Analysis of data from more than 1 million Danish inpatients identifies nearly 4,000 drug pairings that are associated with more frequent dosage adjustments when prescribed together—potentially hinting at previously undiscovered drug interactions. Søren Brunak of the University of Copenhagen, Denmark, and colleagues present these findings in the open-access journal PLOS Digital Health. In some cases, especially among elderly populations, a person may be prescribed several different medications at once in order to treat one or multiple health conditions—a phenomenon known as polypharmacy. Polypharmacy is associated with increased health risks due to the potential ...

Chronic stress is associated with sleep disturbance. In their new study, Lu Huang and colleagues identify the neural pathway behind this behavior, and at the same time, explain how bright-light treatment is able to counter it. The research was conducted in mice at Jinan University in China and published September 7th in the open access journal PLOS Biology. Bright-light treatment is known to improve sleep in those with sleep disorders, but how it works – and whether it works in cases of stress-induced sleep disturbances – was unknown. The researchers hypothesized that a part of the brain called the lateral habenula is deeply involved in this phenomenon because ...

A ‘near total’ lack of transparency is making it impossible to assess the quality of corporate-led ecosystem restoration projects, according to a Lancaster University-led study published today in Science. Efforts to rebuild degraded environments are vital for achieving global biodiversity targets. The United Nations has launched a Decade on Ecosystem Restoration, and in recent years businesses around the world have collectively pledged to plant billions of trees, hundreds of thousands of corals and tens of ...

An implantable sensor provided advanced warning of kidney transplant failure in rats as much as several weeks earlier than commonly used biomarkers of kidney function, researchers report. The device, tested in a rat model of kidney transplantation, provides real-time continuous monitoring of organ temperature and thermal conductivity, detecting inflammatory processes associated with graft rejection. Although lifesaving for patients with end-stage kidney disease, long-term kidney transplantation survival remains a major challenge. Graft failure ...

In 2022, the eruption of the submerged Hunga Tonga–Hunga Ha apai volcano triggered a fast-moving and destructive underwater debris flow that severed telecommunication cables and reshaped the surrounding seafloor. The findings – representing some of the first fieldwork to document what happens when large volumes of erupted volcanic material are delivered directly into the ocean – provide new insights into the behavior and hazards of submerged volcanoes. Explosive volcanic eruptions on land create pyroclastic flows of hot ash and rock that, when they reach the ocean, can trigger damaging ...

Large transnational corporations (TNCs) are positioning themselves as environmental leaders, carrying out environmental restoration projects that go beyond their legal obligations. However, some corporations oversell their efforts. In this Policy Forum, Timothy Lamont and colleagues present an evaluation of sustainability reports of 100 of the world’s largest businesses, revealing the extent to which TNCs are claiming to contribute to, but failing to report on, ecosystem restoration. “Increased rigor, consistency, transparency, and accountability are needed to ensure that corporate-led restoration delivers quantifiable, ...

In 2021, more than 400 million metric tons of plastic waste were produced worldwide, and it is predicted that the world’s plastic waste growth will continue to outpace the efforts to reduce plastic pollution in the coming decades. As food delivery services became increasingly popular during the COVID-19 pandemic, the surge in plastic waste generated by single-use cutlery has become a key environmental challenge for many countries. A new study finds “green nudges” that encouraged customers to skip asking for cutlery with their delivery orders were dramatically successful and could be a powerful policy tool to reduce plastic waste. “Few policies target plastic waste ...

A body can reject a transplanted organ at any time — even decades later Signs of rejection must be caught early to intervene, preserve the organ Current monitoring methods are intermittent, imperfect and sometimes invasive New implant offers continuous monitoring by tracking the organ’s temperature When temperatures change, an alert is sent to a smartphone or tablet in real time EVANSTON, Ill. — Northwestern University researchers have developed the first electronic device for continuously monitoring ...

Who can forget the stomach-churning moments when “Survivor” contestants forced down crunchy insects, among other unappetizing edibles, for a chance to win $1 million? In daring culinary challenges, the TV show’s contestants exhibited gastronomic bravery as viewers watched in discomfort. Digesting a crunchy critter starts with the audible grinding of its rigid protective covering — the exoskeleton. Unpalatable as it may sound, the hard cover might be good for the metabolism, according to a new study, in mice, from Washington University School of Medicine ...

People who primarily use their own gut feeling to determine what is true and false are more likely to believe conspiracy theories. That is the conclusion of researchers at Linköping University, Sweden, who have investigated the relationship between susceptibility to misleading information and the conviction that the truth is relative.  “I think many people who emphasise a more relativistic view of what truth is mean well. They believe that it’s important that everyone should be able to make their voice heard. But these results show that such a view can actually be quite dangerous,” says PhD student ...

DALLAS and Al Mubarraz, Kingdom of Saudi Arabia, September 7, 2023 — Almoosa Specialist Hospital, in Al Ahsa, Saudi Arabia has been recognized by the American Heart Association, the world's leading nonprofit organization focused on heart and brain health for all, as a the first Comprehensive Chest Pain Center in the country. This designation signifies the hospital’s status as a critical element in the kingdom’s effort to create a system of healthcare that seeks to save lives in Saudi Arabia by closing the gaps ...

September 7, 2023 – A growing body of evidence suggests that psychedelic drugs may be useful in treating various mental health conditions. However, many challenges remain in defining their clinical benefits and overcoming the complex regulatory obstacles to their use. The September issue of Journal of Psychiatric Practice presents a research review and update on therapeutic use of psychedelics – focusing on the use of psilocybin for treatment of depression. The journal is published in ...

Using NASA’s Neil Gehrels Swift Observatory, which launched in 2004, scientists have discovered a black hole in a distant galaxy repeatedly nibbling on a Sun-like star. The object heralds a new era of Swift science made possible by a novel method for analyzing data from the satellite’s X-ray Telescope (XRT). “Swift’s hardware, software, and the skills of its international team have enabled it to adapt to new areas of astrophysics over its lifetime,” said Phil Evans, an astrophysicist at the University of Leicester in the United Kingdom and longtime Swift team member. “Neil Gehrels, the ...

MINNEAPOLIS/ST. PAUL (09/07/2023) — Recently published research from the University of Minnesota Medical School suggests individuals with hepatitis C should consider revaccination for hepatitis B. The study was published in the Journal of Infectious Diseases. Previous research has shown individuals with hepatitis C infection have a lower response to the hepatitis B virus (HBV) vaccine.  “This study has broad implications for public health in hepatitis-infected individuals,” said Jose Debes, MD, PhD, an ...

Utility companies are generally well-equipped to handle routine blackouts, but often struggle with extreme weather events like hurricanes.  Conventional hurricane power-outage prediction models often produce incomplete or incorrect results, hampering companies’ abilities to prepare to restore power as quickly as possible, especially in cities that are susceptible to prolonged hurricane-induced power outages.  New research from NYU Tandon School of Engineering may help solve that problem. By combining wind speed and precipitation ...

UNIVERSITY PARK, Pa. — When dairy cows are fed diets with reduced protein concentrations — aimed at decreased environmental nitrogen pollution from their manure such as nitrate leaching, nutrient-laden run-off and ammonia volatilization — their milk production can suffer. Supplementing the amino acid histidine may help in maintaining, and even increasing, milk and milk-protein yields. That’s the conclusion of a new study conducted by an international research team led by Alexander Hristov, Penn State distinguished ...

From the Middle Ages to the Enlightenment, “monstrous births”—malformed or anomalous fetuses—were, to Western medicine, an object of superstition. In 19th-century America, they became instead an object of the “modern scientific study of monstrosity,” a field formalized by French scientist Isidore Geoffroy Saint-Hilaire. This clinical turn was positioned against the backdrop of social, political, and economic activity that codified laws governing slavery, citizenship, immigration, family, ...

(Santa Barbara, Calif.) — Every day we encounter circumstances we consider wrong: a starving child, a corrupt politician, an unfaithful partner, a fraudulent scientist. These examples highlight several moral issues, including matters of care, fairness and betrayal. But does anything unite them all? Philosophers, psychologists and neuroscientists have passionately argued whether moral judgments share something distinctive that separates them from non-moral matters. Moral monists claim that morality is unified by a common characteristic and that all moral issues involve concerns about harm. Pluralists, in contrast, argue that moral ...

Large-bodied mammals play crucial roles in ecosystems. They create habitats, serve as prey, help plants thrive, and even influence how wildfires burn. But now, fewer than half of the large mammal species that were alive 50,000 years ago exist today, and those that remain are threatened with extinction from intensifying climate change and human activities. While mammal extinctions are well-documented, very little research has explored the impact those losses had on the nuanced ways in which mammal communities interact with their environments. Researchers at the Georgia Institute of Technology are using a novel methodology to investigate how mammals’ ability to function in their environments ...

(MEMPHIS, Tenn. – September 07, 2023) As many as 5.8 million Americans are currently living with Alzheimer’s disease, a neurodegenerative condition associated with progressive cognitive decline, including loss of memory capabilities . Protein aggregates, composed of beta-amyloid or other proteins, form in the brains of individuals with Alzheimer’s. These beta-amyloid plaques appear to be a significant contributor to the disease. St. Jude Children’s Research Hospital scientists uncovered a subset of immune cells that appears to slow this beta-amyloid plaque accumulation ...

KERI succeeded in transferring the ‘Ion Implantation and its Evaluation Technology for the SiC (silicon carbide) Power Semiconductor’ to a Hungarian company.   Power semiconductors are key components in electricity and electronics, acting as the muscles of the human body by regulating the direction of current and controlling power conversion. There are many different materials for power semiconductors. Among them, SiC is receiving the most attention due to its excellent material properties, including high durability and excellent power efficiency. When SiC power ...

By A.J. Hostetler Led by the director of Virginia Commonwealth University’s Stravitz-Sanyal Institute of Liver Disease and Metabolic Health, a consortium studying noninvasive tests for liver disease has demonstrated the effectiveness of five noninvasive tests, a significant milestone on the path to regulatory approval. In an article published today in the journal Nature Medicine, institute director Arun Sanyal, M.D., a professor at the VCU School of Medicine, and colleagues report on five biomarker tests that potentially could be given to patients who may have ...

About The Study: In this randomized clinical trial including 64 transgender and gender-diverse adults, immediate testosterone therapy compared with no treatment significantly reduced gender dysphoria, depression, and suicidality in transgender and gender-diverse individuals desiring testosterone therapy.  Authors: Ada S. Cheung, M.B.B.S., Ph.D., of Austin Health in Heidelberg, Victoria, Australia, is the corresponding author.  To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamanetworkopen.2023.31919) Editor’s Note: Please see the article for ...

About The Study: Long- and short-term heat exposure during pregnancy was associated with higher risk of severe maternal morbidity in this study with 403,000 pregnancies from 2008 to 2018 in Southern California. These results might have important implications for severe maternal morbidity prevention, particularly in a changing climate.  Authors: Jun Wu, Ph.D., of the University of California, Irvine, is the corresponding author.  To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamanetworkopen.2023.32780) Editor’s Note: Please ...

About The Study: Calcium channel blocker use was adversely associated with glaucoma prevalence in this study of 427,000 adult UK Biobank participants, suggesting that calcium channel blockers may represent an important modifiable risk factor for glaucoma, potentially through an intraocular pressure–independent mechanism.  Authors: Alan Kastner, M.D., M.Sc., of the Moorfields Eye Hospital National Health Service Foundation Trust and University College London Institute of Ophthalmology in London, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamaophthalmol.2023.3877) Editor’s ...