April 8, 2021 - Routinely collected data on patients undergoing spinal fusion surgery do not provide a valid basis for assessing and comparing hospital performance on patient safety outcomes, reports a study in Spine. The journal is published in the Lippincott portfolio by Wolters Kluwer. At a time when hospitals are increasingly subject to online rankings or "pay-for-performance" reimbursement programs, metrics based on hospital administrative data are "unreliable for profiling hospital performance," concludes the new research by Jacob K. Greenberg, MD, MSCI, of Washington University in St Louis and colleagues. ...

In a medical records study covering thousands of children, a U.S.-Canadian team led by researchers at Johns Hopkins Medicine concludes that while surgery to correct congenital heart disease (CHD) within 10 years after birth may restore young hearts to healthy function, it also may be associated with an increased risk of hypertension -- high blood pressure -- within a few months or years after surgery. ...

Waste materials from the pulp and paper industry have long been seen as possible fillers for building products like cement, but for years these materials have ended up in the landfill. Now, researchers at UBC Okanagan are developing guidelines to use this waste for road construction in an environmentally friendly manner. The researchers were particularly interested in wood-based pulp mill fly ash (PFA), which is a non-hazardous commercial waste product. The North American pulp and paper industry generates more than one million tons of ash annually by burning wood in ...

JUPITER, FL -- Damage to the autism-associated gene Dyrk1a, sets off a cascade of problems in developing mouse brains, resulting in abnormal growth-factor signaling, undergrowth of neurons, smaller-than-average brain size, and, eventually, autism-like behaviors, a new study from Scripps Research, Florida, finds. The study from neuroscientist Damon Page, PhD, describes a new mechanism underlying the brain undergrowth seen in individuals with Dyrk1a mutations. Page's team used those insights to target the affected pathway with an existing medicine, a growth hormone. It restored normal brain growth in the Dyrk1a mutant mice, Page says. "As of now, there's simply no targeted treatments available for individuals with autism spectrum ...

When you think of ways to treat opioid use disorder, you might think methadone clinics and Narcotics Anonymous meetings. You probably don't imagine stretches and strengthening exercises. But Anne Swisher--professor at the West Virginia University School of Medicine--is working to address opioid misuse in an unconventional way: through physical therapy. She and her colleagues have enhanced physical therapy instruction at WVU to emphasize the profession's role in preventing and treating opioid use disorder. "Students have different interests and passions within the profession, and they find their niche," said Swisher, a researcher and director of scholarship in the Division of Physical Therapy. "No matter what their passion is, there ...

EVANSTON, Ill. -- Five-star ratings are no guarantee to lead you to the perfect barber who truly understands your hair or to the espresso machine that brews a perfect cup of coffee. That's because most products online are now rated positively, making it harder than ever to truly discern whether they will succeed in the marketplace. A new study from Northwestern University Kellogg School of Management and the University of Massachusetts Boston was able to predict the success of movies, commercials, books and restaurants by relying on the "emotionality" of reviews instead of the star rating. The researchers explored box office revenue of 2,400 movies, sales of 1.6 million books and real-world reservations at ...

Astronomers at Western University have discovered the most rapidly rotating brown dwarfs known. They found three brown dwarfs that each complete a full rotation roughly once every hour. That rate is so extreme that if these "failed stars" rotated any faster, they could come close to tearing themselves apart. Identified by NASA's Spitzer Space Telescope, the brown dwarfs were then studied by ground-based telescopes including Gemini North, which confirmed their surprisingly speedy rotation. Three brown dwarfs have been discovered spinning faster than any other found before. Astronomers at Western University in Canada first measured the rotation speeds of these brown dwarfs using NASA's Spitzer Space Telescope and confirmed them with follow-up ...

Taiwan is an island of extremes: severe earthquakes and typhoons repeatedly strike the region and change the landscape, sometimes catastrophically. This makes Taiwan a fantastic laboratory for geosciences. Erosion processes, for example, occur up to a thousand times faster in the center of the island than in its far south. This difference in erosion rates influences the chemical weathering of rocks and yields insights into the carbon cycle of our planet on a scale of millions of years. A group of researchers led by Aaron Bufe and Niels Hovius of the German Research Center for Geosciences (GFZ) has now taken advantage of the different erosion rates and investigated how uplift and erosion of rocks determine the balance of carbon emissions ...

Having a responsive, supportive partner minimizes the negative impacts of an individual's depression or external stress on their romantic relationship, according to research by a University of Massachusetts Amherst social psychologist. Paula Pietromonaco, professor emerita of psychological and brain sciences, drew on data from her Growth in Early Marriage project (GEM) to investigate what she had discovered was an under-studied question. Findings are published in the journal Social Psychological and Personality Science. "I was really surprised that although there's a ton of work out there on depression, there ...

Boulder, Colo., USA: Gale Crater's central sedimentary mound (Aeolis Mons or, informally, Mount Sharp) is a 5.5-km-tall remnant of the infilling and erosion of this ancient impact crater. Given its thickness and age, Mount Sharp preserves one of the best records of early Martian climatic, hydrological, and sedimentary history. In this paper, published today in Geology, William Rapin and colleagues present the first description of key facies in the sulfate-bearing unit, recently observed in the distance by the rover, and propose a model for changes in depositional environments. The basal part of this sedimentary sequence is ahead of the Curiosity rover traverse and was recently analyzed with unprecedented resolution by the rover ...

While it isn't surprising that infants and children love to look at people's movements and faces, recent research from Rochester Institute of Technology's National Technical Institute for the Deaf studies exactly where they look when they see someone using sign language. The research uses eye-tracking technology that offers a non-invasive and powerful tool to study cognition and language learning in pre-verbal infants. NTID researcher and Assistant Professor Rain Bosworth and alumnus Adam Stone studied early-language knowledge in young infants and children by recording their gaze patterns as they watched a signer. The goal was to learn, just from gaze patterns alone, ...

"Not all those who wander are lost ... " --J.R.R. Tolkien Known as "the lost years," it is a little-understood journey that unfolds over thousands of miles and as much as two decades or more. Now, a Stanford-led study illuminates secrets of the North Pacific loggerhead turtles' epic migration between their birthplace on the beaches of Japan and reemergence years later in foraging grounds off the coast of Baja California. The study, published April 8 in Frontiers in Marine Science, provides evidence for intermittent passages of warm water that allow sea turtles to cross otherwise inhospitably cold ocean barriers. The findings could help inform the design of conservation measures to protect sea turtles and other migratory sea creatures amid climatic ...

The Perseverance rover has just landed on Mars. Meanwhile, its precursor Curiosity continues to explore the base of Mount Sharp (officially Aeolis Mons), a mountain several kilometres high at the centre of the Gale crater. Using the telescope on the ChemCam instrument to make detailed observations of the steep terrain of Mount Sharp at a distance, a French-US team headed by William Rapin, CNRS researcher at the Institut de Recherche en Astrophysique et Planétologie (CNRS/Université Toulouse III/CNES) (1), has discovered that the Martian climate recorded there alternated between dry and wetter periods, before drying up completely about 3 billion years ago. Spacecraft in orbit ...

Heart failure and stroke are unusual diagnoses among younger people. But they are now clearly on the rise in men below the age of 40, according to a University of Gothenburg study. The scientists have found links to obesity and low fitness in the upper teens. The present study, published in Journal of Internal Medicine, includes data on 1,258,432 men who, at an average age of 18.3 years, enlisted for military service in Sweden between 1971 and 1995. Particulars of the men's weight, height and physical fitness on enlistment were merged with data in the National Board of Health and Welfare's National Patient Register and Cause of Death Register for the period 1991-2016. From when they enlisted, the men were thus monitored over a period exceeding 20 years. The proportion ...

Researchers at GMI - Gregor Mendel Institute of Molecular Plant Biology of the Austrian Academy of Sciences - uncover an ingenious mechanism by which Arabidopsis safeguards the integrity of its genome. The paper is published in the journal Nature Cell Biology. Is it possible for one single gene product to silence undesirable genetic elements? Can such a strong effect be seen in the regulation of Transposable Elements (TEs), or genome parasites? If yes, how does this gene product singlehandedly keep transposons in check? New research from Frédéric Berger's group at GMI provides answers to these questions and dissects a mechanism of gene silencing that has long remained shrouded in mystery. Genome parasites Although jumping transposons promote ...

Flamingo chicks raised by foster parents from another flamingo species develop normally, scientists say. Six Chilean flamingo chicks were reared by Andean flamingos - a species of similar size and behaviour - at WWT Slimbridge Wetland Centre in the summer of 2018. University of Exeter scientists studied the chicks' behaviour after they re-joined the Chilean flamingo flock early in 2019. The results showed fostering had no negative effects, with fostered flamingos still forming stable social ties - making "friends" and behaving like parent-reared birds. "Slimbridge's Andean flamingos hadn't nested for about 20 years," said Dr Paul Rose, of the University of Exeter. "But in the ...

Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability https://doi.org/10.1016/j.apsb.2020.07.016 Of all known small molecules targeting human immunodeficiency virus (HIV) capsid protein (CA), PF74 represents by far the best characterized chemotype, due to its ability to confer antiviral phenotypes in both early and late phases of viral replication. However, the prohibitively low metabolic stability renders PF74 a poor antiviral lead. The authors report on their medicinal chemistry efforts ...

A consortium of researchers from Russia, Belarus, Japan, Germany and France led by a Skoltech scientist have uncovered the way in which Mycobacterium tuberculosis survives in iron-deficient conditions by utilizing rubredoxin B, a protein from a rubredoxin family that play an important role in adaptation to changing environmental conditions. The new study is part of an effort to study the role of M. tuberculosis enzymes in developing resistance to the human immune system and medication. The paper was published in the journal Bioorganic Chemistry. According to the World Health Organization, every year 10 million people fall ill with tuberculosis and about 1.5 million die from it, making it the world's top infectious killer. ...

A great need for better pain treatment After an appendectomy, a quarter (24.8%) of all children wanted a stronger pain treatment in the first 24 hours after their operation. Among children who had a tonsillectomy, this was one-fifth (20.2%). Analysis of the data showed that this desire was primarily associated with sleep impairments and with movement pain. The lead author of the study, Prof. Ulrike M. Stamer, explained: "We are dealing with a large number of affected patients. Appendectomies and tonsillectomies are the most common operations performed on children overall. Just under a quarter of these cases strongly signal a desire for improvement". A comprehensive, multicentre study This study is based on the international pain registry "PAIN OUT infant", which was established ...

TAMPA, Fla. (April 8, 2021) -- A dysfunctional immune system significantly contributes to the development of cancer. Several therapeutic strategies to activate the immune system to target cancer cells have been approved to treat different types of cancer, including melanoma. However, some patients do not show beneficial clinical responses to these novel and very promising immunotherapies. In a new article published in Proceedings of the National Academy of Sciences of the United States of America, Moffitt Cancer Center researchers demonstrate how an important defect in STING gene expression in melanoma cells contributes to their evasion from immune cell detection and destruction. Several different mechanisms have been discovered ...

Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products Endophytic fungi are promising producers of bioactive small molecules. Bioinformatic analysis of the genome of an endophytic fungus Penicillium dangeardii revealed 43 biosynthetic gene clusters, exhibited its strong ability to produce numbers of secondary metabolites. However, this strain mainly produce rubratoxins alone with high yield in varied culture conditions, suggested most gene clusters are silent. Efforts for mining the cryptic gene clusters in P. dangeardii, including epigenetic regulation and one-strain-many-compounds (OSMAC) approach were failed probably due to the high yield of rubratoxins. A metabolic ...

A team of archaeologists in north-west the Kingdom of Saudi Arabia has uncovered the earliest evidence of dog domestication by the region's ancient inhabitants. The discovery came from one of the projects in the large-scale archaeological surveys and excavations of the region commissioned by the Royal Commission for AlUla (RCU). The researchers found the dog's bones in a burial site that is one of the earliest monumental tombs identified in the Arabian Peninsula, roughly contemporary with such tombs already dated further north in the Levant. Evidence ...

Indole, and structures derived from it, are a component of many natural substances, such as the amino acid tryptophan. A new catalytic reaction produces cyclopenta[b]indoles--frameworks made of three rings that are joined at the edges--very selectively and with the desired spatial structure. As a research team reports in the journal Angewandte Chemie, the rates of the different steps of the reaction play a critical role. Indole derivates are widely distributed in nature; they are part of serotonin and melatonin, as well as many alkaloids--some of which are used as drugs, for example, as treatments for Parkinson's disease. Indole is an aromatic six-membered ring fused to a five-membered ring along one edge. The five-membered ring has a double bond and ...

Using a surprisingly simple technique, researchers in the University of Arizona Department of Neuroscience have succeeded in approximating how many brain cells make up the brains of several species of bees, ants and wasps. The work revealed that certain species of bees have a higher density of brain cells than even some species of birds, whereas ants turned out to have fewer brain cells than originally expected. Published in the scientific journal Proceedings of the Royal Society B, the study marks the first time the new cell counting method has been applied to invertebrate animals and provides a robust and reproducible protocol for other research groups studying the brains of ...

Discovery of novel diarylamides as orally active diuretics targeting urea transporters Urea transporters (UT) play a vital role in the mechanism of urine concentration and are recognized as novel targets for the development of salt-sparing diuretics. Thus, UT inhibitors are promising for development as novel diuretics. In this study the authors discovered a novel UT inhibitor with a diarylamide scaffold by high-throughput screening. Optimization of the inhibitor led to the identification of a promising preclinical candidate, N-[4-(acetylamino)phenyl]-5-nitrofuran-2-carboxamide ...