(Press-News.org) Reston, VA (Embargoed until 11:00 a.m. EDT, Friday, June 11, 2021)--Preclinical trials of a new radiopharmaceutical to treat ovarian cancer have produced successful results, dramatically limiting tumor growth and decreasing tumor mass. Designed specifically for ovarian cancers that are resistant to traditional therapies, the new radiopharmaceutical can be produced in 25 minutes at low cost, which leads to better efficiency compared with alternative methods. This research was presented at the Society of Nuclear Medicine and Molecular Imaging 2021 Annual Meeting.
According to the American Cancer Society, more than 20,000 women are diagnosed with ovarian cancer each year and nearly 14,000 will die from the disease. Ovarian cancer patients have a five-year survival rate of 49.1 percent. It is the fifth leading cause of cancer-related death among women.
In the study, researchers utilized a new generator system to develop the targeted alpha-therapy Pb-214-TCMC-trastuzumab to treat HER2-postive ovarian cancer. Ovarian cancer cells and mice bearing ovarian cancer tumors were split into three groups: those treated with Pb-214-TCMC-trastuzumab, those treated with Pb-214-TCMC-IgG and an untreated control group. All groups were imaged over time to determine the effectiveness of the treatment.
Compared to the Pb-214-TCMC-IgG and control groups, the tumor signal for mice and cells treated with Pb-214-TCMC-trastuzumab decreased dramatically over the course of the study, signaling the efficacy of the therapy. There were no adverse side effects from the treatment as determined by weight loss of all animals surviving.
"The short 27-minute half-life of Pb-214 is ideal for fractioned alpha particle therapeutic applications," stated Mike Zamiara, study author and president of Niowave Inc. in East Lansing, Michigan. "The generator system can provide Pb-214 every hour, potentially providing a new source of alpha particle therapy to patients at lower cost. In the future, the generator system will be available for many therapeutic products in a turn-key system under development, providing reliable doses for improved patient care."
Abstract 93. "Therapeutic Efficacy of Pb-214-labeled Trastuzumab in a Preclinical Model of Ovarian Cancer," Abdullah Metebi, Comparative Medicine and Integrative Biology, Michigan State University, East Lansing, Michigan; Chelsea Nayback, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan; Jinda Fan, Departments of Radiology and Chemistry, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan; Nathan Johnson, John Diemer, Terry Grimm, Mike Zamiara, Niowave, Inc., Lansing, Michigan; and Kurt Zinn, Radiology and Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan.
INFORMATION:
All 2021 SNMMI Annual Meeting abstracts can be found online at https://jnm.snmjournals.org/content/62/supplement_1.
About the Society of Nuclear Medicine and Molecular Imaging
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and medical organization dedicated to advancing nuclear medicine and molecular imaging, vital elements of precision medicine that allow diagnosis and treatment to be tailored to individual patients in order to achieve the best possible outcomes.
SNMMI's members set the standard for molecular imaging and nuclear medicine practice by creating guidelines, sharing information through journals and meetings and leading advocacy on key issues that affect molecular imaging and therapy research and practice. For more information, visit http://www.snmmi.org
What The Study Did: This autopsy study examines differences in skeletal muscle and myocardial inflammation in patients who died with COVID-19 versus other diseases.
Authors: Tom Aschman, M.D., and Werner Stenzel, M.D., of the Charite-Universitatsmedizin Berlin, are the corresponding authors.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamaneurol.2021.2004)
Editor's Note: The article includes conflicts of interest and funding/support disclosures. Please see the article for additional information, including ...
The Fenton reaction is a chemical transition involving hydrogen peroxide (H2O2) and the ferrous (iron) ion, which acts as a catalyst. This process is used to destroy hazardous contaminants in wastewater through oxidation. In the atmosphere, a similar reaction, or "Fenton-like" reaction, occurs continuously with ferric oxalate([Fe(III)(C2O4)3]3-) and aerosols suspended in the air. This is the most frequent chemical reaction that occurs in the atmosphere. A particle's ability to oxidize is directly related to its phase, either gaseous or aqueous, which has an important impact on secondary organic aerosol (SOA) formation. Therefore, research is necessary not only to evaluate the contribution of this ...
Researchers at University of California San Diego School of Medicine used an artificial intelligence (AI) algorithm to sift through terabytes of gene expression data -- which genes are "on" or "off" during infection -- to look for shared patterns in patients with past pandemic viral infections, including SARS, MERS and swine flu.
Two telltale signatures emerged from the study, published June 11, 2021 in eBiomedicine. One, a set of 166 genes, reveals how the human immune system responds to viral infections. A second set of 20 signature genes predicts the severity of a patient's disease. For example, the need to hospitalize or use ...
Astronomers from University of Warwick and University of Exeter modelling the future of unusual planetary system found a solar system of planets that will 'pinball' off one another
Today, the system consists of four massive planets locked in a perfect rhythm
Study shows that this perfect rhythm is likely to hold for 3 billion years - but the death of its sun will cause a chain reaction and set the interplanetary pinball game in motion
Four planets locked in a perfect rhythm around a nearby star are destined to be pinballed around their solar system when their sun eventually dies, according to a study led by the University of Warwick that peers into its future.
Astronomers have modelled how the change in gravitational forces in the system as a result ...
When is a weed not a weed?
Can native plants be weeds?
Sweet pittosporum (Pittosporum undulatum) was once a well-behaved tree growing in gullies from Gippsland in Victoria up to Brisbane in Queensland.
But it is now a major problem, leading to an almost complete suppression of native vegetation where it has invaded. Programs to clear it have successfully allowed indigenous plants to return, and within 15 years, with moderate follow up, treated sites are well on the way to successful restoration.
However, there has been some debate on whether this is good or bad for birds such as the threatened Powerful Owl.
New research by Monash University scientists from the School of Biological Sciences published today in Ecological Solutions and ...
Astronomers have spotted a giant 'blinking' star towards the centre of the Milky Way, more than 25,000 light years away.
An international team of astronomers observed the star, VVV-WIT-08, decreasing in brightness by a factor of 30, so that it nearly disappeared from the sky. While many stars change in brightness because they pulsate or are eclipsed by another star in a binary system, it's exceptionally rare for a star to become fainter over a period of several months and then brighten again.
The researchers believe that VVV-WIT-08 may belong to a new class of 'blinking giant' binary star system, where a giant star ? 100 times larger ...
Oncotarget published "The presence of polymorphisms in genes controlling neurotransmitter metabolism and disease prognosis in patients with prostate cancer: a possible link with schizophrenia" reported that polymorphisms of neurotransmitter metabolism genes were studied in patients with prostate cancer (PC) characterized by either reduced or extended serum prostate-specific antigen doubling time corresponding to unfavorable and favorable disease prognosis respectively.
The following gene polymorphisms known to be associated with neuropsychiatric disorders were investigated:
A. The STin2 VNTR in the serotonin transporter SLC6A4 gene;
B. The 30-bp VNTR in the monoamine oxidase A MAOA gene;
C. The Val158Met polymorphism in the catechol-ortho-methyltransferase ...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and NEC Corporation jointly develop a 28-GHz phased-array transceiver that supports efficient and reliable 5G communications. The proposed transceiver outperforms previous designs in various regards by adapting fast beam switching and leakage cancellation mechanism.
With the recent emergence of innovative technologies, such as the Internet of Things, smart cities, autonomous vehicles, and smart mobility, our world is on the brink of a new age. This stimulates the use of millimeter-wave bands, which have far more signal bandwidth, to accommodate these new ideas. 5G can offer data ...
Medulloblastoma is a rare but devastating childhood brain cancer. This cancer can spread through the spinal fluid and be deposited elsewhere in the brain or spine. Radiation therapy to the whole brain and spine followed by an extra radiation dose to the back of the brain prevents this spread and has been the standard of care. However, the radiation used to treat such tumors takes a toll on the brain, damaging cognitive function, especially in younger patients whose brains are just beginning to develop.
A national study led by Washington University School of Medicine in St. Louis and St. Jude Children's Research Hospital suggests that children with what is called "average risk medulloblastoma" can receive a radiation "boost" to a smaller ...
Metformin is a widely prescribed blood sugar-lowering drug. It is often used as an early therapy (in combination with diet and lifestyle changes) for type 2 diabetes, which afflicts more than 34 million Americans.
Metformin works by lowering glucose production in the liver, reducing blood sugar levels that, in turn, improve the body's response to insulin. But scientists have also noted that metformin possesses anti-inflammatory properties, though the basis for this activity was not known.
In a study published online June 8, 2021 in the journal END ...
