80% of all patient data is unstructured. Notes from a conversation with a GP, the evaluation of a specialist in a university medical centre or even a recommendation from a pharmacist. While this 'unstructured’ data is no problem for the human eye, it presents an unsurmountable challenge to an AI-algorithm. One that is "preventing AI from reaching its full potential," in the view of Amsterdam UMC, Assistant Professor Iacer Calixto. To give AI the helping hand that it needs, Calixto is set to lead a project that will "tackle the important challenges ...

Fusion is the process of combining two light atomic nuclei to form a single heavier one while releasing massive amounts of energy. The Sun and all stars are powered through fusion, which makes it the universe's preferred method of producing energy. Recent breakthroughs in fusion research have led to the US government's Bold Vision for Commercial Fusion Energy and the remarkable growth of the global fusion industry. To accelerate the development of fusion-powered reactors on Earth, the US Department ...

‘Let us remember the lessons of the coronavirus to usher in a new era on a global scale with different personal and collective behaviour so that everyone, not just a few, enjoys the dignified life that is their due. We have to remember that we cannot go back to “pre-COVID”. We have to keep in mind that the circumstances before the pandemic most likely contributed in some way to the situation as have had to live it. A radical change of course is indispensable and urgent…” ~Federico Mayor Zaragoza, Former Director-General of UNESCO and Former Member of the European Parliament. Where did COVID-19 originate? Prof Angus Dalgleish ...

AUGUSTA, Ga. (Sept. 1, 2023) – A nationwide assessment of Obstetrics and Gynecology residency programs reveals the need for more training in how to provide the best care for women going through menopause, according to investigators at the Medical College of Georgia. “When you look at projections over the next few decades, by 2060, there will be around 90 million women in the US alone, who will be in the post-menopausal range,” says  Jennifer Allen, MD, associate professor and director of the Obstetrics and Gynecology Residency Program ...

Disadvantaged teenagers are at greater risk of email scams and need better protection, according to an international study published in the peer-reviewed British Journal of Educational Studies.    Findings based on more than 170,000 students aged 15 show that one in five from low-income families or deprived areas could fall victim to phishing. This is much higher than the probability for the age group overall. Email scams leave people vulnerable to identity theft, putting young people at risk of financial fraud and having their savings stripped.     The most vulnerable are those who also have poor learning skills according to the data from 38 countries including ...

Aqueous rechargeable zinc ion batteries are promising in electric grid storage due to their low cost and intrinsic safety. However, their practical implementation is hindered by poor reversibility of the zinc anode, primarily caused by the chaotic Zn deposition present as dendrite and side reactions. Recently, a research group led by Prof. YANG Weishen and Dr. ZHU Kaiyue from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS) has proposed a strategy of "ion ...

Simple strategies to strengthen your bones, implemented by the whole community not just those at higher risk, could lead to a substantial decrease in hip fractures, a new Australian study suggests. A hip fracture, particularly in the elderly, dramatically increases the risk of death. Around 37 per cent of men and 20 per cent of women die within one year of a hip fracture. It also causes significant pain and suffering, loss of mobility and independence, and increased healthcare costs. Distinguished Professor Tuan Nguyen, ...

FINDINGS People from socioeconomically distressed communities who underwent heart transplantation between 2004 and 2018 faced a 10% greater relative risk of experiencing graft failure and dying within five years compared to people from non-distressed communities. In addition, following implementation of the 2018 UNOS Heart Allocation policy, transplant recipients between 2018 and 2022 faced an approximately 20% increase in relative risk of dying or experiencing graft failure within three years compared with the pre-policy period. This is despite the ...

UNIVERSITY PARK, Pa. — Hydrogen spillover is exactly what it sounds like. Small metal nanoparticles anchored on a thermally stable oxide, like silica, comprise a major class of catalysts, which are substances used to accelerate chemical reactions without being consumed themselves. The catalytic reaction usually occurs on the reactive — and expensive — metal, but on some catalysts, hydrogen atom-like equivalents literally spill from the metal to the oxide. These hydrogen-on-oxide species are called "hydrogen ...

DETROIT – Neuroscience researchers at Wayne State University published a review article that confirms the usefulness of neurofilament light (NfL) blood levels to predict the likelihood and rate of progression of neurodegeneration in Alzheimer’s disease. Blood-based NfL is a minimally invasive and easily accessible biomarker, making it a useful clinical biomarker. Youjin Jung and Jessica Damoiseaux, Ph.D., analyzed existing literature to examine the association between serum or plasma NfL and ...

Cedars-Sinai investigators are leaders in the innovation and use of transcatheter aortic valve replacement (TAVR) with balloon-expandable valves. They now show that redo TAVR procedures are both safe and effective when compared with situations in which patients with similar risk profiles undergo the same procedure for the first time.    The novel findings, published today in the peer-reviewed journal The Lancet, are significant because recent randomized clinical trials have shown that TAVR is a meaningful treatment option for both younger and lower-risk surgical ...

Research funded by the National Institute for Health and Care Research (NIHR) has shown that higher levels of inflammation in the blood of patients with obesity undergoing bariatric surgery predicts poorer weight loss six months after the procedure. Published in Psychological Medicine and led by researchers from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King’s College London, this is the first study to investigate the links between depression and inflammation in patients with obesity before and after bariatric surgery. The analysis showed a strong relationship ...

*Note- this is an early release from the Annual Meeting of the European Association for the Study of Diabetes (EASD) meeting in Hamburg, October 2-6. Please credit the meeting if you use this story* New research to be presented at this year’s Annual Meeting of the European Association for the Study of Diabetes (EASD) in Hamburg, Germany (2-6 October) shows that use of low dose (100mg daily) aspirin among older adults aged 65 years and older is associated with a 15% lower risk of developing type 2 diabetes. The authors, led by Professor Sophia Zoungas, School of Public Health and Preventive Medicine, ...

URBANA, Ill. — Love it or hate it, broccoli is chock-full of health-promoting chemicals linked to heart health, cancer prevention, immune function, weight management, and more. However,  some people are less efficient than others at unlocking those chemical benefits. A research team at the University of Illinois Urbana-Champaign suggests gut microbe communities may be responsible for the variation. With a new grant from the USDA’s National Institute of Food and Agriculture, the team plans to identify which microbes maximize the benefits of broccoli and other brassica ...

In the intricate world of light, a journey through inhomogeneous media often leads to distortions in space, time, spectrum, and polarization. These distortions, detrimental to applications like optical manipulation, imaging, and communication, have long posed a challenge. Enter the art of wavefront shaping (WS) — a potent tool for correcting these wave maladies in linear optics. But that's not all. Nonlinearity adds a twist, finding purpose in fields from biological sensing to phototherapy. Now, picture combining these forces — ...

COLUMBUS, Ohio – Scientists have established the effectiveness of vaccines they developed to prevent the disfiguring skin disease leishmaniasis in animal studies, and Phase 1 human trial planning is in motion for the most promising candidate. But in new work, the research team has determined how these vaccine candidates, created using mutated disease-causing parasites, prompt molecular-level changes in host cells that have specific roles in helping generate the immune response. Despite using the same CRISPR ...

Since 2009, the number of veterans experiencing homelessness across the United States has shrunk by more than 50%, according to a 2022 Department of Housing report. With the support of a $150,000 grant from the Department of Veterans Affairs (VA), the University of Missouri School of Law Veterans Clinic is aiming to continue this trend here at home with a new program designed to further empower veterans in taking steps out of homelessness. The Veterans Outreach Program will help attorneys connect with veterans experiencing homelessness with the goal of offering them the legal assistance ...

Although the COVID-19 pandemic was the first time most of humanity learned of the now infamous disease, the family of coronaviruses was first identified in the mid-1960s. In a new study, molecular biologist Steven Van Doren, a scientist in the University of Missouri College of Agriculture, Food and Natural Resources, has uncovered unexpected actions of a key player in how the coronavirus infects its target — a discovery that could guide further vaccine development. Funded by a National Science Foundation (NSF) grant, Van Doren and his team studied the fusion peptide, an important feature of the spike protein that serves to bind the virus with ...

“To our knowledge, our study is the first to evaluate the specific function of Dectin-1 in the setting of aging and HIV-infection.” BUFFALO, NY- August 31, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 16, entitled, “Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging.” Dectin-1 is an innate immune receptor that recognizes and binds β-1, 3/1, 6 glucans on fungi. In this new study, researchers Archit Kumar, Jiawei Wang, Allen Esterly, Chris ...

A recent study published in Nature Metabolism has revealed the pathogenic mechanism underlying a rare pediatric neurodegenerative disorder known as mitochondrial enoyl reductase protein-associated neurodegeneration (MEPAN) syndrome. The study was led by Dr. Hugo J. Bellen, distinguished service professor at Baylor College of Medicine, and Chair of Neurogenetics at the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital (Duncan NRI), and Dr. Debdeep Dutta, a postdoctoral fellow in the Bellen lab. The Duncan NRI team found that in patients and animal models of this disorder, a large number of neurons ...

CLEVELAND– Case Western Reserve University biochemical researchers have identified a new function of a key protein that leads to cancer–a finding they believe could lead to more effective treatments for a range of cancers and other diseases.   The protein is LSD1 (lysine-specific histone demethylase 1A), which functions as a type of traffic cop inside human cells. It controls gene activity during embryonic development and regulating gene expression throughout life.   Scientists have also identified in recent years that the overexpression of LSD1—in this instance, producing too many proteins—can ...

BUFFALO, N.Y. – The ability to accurately detect heat and pain is critical to human survival, but scientists have struggled to understand on a molecular level exactly how our bodies sense these potential risks. Now, University at Buffalo researchers have unraveled the complex biological phenomena that drive these critical functions. Their research, published in the Proceedings of the National Academy of Sciences on Aug. 28, has uncovered a previously unknown and completely unexpected “suicidal” reaction in ion channel receptors that explains the complicated mechanisms that underlie sensitivity to temperature and pain. The ...

Researchers from Trinity College Dublin have discovered some new and surprising ways that viral RNA and influenza virus are detected by human lung cells, which has potential implications for treating people affected by such viruses. Influenza viruses remain a major threat to human health and can cause severe symptoms in young, elderly, and immuno-compromised populations, leading to annual epidemics which endanger between 3 and 5 million people of severe illness and cause 290,000 to 650,000 deaths worldwide. These viruses primarily target respiratory epithelial cells ...

PHILADELPHIA – A broad new strategy could hold hope for treating virtually all blood cancers with CAR T cell therapy, which is currently approved for five subtypes of blood cancer. Scientists in the Perelman School of Medicine at the University of Pennsylvania have demonstrated the potential efficacy of this approach in preclinical tests. In the study, published today in Science Translational Medicine, the researchers used engineered CAR T cells to target CD45—a surface marker found on nearly all blood cells, including nearly all blood cancer cells. Because CD45 is found on healthy blood cells too, the research team used CRISPR base-editing to develop a method ...

JooYoung Seo, assistant professor in the School of Information Sciences at the University of Illinois Urbana-Champaign, has been awarded a $649,921 Early Career Development grant from the Institute of Museum and Library Services (IMLS grant RE-254891-OLS-23), under the Laura Bush 21st Century Librarian Program, which supports “developing a diverse workforce of librarians to better meet the changing learning and information needs of the American public by enhancing the training and professional development of librarians, developing faculty and library leaders, and recruiting and ...