The genetic material, in the form of DNA, contains the information that is crucial for the correct functioning of every human and animal cell. From this information repository, RNA, an intermediate between DNA and protein, the functional unit of the cell, is generated. During this process, the genetic information must be tailored for specific cell functions. Information that is not needed (introns) is cut out of the RNA and the important components for proteins (exons) are preserved. A team of researchers led by Professor Dr Mirka Uhlirova at the University of Cologne’s CECAD Cluster of ...

RICHLAND, Wash.—Doctors have nearly a dozen new targeted drugs to treat patients with acute myeloid leukemia, or AML, yet three of four patients still die within five years. Some patients succumb within just a month or two, despite the battery of drugs used to treat the aggressive blood disease, where blood cells don’t develop properly.   A new study draws on a field of science known as proteogenomics to try to improve the outlook. In a paper published Jan. 16 in Cell Reports Medicine, scientists report new ...

Oxidation can degrade the properties and functionality of metals. However, a research team co-led by scientists from City University of Hong Kong (CityU) recently found that severely oxidized metallic glass nanotubes can attain an ultrahigh recoverable elastic strain, outperforming most conventional super-elastic metals. They also discovered the physical mechanisms underpinning this super-elasticity. Their discovery implies that oxidation in low-dimension metallic glass can result in unique properties for ...

One of the study authors, Professor Hans Frankort, Professor of Strategy at Bayes Business School, City, University of London, said: “Sports – particularly motorsports – can be a good proxy for several other industries as they are extremely competitive: if you don’t perform and progress you may be out. Workers in sectors such as consultancy and financial services face similar pressures.” The peer reviewed paper, which has been published on the website of the Academy of Management Journal, found that riders systematically adjusted their internal ...

The Speech Accessibility Project has begun recruiting U.S. and Puerto Rican adults who have had a stroke. Those interested can sign up online. Funded by Big Tech companies Amazon, Apple, Google, Meta, and Microsoft, the University of Illinois Urbana-Champaign aims to train voice recognition technologies to understand people with diverse speech patterns and disabilities. The project is also recruiting adults with Parkinson’s disease, Down syndrome, cerebral palsy, and amyotrophic lateral sclerosis. “A stroke can cause big changes, including changes to your ability to speak,” said Mark Hasegawa-Johnson, the project’s ...

DALLAS, Feb. 2, 2024 — Black Americans have the highest incidence of cardiac arrest outside of the hospital and are significantly less likely to survive.[1] Cardiac arrest in Black neighborhoods is associated with alarmingly low treatment and survival rates and recent studies have shown lower rates of both bystander CPR and bystander AED use in these neighborhoods. Recognizing the unique intersection of American Heart Month and Black History Month, the American Heart Association, celebrating 100 years of service saving lives, marks the occasion by honoring ...

PHILADELPHIA, PA – NRG Oncology (NRG), a National Cancer Institute (NCI) National Clinical Trials Network (NCTN) group, recently announced that they have named two health equity fellows as a part of the organization’s Health Equity Fellowship Program. Fellowship awardees include Dr. Onyinye Balogun and Dr. Stephanie Rieder. NRG’s Health Equity Fellowship Program was established by Joan Walker, MD, of the University of Oklahoma and an NRG NCI Community Oncology Research Program (NCORP) Principal Investigator, to train selected ...

LAWRENCE — The study of “exoplanets,” the sci-fi-sounding name for all planets in the cosmos beyond our own solar system, is a pretty new field. Mainly, exoplanet researchers like those in the ExoLab at the University of Kansas use data from space-borne telescopes such as the Hubble Space Telescope and Webb Space Telescope. Whenever news headlines offer findings of “Earth-like” planets or planets with the potential to support humanity, they’re talking about exoplanets within our own Milky Way. Jonathan Brande, a doctoral candidate in the ExoLab at the University of Kansas, has just published findings in the open-access ...

East Hanover, NJ – February 2, 2024 – Labor market indicators showed slight declines over the last two months for both people with and without disabilities, according to today’s National Trends in Disability Employment – semi-monthly update (nTIDE), issued by Kessler Foundation and the University of New Hampshire’s Institute on Disability (UNH-IOD). These declines may reflect the end of seasonal employment and the impact of the Federal Reserve’s anti-inflationary measures aimed at minimizing the risk of recession. ...

WASHINGTON  –  U.S. Naval Research Laboratory (NRL) meteorologists, in partnership with NASA, will join a team of international scientists to participate in the Airborne and Satellite Investigation of Asian Air Quality (ASIA-AQ) experiment beginning on February 2.   NRL’s collaborators, David Peterson, Ph.D., meteorologist, Theodore McHardy, Ph.D., American Society for Engineering Education postdoctoral researcher, Nicholas Gapp, Science Applications International Corporation ...

New research has shown a new type of inhibitor drug could prevent microvascular diabetic complications, such as diabetic eye and kidney disease.  The University of Bristol-led research is published in Cardiovascular Diabetology. Diabetes, a disease which results in uncontrolled blood glucose levels, is estimated to affect one in 11 adults worldwide.  Even when managed, this common disease can result in life-altering complications, impacting the small blood vessels of the body, known as the microvasculature.   While treatments ...

The University of Tennessee, Knoxville, continued to expand its impact and research footprint last year, breaking university records for both research expenditures and sponsored project awards for the second straight year. Since 2019, UT has more than doubled its sponsored project awards, reaching a record $428 million in the fiscal year that ended in June 2023. The university also reported $339 million in research expenditures in fiscal year 2023, an increase of nearly $15 million over fiscal year 2022 and the highest amount in UT history. Research expenditures include internal and external funds that support UT research ...

In the fossil record, trees typically are preserved with only their trunks. They don’t usually include any leaves to show what their canopies and overall forms may have looked like. But now, researchers reporting in the journal Current Biology on February 2 describe fossilized trees from New Brunswick, Canada with a surprising and unique three-dimensional crown shape.  “The way in which this tree produced hugely long leaves around its spindly trunk, and the sheer number over a short length of trunk, is startling,” says Robert Gastaldo of Colby College in Waterville, Maine. The forms taken by these ...

Embargoed until 11am ET USA/4pm GMT UK on Friday 2 February (Current Biology embargo) -With pictures- Fruit flies have provided scientists with new insight into the genetic basis for the rapid evolution of male external genitalia driven by sexual selection. Secondary sexual characteristics such as peacocks’ tails and the male external genitalia of insects are known to be among the fastest evolving animal body parts. It is thought that this is driven by sexual selection including through female choice and the different evolutionary needs of each sex to find the right mate and maximise their fitness. Now scientists at Durham University and Oxford ...

About The Study: The findings of this study of 1,404 mental health treatment facilities indicate that there were no differences in the availability of mental telehealth services based on the prospective patient’s clinical condition, perceived race or ethnicity, or sex; however, differences were found at the facility-, county-, and state-level. These findings suggest widespread disparities in who has access to which telehealth services throughout the U.S.  Authors: Jonathan Cantor, Ph.D., of the RAND Corporation in Santa Monica, California, is the corresponding author. To access the embargoed study: Visit ...

About The Study: This study including 432,000 patients who underwent major surgery for eight cancer types found an increased rate of venous thromboembolism associated with cancer surgery. The risk persisted for about two to four months postoperatively but varied between cancer types. The increased rate is likely explained by the underlying cancer disease and adjuvant treatments. The results highlight the need for individualized venous thromboembolism risk evaluation and prophylaxis regimens for patients undergoing different surgery for different cancers. Authors: Johan ...

Telehealth availability for mental health care varies significantly across states -- from less than half of treatment facilities contacted in states like Mississippi and South Carolina to every facility contacted in states like Maine and Oregon, according to a new RAND study.   Researchers found there were differences in services offered depending on whether a mental health treatment facility was located in in a rural or metropolitan area.   The types of services offered -- and the types of telehealth modalities available -- also varied widely among ...

About The Study: The results of this study of 89,000 adults suggest that wellness visits and preventive health screenings in the U.S. have not returned to pre-pandemic levels. Screening rates for blood pressure, cholesterol, blood glucose, and common cancers were lower in 2021 versus 2019, and varied across racial and ethnic groups, with Asian adults experiencing the most pronounced declines. These findings support the need for public health efforts to increase the use of preventive health screenings among eligible adults.  Authors: Rishi K. Wadhera, ...

A team of researchers from the Badalona Applied Research Group in Oncology (B·ARGO) and the Urologic Tumours Unit of the Institut Català d'Oncologia (ICO) and the Germans Trias i Pujol Research Institute (IGTP) have found a new therapeutic strategy for patients with a specific subtype of metastatic prostate cancer resistant to standard chemotherapy treatment with docetaxel. In this study, published in the journal Frontiers in Pharmacology, they propose a new treatment based on a combination of kinase inhibitors in patients who inevitably stop responding to docetaxel. The team found that resistance to this drug is associated with the hyperactivation ...

The aim of this clinical trial, which has just received approval in France, is to assess the safety and efficacy of a new gene therapy drug in children aged between 6 and 31 months with profound hearing loss. Audiogene was developed by a French consortium composed of teams from the Hearing Institute, an Institut Pasteur research center; the ENT Department and Pediatric Audiology Research Center at Necker-Enfants Malades Hospital (AP-HP); Sensorion and Fondation Pour l'Audition. The trial has also been submitted to other European countries and is currently undergoing assessment. Audiogene is the first clinical trial in France to test a gene therapy drug, SENS-501, ...

A new vaccine shows encouraging early results as a potential off-the-shelf treatment for certain patients with pancreatic or colorectal cancer, according to a study co-led by researchers at Memorial Sloan Kettering Cancer Center (MSK). The vaccine targets tumors with mutations (or changes) in the KRAS gene, a driving force in many cancers. This cancer vaccine is different from another type of pancreatic cancer vaccine, which is custom-made for each patient using messenger RNA (mRNA). Both are therapeutic vaccines given after surgery ...

There has been significant progress in the field of quantum computing. Big global players, such as Google and IBM, are already offering cloud-based quantum computing services. However, quantum computers cannot yet help with problems that occur when standard computers reach the limits of their capacities because the availability of qubits or quantum bits, i.e., the basic units of quantum information, is still insufficient. One of the reasons for this is that bare qubits are not of immediate use for running a quantum algorithm. While the binary bits of customary computers store information in the form of fixed values of either 0 or 1, qubits can represent 0 and ...

Researchers at the University of São Paulo (USP) and the Federal University of Viçosa (UFV) in Brazil have developed a sustainable sensor that can be placed directly on the surface of a vegetable or fruit to detect the presence of pesticides. Known for this reason as “plant-wearable”, it is made of cellulose acetate, a material derived from wood pulp. The device has the potential to help assure food safety in a world that increasingly suffers from a shortage of food and the environmental and health problems caused ...

CHAMPAIGN, Ill. — As demand for food from restaurants soars in the U.S., so does the importance in understanding the impacts of foodborne illness outbreaks. A new paper co-written by a University of Illinois Urbana-Champaign expert in food marketing and food policy finds that outbreaks spanning multiple states bring swift financial losses, increased media attention and a public-relations hit that makes smaller outbreaks more financially damaging.  In the U.S., more than 60% of foodborne illness outbreaks occur at restaurants, and the vast majority of those outbreaks are confined ...

As the effectiveness of radiotherapy varies greatly between tumours, finding gene signatures to predict the radiation response could better guide the clinicians to personalize treatment plans. Professor Venkata Manem, affiliated with the Faculty of Medicine at Université Laval and the Centre de recherche CHU de Québec - Université Laval, has made a promising step to advance pre-clinical research in the field of precision radiation oncology. Currently, doctors use a “one-size-fits-all” paradigm for radiotherapy, with a given dose and frequency ...