COLUMBUS, Ohio – Scientists have found that eliminating an enzyme from mice with symptoms of Alzheimer's disease leads to a 90 percent reduction in the compounds responsible for formation of the plaques linked to Alzheimer's disease. That is the most dramatic reduction in this compound reported to date in published research. The compounds are amyloid beta, or A-beta peptides; peptides are proteins, but are shorter in length. When A-beta peptides accumulate in excessive amounts in the brain, they can form plaques, which are a hallmark of Alzheimer's disease. "These ...

The United Kingdom is preparing to convert the London 2012 Olympics anti-doping center, which conducted more than 6,000 drug tests on athletes during the Olympic and Paralympic Games, into a facility that could help revolutionize 21st century health care. That new facility — the world's first national "phenome center" — is the topic of a story in the current edition of Chemical & Engineering News (C&EN). C&EN is the weekly newsmagazine of the American Chemical Society, the world's largest scientific society. Alex Scott, C&EN senior editor in London, explains that a phenome ...

The Canadian government's plans to discontinue in 2013 a unique environmental research project that has yielded insights into water pollution, climate change and other topics for almost 40 years would be a "huge loss not only to science but to the scientific heritage of humanity." That's the focus of a viewpoint article in ACS' journal Environmental Science & Technology. J. G. Hering, D. L. Swackhamer and W. H. Schlesinger explain that the Experimental Lakes Area (ELA) comprises 58 freshwater lakes and their watersheds in remote areas of the province of Ontario, where ...

The great Italian scientist Galileo may have been the first person to use a telescope to observe the heavens, helping spark the scientific revolution of the 16th century, but Galileo definitely did not invent the famous thermometer and captivating curiosity that bears his name. That's the message of an article in ACS' Journal of Chemical Education. Peter Loyson explains that a number of companies sell so-called "Galilean thermometers," sealed tubes of liquid in which glass spheres float and sink with changes in ambient temperature. Modern versions have morphed into elegant ...

Borrowing a technology used to improve the effectiveness of drugs, scientists are reporting discovery of a new explosive more powerful than the current state-of-the-art explosive used by the military, and just as safe for personnel to handle. Their report appears in ACS' journal Crystal Growth & Design. Adam J. Matzger and colleagues explain that a technique for engineering medicines and other materials, termed cocrystallization, is attracting attention as a way to make improved explosives, rocket propellants and fireworks. Most solid materials consist of crystals — with ...

New Rochelle, NY, September 5, 2012—A group of experts has developed consensus recommendations for future research directions to determine why nearly two-thirds of Americans with Alzheimer's disease (AD) are women. The recommendations are published in a Roundtable discussion in Journal of Women's Health, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Women's Health website at http://www.liebertpub.com/jwh. An estimated 5.4 million Americans are affected by AD and related dementias, and that number will ...

Children exposed in the womb to the widely used pesticide additive piperonyl butoxide (PBO) have heightened risk of noninfectious cough at ages 5 and 6, according to researchers at the Columbia Center for Children's Environmental Health (CCCEH) at the Mailman School of Public Health and of Columbia University Medical Center. The findings, which appear in the August 31 online edition of the journal Environment International, support the premise that the children's respiratory system is susceptible to damage from toxic exposures during the prenatal period. A common symptom, ...

COLUMBIA, Mo. – About 73 percent of online American teens use social networking sites, such as Facebook, to share photos, interests and experiences with others, according to Pew Research Center. For youths in the foster care system, sharing information online presents additional safety and privacy issues. A University of Missouri researcher recommends that child welfare agencies develop policies to guide how adolescents in foster care use social media. Dale Fitch, an assistant professor in the MU School of Social Work, says agencies usually advocate restricting how youths ...

UCLA stem cell scientists have shown that two common tumor suppressor genes, TSC and PTEN, are vital to regulating the stem cell-like precursor cells that create the blood supply in Drosophila, the common fruit fly. The researchers examined a signaling pathway called TOR that the cells use to gauge nutrition levels and stress, said study senior author Dr. Julian A. Martinez-Agosto, an assistant professor of human genetics and pediatrics and a researcher with the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA. "We wondered how an ...

Higher average temperatures and increasing salt concentrations are stress factors that many ecosystems face today in the wake of climate change. However, do all ecosystems react to stress in the same way and what impact does stress have on ecosystem services, such as biomass production? Botanists and ecologists from the universities of Zurich and Göttingen demonstrate that a high level of biodiversity aids stress resistance. Higher number of species leads to greater stress resistance The scientists studied a total of 64 species of single-celled microalgae from the SAG ...

West Orange, NJ. September 5, 2012. Kessler Foundation has released preliminary research findings from its clinical study of the wearable robotic exoskeletal device, Ekso (Ekso Bionics). Gail Forrest, PhD, assistant director of Human Performance and Engineering Research, presented the Ekso research data on September 3, at the meeting of the Academy of Spinal Cord Injury Professionals at the Rio Suites in Las Vegas. Dr. Forrest directs mobility research at the Foundation, including activity-based locomotor therapy, functional electrical stimulation, and treadmill training ...

Research from Karolinska Institutet in Sweden shows that sorafenib, a drug used for advanced cancer of the kidneys and liver, could also be effective against multiple myeloma. The disease is one of the more common forms of blood cancer and is generally incurable. "Recently developed drugs, like bortezomib, have increased the survival rate for people with this serious and complex disease," says study leader Theocharis Panaretakis, docent of experimental oncology. "Having said this, the heterogeneity of the disease progression, the treatment response and the development ...

It has long been believed that drinking green tea is good for the memory. Now researchers have discovered how the chemical properties of China's favorite drink affect the generation of brain cells, providing benefits for memory and spatial learning. The research is published in Molecular Nutrition & Food Research. "Green tea is a popular beverage across the world," said Professor Yun Bai from the Third Military Medical University, Chongqing, China. "There has been plenty of scientific attention on its use in helping prevent cardiovascular diseases, but now there is emerging ...

New Rochelle, NY, September 5, 2012—According to the Centers for Disease Control and Prevention (CDC), 1 in 88 children in the U.S. has autism spectrum disorder (ASD), a broad group of neurodevelopmental disorders. Children and adolescents with ASD are typically fascinated by screen-based technology such as videogames and these can be used for educational and treatment purposes as described in an insightful Roundtable Discussion published in Games for Health Journal: Research Development, and Clinical Applications, a peer-reviewed publication from Mary Ann Liebert, Inc.. ...

Climate change, pollution, the extraction of water for irrigation and overfishing all threaten the survival of the common trout. This fish is very sensitive to changes in its environment and, according to the Spanish study, its habitat will have reduced by half by the year 2040 and will have completely disappeared from Iberian rivers by 2100, so its population will become extinct. Global warming is threatening the existence of many fish species, especially those in the salmonid family, which are sensitive to temperature changes as they require clear and fresh water to ...

ROCHESTER, Minn. -- Rheumatoid arthritis alone is painful and disabling, but it also puts patients at higher risk of death. The greater susceptibility to infections that accompanies the autoimmune disorder is one reason. Assessing the danger of infection a particular patient faces so it can be addressed can prove challenging for physicians. A Mayo Clinic study finds that a risk score can be developed to predict a patient's chances of having serious infections. The score uses information about how rheumatoid arthritis is affecting a patient, plus factors including age, corticosteroid ...

This press release is available in German. In about half of all prostate tumours, there are two genetic areas that are fused with one another. When this is not the case, the exact way cancer cells originate in prostate tumours was not clear until now. Scientists at the Max Planck Institute for Molecular Genetics in Berlin, in cooperation with a team of international researchers, were able to show that the genesis of this fusion-negative prostate cancer has epigenetic causes: methyl groups are distributed differently over the DNA in the cancer cells than in healthy cells. ...

Medical Systems Virology group at the Institute for Molecular Medicine Finland (FIMM) at the University of Helsinki, together with its national and international collaborators, developed a new cell screening method that can be used to identify potential anti-influenza drugs. The researchers were able to identify two novel compounds with anti-influenza activity, obatoclax and gemcitabine and prove the efficacy of a previously known drug saliphenylhalamide. The study was recently accepted for publication in the Journal of Biological Chemistry and is now available online. Influenza ...

Like all sources of information, DNA sequences come in various degrees of quality and reliability. To identify, proof, and discard compromised molecular data has thus become a critical component of the scientific endeavor - one that everyone generating sequence data is assumed to carry out before using the sequences for research purposes. "Many researchers find sequence quality control difficult, though", says Dr. Henrik Nilsson of the University of Gothenburg and the lead author of a new article on sequence reliability, published in the Open Access journal MycoKeys. ...

Archaeologists from the University of Leicester who are leading the search for King Richard III have announced they have overcome the first significant hurdle of their investigation – and made a huge step forward in the search for the King by locating the church where he was buried. The University of Leicester is leading the archaeological search for the burial place of King Richard III with Leicester City Council, in association with the Richard III Society. In 1485 King Richard III was defeated at the battle of Bosworth. His body, stripped and despoiled, was brought ...

WOMEN having surgery for breast cancer are up to three times more likely to have severe pain in the first week after surgery if they suffer from other painful conditions, such as arthritis, low back pain and migraine, according to a Cancer Research UK study published today (Wednesday) in the British Journal of Cancer. Of the women surveyed, 41 per cent reported moderate to severe pain at rest, and 50 per cent on movement, one week after their surgery. Most patients having breast cancer surgery are discharged home by this time. Psychological state was also important, ...

Almost all of us have been tempted to lie at some point, whether about our GPA, our annual income, or our age. But what makes us actually do it? In a study forthcoming in Psychological Science, a journal of the Association for Psychological Science, psychological scientists Shaul Shalvi of the University of Amsterdam and Ori Eldar and Yoella Bereby-Meyer of Ben Gurion University investigated what factors influence dishonest behavior. Previous research shows that a person's first instinct is to serve his or her own self-interest. And research also shows that people are ...

Children exposed to diethyl phthalate (DEP) and butylbenzyl phthalate (BBzP)—phthalate chemicals commonly found in personal care and plastic products—have elevated risk of asthma-related airway inflammation, according to researchers at Columbia Center for Children's Environmental Health (CCCEH) at the Mailman School of Public Health. Of the 244 children aged 5 to 9 in the study, all had detectable levels of phthalates in their urine although these varied over a wide range. Higher levels of both phthalates were associated with higher levels of nitric oxide in exhaled ...

The drug telaprevir (trade name: Incivo®) has been available for treatment of chronic hepatitis C infection of genotype 1 since autumn 2011. In an early benefit assessment pursuant to the "Act on the Reform of the Market for Medicinal Products" (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) examined whether telaprevir offers an added benefit compared with the present standard therapy. According to the findings of the assessment, the new drug telaprevir offers advantages in various groups of patients with chronic hepatitis C infection ...

Durham, NC — A new study of deep-sea species across the globe aims to understand how natural gradients in food and temperature in the dark, frigid waters of the deep sea affect the snails, clams, and other creatures that live there. Similar studies have been conducted for animals in the shallow oceans, but our understanding of the impact of food and temperature on life in the deep sea — the Earth's largest and most remote ecosystem — has been more limited. The results will help scientists understand what to expect in the deep sea under future climate change, the researchers ...