PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Study shows higher healing rate using unique cell-based therapy in chronic venous leg ulcers

2012-08-03
(Press-News.org) CHAPEL HILL, N.C. -- Treating chronic venous leg ulcers with a topical spray containing a unique living human cell formula provides a 52 percent greater likelihood of wound closure than treatment with compression bandages only.

That's the conclusion of a new study conducted in part at the University of North Carolina School of Medicine and published online by The Lancet this week.

The Phase II clinical trial, which investigates the efficacy of HP802-247 from Healthpoint® Biotherapeutics, was designed to determine effectiveness of certain cell concentrations and dosing frequencies of HP802-247, when combined with standard care in treatment of chronic venous leg ulcers.

William Marston, MD, professor of surgery in the UNC School of Medicine and medical director of the UNC Wound Healing Clinic, is an investigator in the study and one of the article authors.

Venous leg ulcers are caused by impaired circulation in the vein system of the legs from blockages or damage. Typically, venous leg ulcers become chronic wounds if, after three months of standard treatment, they fail to heal. Chronic venous leg ulcers appear as open lesions and need specialized medical care. An estimated 1-2 million Americans suffer from venous leg ulcers.

HP802-247 is a living human cell formula consisting of skin cells (keratinocytes and fibroblasts), which release growth factors into the wound on a cellular level for tissue regeneration, along with fibrinogen, which forms a "cellular web" for blood clotting and elasticity. During the study, 228 patients were enrolled at 28 medical centers in the United States, including UNC. Two different cell concentrations and two separate dosing frequencies were tested with standard care, in addition to a control group, over a 12-week period.

Dr. Marston says, "In the past, some chronic venous leg ulcers were treated with skin grafts, which occasionally could break down and also required the patient to heal a partial thickness wound at the skin graft harvest site. During this study, unique living cells were sprayed on the patient's wound, which interacted with the patient's cells for improved wound healing."

"In the study, we determined the best dosing of the fibroblast/keratinocyte preparation that markedly accelerated the rate of healing of the wounds. We are currently preparing a Phase III pivotal trial to start late this year," adds Dr. Marston.

INFORMATION:

The citation for the Phase II study manuscript is: Kirsner RS, Marston WA, Snyder RJ, Lee TD, Cargill DI, Slade HB. A Multicentre Randomised Dosing Trial of Spray-Applied Cell Therapy With Human Allogeneic Fibroblasts and Keratinocytes for the Treatment of Chronic Venous Leg Ulcers. Lancet 2012; pending.

The study was funded by Healthpoint® Biotherapeutics.



ELSE PRESS RELEASES FROM THIS DATE:

Mapping the future of climate change in Africa

Mapping the future of climate change in Africa
2012-08-03
Our planet's changing climate is devastating communities in Africa through droughts, floods and myriad other disasters. Using detailed regional climate models and geographic information systems, researchers with the Climate Change and African Political Stability (CCAPS) program developed an online mapping tool that analyzes how climate and other forces interact to threaten the security of African communities. The program was piloted by the Robert S. Strauss Center for International Security and Law at The University of Texas at Austin in 2009 after receiving a $7.6 ...

New bat virus could hold key to Hendra virus

New bat virus could hold key to Hendra virus
2012-08-03
VIDEO: Gary Crameri, part of CSIRO’s bat virus team, discusses Cedar virus. Click here for more information. Australian scientists have discovered a new virus in bats that could help shed light on how Hendra and Nipah viruses cause disease and death in animals and humans. The new virus - named 'Cedar' after the Queensland location where it was discovered - is a close relative of the deadly Hendra and Nipah viruses. However, CSIRO's initial studies have discovered ...

www.AutismSeminarsOnDemand Offers Biomedical Autism Seminars at Drastic Discounts for month of August, 2012

2012-08-03
http://www.AutismSeminarsOnDemand.com, a website created by Dr. Kurt Woeller featuring a compilation of his lecture presentations on biomedical autism intervention, announced today that it's offering drastically reduced pricing for the month of August. Dr. Woeller's ability to provide detailed information regarding diagnostic testing, therapies, and protocols that is understandable for all parties makes his information unique in the world of autism education. Each seminar available via the website is a presentation Dr. Woeller has previously given on a specific topic ...

FASTSIGNS Receives Multiple Accolades for Excellence in Franchising

2012-08-03
With more than 25 years of experience in franchising, FASTSIGNS International Inc., the worldwide franchisor of FASTSIGNS visual communications, signage and graphics centers, was recently recognized for its strides in franchising by the Franchise Yardstick Index and 1851 Magazine. Listed alongside some of the franchise industry's biggest players, including Dunkin Donuts, Super 8 Motels and Subway, FASTSIGNS has been recognized as No. 3 on Franchise Yardstick Index's 2012 400 list. The ranking, which compared 20 different criteria, acknowledges FASTSIGNS for its consistent ...

How to Choose the Right Dorm Mattress

2012-08-03
You've done all your planning, purchased all your toiletries and linens and you think you are ready to send your child off to school. But did you think about the mattress he would sleep on? Of course, this may be provided by the dorm, but it is often a cheap mattress that is lumpy and worn. Wouldn't you feel better knowing that your child is getting the rest he needs to keep up with his demanding schedule? Due to the unique situation of living in a dormitory, you should take a few things into consideration before purchasing a dorm mattress: - Consider the space! Since ...

USAABT Fundraiser Sponsorship Opportunities

2012-08-03
Members of the US Bobsled and Skeleton Federation, including athletes from The United States of America Adaptive Bobsled Team (USAABT) and the US Paralympic Bobsled & Skeleton Association, Inc. located in Park City, Utah are scheduled to participate in 5 international driving schools this upcoming winter season. Teams will then compete in races across the US and Canada. A fundraising event will be held Friday, August 24, 2012 from 7-10pm at Molly Blooms Restaurant and Pub located at 6180 Ute Boulevard, Park City, Utah to raise funds to build a new modified bobsled. Driving ...

Werner Announces National Sweepstakes for Adventure Seeking Enthusiasts

2012-08-03
Werner Co., the world's leading ladder manufacturer, today announced a national sweepstakes with a chance to win an amazing, three-day adventure at Cabin Bluff, a world-class hunting and fishing destination located near Cumberland Island, Georgia. All outdoor adventure enthusiasts can now enter the contest by going to http://us.wernerco.com/adventuresweeps between August 1, 2012- September 28, 2012. "Werner is a brand that offers the best climbing solutions for both pros and consumers. Our products are rugged and durable and we want to give away an experience that ...

Art Activity Kits for Young Children Delivered to Your Home Each Month

2012-08-03
Create Abilities For Kids offers a unique solution to busy parents looking for ways to maximize quality time with their young children. Our art activity kits include everything you need to create a "masterpiece" with your little one. You won't need to shop around for anything. Our age-appropriate art kits are designed for ages three, four, or five. These all-inclusive kits will be delivered to your mailbox each month. This means you save time in planning, getting the materials, and doing the prep work because we've already done all of that for you. The art ...

Designer Curtains Affects Interior Designing Positively

2012-08-03
Interior designing is greatly affected by the change in the designs of curtains. It is said that the introduction of designer curtains has affected the way Interior designers deal with designs and planning. The introduction of designer curtains caused a great change for interior designers. Most of them studied again to apply the new way of designing the interiors of houses and establishments. Basically, the designer curtains nowadays are now part of the designing process. Some experts said that that the Interior designers had a tough time organizing their traditional ...

Onepath Systems Achieves Coveted Cisco Gold Status Certification

2012-08-03
Onepath Systems, LLC, a Marietta-based leading technology solutions provider, announced that it has acquired the coveted Gold Certification from Cisco Systems. The Cisco Channel Partner program provides Onepath with the resource framework to develop an expertise to sell, plan, design, implement and operate Cisco networking solutions. To earn Gold certification, Onepath was required to meet or surpass the rigorous service, support, customer satisfaction and networking competency requirements set forth by Cisco. "Receiving the Gold Partner status is a great achievement ...

LAST 30 PRESS RELEASES:

Landmark 20-year study of climate change impact on permafrost forests

Researchers take broadband high-resolution frequency combs into the UV

Not going out is the “new normal” post-Covid, say experts

Study shows broader screening methods help prevent spread of dangerous fungal pathogen in hospitals

Research spotlight: Testing a model for depression care in Malawi using existing medical infrastructure

Depression care in low-income nations can improve overall health

The BMJ investigates dispute over US group’s involvement in WHO’s trans health guideline

Personal info and privacy control may be key to better visits with AI doctors

NIH study demonstrates long-term benefits of weight-loss surgery in young people

Sustained remission of diabetes and other obesity-related conditions found a decade after weight loss surgery in adolescence

Low-level lead poisoning is still pervasive in the US and globally

How researchers can maximize biological insights using animal-tracking devices

Research shows new method helps doctors safely remove dangerous heart infections without surgery

Rapid horizontal eye movement can improve stability in people with Parkinson’s

Study finds COVID-19 pandemic worsened patient safety measures

Costs still on the rise for drugs for neurological diseases

Large herbivores have lived in Yellowstone National Park for more than 2,000 years

Antarctic penguin colonies can be identified and tracked from tourists' photos, using a computer model to reconstruct the 3D scene

For patients with alcohol use disorder, exercise not only reduces alcohol dependence, but also improves mental and physical health, per systematic review

Bones from Tudor Mary Rose shipwreck suggest handedness might affect collarbone chemistry

Farewell frost! New surface prevents frost without heat

Similarities in brain development between marmosets and humans

Can we protect nerve cells from dying?

Why does Lake Geneva emit large quantities of CO2? UNIL scientists provide the answer and solve a scientific enigma

Double strike against blood cancer

Combining VR and non-invasive brain stimulation: a neurotechnology that boosts spatial memory without surgery

A rudimentary quantum network link between Dutch cities

Accounting for bias in medical data helps prevent AI from amplifying racial disparity

MD Anderson Research Highlights for October 30, 2024

Three Baycrest leaders named 2024 Canada’s Most Powerful Women: WXN’s Top 100 Award winners

[Press-News.org] Study shows higher healing rate using unique cell-based therapy in chronic venous leg ulcers