(Press-News.org) Recent studies have found that anesthesia drugs have neurotoxicity on the developing neurons, causing learning and memory disorders and behavioral abnormalities. Ketamine is commonly used in pediatric anesthesia. A clinical retrospective study found that children below 3 years old who receive a long time surgery, or because of surgery require ketamine repeatedly will exhibit the performance of school-age learning and memory disorders and behavioral abnormalities. Research group speculates that these abnormalities may be related to the potential neurotoxicity of ketamine. A recent study published in the Neural Regeneration Research (Vol. 8, No. 17, 2013) showed that ketamine could induce tau phosphorylation and neuronal toxicity in the development of neurons detected using molecular biology techniques from aspects of gene and protein levels. The relevant findings suggest that ketamine induces tau hyperphosphorylation at serine 404, resulting in damage to microtubule and axonal transport. Such damage may cause neurotoxicity and neuronal death in neonatal rats, consistent with previous studies demonstrating ketamine-induced neuronal apoptosis.
INFORMATION:
Article: " Ketamine induces tau hyperphosphorylation at serine 404 in the hippocampus of neonatal rats " by Haiyan Jin1, Zhiyong Hu1, Mengjie Dong2, Yidong Wu3, Zhirui Zhu1, Lili Xu4 (1 Department of Anesthesiology, The Children's Hospital, School of Medicine, Key Laboratory of Reproductive Genetics, Ministry of Education, Zhejiang University, Hangzhou 310003, Zhejiang Province, China; 2 PET Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China; 3 Department of Central Laboratory, The Children's Hospital, School of Medicine, Key Laboratory of Reproductive Genetics, Ministry of Education, Zhejiang University, Hangzhou 310003, Zhejiang Province, China; 4 Department of Anesthesiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China)
Jin HY, Hu ZY, Dong MJ, Wu YD, Zhu ZR, Xu LL. Ketamine induces tau hyperphosphorylation at serine 404 in the hippocampus of neonatal rats. Neural Regen Res. 2013;8(17):1590-1596.
Contact:
Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
http://www.nrronline.org/
Full text: http://www.sjzsyj.org:8080/Jweb_sjzs/CN/article/downloadArticleFile.do?attachType=PDF&id=643
Ketamine as anesthetics can damage children's learning and memory ability
2013-07-19
ELSE PRESS RELEASES FROM THIS DATE:
Desktop printing at the nano level
2013-07-19
EVANSTON, Ill. --- A new low-cost, high-resolution tool is primed to revolutionize how nanotechnology is produced from the desktop, according to a new study by Northwestern University researchers.
Currently, most nanofabrication is done in multibillion-dollar centralized facilities called foundries. This is similar to printing documents in centralized printing shops. Consider, however, how the desktop printer revolutionized the transfer of information by allowing individuals to inexpensively print documents as needed. This paradigm shift is why there has been community-wide ...
Scientists discover new variability in iron supply to the oceans with climate implications
2013-07-19
The supply of dissolved iron to oceans around continental shelves has been found to be more variable by region than previously believed – with implications for future climate prediction.
Iron is key to the removal of carbon dioxide from the Earth's atmosphere as it promotes the growth of microscopic marine plants (phytoplankton), which mop up the greenhouse gas and lock it away in the ocean.
A new study, led by researchers based at the National Oceanography Centre Southampton, has found that the amount of dissolved iron released into the ocean from continental ...
Cheaper anti-cancer drug as effective as expensive drug in treating wet AMD
2013-07-19
An anti-cancer drug has been proven to be equally as effective in treating the most common cause of blindness in older adults as a more expensive drug specifically formulated for this purpose.
The results of a two-year trial, led by Queen's scientist Professor Usha Chakravarthy, and published in The Lancet today (Friday 19 July), show that two drug treatments Lucentis and Avastin are equally effective in treating neovascular or wet age-related macular degeneration (wet AMD).
Wet AMD is a common cause of sight loss in older people with at least 23,000 older people diagnosed ...
Overnights away from home affect children's attachments, U.Va. study shows
2013-07-19
Babies have an innate biological need to be attached to caregivers, usually their parents. But what happens when babies spend a night or more per week away from a primary caregiver, as increasingly happens in cases where the parents share custody, but do not live together?
In a new national study, University of Virginia researchers found that infants who spent at least one night per week away from their mothers had more insecure attachments to the mother compared to babies who had fewer overnights or saw their fathers only during the day.
The finding is reported in the ...
The hair of the dog
2013-07-19
Just over a century ago, Harvey Cushing published an account of a young woman who showed unusual symptoms because her glands were making excessive amounts of something. Subsequent research has shown that the thing in question is a set of hormones known as glucocorticoids that are produced by the adrenal glands, so "Cushing's disease" is now more commonly known as hyperadrenocorticism, at least by those who can pronounce it. The condition is particularly common in dogs, particularly as the animals grow older. Most cases result from a tumor in the pituitary gland but some ...
Haste and waste on neuronal pathways
2013-07-19
This news release is available in German. To write this little piece of text, the brain sends commands to arms and fingers to tap on the keyboard. Neuronal cells with their cable-like extensions, such as axons, transfer this information as electrical pulses that trigger muscles to move. The axonal signal speed can be to up to 100m/s in myelinated axons along the spinal cord.
For a long time, scientists assumed that axonal signal conduction is by and large digital: either there is a signal, "1", or there is no signal, "0".
Strong propagation speed variations
Now, ...
Disney Research develops method to provide tactile feedback in free air
2013-07-19
Depth cameras and other motion-tracking devices allow people to use natural gestures to play computer games, yet the experience remains unnatural because they can't feel what their eyes can see. Disney Research, Pittsburgh, has developed a solution, however, that could enhance not only games, but a variety of virtual experiences.
Called AIREAL, the new technology uses controlled puffs of compressed air – something akin to smoke rings – to create the impression of a ball bouncing off a hand, of an arm tingling from the flutter of a butterfly's wings, or of the rippling ...
Disney researchers reconstruct detailed 3D scenes from hundreds of high-resolution 2D images
2013-07-19
Investigators at Disney Research, Zürich have developed a method for using hundreds of photographic images to build 3D computer models of complex, real-life scenes that meet the increasing demands of today's movie, TV and game producers for high-resolution imagery.
Building 3D models from multiple 2D images captured from a variety of viewing positions is nothing new, but doing so for highly detailed or cluttered environments at high resolution has proved difficult because of the large amounts of data involved. The Disney Research, Zürich team, however, developed an algorithm ...
Controlling friction by tuning van der Waals forces
2013-07-19
This news release is available in German. For a car to accelerate there has to be friction between the tire and the surface of the road. The amount of friction generated depends on numerous factors, including the minute intermolecular forces acting between the two surfaces in contact – so-called van der Waals forces. The importance of these intermolecular interactions in generating friction has long been known, but has now been demonstrated experimentally for the first time by a research team led by Physics Professor Karin Jacobs from Saarland University and Professor ...
It's not just the heat -- it's the ozone: Study highlights hidden dangers
2013-07-19
During heat waves -- when ozone production rises -- plants' ozone absorption is curtailed, leaving more pollution in the air, and costing an estimated 460 lives in the UK in the hot summer of 2006.
Vegetation plays a crucial role in reducing air pollution, but new research by the Stockholm Environment Institute (SEI) at the University of York shows that they may not protect us when we need it most: during extreme heat, when ozone formation from traffic fumes, industrial processes and other sources is at its worst.
The reason, explained lead author Dr Lisa Emberson, is ...