease, leg, foot, and kidney complications, and the sight-threatening eye disease diabetic retinopathy are all higher in men, regardless of whether they had diabetes for more or less than 10 years, the findings show. The global prevalence of diabetes is similar in men and women, and is projected to rise to 783 million by 2045, note the researchers. But ...

The more time spent on social media, the greater the likelihood that children and young people will both smoke and/or vape, suggests research published online in the respiratory  journal Thorax.   Clocking up a weekday tally of 7 or more hours was associated with a more than a doubling in risk among 10 to 25 year olds, the findings indicate, reinforcing concerns about the marketing clout of these platforms, say the researchers. The existing body of research on social media use and smoking and ...

**Embargo: 23.30 [UK time], 6:30 p.m. [EDT] May 16, 2024** Global Burden of Disease  The latest findings from the Global Burden of Disease Study (GBD) 2021, published today in The Lancet, forecast that global life expectancy will increase by 4.9 years in males and 4.2 years in females between 2022 and 2050. Increases are expected to be largest in countries where life expectancy is lower, contributing to a convergence of increased life expectancy across geographies. The trend is largely driven by public health measures that ...

The implementation of primary health care (PHC) over the last two decades has prevented more than 300,000 child deaths in four Latin American countries, and could prevent more than 140,000 by 2030 in a scenario of economic crisis. This is the main conclusion of a study coordinated by the Barcelona Institute for Global Health (ISGlobal), a centre supported by “la Caixa” Foundation, published in The Lancet Global Health. The 2018 Astana Declaration highlighted the critical role of PHC in ensuring that everyone enjoys the highest possible standard of health, and in achieving universal health coverage. The Declaration also stressed the ...

WEHI division head and pioneer of ubiquitination Professor David Komander has been elected a Fellow of the esteemed Royal Society, the UK’s national science academy.   Prof Komander was recognised for his significant research contributions towards understanding ubiquitin, the ‘kiss of death’ protein which tells our cells which proteins to break down or recycle – a vital process that helps cells stay healthy and function correctly. Prof Komander’s work has helped unravel the ‘ubiquitin code’ that enables ubiquitin to perform many ...

By Darrin S. Joy A molecular biologist at the USC Dornsife College of Letters, Arts and Sciences may have found a new “rule of biology.” A rule of biology, sometimes called a biological law, describes a recognized pattern or truism among living organisms. Allen’s rule, for example, states that among warm-blooded animals, those found in colder areas have shorter, thicker limbs (to conserve body heat) than those in hotter regions, which need more body surface area to dissipate heat.  Zoologist Joel Allen formulated this idea in 1877, and though he wasn’t the first or the last to present a rule of biology, his ...

LA JOLLA, CA—Scripps Research chemists have accomplished a long elusive feat in synthetic chemistry: the invention of a broadly useful method for constructing “gamma chiral centers” on simple starting compounds called carboxylic acids. The method, published on May 16, 2024 in Science, significantly extends the ability of chemists to build and modify complex pharmaceutical molecules and other valuable chemical products. The term chiral refers to a type of asymmetry that allows some chemical compounds to exist in left-handed and right-handed forms. Often, only one of these forms has the ...

The SIAM Annual Meeting provides a broad view of the state of the art in applied mathematics, computational and data science, and their applications through invited presentations, prize lectures, minitutorials, minisymposia, contributed presentations, and posters. END ...

In the age of generative-AI and large language models (LLMs), massive amounts of inauthentic content can be rapidly broadcasted on social media platforms. As a result, malicious actors are becoming more sophisticated, hijacking hashtags, artificially amplifying misleading content, and mass resharing propaganda.  These actions are often orchestrated by state-sponsored information operations (IOs), which attempt to sway public opinion during major geopolitical events such as the US elections, the Covid-19 pandemic, and more.  Combating ...

The rate of colorectal cancer screenings more than doubled when patients were given a choice between which type of screening they wanted—a take-home kit or colonoscopy—compared to those who were only offered the colonoscopy, according to new research led by the Perelman School of Medicine at the University of Pennsylvania. Facilitated through a community health center in which about half of patients had Medicaid insurance, the study—published in Clinical Gastroenterology and Hepatology—provides insights about how to boost screenings among groups ...

HOUSTON, May 16, 2024 – Thermoelectric materials could play an important role in the clean energy transition, as they can produce electricity from sources of heat that would otherwise go to waste without generating additional greenhouse gases or requiring large up-front investment. But their promise has been slowed by the fact that most current thermoelectric materials don’t efficiently produce enough power to be useful for many practical applications. The search for new, more efficient materials involving complex chemical ...

About The Study: The results of this study suggest that artificial intelligence may be associated with enhanced patient care and oncological decision-making in patients with oropharyngeal squamous cell carcinoma through detection of localized versus advanced cancer stages. Further model refinement and external validation with electronic health records at different institutions are necessary to improve algorithm accuracy and clinical applicability. Corresponding Author: To contact the corresponding author, Antoine Eskander, M.D., email antoine.eskander@mail.utoronto.ca. To access the ...

Water shortages are expanding across the Earth. This is particularly acute in desert areas of the Middle East that are subject to both drought and extreme conditions such as flooding. As a result of these uncertainties, there is an increasing reliance on shallow aquifers to mitigate these shortages. However, the characteristics of these aquifers remain poorly understood due to the reliance on sporadic well logs for their management. To address this challenge a team of researchers at the USC Viterbi School of Engineering Ming Hsieh Department of Electrical and Computer Engineering along with collaborators ...

Women’s health experts from the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai will present new research at the 2024 American College of Obstetricians and Gynecologists (ACOG) Annual Clinical and Scientific Meeting in San Francisco from May 17–19. Please let me know if you would like to coordinate an interview about their forthcoming presentations. Mount Sinai obstetricians and gynecologists are also available to comment on breaking news and other trending topics on prenatal care and women’s ...