Research provides new insights into role of mechanical forces in gene expression
The genome inside each of our cells is modelled by tension and torsion — due in part to the activity of proteins that compact, loop, wrap and untwist DNA — but scientists know little about how those forces affect the transcription of genes. “There are a lot of mechanical forces at play all the time that we never consider, we have very little knowledge of, and they’re not talked about in textbooks,” said Laura Finzi, the Dr. Waenard L. Miller, Jr. ’69 and Sheila M. Miller Endowed Chair in Medical Biophysics at Clemson University. Transcription is the process by which a cell makes an RNA copy of a segment of DNA. One ...
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